Attention-deficit/hyperactivity disorder in adults: An overview

Biological Psychiatry

Volumn 48, Issue 1, 2000, Pages 9-20

  Faraone, Stephen V ^a   Biederman, Joseph ^a,c   Spencer, Thomas ^a,c   Wilens, Tim ^a,c   Seidman, Larry J ^b,c   Mick, Eric ^a,c   Doyle, Alysa E ^a,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS MENTAL HEALTH CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Attention deficit hyperactivity disorder; Developmental psychopathology; Diagnostic validity

Indexed keywords

AMPHETAMINE; DESIPRAMINE; METHYLPHENIDATE; PEMOLINE MAGNESIUM;

ADULT; ADULTHOOD; ANTISOCIAL BEHAVIOR; ANXIETY NEUROSIS; ATTENTION DEFICIT DISORDER; BRAIN REGION; CHILDHOOD; CLINICAL FEATURE; COMORBIDITY; DEPRESSION; DEVELOPMENTAL DISORDER; FAMILY HISTORY; FOLLOW UP; HUMAN; HYPERACTIVITY; IMAGING; IMPULSIVENESS; MENTAL DISEASE; MOLECULAR GENETICS; NEUROBIOLOGY; NEUROPSYCHOLOGY; OCCUPATION; OUTCOMES RESEARCH; PRIORITY JOURNAL; RESTLESSNESS; REVIEW; SCHOOL; TRAFFIC ACCIDENT;

ADULT; AGE FACTORS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CENTRAL NERVOUS SYSTEM STIMULANTS; COMORBIDITY; DESIPRAMINE; DOPAMINE; DOPAMINE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENETIC PREDISPOSITION TO DISEASE; HUMANS; METHYLPHENIDATE; PROGNOSIS; REMISSION, SPONTANEOUS;

EID: 0034237269     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(00)00889-1     Document Type: Review

References (93)

1. Alpert J., Maddocks A., Nierenberg A., O'Sullivan R., Pava J., Worthington J., et al. Attention deficit hyperactivity disorder in childhood among adults with major depression. Psychiatry Res. 62:1996;213-219.
2. Alterman A.I., Petrarulo E., Tarter R., McGowan J.R. Hyperactivity and alcoholism Familial and behavioral correlates . Addict Behav. 7:1982;413-421.
3. Amen D., Paldi J., Thisted R. Brain SPECT imaging. J Am Acad Child Adolesc Psychiatry. 32:1993;1080-1081.
4. American Psychiatric Association (1994): Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: American Psychiatric Association.
5. Applegate B., Lahey B., Hart E., Biederman J., Hynd G., Barkley R., et al. Validity of the age of onset criterion for attention-deficit/hyperactivity disorder A report from the DSM-IV field trials . J Am Acad Child Adolesc Psychiatry. 36:1997;1211-1221.
6. Asghari V., Sanyal S., Buchwaldt S., Paterson A., Jovanovic V., Van Tol H.H. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem. 65:1995;1157-1165.
7. August G.J., Stewart M.A., Holmes C.S. A four-year follow-up of hyperactive boys with and without conduct disorder. Br J Psychiatry. 143:1983;192-198.
8. Barkley R. Age dependent decline in ADHD True recovery or statistical illusion? ADHD Rep. 5:1997;1-5.
9. Barkley R., Murphy K., Kwasnik D. Motor vehicle driving competencies and risks in teens and young adults with attention deficit hyperactivity disorder. Pediatrics. 98:1996;1089-1095.
10. Barkley R., Murphy K., Kwasnik D. Psychological adjustment and adaptive impairments in young adults with ADHD. J Attention Disord. 1:1996;41-54.
11. Barkley R.A. Attention Deficit Hyperactivity Disorder A Handbook for Diagnosis and Treatment . 1998;Guilford, New York.
12. Barkley R.A., Biederman J. Toward a broader definition of the age-of-onset criterion for attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 36:1997;1204-1210.
13. Barkley R.A., Grodzinsky G., DuPaul G.J. Frontal lobe functions in attention deficit disorder with and without hyperactivity a review and research report . J Abnorm Child Psychol. 20:1992;163-188.
14. Biederman J., Baldessarini R.J., Wright V., Knee D., Harmatz J. A double-blind placebo controlled study of desipramine in the treatment of attention deficit disorder I. Efficacy . J Am Acad Child Adolesc Psychiatry. 28:1989;777-784.
15. Biederman J., Faraone S.V., Knee D., Munir K. Retrospective assessment of DSM-III attention deficit disorder in non-referred individuals. J Clin Psychiatry. 51:1990;102-106.
16. Biederman J., Faraone S.V., Milberger S., Curtis S., Chen L., Marrs A., et al. Predictors of persistence and remission of ADHD Results from a four-year prospective follow-up study of ADHD children . J Am Acad Child Adolesc Psychiatry. 35:1996;343-351.
17. Biederman J., Faraone S.V., Spencer T., Wilens T., Mick E., Lapey K.A. Gender differences in a sample of adults with attention deficit hyperactivity disorder. Psychiatry Res. 53:1994;13-29.
18. Biederman J., Faraone S.V., Spencer T., Wilens T., Norman D., Lapey K.A., et al. Patterns of psychiatric comorbidity, cognition, and psychosocial functioning in adults with attention deficit hyperactivity disorder. Am J Psychiatry. 150:1993;1792-1798.
19. Biederman J., Faraone S.V., Taylor A., Sienna M., Williamson S., Fine C. Diagnostic continuity between child and adolescent ADHD Findings from a longitudinal clinical sample . J Am Acad Child Adolesc Psychiatry. 37:1998;305-313.
20. Biederman J, Mick E, Faraone SV (2000): Age dependent decline of ADHD symptoms revisited: impact of remission definition and symptom subtype. Am J Psychiatry 157:816-818.
21. Biederman J., Newcorn J., Sprich S. Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders. Am J Psychiatry. 148:1991;564-577.
22. Biederman J., Wilens T., Mick E., Milberger S., Spencer T., Faraone S. Psychoactive substance use disorder in adults with attention deficit hyperactivity disorder Effects of ADHD and psychiatric comorbidity . Am J Psychiatry. 152:1995;1652-1658.
23. Biederman J., Wilens T., Mick E., Spencer T., Faraone S.V. Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder. Pediatrics. 104:1999;e20.
24. Biederman J., Wilens T.E., Mick E., Faraone S.V., Weber W., Curtis S., et al. Is ADHD a risk factor for psychoactive substance use disorders? Findings from a four-year prospective follow-up study. J Am Acad Child Adolesc Psychiatry. 36:1997;21-29.
25. Borland B.L., Heckman H.K. Hyperactive boys and their brothers A 25-year follow-up study . Arch Gen Psychiatry. 33:1976;669-675.
26. Buchsbaum M.S., Haier R.J., Sostek A.J., Weingartner H., Zahn T.P., Siever L.J., et al. Attention dysfunction and psychopathology in college men. Arch Gen Psychiatry. 42:1985;354-360.
27. Bush G., Frazier J.A., Rauch S.L., Seidman L.J., Whalen P.J., Jenike M.A., et al. Anterior cingulate cortex dysfunction in attention deficit/hyperactivity disorder revealed by fMRI and the counting stroop. Biol Psychiatry. 45:1999;1542-1552.
28. Castellanos F.X. Toward a pathophysiology of attention-deficit/hyperactivity disorder. Clin Pediatr. 36:1997;381-393.
29. De Obaldia R., Parsons O. Relationship of neuropsychological performance to primary alcoholism and self-reported symptoms of childhood minimal brain dysfunction. J Stud Alcohol. 45:1984;386-391.
30. Dougherty DD, Bonab AA, Spencer TJ, Rauch SL, Madras BK, Fischman AJ (1999): Dopamine transporter density is elevated in patients with ADHD. Lancet354(9196):2132-2133.
31. Downey K., Stelson F., Pomerleau O., Giordiani B. Adult attention deficit hyperactivity disorder Psychological test profiles in a clinical population . J Nerv Ment Dis. 185:1997;32-38.
32. Ernst M., Zametkin A., Matochik J., Jons P., Cohen R. DOPA decarboxylase activity in attention deficit hyperactivity disorder adults. A [fluorine-18]fluorodopa positron emission tomographic study. J Neurosci. 18:1998;5901-5907.
33. Ernst M., Zametkin A., Matochik J., Liebenauer L., Fitzgerald G., Cohen R. Effects of intravenous dextroamphetamine on brain metabolism in adults with attention-deficit/hyperactivity disorder (ADHD). Preliminary findings. Psychopharmacology. 30:1994;219-225.
34. Eyre S., Rounsaville B., Kleber H. History of childhood hyperactivity in a clinical population of opiate addicts. J Nerv Ment Dis. 170:1982;522-529.
35. Faraone S., Biederman J. Is attention deficit hyperactivity disorder familial? Harvard Rev Psychiatry. 1:1994;271-287.
36. Faraone S., Biederman J., Mick E. Symptom reports by adults with attention deficit hyperactivity disorder Are they influenced by attention deficit hyperactivity disorder in their children? J Nerv Ment Dis. 185:1997;583-584.
37. Faraone SV (in press): Attention deficit hyperactivity disorder in adults: Implications for theories of diagnosis. Curr Dir Psychol Sci.
38. Faraone S.V., Biederman J. Neurobiology of attention-deficit hyperactivity disorder. Biol Psychiatry. 44:1998;951-958.
39. Faraone SV, Biederman J (1999): The neurobiology of attention deficit hyperactivity disorder. In: Charney DS, Nestler EJ, Bunney BS, editors. Neurobiology of Mental Illness. New York: Oxford University Press, 788-801.
40. Faraone S.V., Biederman J., Monuteaux M.C. Toward guidelines for pedigree selection in genetic studies of attention deficit hyperactivity disorder. Genet Epidemiol. 18:2000;1-16.
41. Faraone S.V., Biederman J., Weiffenbach B., Keith T., Chu M.P., Weaver A., et al. Dopamine D4 gene 7-repeat allele and attention deficit hyperactivity disorder. Am J Psychiatry. 156:1999;768-770.
42. Fischer M. The persistence of ADHD into adulthood It depends on whom you ask . ADHD Rep. 5:1997;8-10.
43. Gansler D.A., Fucetola R., Krengel M., Stetson S., Zimering R., Makary C. Are there cognitive subtypes in adult attention deficit/hyperactivity disorder? J Nerv Ment Dis. 186:1998;776-781.
44. Gaub M., Carlson C.L. Gender differences in ADHD A meta-analysis and critical review . J Am Acad Child Adolesc Psychiatry. 36:1997;1036-1045.
45. Gittelman R., Mannuzza S., Shenker R., Bonagura N. Hyperactive boys almost grown up I. Psychiatric status . Arch Gen Psychiatry. 42:1985;937-947.
46. Gualtieri C.T., Ondrusek M.G., Finley C. Attention deficit disorders in adults. Clin Neuropharmacol. 8:1985;343-356.
47. Heiligenstein E., Conyers L.M., Berns A.R., Miller M.A., Smith M.A. Preliminary normative data on DSM-IV attention deficit hyperactivity disorder in college students. J Am Coll Health. 46:1998;185-188.
48. Heiligenstein E., Guenther G., Levy A., Savino F., Fulwiler J. Psychological and academic functioning in college students with attention deficit hyperactivity disorder. J Am Coll Health. 47:1999;181-185.
49. Heiligenstein E., Johnston H.F., Nielsen J.K. Pemoline therapy in college students with attention deficit hyperactivity disorder A retrospective study . J Am Coll Health. 45:1996;35-39.
50. Heiligenstein E., Keeling R.P. Presentation of unrecognized attention deficit hyperactivity disorder in college students. J Am Coll Health. 43:1995;226-228.
51. Hill J., Schoener E. Age-dependent decline of attention deficit hyperactivity disorder. Am J Psychiatry. 153:1996;1143-1146.
52. Hinshaw S.P. Externalizing behavior problems and academic underachievement in childhood and adolescence Causal relationships and underlying mechanisms . Psychol Bull. 111:1992;127-155.
53. Holdnack J.A., Moberg P.J., Arnold S.E., Gur R.C., Gur R.E. Speed of processing and verbal learning deficits in adults diagnosed with attention deficit disorder. Neuropsychiatry Neuropsychol Behav Neurol. 8:1995;282-292.
54. Katz L.J., Wood D.S., Goldstein G., Auchenbach R.C., Geckle M. The utility of neuropsychological tests in evaluation of Attention-deficit/hyperactivity disorder (ADHD) versus depression in adults. Assessment. 5:1998;45-52.
55. Keck P., McElroy S., Strakowski S., West S., Sax K., Hawkins J., et al. 12-month outcome of patients with bipolar disorder following hospitalization for a manic or mixed episode. Am J Psychiatry. 155:1998;646-652.
56. Klee S., Garfinkel B., Beauchesne H. Attention deficits in adults. Psychiatr Ann. 16:1986;52-56.
57. Kovner R., Budman C., Frank Y., Sison C., Lesser M., Halperin J. Neuropsychological testing in adult attention deficit hyperactivity disorder A pilot study . Int J Neurosci. 96:1998;225-235.
58. Lahey B., Applegate B., McBurnett K., Biederman J., Greenhill L., Hynd G., et al. DSM-IV field trials for attention deficit hyperactivity disorder in children and adolescents. Am J Psychiatry. 151:1994;1673-1685.
59. Levin F.R., Evans S.M., McDowell D.M., Kleber H.D. Methylphenidate treatment for cocaine abusers with adult attention-deficit/hyperactivity disorder a pilot study . J Clin Psychiatry. 59:1998;300-305.
60. Lovejoy D.W., Ball J.D., Keats M., Stutts M.L., Spain E., Janda L., et al. Neuropsychological performance of adults with attention deficit hyperactivity disorder (ADHD) Diagnostic classification estimates for measures of frontal lobe/executive functioning . J Int Neuropsychol Soc. 5:1999;222-233.
61. Manshadi M., Lippmann S., O'Daniel R., Blackman A. Alcohol abuse and attention deficit disorder. J Clin Psychiatry. 44:1983;379-380.
62. Matochik J., Liebenauer L., King A., Szymanski H., Cohen R., Zametkin A. Cerebral glucose metabolism in adults with attention deficit hyperactivity disorder after chronic stimulant treatment. Am J Psychiatry. 151:1994;658-664.
63. Matochik J.A., Nordahl T.E., Gross M., Semple W.E., King A.C., Cohen R.M., et al. Effects of acute stimulant medication on cerebral metabolism in adults with hyperactivity. Neuropsychopharmacology. 8:1993;377-386.
64. Mattes J.A., Boswell L., Oliver H. Methylphenidate effects on symptoms of attention deficit disorder in adults. Arch Gen Psychiatry. 41:1984;1059-1063.
65. Millstein R., Wilens T., Biederman J., Spencer T. Presenting ADHD symptoms and subtypes in clinically referred adults with ADHD. J Attention Disord. 2:1997;159-166.
66. Morrison J.R. Adult psychiatric disorders in parents of hyperactive children. Am J Psychiatry. 137:1980;825-827.
67. Morrison J.R. Childhood hyperactivity in an adult psychiatric population Social factors . J Clin Psychiatry. 41:1980;40-43.
68. Murphy K., Barkley R. Prevalence of DSM-IV symptoms of ADHD in adult licensed drivers Implications for clinical diagnosis . J Attention Disord. 1:1996;147-161.
69. Murphy K., Barkley R.A. Attention deficit hyperactivity disorder adults Comorbidities and adaptive impairments . Compr Psychiatry. 37:1996;393-401.
70. Pennington B.F., Ozonoff S. Executive functions and developmental psychopathology. J Child Psychol Psychiatry. 37:1996;51-87.
71. Ratey J., Greenberg M., Bemporad J., Lindem K. Unrecognized attention-deficit hyperactivity disorder in adults presenting for outpatient psychotherapy. J Child Adolesc Psychopharmacol. 2:1992;267-275.
72. Robins E., Guze S.B. Establishment of diagnostic validity in psychiatric illness Its application to schizophrenia . Am J Psychiatry. 126:1970;983-987.
73. Seidman L.J., Biederman J., Faraone S.V., Weber W., Ouellette C. Toward defining a neuropsychology of attention deficit-hyperactivity disorder Performance of children and adolescents from a large clinically referred sample . J Consult Clin Psychol. 65:1997;150-160.
74. Seidman L.J., Biederman J., Weber W., Hatch M., Faraone S.V. Neuropsychological function in adults with attention-deficit hyperactivity disorder. Biol Psychiatry. 44:1998;260-268.
75. Shekim W.O., Asarnow R.F., Hess E., Zaucha K., Wheeler N. A clinical and demographic profile of a sample of adults with attention deficit hyperactivity disorder, residual state. Compr Psychiatry. 31:1990;416-425.
76. Silverstein S.M., Como P.G., Palumbo D.R., West L.L., Osborn L.M. Multiple sources of attentional dysfunction in adults with Tourette's syndrome Comparison with attention deficit-hyperactivity disorder . Neuropsychology. 9:1995;157-164.
77. Spencer T., Biederman J., Wilens T. Tricyclic antidepressant treatment of children with ADHD and tic disorders. J Am Acad Child Adolesc Psychiatry. 33:1994;1203-1204.
78. Spencer T., Biederman J., Wilens T., Faraone S. Is attention deficit hyperactivity disorder in adults a valid disorder? Harvard Rev Psychiatry. 1:1994;326-335.
79. Spencer T., Biederman J., Wilens T., Prince J., Hatch M., Jones J., et al. Effectiveness and tolerability of tomoxetine in adults with attention deficit hyperactivity disorder. Am J Psychiatry. 155:1998;693-695.
80. Spencer T, Wilens T, Biederman J, Bostic J, Prince J, Gerard K, et al (1999, October): Efficacy and tolerability of a mixed amphetamine salts compound in adults with attention deficit hyperactivity disorder. Paper presented at the 46th annual meeting of the American Academy of Child and Adolescent Psychiatry, Chicago.
81. Spencer T., Wilens T., Biederman J., Faraone S.V., Ablon J.S., Lapey K. A double-blind, crossover comparison of methylphenidate and placebo in adults with childhood-onset attention-deficit hyperactivity disorder. Arch Gen Psychiatry. 52:1995;434-443.
82. Spencer T.J., Biederman J., Wilens T., Harding M., O'Donnell D., Griffin S. Pharmacotherapy of attention deficit hyperactivity disorder across the lifecycle A literature review . J Am Acad Child Adolesc Psychiatry. 35:1996;409-432.
83. Tarter R.E. Psychosocial history, minimal brain dysfunction and differential drinking patterns of male alcoholics. J Clin Psychol. 38:1982;867-873.
84. Taylor C.J., Miller D.C. Neuropsychological assessment of attention in ADHD adults. J Attention Disord. 2:1997;77-88.
85. Wender P.H., Reimherr F.W., Wood D.R., Ward M. A controlled study of methylphenidate in the treatment of attention deficit disorder, residual type, in adults. Am J Psychiatry. 142:1985;547-552.
86. Wilens T., Biederman J. The stimulants. Psychiatr Clin North Am. 15:1992;191-222.
87. Wilens T.E., Biederman J., Mick E. Does ADHD impact the course of substance abuse? Findings from a sample of adults with and without ADHD. Am J Addict. 7:1998;156-163.
88. Wilens T.E., Biederman J., Mick E., Spencer T. A systematic assessment of tricyclic antidepressants in the treatment of adult attention-deficit hyperactivity disorder. J Nerv Ment Dis. 183:1995;48-50.
89. Wilens T.E., Biederman J., Prince J., Spencer T.J., Faraone S.V., Warburton R., et al. Six-week, double-blind, placebo-controlled study of desipramine for adult attention deficit hyperactivity disorder. Am J Psychiatry. 153:1996;1147-1153.
90. Wilens T.E., Biederman J., Spencer T.J., Frazier J., Prince J., Bostic J., et al. Controlled trial of high doses of pemoline for adults with attention-deficit/hyperactivity disorder. J Clin Psychopharmacol. 19:1999;257-264.
91. Wood D.R., Reimherr F.W., Wender P.H., Johnson G.E. Diagnosis and treatment of minimal brain dysfunction in adults A preliminary report . Arch Gen Psychiatry. 33:1976;1453-1460.
92. Zametkin A., Liebenauer L., Fitzgerald G., King A., Minkunas D., Herscovitch P., et al. Brain metabolism in teenagers with attention-deficit hyperactivity disorder. Arch Gen Psychiatry. 50:1993;330-340.
93. Zametkin A.J., Nordahl T.E., Gross M., King A.C., Semple W.E., Rumsey J., et al. Cerebral glucose metabolism in adults with hyperactivity of childhood onset. N Engl J Med. 323:1990;1361-1366.