Presenilin-1: A component of synaptic and endothelial adherens junctions

Annals of the New York Academy of Sciences

Volumn 920, Issue , 2000, Pages 209-214

  Georgakopoulos, Anastasios ^a   Marambaud, Philippe ^a   Friedrich Jr , Victor L ^a   Shioi, Junichi ^a   Efthimiopoulos, Spiros ^a   Robakis, Nikolaos K ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRESENILIN 1;

ALZHEIMER DISEASE; CELL ADHESION; CELL INTERACTION; COMPLEX FORMATION; CONFERENCE PAPER; ENDOPLASMIC RETICULUM; PEPTIDE SYNTHESIS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN PROCESSING; SYNAPTIC TRANSMISSION;

EID: 0034531647     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06924.x     Document Type: Conference Paper

References (25)

1. Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts
2. Presenilins: Molecular switches between proteolysis and signal transduction
3. Translation cell biology into therapeutic advances in Alzheimer's disease
4. Molecular and functional analysis of cadherin-based adherens junctions
5. Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles
6. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
7. In search of gamma secretase
8. Cadherins in the developing central nervous system: An adhesive code for segmental and functional subdivisions
9. The cadherin superfamily at the synapse more members, more missions
10. A role for the cadherin family of cell adhesion molecules in hippocampal long-term potentiation
11. Identification and neuron specific expression of the S182/presenilin 1 protein in human and rodent brains
12. Presenilin-1-immunoreactive neurons are preserved in late-onset Alzheimer's disease
13. Skeletal and CNS defects in presenilin-1-deficient mice
14. Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression
15. Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis
16. Structure and function in rhodopsin. 7. Point mutations associated with autosomal dominant retinitis pigmentosa
17. Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex
18. Structural basis of the cognitive alterations in Alzheimer disease
19. Intracellular routing of human amyloid protein precursor: Axonal delivery followed by transport to dendrites
20. Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system
21. Beta amyloid precursor protein mediates neuronal cell-cell and cell-surface adhesion
22. The regulation of amyloid beta protein precursor secretion and its modulatory role in cell adhesion
23. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
24. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
25. E-cadherin null mutant embryos fail to form a trophectoderm epithelium