Modulation and function of kynurenic acid in the immature rat brain

Advances in Experimental Medicine and Biology

Volumn 467, Issue , 2000, Pages 113-123

  Schwarcz, R ^a   Ceresoli Borroni, G ^a   Wu, H Q ^a   Rassoulpour, A ^a   Poeggeler, B ^a   Hodgkins, P S ^a   Guidetti, P ^a  

^a MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4 METHYL 5 PHOSPHONO 3 PENTENOIC ACID; ALANINE DERIVATIVE; DEXAMPHETAMINE; GLUCOSE; KYNURENIC ACID; KYNURENINE 3 MONOOXYGENASE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PYRUVIC ACID;

AMINO ACID SYNTHESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; BRAIN TOXICITY; COMPETITIVE INHIBITION; CONFERENCE PAPER; CONTROLLED STUDY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; REGULATORY MECHANISM;

2-AMINO-5-PHOSPHONOVALERATE; AGING; ALANINE; ANIMALS; BRAIN; DEXTROAMPHETAMINE; ENZYME INHIBITORS; EXCITATORY AMINO ACID ANTAGONISTS; GLUCOSE; KYNURENIC ACID; KYNURENINE 3-MONOOXYGENASE; MALE; MICRODIALYSIS; MIXED FUNCTION OXYGENASES; N-METHYLASPARTATE; NEURONS; PYRUVATES; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 0034467643     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (41)

1. Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities
2. Excitotoxic lesions of the rat striatum: Different responses of kynurenine pathway enzymes during ontogeny
3. Die Entstehung der Kynurensäure
4. Acidic amino acid binding sites in mammalian neuronal membranes: Their characteristics and relationship to synaptic receptors
5. Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid
6. Kynurenic acid inhibits synaptic and acidic amino acid-induced responses in the rat hippocampus and spinal cord
7. Brain-specific modulation of kynurenic acid synthesis in the rat
8. Characterization of rat brain kynurenine amino-transferases I and II
9. Interference with cellular energy metabolism reduces kynurenic acid formation in rat brain slices: Reversal by lactate and pyruvate
10. Metabolic control of kynurenic acid formation in the rat brain
11. 2-Oxoacids regulate kynurenic acid production in the rat brain: Studies in vitro and in vivo
12. A glycine site associated with N-methyl-D-aspartic acid receptors: Characterization and identification of a new class of antagonists
13. Modulation of neuronal migration by NMDA receptors
14. Reduction of excitotoxicity-induced brain damage by the competitive NMDA antagonist CGP 40116: A longitudinal study using diffusion-weighted imaging
15. Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor
16. On the nature of the receptors for various excitatory amino acids in the mammalian central nervous system
17. Presence of kynurenic acid in the mammalian brain
18. Modulation of quinolinic and kynurenic acid content in the rat brain: Effects of endotoxins and nicotinylalanine
19. Cerebral energy metabolism, glucose transport and blood flow: Changes with maturation and adaptation to hypoglycemia
20. Measurement of rat brain kynurenine aminotransferase at physiological kynurenine concentrations
21. Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system
22. Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: Electrophysiological, biochemical and behavioral characterization
23. Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)-alanine, a potent inhibitor of kynurenine-3-hydroxylase
24. An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid
25. Dopaminergic control of kynurenate levels and NMDA toxicity in the developing rat striatum
26. Systemic d-amphetamine administration causes a reduction of kynurenic acid levels in rat brain
27. Further evidence that amphetamines produce long-lasting dopamine neurochemical deficits by destroying dopamine nerve fibers
28. Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzene-sulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase
29. Excitotoxins, kynurenines and neuropsychiatric diseases: Implications for drug development
30. Excitotoxic models for neurodegenerative disorders
31. Rotational behavior in rats with unilateral striatal kainic acid lesions: A behavioral model for studies on intact dopamine receptors
32. Fluorimetric micro-determination of kynurenic acid, an endogenous blocker of neurotoxicity, by high-performance liquid chromatography
33. Kynurenic acid-enhancing and anti-ischemic effects of the potent kynurenine 3-hydroxylase inhibitor FCE 28833 in rodents
34. (R,S)-3,4-dichlorobenzoylalanine (FCE 28833A) causes a large and persistent increase in brain kynurenic acid levels in rats
35. Identification and quantification of kynurenic acid in human brain tissue
36. Rat brain slices produce and liberate kynurenic acid upon exposure to L-kynurenine
37. Excitatory amino acids
38. Kynurenic acid in the quinolinate-lesioned rat hippocampus: Studies in vitro and in vivo
39. Seizure activity causes elevation of endogenous extracellular kynurenic acid in the rat brain