The peripheral T-cell pool: Regulation by non-antigen induced proliferation?

Seminars in Immunology

Volumn 9, Issue 6, 1997, Pages 347-353

  Bell, Eric B ^a   Sparshott, Sheila M ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

CD4 T cells; Extrathymic proliferation; Lymphocyte homeostasis; T cell deficit

Indexed keywords

CD4 ANTIGEN;

CELL LOSS; HOMEOSTASIS; LYMPHOCYTE DEPLETION; LYMPHOCYTE PROLIFERATION; PERIPHERAL LYMPHOCYTE; REVIEW; T LYMPHOCYTE;

EID: 0031465301     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.1997.0092     Document Type: Article

References (57)

1. 1. Leuchars E, Wallis VJ, Doenhoff MJ, Davies AJS, Kruger J (1978) Studies on hyperthymic mice. 1. The influence of multiple thymus grafts on the size on the peripheral T cell pool and immunological performance. Immunology 35:801-809
2. 2. Wallis VJ, Leuchars E, Chaudhuri M, Davies AJS (1979) Studies on hyperlymphoid mice. Immunology 38:163-171
3. 3. Miller RA, Stutman O (1984) T cell repopulation from functionally restricted splenic progenitors: 10,000-fold expansion documented by using limiting dilution analyses. J Immunol 133:2925-2932
4. 4. Bell EB, Sparshott SM, Drayson MT, Ford WL (1987) The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells. J Immunol 139:1379-1384
5. 5. Rocha B, Dautigny N, Pereira P (1989) Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/ CDS ratios in vivo. Eur J Immunol 19:905-911
6. 6. Sprent J, Schaefer M, Hurd M, Surh CD, Ron Y (1991) Mature murine T and B cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype. J Exp Med 174:717-728
7. 7. Yang C-p, Bell EB (1994) Thymic education curtailed: defective immune responses in nude rats reconstituted with immature thymocytes. Int Immunol 6:569-577
8. 8. McDonagh M, Bell EB (1995) The survival and turnover of mature and immature CD8 T cells. Immunology 84:514-520
9. 9. Bell EB, Sparshott SM, Drayson MT, Hunt SV (1989) The origin of T cells in permanently reconstituted old athymic nude rats. Analysis using chromosome or allotype markers. Immunology 68:547-556
10. 10. Mackall CL, Bare CV, Titus JA, Sharrow SO, Granger LA, Gress RE (1996) Thymic independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing. J Immunol 156:46094616
11. 11. McHeyzer-Williams MG, Davis MM (1995) Antigen-specific development of primary and memory T cells in vivo. Science 268:106-111
12. 12. Rocha B, von Boehmer H (1991) Peripheral selection of the T cell repertoire. Science 251:1225-1227
13. 13. Zhang L (1996) The fate of adoptively transferred antigen-specific T cells in vivo. Eur J immunol 26:2208-2214
14. a antigens. Long term progeny of dividing cells include cells with a naive phenotype. J Immunol 156:48-55
15. 15. Lanoue A, Bona C, von Boehmer H, Sarukhan A (1997) Conditions that induce tolerance in mature T cells. J Exp Med 185:405414
16. + T cell disposal. Eur J Immunol 27:577-583
17. 17. Freitas AA, Rocha B, Forni L, Coutinho A (1982) Population dynamics of B lymphocytes and their precursors. Demonstration of high turnover in the central and peripheral lymphoid organs. J Immunol 128:54-60
18. 18. Rocha B, Freitas AA, Coutinho AA (1983) Population dynamics of T lymphocytes. Renewal rate and expansion in the peripheral lymphoid organs. J Immunol 131:2158-2164
19. 19. Egerton M, Scollay R, Shortman K (1990) Kinetics of mature T cell development in the thymus. Proc Natl Acad Sci USA 87:2579-2582
20. 20. Scollay R, Butcher E, Weissman I (1980) Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice. Eur J Immunol 10:210-218
21. 21. Mackall CL, Hakim FT, Gress RE (1997) T cell regeneration: All repertoires are not created equal. Immunol Today 18:245-251
22. 22. Moskophidis D, Lechner F, Pircher H, Zinkernagel RM (1993) Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector cells. Nature 362:758-761
23. 23. Heath WR, Miller JFAP (1993) Expression of two α chains on the surface of T cells in T cell receptor transgenic mice. J Exp Med 178:1807-1811
24. 24. Bruno L, von Boehmer H, Kirberg J (1996) Cell division in the compartment of naive and memory T lymphocytes. Eur J Immunol 26:3179-3184
25. 25. Tough DF, Borrow P, Sprent J (1996) Induction of bystander T cell proliferation by viruses and type 1 Interferon in vivo. Science 272:1947-1950
26. 26. Spickett GP, Brandon MR, Mason DW, Williams AE, Woollett GR (1983) MRC OX-22, a monoclonal antibody that labels a new subset of T lymphocytes and reacts with the high molecular weight form of the leukocyte-common antigen. J Exp Med 158:795-810
27. 27. Smith SH, Brown MH, Rowe D, Callard RE, Beverley PC (1986) Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1. Immunology 58:63-70
28. 28. Birkeland ML, Metlay J, Sanders VM, Fernandez-Bottram R, Vitetta ES, Steinman RM, Pure E (1988) Epitopes of CD45R [T200] molecules define differentiation antigens on murine B and T lymphocytes. J Mol Cell Immunol 4:71-85
29. 29. Beverley PCL (1992) Functional analysis of human T cell subsets defined by CD45 isoform expression. Semin Immunol 4:3541
30. 30. Swain SL, Croft M, Dubey C, Haynes L, Rogers P, Zhang X, Bradley LM (1996) From naive to memory T cells. Immunol Rev 150:142-167
31. 31. Bell EB (1992) Function of CD4 T cell subsets in vivo: expression of CD45R isoforms. Semin Immunol 4:43-50
32. 32. Merkenschlager M, Terry L, Edwards R, Beverley PCL (1988) Limiting dilution analysis of proliferative responses in human lymphocyte populations defined by the monoclonal antibody UCHL1: implications for differential CD45 expression in T cell memory formation. Eur J Immunol 18:1653-1166
33. 33. Morimoto C, Letvin NL, Distaso JA, Aldrich WR, Schlossman SF (1985) The isolation and characterization of the human suppressor inducer T cell subset. J Immunol 134:1508-1515
34. 34. Michie CA, McLean A, Alcock C, Beverley PCL (1992) Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature 360:264-265
35. 35. Sparshott SM, Bell EB (1994) Membrane CD45R isoform exchange on CD4 T cells is rapid, frequent and dynamic in vivo. Eur J Immunol 24:2573-2578
36. 36. Tough DF, Sprent J (1994) Turnover of naive-and memory-phenotype T cells. J Exp Med 179:1127-1135
37. 37. Akbar AN, Borthwick N, Salmon M, Gombert W, Bofill M, Shamsadeen N, Pilling D, Pett S, Grundy JE, Janossy G (1993) The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory. J Exp Med 178:427438
38. 38. Salmon M, Pilling D, Borthwick NJ, Viner N, Janossy G, Bacon PA, Akbar AN (1994) The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis. Eur J Immunol 24:892-899
39. 39. Bell EB, Sparshott SM (1990) Interconversion of CD45R subsets of CD4 T cells in vivo. Nature 348:163-166
40. 40. Sarawar SR, Sparshott SM, Sutton P, Yang C.-p, Hutchinson IV, Bell EB (1993) Rapid re-expression of CD45RC on rat CD4 T cells in vitro correlates with a change in function. Eur J Immunol 23:103-107
41. 41. Bunce C, Bell EB (1997) CD45RC isoforms define two types of CD4 memory T cells, one of which depends on persisting antigen. J Exp Med 185:767-776
42. + naive CD4 T cells. Immunology 91:323-330
43. 43. Sparshott SM, Bell EB, Sarawar SR (1991) CD45R CD4 T cell subset-reconstituted nude rats: subset-dependent survival of recipients and bi-directional isoform switching. Eur J Immunol 21:993-1000
44. low subset. J Exp Med 172:1701-1708
45. + T cells. J Exp Med 178:237-244
46. + T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Inter Immunol 5:1461-1471
47. + T cells. J Exp Med 183:2669-2674
48. + phenotype. J Exp Med 169:653-662
49. + T cells. J Immunol 144:3288-3295
50. high T cells to SCID recipients. J Immunol 158:3464-3473
51. 51. Beverley PCL (1990) Is T-cell memory maintained by cross-reactive stimulation?. Immunol Today 11:203-205
52. 52. Unutmatz D, Pileri P, Abrignani S (1994) Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J Exp Med 180:1159-1164
53. 53. Linsley PS, Ledbetter JA (1993) The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol 11:191-212
54. 54. Tacke B, Hanke G, Hanke T, Hünig T (1997) CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: evidence for functionally distinct forms of CD28. Eur J Immunol 27:239-247
55. 55. Azuma M, Ito D, Yagita H, Okumura K, Phillips JH, Lanier LL, Somoza C (1993) B70 antigen is a second ligand for CTLA4 and CD28. Nature 366:76-79
56. 56. Hathcock KS, Laszlo G, Dickeler HB, Bradshaw J, Linsley P, Hodes RJ (1993) Identification of an alternative CTLA4 ligand costimulatory for T cell activation. Science 262:905-907
57. 57. Drayson MT, Sparshott SM, Bell EB (1989) Fidelity of the repertoire in T cell reconstituted athymic nude rats. Preservation of a deficit in alloresponsiveness over one year. J Exp Med 170:691-702