Glycine receptors in cultured chick sympathetic neurons are excitatory and trigger neurotransmitter release

Journal of Physiology

Volumn 504, Issue 3, 1997, Pages 683-694

  Boehm, Stefan ^a,b   Harvey, Robert J ^a   Von Holst, Alexander ^a   Rohrer, Hermann ^a   Betz, Heinrich ^a  

^a MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ALANINE; CHLORIDE; FUROSEMIDE; GLYCINE RECEPTOR; HEXAMETHONIUM; ISONIPECOTIC ACID; PICROTOXIN; STRYCHNINE; TAURINE; TRITIUM; 7 TRIFLUOROMETHYL 4 HYDROXYQUINOLINE 3 CARBOXYLIC ACID; BETA ALANINE; CALCIUM ION; COMPLEMENTARY DNA; CYANOTRIPHENYLBORATE; FURA 2 ACETOXYMETHYL ESTER; GLYCINE; GLYCINE RECEPTOR ANTAGONIST; NORADRENALIN; RNA; TETRODOTOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHICK EMBRYO; EMBRYO; NERVE CELL CULTURE; NEUROTRANSMITTER RELEASE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYMPATHETIC NERVE CELL; VOLTAGE CLAMP; ANIMAL TISSUE; CALCIUM CELL LEVEL; CHICK; CONTROLLED STUDY; EXCITATORY JUNCTION POTENTIAL; PROTEIN FUNCTION; REVERSAL POTENTIAL; SLOW INWARD CURRENT; STEADY STATE;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CELLS, CULTURED; CHICK EMBRYO; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; GLYCINE AGENTS; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; NEURONS; NEUROTRANSMITTER AGENTS; NOREPINEPHRINE; PATCH-CLAMP TECHNIQUES; POLYMERASE CHAIN REACTION; RECEPTORS, GLYCINE; STRYCHNINE; SYMPATHETIC NERVOUS SYSTEM;

EID: 0030733142     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1997.683bd.x     Document Type: Article

References (41)

1. ADAMS, R. H., SATO, K., SHIMADA, S., TOHYAMA, M., PÜSCHEL, A. W. & BETZ, H. (1995). Gene structure and glial expression of the glycine transporter GlyT1 in embryonic and adult rodents. Journal of Neuroscience 15, 2524-2532.
2. AKAIKE, N. & KANEDA, M. (1989). Glycine-gated chloride current in acutely isolated rat hypothalamic neurons. Journal of Neurophysiology 62, 1400-1409.
3. APRISON, M. H. (1990). The discovery of the neurotransmitter role of glycine. In Glycine Neurotransmission, ed. OTTERSEN, O. P. & STORM-MATHIESEN, J., pp. 1-23. John Wiley and Sons Ltd., New York.
4. BALLANYI, K. & GRAFE, P. (1985). An intracellular analysis of γ-aminobutyric-acid-associated ion movements in rat sympathetic neurones. Journal of Physiology 365, 41-58.
5. BETZ, H. (1991). Glycine receptors: heterogeneous and widespread in the mammalian brain. Trends in Neurosciences 14, 458-461.
6. BOEHM, S. & BETZ, H. (1997). Somatostatin inhibits excitatory transmission at rat hippocampal synapses via presynaptic receptors. Journal of Neuroscience 17, 4066-4075.
7. BOEHM, S. & HUCK, S. (1997). Receptors controlling transmitter release from sympathetic neurons in vitro. Progress in Neurobiology 51, 225-242.
8. BOEHM, S., HUCK, S., DROBNY, H. & SINGER, E. A. (1991). Electrically evoked noradrenaline release from cultured chick sympathetic neurons: modulation via presynaptic α2-adrenoceptors and lack of autoinhibition. Naunyn-Schmiedeberg's Archives of Pharmacology 344, 130-132.
9. BORMANN, J., HAMILL, O. P. & SAKMANN, B. (1987). Mechanism of anion permeation through channels gated by glycine and γ-aminobutyric acid in mouse cultured spinal neurones. Journal of Physiology 385, 243-286.
10. BORMANN, J., RUNDSTRÖM, N., BETZ, H. & LANGOSCH, D. (1993). Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and hetero-oligomers. EMBO Journal 12, 3729-3737.
11. 3H]γ-Aminobutyric acid uptake into neuroglial cells of rat superior cervical sympathetic ganglia. Journal of Physiology 293, 51-74.
12. CHERUBINI, E., GAIARSA, J. L. & BEN-ARI, Y. (1991). GABA: an excitatory transmitter in early postnatal life. Trends in Neurosciences 14, 515-519.
13. DELEAN, A., MUNSON, P. J. & RODBARD, D. (1978). Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. American Journal of Physiology 235, 97-102.
14. ERNSBERGER, U. & ROHRER, H. (1996). The development of the noradrenergic transmitter phenotype in postganglionic sympathetic neurons. Neurochemical Research 21, 823-829.
15. 2+ indicators with greatly improved fluorescence properties. Journal of Biological Chemistry 260, 3440-3450.
16. HAMILL, O. P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F. J. (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Archiv 391, 85-100.
17. HELLER, S., ERNSBERGER, U. & ROHRER, H. (1996). Extrinsic signals in the developing nervous system: the role of neurokines during neurogenesis. Perspectives on Developmental Neurobiology 4, 19-34.
18. JURSKY, F. & NELSON, N. (1996). Developmental expression of the glycine transporters GLYT1 and GLYT2 in mouse brain. Journal of Neurochemistry 67, 336-344.
19. KUHSE, J., BETZ, H. & KIRSCH, J. (1995). The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex. Current Opinion in Neurobiology 5, 318-323.
20. KUHSE, J., LAUBE, B., MAGALEI, D. & BETZ, H. (1993). Assembly of the inhibitory glycine receptor: identification of amino acid sequence motifs governing subunit stoichiometry. Neuron 11, 1049-1056.
21. MCGALE, E. H. F., PYE, I. F., STONIER, C., HUTCHINSON, E. C. & ABER, G. M. (1977). Studies of the inter-relationship between cerebrospinal fluid and plasma amino acid concentrations in normal individuals. Journal of Neurochemistry 29, 291-297.
22. MATZENBACH, B., MAULET, Y., SEFTON, L., COURTIER, B., AVNER, P., GUÉNET, J.-L. & BETZ, H. (1994). Structural analysis of mouse glycine receptor subunit genes. Identification and chromosomal localization of a novel variant, α4. Journal of Biological Chemistry 269, 2607-2612.
23. O'LAGUE, P. H., OBATA, K., CLAUDE, P., FURSHPAN, E. J. & POTTER, D. D. (1974). Evidence for cholinergic synapses between dissociated rat sympathetic neurons in cell cultures. Proceedings of the National Academy of Sciences of the USA 71, 3602-3606.
24. OWENS, D. F., BOYCE, L. H., DAVIS, M. B. E. & KRIEGSTEIN, A. R. (1996). Excitatory GABA responses in embryonic and neonatal cortical slices demonstrated by gramicidin perforated-patch recordings and calcium imaging. Journal of Neuroscience 16, 6414-6423.
25. PRIBILLA, I., TAKAGI, T., LANGOSCH, D., BORMANN, J. & BETZ, H. (1992). The atypical M2 segment of the β subunit confers picrotoxinin resistance to inhibitory glycine receptor channels. EMBO Journal 11, 4305-4311.
26. REICHLING, D. B., KYROZIS, A., WANG, J. & MACDERMOTT, A. B. (1994). Mechanisms of GABA and glycine depolarization-induced calcium transients in rat dorsal horn neurons. Journal of Physiology 476, 411-421.
27. RUNDSTRÖM, N., SCHMIEDEN, V., BETZ, H., BORMANN, J. & LANGOSCH, D. (1994). Cyanotriphenylborate: subtype-specific blocker of glycine receptor chloride channels. Proceedings of the National Academy of Sciences of the USA 91, 8950-8954.
28. 3H]norepinephrine from rat hippocampal slices. Journal of Neurochemistry 54, 2077-2081.
29. SCHMIEDEN, V. & BETZ, H. (1995). Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Molecular Pharmacology 48, 919-927.
30. SCHMIEDEN, V., GRENNINGLOH, G., SCHOFIELD, P. R. & BETZ, H. (1989). Functional expression in Xenopus oocytes of the strychnine binding 48 kd subunit of the glycine receptor. EMBO Journal 8, 695-700.
31. SCHMIEDEN, V., JEZEQUEL, S. & BETZ, H. (1996). Novel antagonists of the inhibitory glycine receptor derived from quinolinic acid compounds. Molecular Pharmacology 50, 1200-1206.
32. SCHMIEDEN, V., KUHSE, J. & BETZ, H. (1992). Agonist pharmacology of neonatal and adult glycine receptor α-subunits: identification of amino acid residues involved in taurine activation. EMBO Journal 11, 2025-2032.
33. SHIRASAKI, T., KLEE, M. R., NAKAYE, T. & AKAIKE, N. (1991). Differential blockade of bicuculline and strychnine on GABA- and glycine-induced responses in dissociated rat hippocampal pyramidal cells. Brain Research 561, 77-83.
34. A receptor function following gene transfer of the CLC-2 chloride channel. Neuron 17, 543-551.
35. SUDA, K., BARDE, Y.-A. & THOENEN, H. (1978). Nerve growth factor in rat and mouse serum: correlation between bioassay and radioimmunoassay determinations. Proceedings of the National Academy of Sciences of the USA 75, 4042-4046.
36. TOKUTOMI, N., KANEDA, M. & AKAIKE, N. (1989). What confers specificity on glycine for its receptor site? British Journal of Pharmacology 97, 353-360.
37. TROMBLEY, P. Q. & SHEPHERD, G. M. (1994). Glycine exerts potent inhibitory actions on mammalian olfactory bulb neurons. Journal of Neurophysiology 71, 761-767.
38. VON HOLST, A., RODRIGUEZ-TÉBAR, A., MICHAILLE, J.-J., DHOUAILLY, D., BÄCKSTRÖM, A., EBENDAL, T. & ROHRER, H. (1995). Retinoic acid-mediated increase in TrkA expression is sufficient to elicit NGF-dependent survival of sympathetic neurons. Molecular and Cellular Neuroscience 6, 185-198.
39. 2+ transients in embryonic rat dorsal horn neurons in culture. European Journal of Neuroscience 6, 1275-1280.
40. YOUNG, A. B. & SNYDER, S. H. (1973). Strychnine binding associated with glycine receptors of the central nervous system. Proceedings of the National Academy of Sciences of the USA 70, 2832-2836.
41. ZHANG, Z.-W. & BERG, D. K. (1995). Patch-clamp analysis of glycine-induced currents in chick ciliary ganglion neurons. Journal of Physiology 487, 395-405.