Neural roles of immunophilins and their ligands

Molecular Neurobiology

Volumn 15, Issue 2, 1997, Pages 223-239

  Sabatini, David M ^a   Lai, Michael M ^a   Snyder, Solomon H ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Calcineurin; Cyclosporin A; Dopamine; FK506; Glutamate; Inositol 1,4,5 trisphosphate; IP3; N methyl D aspartate (NMDA); Nerve growth factor; Nitric oxide; Rapamycin; Ryanodine; Serotonin

Indexed keywords

CALCINEURIN; CARRIER PROTEIN; CYCLOSPORIN; DNA BINDING PROTEIN; FK 506 BINDING PROTEIN; FRAP1 PROTEIN, HUMAN; FRAP1 PROTEIN, RAT; HEAT SHOCK PROTEIN; IMMUNOSUPPRESSIVE AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NERVE PROTEIN; NEUROPROTECTIVE AGENT; NEUROTOXIN; NITRIC OXIDE SYNTHASE; PEPTIDYLPROLYL ISOMERASE; PHOSPHOTRANSFERASE; POLYENE; RAPAMYCIN; TACROLIMUS;

ANIMAL; BIOLOGICAL MODEL; CHICKEN; CYTOTOXIC T LYMPHOCYTE; DEGENERATIVE DISEASE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; NERVE REGENERATION; PHYSIOLOGY; RAT; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CALCINEURIN; CARRIER PROTEINS; CHICKENS; CYCLOSPORINE; DNA-BINDING PROTEINS; HEAT-SHOCK PROTEINS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE ACTIVATION; MODELS, IMMUNOLOGICAL; NERVE REGENERATION; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; NEUROTOXINS; NITRIC OXIDE SYNTHASE; PEPTIDYLPROLYL ISOMERASE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); POLYENES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; SIROLIMUS; T-LYMPHOCYTES, CYTOTOXIC; TACROLIMUS; TACROLIMUS BINDING PROTEINS;

EID: 0031243290     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02740635     Document Type: Article

References (88)

1. Attisano L., Wrana J. L., Lopez-Casillas F., and Massague J. (1994) TGF-beta receptors and actions. Biochim. Biophys. Acta 1222, 71-80.
2. Baker H., Sidorowicz A., Sehgal S. N., and Vezina C. (1978) Rapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluation. J. Antibiot. (Tokyo) 31, 539-545.
3. Beretta L., Gingras A. C., Svitkin Y. V., Hall M. N., and Sonenberg N. (1996) Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap dependent initiation of translation. EMBO J. 15, 658-664.
4. Bierer B. E., Jin Y. J., Fruman D. A., Calvo V., and Burakoff S. J. (1991) FK 506 and rapamycin: molecular probes of T-lymphocyte activation. Transplant. Proc. 23, 2850-2855.
5. Bierer B. E., Mattila P. S., Standaert R. F., Herzenberg L. A., Burakoff S. J., Crabtree G., and Schreiber S. L. (1990a) Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Proc. Natl. Acad. Sci. USA 87, 231-9235.
6. Bierer B. E., Somers P. K., Wandless T. J., Burakoff S. J., and Schreiber S. L. (1990b) Probing immunosuppressant action with a nonnatural immunophilin ligand. Science 250, 56-559.
7. Borel J. F., Feurer C., Gubler H. U., and Stahelin H. (1976) Biological effects of cyclosporin A: a new antilymphocytic agent. Agents Actions 6, 68-475.
8. Bram R. J., Hung D. T., Martin P. K., Schreiber S. L., and Crabtree G. R. (1993) Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and F-K506: roles of calcineurin binding and cellular location. Mol. Cell Biol. 13, 760-4769.
9. Bredt D. S., Ferris C. D., and Snyder S. H. (1992) Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/ calmodulin protein kinase; identification of flavin and calmodulin binding sites. J. Biol. Chem. 267, 10,976-10,981.
10. Brillantes A. B., Ondrias K., Scott A., Kobrinsky E., Ondriasova E., Moschella M. C., Jayaraman T., Landers M., Ehrlich B. E, and Marks A. R. (1994) Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. Cell 77, 513-523.
11. Brown E. J., Albers M. W., Shin T. B., Ichikawa K., Keith C. T., Lane W. S., and Schreiber S. L. (1994) A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369, 756-758.
12. Brown E. J., Beal P. A., Keith C. T., Chen J., Shin T. B., and Schreiber S. L. (1995) Control of p70 S6 kinase by kinase activity of FRAP in vivo. Nature 377, 441-446.
13. Cameron A. M., Nucifora F. C., Fung E. T., Livingston D. J., Aldape R. A., Ross C. R., and Snyder S. H. (1997) FKBP12 binds the inositol 1,4,5 triphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain. J. Biol. Chem., in press.
14. 2+ flux. Cell 83, 463-472.
15. Cameron A. M., Steiner J. P., Sabatini D. M., Kaplin A. I., Walensky L. D., and Snyder S. H. (1995b) Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor nnodulates calcium flux. Proc. Natl. Acad. Sci. USA 92, 1784-1788.
16. Carpenter C. L., Duckworth B. C., Auger K. R., Cohen B., Schaffhausen B. S., and Cantley L. C. (1990) Purification and characterization of phosphoinositide 3-kinase from rat liver. J. Biol. Chem. 265, 19,704-19,711.
17. Chambraud B., Radanyi C., Camonis J. H., Shazand K., Rajkowski K., and Baulieu E. E. (1996) FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin. J. Biol. Chem. 271, 32,923-32,929.
18. Chen H., Wu J., Xu D., Luo H., and Daloze P. (1992) Efficacy and mechanism of action of rapamycin in presensitized recipients of experimental allografts. Transplant. Proc. 24, 1669,1670.
19. Chiu M. I., Katz H., and Berlin V. (1994) RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. Proc. Natl. Acad. Sci. USA 91, 12,574-12,578.
20. Choi D. W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623-634.
21. Choi D. W. (1992) Bench to bedside: the glutamate connection. Science 258, 241-243.
22. Chung J., Grammer T. C., Lemon K. P., Kazlauskas A., and Blenis J. (1994) PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature 370, 71-75.
23. Chung J., Kuo C. J., Crabtree G. R., and Blenis J. (1992) Rapamycin FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell 69, 1227-1236.
24. Coghlan V. M., Perrino B. A., Howard M., Langeberg L. K., Hicks J. B., Gallatin W. M., and Scott J. D. (1995) Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. Science 267, 108-111.
25. Collins J. H. (1991) Sequence analysis of the ryanodine receptor: possible association with a 12K, FK506-binding immunophilin/protein kinase C inhibitor. Biochem. Biophys. Res. Commun. 178, 1288-1290.
26. Dawson T. M., Steiner J. P., Dawson V. L., Dinerman J. L., Uhl G. R., and Snyder S. H. (1993) Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity [see comments]. Proc. Natl. Acad. Sci. USA 90, 9808-9812.
27. Dawson T. M., Steiner J. P., Lyons W. E., Fotuhi M., Blue M., and Snyder S. H. (1994) The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: relationship to calcineurin. Neuroscience 62, 569-580.
28. Dawson V. L., Bredt D. S., Fotuhi M., Hwang P. M., and Snyder S. M. (1991) Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. USA 88, 7797-7801.
29. Dawson V. L., Kizushi V. M., Huang P. L., Snyder S. H., and Dawson T. M. (1996) Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice. J. Neurosci. 16, 2479-2487.
30. De Camilli P. and Takei K. (1996) Molecular mechanisms in synaptic vesicle endocytosis and recycling. Neuron 16, 481-486.
31. De Camilli P., Takei K., and McPherson P. S. (1995) The function of dynamin in endocytosis. Curr. Opin. Neurobiol 5, 559-565.
32. Dumont F. J., Melino M. R., Staruch M. J., Koprak S. L., Fischer P. A., and Sigal N. H. (1990a) The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells. J. Immunol. 144, 1418-1424.
33. Dumont F. J., Staruch M. J., Koprak S. L., Melino M. R., and Sigal N. H. (1990b) Distinct mechanisms of suppression of murine T cell activation by the reiated macrolides FK-506 and rapamycin. J. Immunol. 144, 251-258.
34. Dumont F. J., Staruch M. J., Koprak S. L., Siekierka J. J., Lin C. S., Harrison R., Sewell T., Kindt V. M., Beattie T. R., Wyvratt M., et al. (1992) The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin. J. Exp. Med. 176, 751-760.
35. Ferris C. D., Huganir R. L., Supattapone S., and Snyder S. H. (1989) Purified inositol 1,4,5-trisphosphate receptor mediates calcium flux in reconstituted lipid vesicles. Nature 342, 87-89.
36. Fields S. and Song O. (1989) A novel genetic system to detect protein protein interactions. Nature 340, 245-246.
37. Fischer G., Wittmann-Liebold B., Lang K., Kiefhaber T., and Schmid F. X. (1989) Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins. Nature 337, 476-478.
38. Friedman J. and Weissman I. (1991) Two cytoplasmic candidates for immunophilin action are related by affinity for a new cyclophilin: one in the presence and one in the absence of CsA. Cell 66, 799-806.
39. Fruman D. A., Burakoff S. J., and Bierer B. E. (1994) Immunophilins in protein folding and immunosuppression. FASEB J. 8, 391-400.
40. Gold B. G., Katoh K., and Storm-Dickerson T. (1995) The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve. J. Neurosci. 15, 7509-7516.
41. Gold B. G., Storm-Dickerson T., and Austin D. R. (1994) The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury. Restorative Neurol. Neurosci. 6, 287-296.
42. Gressner A. M. and Wool I. G. (1974) The stimulation of the phosphorylation of ribosomal protein S6 by cycloheximide and puromycin. Biochem. Biophys. Res. Commun. 60, 1482-1490.
43. Handschumacher R., Harding M., Rice J., and Drugge R. (1984) Cyclophilin: a specific cytosolic binding protein for the cyclosporin A. Nature 226, 544-547.
44. Harding M. W., Galat A., Uehling D. E., and Schreiber S. L. (1989) A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Nature 341, 758-760.
45. Hartley K. O., Cell D., Smith G. C., Zhang H., Divecha N., Connelly M. A., Admon A., Lees-Miller S. P., Anderson C. W., and Jackson S. P. (1995) DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82, 849-856.
46. Heitman J., Movva N. R., and Hall M. N. (1991) Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253, 905-909.
47. Hirsch D. B., Steiner J. P., Dawson T. M., Mammen A., Hayek E., and Snyder S. H. (1993) Neurotransmitter release regulated by nitric oxide in PC12 cells and brain synaptosomes. Curr. Biol. 3, 749-754.
48. Jayaraman T., Brillantes A. M., Timerman A. P., Fleischer S., Erdjument-Bromage H., Tempst P., and Marks A. R. (1992) FK506 binding protein associated with the calcium release channel (ryanodine receptor). J. Biol. Chem. 267, 9474-9477.
49. Jefferies H. B., Reinhard C., Kozma S. C., and Thomas G. (1994) Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family. Proc. Natl. Acad. Sci. USA 91, 4441-4445.
50. Kay J. E. (1996) Structure-function relationships in the FK506-binding protein (FKBP) family of peptidylprolyl cis-trans isomerases. Biochem J. 314, 361-385.
51. Kay J. E., Benzie C. R., and Borghetti A. F. (1983) Effect of cyclosporin A on lymphocyte activation by the calcium ionophore A23187. Immunology 50, 441-446.
52. Kunz J., Henriquez R., Schneider U., Deuter-Reinhard M., Movva N. R., and Hall M. N. (1993) Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell 73, 585-596.
53. Kuo C. J., Chung J., Fiorentino D. F., Flanagan W. M., Blenis J., and Crabtree G. R. (1992) Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature 358, 70-73.
54. Lavin M. F., Khanna K. K., Beamish H., Spring K., Watters D., and Shiloh Y. (1995) Relationship of the ataxia-telangiectasia protein ATM to phosphoinositide 3-kinase. Trends Biochem. Sci. 20, 382,383.
55. Liu J., Farmer J. D. Jr., Lane W. S., Friedman J., Weissman I., and Schreiber S. L. (1991) Calcineurin is a common target of cyclophilin cyclosporin A and FKBP-FK506 complexes. Cell 66, 807-815.
56. Liu J., Sim A. T. R., and Robinson P. J. (1994) Calcineurin inhibition of dynamin I GTPase activity coupled to nerve terminal depolarization. Science 265, 970-973.
57. Lyons W. E., George E. B., Dawson T. M., Steiner J. P., and Snyder S. H. (1994) Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia. Proc. Natl. Acad. Sci. USA 91, 3191-3195.
58. Lyons W. E., Steiner J. P., Snyder S. H., and Dawson T. M. (1995) Neuronal regeneration enhances the expression of the immunophilin FKBP-12. J. Neurosci. 15, 2985-2994.
59. Maki N., Sekiguchi F., Nishimaki J., Miwa K., Hayano T., Takahashi N., and Suzuki M. (1990) Complementary DNA encoding the human T-cell FK506 binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin. Proc. Natl. Acad. Sci. USA 87, 5440-5443.
60. Marks A. R. (1996) Cellular functions of immunophilins. Physiol. Rev. 76, 631-649.
61. Meyer G., Kirsch J., Betz H., and Langosch D. (1995) Identification of a gephyrin binding motif on the glycine receptor beta subunit. Neuron 15, 563-572.
62. Nichols R. A., Suplick G. R., and Brown J. M. (1994) Calcineurin mediated protein dephosphorylation in brain nerve terminals regulates the release of glutamate. J. Biol. Chem. 269, 23,817-23,823.
63. Prior P., Schmitt B., Grenningloh G., Pribilla I., Multhaup G., Beyreuther K., Maulet Y., Werner P., Langosch D., Kirsch J., et al. (1992) Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein. Neuron 8, 1161-1170.
64. Redpath N. T., Foulstone E. J., and Proud C. G. (1996) Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway. EMBO J. 15, 2291-2297.
65. Sabatini D. M., Erdjument-Bromage H., Lui M., Tempst P., and Snyder S. H. (1994) RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin dependent fashion and is homologous to yeast TORs. Cell 78, 35-43.
66. Sabers C. J., Martin M. M., Brunn G. J., Williams J. M., Dumont F. J., Wiederrecht G., and Abraham R. T. (1995) Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J. Biol. Chem. 270, 815-822.
67. Schreiber S. L. (1991) Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 251, 283-287.
68. Schreiber S. L. and Crabtree G. R. (1992) The mechanism of action of cyclosporin A and FK506. Immunol. Today 13, 136-142.
69. Sharkey J. and Butcher S. P. (1994) Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia. Nature 371, 336-339.
70. Sharkey J., Crawford J. H., Butcher S. P., and Marston H. M. (1996) Tacrolimus (FK506) ameliorates skilled motor deficits produced by middle cerebral artery occlusion in rats. Stroke 27, 2282-2286.
71. Showstack J., Katz P., Amend W., Bernstein L., Lipton H., O'Leary M., Bindman A., and Salvatierra O. (1989) The effect of cyclosporine on the use of hospital resources for kidney transplantation. N. Engl. J. Med. 321, 1086-1092.
72. Siekierka J. J., Hung S. H., Poe M., Lin C. S., and Sigal N. H. (1989) A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature 341, 755-757.
73. Snyder S. H. and Sabatini D. M. (1995) Immunophilins and the nervous system. Nature Med. 1, 32-37.
74. Stamnes M. A. and Zuker C. S. (1990) Peptidyl-prolyl cis-trans isomerases, cyclophilin, FK506-binding protein, and ninaA: four of a kind. Curr. Opin. Cell Biol. 2, 1104-1107.
75. Starzl T. E., Demetris A. J., and Van Thiel D. (1989a) Liver transplantation (1). N. Engl. J. Med. 321, 1014-1022.
76. Starzl T. E., Demetris A. J., and Van Thiel D. (1989b) Liver transplantation (2). N. Engl. J. Med. 321, 1092-1099.
77. Steiner J. P., Connolly M. A., Valentine H. L., Hamilton G. S., Dawson T. M., Hester L., and Snyder S. H. (1997a) Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A. Nature Med. 3, 421-428.
78. Steiner J. P., Hamilton G. S., Ross D. T., Valentine H. L., Guo H., Connolly M. A., Liang S., Ramsey C., Li J. H., Huang W., Howorth P., Soni R., Fuller M., Sauer H., Nowotnik A. C., and Suzdak P. D. (1997b) Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models. Proc. Natl. Acad. Sci. USA 94, 2019-2024.
79. Steiner J. P., Dawson T. M., Fotuhi M., Glatt C. E., Snowman A. M., Cohen N., and Snyder S. H. (1992) High brain densities of the immunophilin FKBP colocalized with calcineurin. Nature 358, 584-587.
80. Steiner J. P., Dawson T. M., Fotuhi M., and Snyder S. H. (1996) Immunophilin regulation of neurotransmitter release. Mol. Med. 2, 325-333.
81. Supattapone S., Worley P. F., Baraban J. M., and Snyder S. H. (1988) Solubilization, purification, and characterization of an inositol trisphosphate receptor. J. Biol. Chem. 263, 1530-1534.
82. Takahashi N., Hayano T., and Suzuki M. (1989) Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin. Nature 337, 473-475.
83. Terada N., Patei H. R., Takase K., Kohno K., Nairn A. C., and Gelfand E. W. (1994) Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc. Natl. Acad. Sci. USA 91, 11,477-11,481.
84. Urrutia R., Henley J. R., Cook T., and McNiven M. A. (1997) The dynamins: Redundant or distinct functions for an expanding family of related GTPases? Proc. Natl. Acad. Sci. USA 94, 377-384.
85. von Manteuffel S. R., Gingras A. C., Ming X. F., Sonenberg N., and Thomas G. (1996) 4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase. Proc. Natl. Acad. Sci. USA 93, 4076-4080.
86. Wang T., Donahoe P. K., and Zervos A. S. (1994) Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12. Science 265, 674-676.
87. Wang T., Li B. Y., Danielson P. D., Shah P. C., Rockwell S., Lechleider R. J., Martin J., Manganaro T., and Donahoe P. K. (1996) The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors. Cell 86, 435-444.
88. Wrana J. L., Attisano L., Wieser R., Ventura F., and Massague J. (1994) Mechanism of activation of the TGF-beta receptor. Nature 370, 341-347.