Research progresses of artificial nucleic acid cleavage agents

Chinese Science Bulletin

Volumn 45, Issue 22, 2000, Pages 2017-2028

  Rong, W ^a   Gang, Z ^a   Jing, C ^a   Yufen, Z ^a  

^a TSINGHUA UNIVERSITY   (China)

Author keywords

Elimination; Free radical; Nucleic acid cleavage agents; Phosphodiester bond hydrolysis; Site and sequence specific cleavage agents

Indexed keywords

FREE RADICAL; NUCLEIC ACID; NUCLEIC ACID CLEAVAGE AGENT; ORGANOPHOSPHATE; UNCLASSIFIED DRUG;

HYDROLYSIS; NUCLEIC ACID METABOLISM; RESEARCH; REVIEW; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS;

EID: 0034483146     PISSN: 10016538     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03183520     Document Type: Review

References (82)

1. Bifunctional acid-base catalysis by imidazole groups in enzyme mimics
2. Antisense oligonucleotides
3. DNA footprinting with hydroxyl radical
4. Cleavage of a 23s rRNA pseudoknot by phenanthroline-Cu(II)
5. Oxidative strand scission of nucleic acids: Routes initiated by hydrogen abstraction from the sugar moiety
6. The ensemble reactions of hydroxyl radical exhibit no specificity for primary or secondary structure of DNA
7. Hydroxyl radical "footprinting": High-resolution information about DNA-protein contacts and application to λ repressor and cro protein
8. Oxygen-dependent cleavage of DNA by the 1,10-phenanthroline cuprous complex
9. Nuclease activity of 1,10-phenanthroline-copper ion: Reaction with CGCGAATTCGCG and its complexes with netropsin and EcoRI
10. Scission of RNA by the chemical nuclease of 1,10-phenanthroline-copper ion: Preference for single-stranded loops
11. Tris(tetramethylphenanthroline)ruthenium(II): A chrial proke that cleaves A-DNA conformations
12. Kinetics and mechanism of the oxidation of sugars and nucleotides by oxoruthenium(IV): Model studies for predicting cleavage patterns in polymeric DNA and RNA
13. DNA photocleavage by phenanthrenequinone diimine complexes of rhodium(III): Shape-selective recognition and reaction
14. Design and chemical synthesis of a sequence-specific DNA-cleaving protein
15. Single-strand cleavage of DNA by Cu(II) and thiols: A powerful chemical DNA-cleaving system
16. A common chemical mechanism used for DNA cleavage by copper(II) activated by thiols and ascorbate is distinct from that for copper(II): Hydrogen peroxide cleavage
17. DNA cleavage specificity of a group of cationic metalloporphyrins
18. Uranyl salts as photochemical agents for cleavage of DNA and probing of protein-DNA contacts
19. Effects of secondary structure on DNA and RNA cleavage by diplatinum(II)
20. 60
21. Photochemical DNA cleavage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide
22. Oligonucleotides shackled with tetraphenylporphyrin
23. A peptide molecule mimicking the copper(II) transport site of human serum albumin
24. ESR evidence for superoxide, hydroxyl radicals and singlet oxygen produced from hydrogen peroxide and nickel(II) complex of glycylglycyl-l-histidine
25. aa-his metallotripeptide domain
26. aa-gly-his metallopeptides
27. Structure of the glycyl-l-histidyl-l-lysine-copper(II) complexes in solution
28. Footprinting studies on the sequence-selective binding of tilorone to DNA
29. Cleavage of nucleic acids by bleomycin
30. Bleomycin: Synthetic and mechanistic studies
31. Double-stranded damage of DNA-RNA hybrids by neocarzinostatin chromophore: Selective c-1′ chemistry on the RNA strand
32. Synthetic RNA-cleaving molecules mimicking ribonuclease an active center: Design and cleavage of tRNA transcripts
33. Synthesis of imidazole-acridine conjugates as ribonuclease A mimics
34. Sequential general base-acid catalysis in the hydrolysis of RNA by imidazole
35. Artificial ribonucleases: Synthesis and RNA cleaving properties of cationic conjugates bearing imidazole residues
36. How do imidazole groups catalyze the cleavage of RNA in enzyme models and in enzymes? Evidence from "negative catalysis"
37. One-metal and 2-metal ion catalysis of the hydrolysis of adenosine 3′-alkyl phosphate-esters - Models for one-metal and 2-metal ion catalysis of RNA hydrolysis
38. Developing artificial hydrolytic metalloenzymes by a unified mechanism approach
39. Structure-reactivity relationship for the cobalt(III) complex-catalysed hydrolysis of adenosine 3′,5′-cyclic monophosphate
40. "Decapitation" of a 5′-capped oligoribonucleotide by O-phenanthroline: Cu(II)
41. Hydrolysis of RNA by transition-metal complexes
42. 2+ and lanthanides, on the cleavage of ribonucleotides and RNA model compounds
43. Unprecedentedly fast hydrolysis of the RNA dinucleoside monophosphates ApA and UpU by rare earth metal ions
44. Specific RNA cleavages induced by manganese ions
45. Enormously fast RNA hydrolysis by lanthanide(III) ions under physiological conditions: Eminent candidates for novel tools of biotechnology
46. Site-selective hydrolysis of RNA by lanthanide metal complexes
47. Efficient catalytic cleavage of RNA by lanthanide(III) macrocyclic complexes: Toward synthetic nucleases for in vivo applications
48. Trivalent lanthanide ions do not cleave RNA in DNA-RNA hybrid
49. Cleavage of the phosphate diester backbone of DNA with cerium(III) and molecular oxygen
50. Hydrolysis of phosphomonoesters in nucleotides by cerium(IV) ions: Highly selective hydrolysis of monoesters over diester in concentrated buffers
51. DNA hydrolysis by cerium(IV)-saccharide complexes
52. Hydrolysis of DNA and RNA through cooperation of two metal ions: A novel mimic of phosphoesterases
53. Rapid cleavage of RNA with a La(III) dimer
54. Highly efficient phosphate diester transesterification by a calix[4]arene-based dinuclear zinc(II) catalyst
55. Double-stranded cleavage of pBR322 by a diiron complex via a "hydrolytic" mechanism
56. Rapid and highly base selective RNA cleavage by a dinuclear Cu(II) complex
57. Structure and reactivity of dinuclear cobalt(III) complex with peroxide and phosphate diester analogues binding the metal ions
58. Unprecedentedly fast DNA hydrolysis by the synergism of the cerium(IV)-preseodymium(III) and the cerium(IV)-neodymium(III) combinations
59. Synergetic catalysis by two non-lanthanide metal ions for hydrolysis of diribonucleotides
60. Kinetic analysis of diamine-catalyzed RNA hydrolysis
61. Oligoamines as simple and efficient catalysts for RNA hydrolysis
62. Kinetics and mechanisms for the cleavage and isomerization of the phosphodiester bonds of RNA by bronsted acids and bases
63. Conformation-controlled hydrolysis of polyribonucleotides by sequential basic polypeptides
64. The interactions of amino acids and peptides with DNA
65. Tryptophan-containing peptide recognized and cleaves DNA at apurinic sites
66. Release of 7-methylguanine residues from alkylated DNA by extracts of micrococcus luteus and Escherichia coli
67. Molecular design for a pinpoint RNA scission, interposition of oligoamines between two DNA oligomers
68. Ethylenediamine-oligo DNA hybrid as sequence-selective artificial ribonuclease
69. Design of ribonuclease mimics for sequence specific cleavage of RNA
70. Sequence specific scission of DNA by the chemical nuclease activity of 1,10-phenanthroline-copper(I) targeted by RNA
71. Conversion of a helix-turn-helix motif sequence-specific DNA binding protein into a site-specific DNA cleavage agent
72. A novel zinc finger-based DNA cutter: Biosynthetic design and highly selective DNA cleavage
73. Sequence-specific oxidation cleavage of DNA by a designed metalloprotein, Ni(II) · GGH(Hin 139-190)
74. Peptide nucleic-acid (PNA) - A DNA mimic with a peptide backbone
75. Sequence selective DNA cleavage by PNA-NTA conjugates
76. Biochemical-evidence that a D-loop is part of a 4-stranded PNA-DNA bundle - Nickel-mediated cleavage of duplex DNA by a Gly-Gly-His bis-PNA
77. DNA-binding and cleavage by a cationic manganese porphyrin-peptide nucleic-acid conjugate
78. Recognition of the four watson-crick base pairs in the DNA minor groove by synthetic ligands
79. Phospholipid membrane-permeability of peptide nucleic-acid