Contrasting antioxidant and cytotoxic effects of peroxiredoxin I and II in PC12 and NIH3T3 cells

Neurochemical Research

Volumn 25, Issue 12, 2000, Pages 1613-1621

  Simzar, Soheil ^a   Ellyin, Raymond ^a   Shau, Hungyi ^b   Sarafian, Theodore A ^a  

^a Departments of Laboratory Medicine   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Caspase 3; Fibroblats; Glutathione; Neurons; Peroxiredoxin; ROS

Indexed keywords

CASPASE 3; GLUTATHIONE; ISOENZYME; MENADIONE; NITRIC OXIDE SYNTHASE; PEROXIREDOXIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL VIABILITY; CYTOTOXICITY; ENZYME ACTIVITY; FIBROBLAST; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

3T3 CELLS; ANIMALS; CASPASE 3; CASPASES; CELL SURVIVAL; FIBROBLASTS; GLUTATHIONE; MICE; NEURONS; PC12 CELLS; PEROXIDASES; RATS; REACTIVE OXYGEN SPECIES; TRANSFECTION;

ANIMALIA;

EID: 0034527098     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026670620633     Document Type: Article

References (67)

1. The roles of free radicals in amyotrophic lateral selemsis: Reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids
2. Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients
3. Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis
4. Free radicals as mediators of neuronal injury
5. Amyloid peptides are toxic via a common oxidative mechanism
6. All assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease
7. Cytochemical demonstration oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenythydrazine
8. Transgenic mice and knockout mutants in the study of oxidative stress in brain injury
9. Endogenous glutathione protects cerebral endothelial cells from traumatic injury
10. Review of oxidative stress in brain and spinal cord injury: Suggestions for pharmacological and nutritional management strategies
11. The presence of 4-hydroxynonenal/protein complex as an indicator of oxidative stress after experimental spinal cord contusion in a rat model
12. Reactive oxygen species: Relation to aging and neurotoxic damage
13. Positron emission tomography: Human brain function and biochemistry
14. Oxygen-derived free radicals in postischemic tissue injury
15. Isoquinoline neurotoxins in the brain and Parkinson's disease
16. Stimulation of synaptosomal free radical production by fatty acids: Relation to esterification and to degree of unsaturation
17. Nitric oxide neurotoxicity
18. Calcium in ischemic cell death
19. Global brain ischemia and reperfusion
20. Oxidants, antioxidants, and the degenerative diseases of aging
21. Cell and tissue responses to oxidative damage
22. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress
23. Oxidative stress: Oxidants and antioxidants
24. Cloning and sequencing of thiol-specific antioxidant from mammalian brain: Alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes
25. Cloning and sequence analysis of candidate human natural killer-enhancing factor genes
26. Characterization of three isoforms of mammalian peroxiredoxin that reduce peroxides in the presence of thioredoxin
27. On the protective mechanism of the thiol-specific antioxidant enzyme against the oxidative damage of biomacromolecules
28. Cellular antioxidant properties of human natural killer enhancing factor B
29. Removal of hydrogen peroxide by thiol-specific antioxidant enzyme (TSA) is involved with its antioxidant properties. TSA possesses thiol peroxidase activity
30. Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product
31. The type II peroxiredoxin gene family of the mouse: Molecular structure, expression and evolution
32. Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury
33. Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha
34. Rapid degradation of PrxI and PrxII induced by silica in Rat2 cells
35. Expression of the antioxidant gene NKEF in the central nervous system
36. Differential expression of peroxiredoxin subtypes in human brain cell types
37. Induction of peroxiredoxins in transplanted livers and demonstration of their in vitro cytoprotection activity
38. bcl-2 expression decreases methyl mercury-induced free-radical generation and cell killing in a neural cell line
39. Thalidomide inhibits angiogenesis in embryoid bodies by the generation of hydroxyl radicals
40. Flow cytometric studies of oxidative product formation by neutrophils: A graded response to membrane stimulation
41. Determination of nitric oxide generation in mammalian neurons using dichlorofluorescin diacetate and flow cytometry
42. 2,7-Dihydrodichlorofluorescein diacetate as a fluorescent marker for peroxynitrite formation
43. In vivo quantitation of peroxides in the vitreous humor by fluorophotometry
44. Phenoxyl free radical formation during the oxidation of the fluorescent dye 2′, 7′-dichlorofluorescein by horseradish peroxidase. Possible consequences for oxidative stress measurements
45. Dual regulation of caspase activity by hydrogen peroxide: Implications for apoptosis
46. Fas-induced caspase denitrosylation
47. Antioxidant function of recombinant human natural killer enhancing factor
48. Cloning and characterization of AOEB 166, a novel mammalian antioxidant enzyme of the peroxiredoxin family
49. Enhancement of gamma-glutamylcysteine synthetase mRNA in rat kidney by methyl mercury
50. An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamylcysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site
51. Relationships between neuronal death and the cellular redox stares. Focus on the developing nervous system
52. Nitric oxide in cerebral ischemic neurodegeneration and excitotoxicity
53. Redox modulatory site of the NMDA receptor-channel complex: Regulation by oxidized glutathione
54. Modulation of N-methyl-D-aspartate receptors by hydroxyl radicals in rat cortical neurons in vitro
55. Effects of pyrroloquinoline quinone on glutamate-induced production of reactive oxygen species in neurons
56. Functional N-methyl-D-aspartate receptors in clonal rat phaeochromocytoma cells
57. Expression of N-methyl-D-aspartate receptor subunit mRNAs in the rat pheochromocytoma cell line PC12
58. Both neuronal NO synthase and nitric oxide are required for PC12 cell differentiation: A cGMP independent pathway
59. Oxidative stress hypothesis in Alzheimer's disease
60. ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis
61. Co-localization of P450 enzymes in the rat substantia nigra with tyrosine hydroxylase
62. Oxidative mechanisms in nigral cell death in Parkinson's disease
63. Antioxidant enzymatic systems in neuronal and glial cell-enriched fractions of rat brain during aging
64. Cellular and regional distribution of reduced glutathione in the nervous system of the rat: Histochemical localization by mercury orange and o-phthaldialdehyde-induced histofluorescence
65. Cellular resistance to methylmercury
66. Response of glial cells to ischemia: Roles of reactive oxygen species and glutathione
67. Astrocytes protect neurons from hydrogen peroxide toxicity