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Volumn 165, Issue 1, 2000, Pages 25-33

T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity

Author keywords

[No Author keywords available]

Indexed keywords

ELONGATION FACTOR 1ALPHA; PEPTIDE;

EID: 0034235795     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.1.25     Document Type: Article
Times cited : (68)

References (66)
  • 2
    • 0023663430 scopus 로고
    • T cell tolerance by clonal elimination in the thymus
    • Kappler, J. W., N. Roehm, and P. Marrack. 1987. T cell tolerance by clonal elimination in the thymus. Cell 49:273.
    • (1987) Cell , vol.49 , pp. 273
    • Kappler, J.W.1    Roehm, N.2    Marrack, P.3
  • 3
    • 0029965138 scopus 로고    scopus 로고
    • Balancing immunity and tolerance: Deleting and tuning lymphocyte repertoires
    • Goodnow, C. C. 1996. Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. Proc. Natl. Acad. Sci. USA 93:2264.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2264
    • Goodnow, C.C.1
  • 4
    • 0028151819 scopus 로고
    • Negative selection of lymphocytes
    • Nossal, G. J. 1994. Negative selection of lymphocytes. Cell 76:229.
    • (1994) Cell , vol.76 , pp. 229
    • Nossal, G.J.1
  • 5
    • 0031058466 scopus 로고    scopus 로고
    • Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo
    • Brocker, T., M. Riedinger, and K. Karjalainen. 1997. Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J. Exp. Med. 185:541.
    • (1997) J. Exp. Med. , vol.185 , pp. 541
    • Brocker, T.1    Riedinger, M.2    Karjalainen, K.3
  • 6
    • 0024571804 scopus 로고
    • Does T-cell tolerance require a dedicated antigen-presenting cell?
    • Matzinger, P., and S. Guerder. 1989. Does T-cell tolerance require a dedicated antigen-presenting cell? Nature 338:74.
    • (1989) Nature , vol.338 , pp. 74
    • Matzinger, P.1    Guerder, S.2
  • 9
    • 0025754853 scopus 로고
    • Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response
    • Oldstone, M. B., M. Nerenberg, P. Southern, J. Price, and H. Lewicki. 1991. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell 65:319.
    • (1991) Cell , vol.65 , pp. 319
    • Oldstone, M.B.1    Nerenberg, M.2    Southern, P.3    Price, J.4    Lewicki, H.5
  • 11
    • 0027532184 scopus 로고
    • Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen
    • Rocha, B., C. Tanchot, and H. Von Boehmer. 1993. Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen. J. Exp. Med. 177:1517.
    • (1993) J. Exp. Med. , vol.177 , pp. 1517
    • Rocha, B.1    Tanchot, C.2    Von Boehmer, H.3
  • 12
    • 0023143676 scopus 로고
    • Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
    • Jenkins, M. K., and R. H. Schwartz. 1987. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165:302.
    • (1987) J. Exp. Med. , vol.165 , pp. 302
    • Jenkins, M.K.1    Schwartz, R.H.2
  • 16
    • 0028017808 scopus 로고
    • A differential-avidity model for T-cell selection
    • Ashton-Rickardt, P. G., and S. Tonegawa. 1994. A differential-avidity model for T-cell selection. Immunol. Today 15:362.
    • (1994) Immunol. Today , vol.15 , pp. 362
    • Ashton-Rickardt, P.G.1    Tonegawa, S.2
  • 18
    • 0030806085 scopus 로고    scopus 로고
    • In thymic selection, peptide diversity gives and takes away
    • Bevan, M. J. 1997. In thymic selection, peptide diversity gives and takes away. Immunity 7:175.
    • (1997) Immunity , vol.7 , pp. 175
    • Bevan, M.J.1
  • 19
    • 0030873556 scopus 로고    scopus 로고
    • Differential requirements for survival and proliferation of CD8 naive or memory T cells
    • Tanchot, C., F. A. Lemonnier, B. Perarnau, A. A. Freitas, and B. Rocha. 1997. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276:2057.
    • (1997) Science , vol.276 , pp. 2057
    • Tanchot, C.1    Lemonnier, F.A.2    Perarnau, B.3    Freitas, A.A.4    Rocha, B.5
  • 21
    • 0030775139 scopus 로고    scopus 로고
    • Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompalibility complex-encoded molecules
    • Kirberg, J., A. Berns, and H. von Boehmer. 1997. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompalibility complex-encoded molecules. J. Exp. Med. 186:1269.
    • (1997) J. Exp. Med. , vol.186 , pp. 1269
    • Kirberg, J.1    Berns, A.2    Von Boehmer, H.3
  • 22
    • 0030727150 scopus 로고    scopus 로고
    • Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells
    • Brocker, T. 1997. Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells. J. Exp. Med. 186: 1223.
    • (1997) J. Exp. Med. , vol.186 , pp. 1223
    • Brocker, T.1
  • 23
    • 0344026273 scopus 로고    scopus 로고
    • + T cell specificity and compensates for loss of T cell receptor contacts with the specific peptide
    • + T cell specificity and compensates for loss of T cell receptor contacts with the specific peptide. J. Exp. Med. 189:883.
    • (1999) J. Exp. Med. , vol.189 , pp. 883
    • Sandberg, J.K.1    Karre, K.2    Glas, R.3
  • 25
    • 0027399243 scopus 로고
    • Peptides naturally presented by MHC class I molecules
    • Rammensee, H. G., K. Falk, and O. Rotzschke. 1993. Peptides naturally presented by MHC class I molecules. Annu. Rev. Immunol. 11:213.
    • (1993) Annu. Rev. Immunol. , vol.11 , pp. 213
    • Rammensee, H.G.1    Falk, K.2    Rotzschke, O.3
  • 26
    • 0028979705 scopus 로고
    • Specific T cell recognition of minimally homologous peptides: Evidence for multiple endogenous ligands
    • Evavold, B. D., J. Sloan-Lancaster, K. J. Wilson, J. B. Rothbard, and P. M. Allen. 1995. Specific T cell recognition of minimally homologous peptides: evidence for multiple endogenous ligands. Immunity 2:655.
    • (1995) Immunity , vol.2 , pp. 655
    • Evavold, B.D.1    Sloan-Lancaster, J.2    Wilson, K.J.3    Rothbard, J.B.4    Allen, P.M.5
  • 27
    • 0029005514 scopus 로고
    • Decrypting the structure of major histocompatibility complex class I-restricted cytotoxic T lymphocyte epitopes with complex peptide libraries
    • Udaka, K., K. H. Wiesmuller, S. Kienle, G. Jung, and P. Walden. 1995. Decrypting the structure of major histocompatibility complex class I-restricted cytotoxic T lymphocyte epitopes with complex peptide libraries. J. Exp. Med. 181:2097.
    • (1995) J. Exp. Med. , vol.181 , pp. 2097
    • Udaka, K.1    Wiesmuller, K.H.2    Kienle, S.3    Jung, G.4    Walden, P.5
  • 28
    • 0032521903 scopus 로고    scopus 로고
    • Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology
    • Hemmer, B., M. Vergelli, B. Gran, N. Ling, P. Conlon, C. Pinilla, R. Houghten, H. F. McFarland, and R. Martin. 1998. Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology. J. Immunol. 160:3631.
    • (1998) J. Immunol. , vol.160 , pp. 3631
    • Hemmer, B.1    Vergelli, M.2    Gran, B.3    Ling, N.4    Conlon, P.5    Pinilla, C.6    Houghten, R.7    McFarland, H.F.8    Martin, R.9
  • 29
    • 0031966527 scopus 로고    scopus 로고
    • Probing degeneracy in T-cell recognition using peptide combinatorial libraries
    • Hemmer, B., M. Vergelli, C. Pinilla, R. Houghten, and R. Martin. 1998. Probing degeneracy in T-cell recognition using peptide combinatorial libraries. Immunol. Today 19:163.
    • (1998) Immunol. Today , vol.19 , pp. 163
    • Hemmer, B.1    Vergelli, M.2    Pinilla, C.3    Houghten, R.4    Martin, R.5
  • 30
    • 0029961893 scopus 로고    scopus 로고
    • Structural basis for T cell recognition of altered peptide ligands: A single T cell receptor can productively recognize a large continuum of related ligands
    • Kersh, G. J., and P. M. Allen. 1996. Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands. J. Exp. Med. 184:1259.
    • (1996) J. Exp. Med. , vol.184 , pp. 1259
    • Kersh, G.J.1    Allen, P.M.2
  • 32
    • 0028085101 scopus 로고
    • T-cell receptors from virus-specific cytotoxic T lymphocytes recognizing a single immunodominant nine-amino-acid viral epitope show marked diversity
    • Horwitz, M. S., Y. Yanagi, and M. B. Oldstone. 1994. T-cell receptors from virus-specific cytotoxic T lymphocytes recognizing a single immunodominant nine-amino-acid viral epitope show marked diversity. J. Virol. 68:352.
    • (1994) J. Virol. , vol.68 , pp. 352
    • Horwitz, M.S.1    Yanagi, Y.2    Oldstone, M.B.3
  • 33
    • 0028075608 scopus 로고
    • The MHC class I-restricted T cell response to Sendai virus infection in C57BL/6 mice: A single immunodominant epitope elicits an extremely diverse repertoire of T cells
    • Cole, G. A., T. L. Hogg, and D. L. Woodland. 1994. The MHC class I-restricted T cell response to Sendai virus infection in C57BL/6 mice: a single immunodominant epitope elicits an extremely diverse repertoire of T cells. Int. Immunol. 6:1767.
    • (1994) Int. Immunol. , vol.6 , pp. 1767
    • Cole, G.A.1    Hogg, T.L.2    Woodland, D.L.3
  • 34
    • 0026718508 scopus 로고
    • Mechanism and regulation of eukaryotic protein synthesis
    • Merrick, W. C. 1992. Mechanism and regulation of eukaryotic protein synthesis. Microbiol. Rev. 56:291.
    • (1992) Microbiol. Rev. , vol.56 , pp. 291
    • Merrick, W.C.1
  • 35
    • 0027292202 scopus 로고
    • Tissue-dependent variation in the expression of elongation factor-1α isoforms: Isolation and characterization of a cDNA encoding a novel variant of human elongation-factor 1α
    • Knudsen, S. M., J. Frydenberg, B. F. Clark, and H. Leffers. 1993. Tissue-dependent variation in the expression of elongation factor-1α isoforms: isolation and characterization of a cDNA encoding a novel variant of human elongation-factor 1α. Eur. J. Biochem. 215:549.
    • (1993) Eur. J. Biochem. , vol.215 , pp. 549
    • Knudsen, S.M.1    Frydenberg, J.2    Clark, B.F.3    Leffers, H.4
  • 36
    • 0027095979 scopus 로고
    • Tissue-specific expression in mammalian brain, heart, and muscle of S1, a member of the elongation factor-1α gene family
    • Lee, S., A. M. Francoeur, S. Liu, and E. Wang. 1992. Tissue-specific expression in mammalian brain, heart, and muscle of S1, a member of the elongation factor-1α gene family. J. Biol. Chem. 267:24064.
    • (1992) J. Biol. Chem. , vol.267 , pp. 24064
    • Lee, S.1    Francoeur, A.M.2    Liu, S.3    Wang, E.4
  • 37
    • 0032084506 scopus 로고    scopus 로고
    • Wasted by an elongation factor
    • Hafezparast, M., and E. Fisher. 1998. Wasted by an elongation factor. Trends Genet. 14:215.
    • (1998) Trends Genet. , vol.14 , pp. 215
    • Hafezparast, M.1    Fisher, E.2
  • 38
    • 0022317963 scopus 로고
    • Host resistance directed selectively against H-2-deficient lymphoma variants: Analysis of the mechanism
    • Ljunggren, H. G., and K. Karre. 1985. Host resistance directed selectively against H-2-deficient lymphoma variants: analysis of the mechanism. J. Exp. Med. 162: 1745.
    • (1985) J. Exp. Med. , vol.162 , pp. 1745
    • Ljunggren, H.G.1    Karre, K.2
  • 39
    • 0026481133 scopus 로고
    • Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
    • Inaba, K., M. Inaba, N. Romani, H. Aya, M. Deguchi, S. Ikehara, S. Muramatsu, and R. M. Steinman. 1992. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176:1693.
    • (1992) J. Exp. Med. , vol.176 , pp. 1693
    • Inaba, K.1    Inaba, M.2    Romani, N.3    Aya, H.4    Deguchi, M.5    Ikehara, S.6    Muramatsu, S.7    Steinman, R.M.8
  • 40
    • 0026057983 scopus 로고
    • Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide
    • Kast, W. M., L. Roux, J. Curren, H. J. Blom, A. C. Voordouw, R. H. Meloen, D. Kolakofsky, and C. J. Melief. 1991. Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide. Proc. Natl. Acad. Sci. USA 88:2283.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 2283
    • Kast, W.M.1    Roux, L.2    Curren, J.3    Blom, H.J.4    Voordouw, A.C.5    Meloen, R.H.6    Kolakofsky, D.7    Melief, C.J.8
  • 44
    • 0027420794 scopus 로고
    • Immunization against tumor and minor histocompatibility antigens by eluted cellular peptides loaded on antigen processing defective cells
    • Franksson, L., M. Petersson, R. Kiessling, and K. Karre. 1993. Immunization against tumor and minor histocompatibility antigens by eluted cellular peptides loaded on antigen processing defective cells. Eur. J. Immunol. 23:2606.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 2606
    • Franksson, L.1    Petersson, M.2    Kiessling, R.3    Karre, K.4
  • 47
  • 48
    • 0032101405 scopus 로고    scopus 로고
    • Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes
    • Crawford, F., H. Kozono, J. White, P. Marrack, and J. Kappler. 1998. Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes. Immunity 8:675.
    • (1998) Immunity , vol.8 , pp. 675
    • Crawford, F.1    Kozono, H.2    White, J.3    Marrack, P.4    Kappler, J.5
  • 49
    • 0030176270 scopus 로고    scopus 로고
    • Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response
    • Sykulev, Y., M. Joo, I. Vturina, T. J. Tsomides, and H. N. Eisen. 1996. Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response. Immunity 4:565.
    • (1996) Immunity , vol.4 , pp. 565
    • Sykulev, Y.1    Joo, M.2    Vturina, I.3    Tsomides, T.J.4    Eisen, H.N.5
  • 50
    • 0025273755 scopus 로고
    • Limit of T cell tolerance to self proteins by peptide presentation
    • Schild, H., O. Rotzschke, H. Kalbacher, and H. G. Rammensee. 1990. Limit of T cell tolerance to self proteins by peptide presentation. Science 247:1587.
    • (1990) Science , vol.247 , pp. 1587
    • Schild, H.1    Rotzschke, O.2    Kalbacher, H.3    Rammensee, H.G.4
  • 51
    • 0032526853 scopus 로고    scopus 로고
    • Endogenous myelin basic protein inactivates the high avidity T cell repertoire
    • Targoni, O. S., and P. V. Lehmann. 1998. Endogenous myelin basic protein inactivates the high avidity T cell repertoire. J. Exp. Med. 187:2055.
    • (1998) J. Exp. Med. , vol.187 , pp. 2055
    • Targoni, O.S.1    Lehmann, P.V.2
  • 53
    • 0027180397 scopus 로고
    • Hen egg-white lysozyme-specific T cells elicited in hen egg-white lysozyme-transgenic mice retain an imprint of self-tolerance
    • Yule, T. D., A. Basten, and P. M. Allen. 1993. Hen egg-white lysozyme-specific T cells elicited in hen egg-white lysozyme-transgenic mice retain an imprint of self-tolerance. J. Immunol. 151:3057.
    • (1993) J. Immunol. , vol.151 , pp. 3057
    • Yule, T.D.1    Basten, A.2    Allen, P.M.3
  • 54
    • 0028824098 scopus 로고
    • Low avidity recognition of self-antigen by T cells permits escape from central tolerance
    • Liu, G. Y., P. J. Fairchild, R. M. Smith, J. R. Prowle, D. Kioussis, and D. C. Wraith. 1995. Low avidity recognition of self-antigen by T cells permits escape from central tolerance. Immunity 3:407.
    • (1995) Immunity , vol.3 , pp. 407
    • Liu, G.Y.1    Fairchild, P.J.2    Smith, R.M.3    Prowle, J.R.4    Kioussis, D.5    Wraith, D.C.6
  • 55
    • 0022483534 scopus 로고
    • The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides
    • Townsend, A. R., J. Rothbard, F. M. Gotch, G. Bahadur, D. Wraith, and A. J. McMichael. 1986. The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell 44: 959.
    • (1986) Cell , vol.44 , pp. 959
    • Townsend, A.R.1    Rothbard, J.2    Gotch, F.M.3    Bahadur, G.4    Wraith, D.5    McMichael, A.J.6
  • 56
    • 0032961752 scopus 로고    scopus 로고
    • Structural features of autoreactive TCR that determine the degree of degeneracy in peptide recognition
    • Hausmann, S., M. Martin, L. Gauthier, and K. W. Wucherpfennig. 1999. Structural features of autoreactive TCR that determine the degree of degeneracy in peptide recognition. J. Immunol. 162:338.
    • (1999) J. Immunol. , vol.162 , pp. 338
    • Hausmann, S.1    Martin, M.2    Gauthier, L.3    Wucherpfennig, K.W.4
  • 58
    • 0028839022 scopus 로고
    • Immunological function of a defined T-cell population tolerized to low-affinity self antigens
    • Kawai, K., and P. S. Ohashi. 1995. Immunological function of a defined T-cell population tolerized to low-affinity self antigens. Nature 374:68.
    • (1995) Nature , vol.374 , pp. 68
    • Kawai, K.1    Ohashi, P.S.2
  • 60
    • 0033198562 scopus 로고    scopus 로고
    • The makings of a tumor rejection antigen
    • Gilboa, E. 1999. The makings of a tumor rejection antigen. Immunity 11:263.
    • (1999) Immunity , vol.11 , pp. 263
    • Gilboa, E.1
  • 61
    • 0033523640 scopus 로고    scopus 로고
    • The stimulation of low-affinity, nontolerized clones by heteroclitic antigen analogues causes the breaking of tolerance established to an immunodominant T cell epitope
    • Wang, R., Y. Wang-Zhu, C. R. Gabaglia, K. Kimachi, and H. M. Grey. 1999. The stimulation of low-affinity, nontolerized clones by heteroclitic antigen analogues causes the breaking of tolerance established to an immunodominant T cell epitope. J. Exp. Med. 190:983.
    • (1999) J. Exp. Med. , vol.190 , pp. 983
    • Wang, R.1    Wang-Zhu, Y.2    Gabaglia, C.R.3    Kimachi, K.4    Grey, H.M.5
  • 63
    • 0020474114 scopus 로고
    • "Wasted," a new mutant of the mouse with abnormalities characteristic to ataxia telangiectasia
    • Shultz, L. D., H. O. Sweet, M. T. Davisson, and D. R. Coman. 1982. "Wasted," a new mutant of the mouse with abnormalities characteristic to ataxia telangiectasia. Nature 297:402.
    • (1982) Nature , vol.297 , pp. 402
    • Shultz, L.D.1    Sweet, H.O.2    Davisson, M.T.3    Coman, D.R.4
  • 64
    • 0032515985 scopus 로고    scopus 로고
    • The lethal mutation of the mouse wasted (wst) is a deletion that abolishes expression of a tissue-specific isoform of translation elongation factor 1", encoded by the Eef1a2 gene
    • Chambers, D. M., J. Peters, and C. M. Abbott. 1998. The lethal mutation of the mouse wasted (wst) is a deletion that abolishes expression of a tissue-specific isoform of translation elongation factor 1", encoded by the Eef1a2 gene. Proc. Natl. Acad Sci. USA 95:4463.
    • (1998) Proc. Natl. Acad Sci. USA , vol.95 , pp. 4463
    • Chambers, D.M.1    Peters, J.2    Abbott, C.M.3
  • 65
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392:245.
    • (1998) Nature , vol.392 , pp. 245
    • Banchereau, J.1    Steinman, R.M.2


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