Endogenous glutathione protects cerebral endothelial cells from traumatic injury

Journal of Neurotrauma

Volumn 16, Issue 1, 1999, Pages 27-36

  Gidday, Jeffrey M ^a   Beetsch, Joel W ^a   Park, T S ^a  

^a ST LOUIS CHILDREN S HOSPITAL   (United States)

Author keywords

Blood brain barrier; Edema; Endothelium; Glutathione peroxidase; Oxygen free radicals; Oxypurinol; Traumatic brain injury

Indexed keywords

GLUTATHIONE; GLUTATHIONE PEROXIDASE; LACTATE DEHYDROGENASE; OXIPURINOL;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; BLOOD VESSEL INJURY; BRAIN EDEMA; BRAIN INJURY; CELL PROTECTION; CEREBROVASCULAR DISEASE; DOSE RESPONSE; ENDOTHELIUM CELL; ENZYME INHIBITION; GLUTATHIONE METABOLISM; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; SWINE; VASCULAR ENDOTHELIUM;

EID: 0032917087     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.1999.16.27     Document Type: Article

References (54)

1. BARKER, J.E., BOLANOS, J.P., LAND, J.M., CLARK, J.B., and HEALES, S.J.R. (1996). Glutathione protects astrocytes from peroxynitrite-mediated mitochondrial damage: implications for neuronal/astrocytic trafficking and neurodegeneration. Dev. Neurosci. 18, 391-396.
2. BECKMAN, J.S., YE, Y.Z., CHEN, J., and CONGER, K.A. (1996). The interactions of nitric oxide with oxygen radicals and scavengers in cerebral ischemic injury. Adv. Neurol. 71, 339-354.
3. BEETSCH, J.W., PARK, T.S., DUGAN, L.L., SHAH, A.R., and GIDDAY, J.M. (1998). Xanthine oxidase-derived superoxide causes reoxygenation injury of ischemic cerebral endothelial cells. Brain Res. 786, 89-95.
4. BETZ, A.L. (1985). Identification of hypoxanthine transport and xanthine oxidase activity in brain capillaries. J. Neurochem. 44, 574-579.
5. BETZ, A.L. (1993). Oxygen free radicals and the brain microvasculature, in: The Blood-Brain Barrier. W.M. Pardridge (ed), Raven: NY, pps. 303-321.
6. BLUM, J., and FRIDOVICH, I. (1985). Inactivation of glutathione peroxidase by superoxide radical. Arch. Biochem. Biophys. 240, 500-508.
7. CHAN, P.H., LONGAR, S., and FISHMAN, R.A. (1987). Protective effects of liposome-entrapped superoxide dismutase on posttraumatic brain edema. Ann. Neurol. 21, 540-547.
8. CHEN, S.-H., WU, H.-L., LIN, M.T., et al. (1992). Cytoprotective effect of reduced glutathione in hydrogen peroxide-induced endothelial cell injury. Prostaglandins Leukot. Essent. Fatty Acids 45, 299-305.
9. CLARK, R.S.B., CARCILLO, J.A., KOCHANEK, P.M., et al. (1997). Cerebrospinal fluid adenosine concentration and uncoupling of cerebral blood flow and oxidative metabolism after severe head injury in humans. Neurosurgery 41, 1284-1292.
10. DEWITT, D.S., SMITH, T.G., DEYO, D.J., MILLER, K.R., UCHIDA, T., and PROUGH, D.S. (1997). L-Arginine and superoxide dismutase prevent or reverse cerebral hypoperfusion after fluid-percussion traumatic brain injury. J. Neurotrauma 14, 223-233.
11. DIETRICH, W.D., ALONSO, O., BUSTO, R., et al. (1996). Widespread hemodynamic depression and focal platelet accumulation after fluid percussion brain injury: a double-label autoradiographic study in rats. J. Cereb. Blood Flow Metab. 16, 481-489.
12. 2+ signaling in endothelial cells. Am. J. Physiol. 268, H278-H287.
13. ELLIS, E.F., McKINNEY, J.S., WILLOUGHBY, K.A., LIANG, S., and POVLISHOCK, J.T. (1995). A new model for rapid stretch-induced injury of cells in culture: characterization of the model using astrocytes. J. Neurotrauma 12, 325-339.
14. FUKUDA, K., TANNO, H., OKIMURA, Y., NAKARMURA, M., and YAMAURA, A. (1995). The blood-brain barrier disruption to circulating proteins in the early period after fluid percussion brain injury in rats. J. Neurotrauma 12, 315-324.
15. GOBBEL, G.T., CHAN, T.Y.Y., and CHAN, P.H. (1997). Nitric oxide- and superoxide-mediated toxicity in cerebral endothelial cells. J. Pharmacol. Exp. Ther. 282, 1600-1607.
16. GOLDMAN, H., HODGSON, V., MOREHEAD, M., HAZLETT, J., and MURPHY, S. (1991). Cerebrovascular changes in a rat model of moderate closed-head injury. J. Neurotrauma 8, 129-144.
17. GOSS, J.R., KOCHANEK, P.M., and DEKOSKY, S.T. (1997). The antioxidant enzymes glutathione peroxidase and catalase increase following traumatic brain injury in the rat. Exp. Neurol. 146, 291-294.
18. GOURIN, C.G., and SHACKFORD, S.R. (1996). Influence of piercussion trauma on expression of intercellular adhesion molecule-1 (ICAM-1) by human cerebral microvascular endothelium. J. Trauma 41, 129-135.
19. HALL, E.D. (1996). Free radicals and lipid peroxidation, in: Neurotrauma. R.K. Narayan, I.E. Wilberger, and J.T. Povlishock (eds), McGraw-Hill: NY, pps. 1405-1419.
20. HALL, E.D., ANDRUS, P.K., and YONKERS, P.A. (1993). Brain-hydroxyl radical generation in acute experimental head injury. J. Neurochem. 60, 588-594.
21. HALL, E.D., YONKERS, P.A., ANDRUS, P.K., COX, J.W., and ANDERSON, D.K. (1992). Biochemistry and pharmacology of lipid antioxidants in acute brain and spinal cord injury. J. Neurotrauma 9, Suppl. 2, S425-S442.
22. HEADRICK, J.P., BENDALL, M.R., FADEN, A.I., and VINK, Fl. (1994). Dissociation of adenosine levels from bioenergetic state in experimental brain trauma: potential role in secondary injury. J. Cereb. Blood Flow Metab 14, 853-861.
23. HEKMATPANAH, I., and HEKMATPANAH, C.R. (1985). Microvascular alterations following cerebral contusion in rats. J. Neurosurg. 62, 888-897.
24. HSU, C.Y., HU, Z.Y., and DOSTER, S.K. (1996). Cell-mediated injury, in: Neurotrauma. R.K. Narayan, J.E. Wilberger, and J.T. Povlishock (eds), McGraw-Hill: New York, pps. 1433-1444.
25. 2 in newborn pig brain microvascular endothelial cells. Am. J. Physiol. 264, H1485-H1492.
26. KALARIA, R.N., and HARIK, S.I. (1986). Nucleoside transporter of cerebral microvessels and choroid plexus. J. Neurochem. 47, 1849-1856.
27. KINNULA, V.L., WHORTON, A.R., CHANG, L.-Y., and CRAPO, J.D. (1992). Regulation of hydrogen peroxide generation in cultured endothelial cells. Am. J. Respir. Cell Mol. Biol. 6, 175-182.
28. KOCHANEK, O.M., MARION, D.W., ZHANG, W.G., et al. (1995). Severe controlled cortical impact in rats: assessment of cerebral edema, blood flow, and contusion volume. J. Neurotrauma 12, 1015-1025.
29. KONTOS, H.A., and WEI, E.P. (1986). Superoxide production in experimental brain injury. J. Neurosurg. 64, 803-807.
30. KONTOS, H.A., and WEI, E.P. (1992). Endothelium-dependent responses after experimental brain injury. J. Neurotrauma 9, 349-354.
31. McINTOSH, T.K. (1994). Neurochemical sequelae of traumatic brain injury: therapeutic implications. Cerebrovasc. Brain Metab. Rev. 6, 109-162.
32. McINTOSH, T.K., THOMAS, M., SMITH, D., and BANBURY, M. (1992). The novel 21-aminosteroid U74006F attenuates cerebral edema and improves survival after brain injury in the rat. J. Neurotrauma 9, 33-46.
33. McFINNEY, J.S., WILLOUGHBY, K.A., LIANG, S., and ELLIS, E.F. (1996). Stretch-induced injury of cultured neuronal, glial, and endothelial cells. Effect of polyethylene glycol-conjugated superoxide dismutase. Stroke 27, 934-940.
34. MESENGE, C., VERRECCHIA, C., ALLIX, M., BOULU, R. R., and PLOTKINE, M. (1996). Reduction of the neurological deficit in mice with traumatic brain injury by nitric oxide synthase inhibitors. J. Neurotrauma 13, 209-214.
35. MIKAWA, S., KINOUCHI, H., KAMII, H., et al. (1996). Attenuation of acute and chronic damage following traumatic brain injury in copper, zinc-superoxide dismutase transgenic mice. J. Neurosurg. 85, 885-891.
36. MIZUI, T., KINOUCHI, H., and CHAN, P.H. (1992). Depletion of brain glutathione by buthionine sulfoximine enhances cerebral ischemic injury in rats. Am. J. Physiol. 262, H313-H317.
37. MOORHOUSE, P.C., GROOTVELD, M., HALLIWELL, B., QUINLAN, J.G., and GUTTERIDGE, J.M.C. (1987). Allopurinol and oxypurinol are hydroxyl radical scavengers. F.E.B.S. Lett. 213, 23-28.
38. MUIR, J.K., BOERSCHEL, M., and ELLIS, E.F. (1992). Continuous monitoring of posttraumatic cerebral blood flow using laser-doppler flowmetry. J. Neurotrauma 9, 355-362.
39. MUIR, J.K., TYNAN, M., CALDWELL, R., and ELLIS, E.F. (1995). Superoxide dismutase improves posttraumatic cortical blood flow in rats. J. Neurotrauma 12, 179-188.
40. MUIZELAAR, J.P., MARMAROU, A., YOUNG, H.F., et al. (1993). Improving the outcome of severe head injury with the oxygen radical scavenger polyethylende glycol-conjugated superoxide dismutase: a phase II trial. J. Neurosurg. 78, 375-382.
41. PLATEEL, M., DEHOUCK, M.-P., TORPIER, G., CECCHELLI, R., and TEISSIER, E. (1995). Hypoxia induces the susceptibility to oxidant stress and the permeability of the blood-brain barrier endothelial cell monolayer. J. Neurochem. 65, 2138-2145.
42. SEN, S., GOLDMAN, H., MOREHEAD, M., MURPHY, S., and PHILLIS, J.W. (1993). Oxypurinol inhibits free radical release from the cerebral cortex of closed head-injured rats. Neurosci. Lett. 162, 117-120.
43. SHI, M.M., IWAMOTO, T., and FORMAN, H.J. (1994). Gamma-glutamylcysteine synthetase and GSH increase in quinone-induced oxidative stress in BPAEC. Am. J. Physiol. 267, L414-L421.
44. SHIVAKUMAR, B.R., KOLLURI, S.V.R., and RAVINDRANATH, V. (1995). Glutathione and protein thiol homeostasis in brain during reperfusion after cerebral ischemia. J. Pharmacol. Exp. Ther. 274, 1167-1173.
45. SIES, H., SHAROV, V.S., KLOTZ, L.O., and BRIVIBA, K. (1997). Glutathione peroxidase protects against peroxynitrite-mediated oxidations - a new function for selenoproteins as peroxynitrite reductase. J. Biol. Chem. 272, 27812-27817.
46. SIFLINGER-BIRNBOIM, A., and MALIK, A.B. (1993). Neutrophil adhesion to endothelial cells impairs the effects of catalase and glutathione in preventing endothelial injury. J. Cell. Physiol. 155, 234-239.
47. SMITH, S.L., ANDRUS, P.K., ZHANG, J., and HALL, E.D. (1994). Direct measurement of hydroxyl radicals, lipid peroxidation, and blood-brain barrier disruption following unilateral cortical impact head injury in the rat. J. Neurotrauma 11, 393-404.
48. SMITH, C.V., JONES, D.P., GUENTHNER, T.M., LASH, L.H., and LAUTERBURG, B.H. (1996). Compartmentation of glutathione: implications for the study of toxicity and disease. Toxicol. Appl. Pharmacol. 140, 1-12.
49. SUTTON, R.L., LESCAUDRON, L., and STEIN, D.G. (1993). Unilateral cortical contusion injury in the rat: vascular disruption and temporal development of cortical necrosis. J. Neurotrauma 10, 135-149.
50. WEISBROT-LEFKOWITZ, M., REUHL, K., PERRY, B., CAHN, P.H., INOUYE, M., and MIROCHNITCHENKO, O. (1998). Overexpression of human glutathione peroxidase protects transgenic mice against focal cerebral ischemia/reperfusion damage. Mol. Brain Res. 53, 333-338.
51. WOLIN, M.S. (1996). Reactive oxygen species and vascular signal transduction mechanisms. Microcirculation 3, 1-17.
52. XU, J., BECKMAN, J.S., HOGAN, E.L., and HSU, C.Y. (1991). Xanthine oxidase in experimental spinal cord injury. J. Neurotrauma 8, 11-16.
53. 2+ blockade of NMDA current in mechanically injured neurons. Science 274, 1921-1923.
54. ZIMMERMAN, B.J., PARKS, D.A., GRISHAM, M.B., and GRANGER, D.N. (1988). Allopurinol does not enhance antioxidant properties of extracellular fluid. Am. J. Physiol. 255, H202-H206.