Structural features of autoreactive TCR that determine the degree of degeneracy in peptide recognition

Journal of Immunology

Volumn 162, Issue 1, 1999, Pages 338-344

  Hausmann, Stefan ^a   Martin, Margarita ^a   Gauthier, Laurent ^a   Wucherpfennig, Kai W ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; BACTERIAL PROTEIN; LYSINE; MYELIN BASIC PROTEIN; PROLINE; SERINE; T LYMPHOCYTE RECEPTOR;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIGEN RECOGNITION; ARTICLE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; CROSS REACTION; ESCHERICHIA COLI; GENE REARRANGEMENT; HAEMOPHILUS INFLUENZAE; HUMAN; HUMAN CELL; LYMPHOCYTE CLONE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, BACTERIAL; AUTOANTIGENS; CELL LINE; CROSS REACTIONS; EPITOPES, T-LYMPHOCYTE; HUMANS; HYBRIDOMAS; MICE; MOLECULAR SEQUENCE DATA; MYELIN BASIC PROTEINS; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL;

EID: 0032961752     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Zamvil, S. S., and L. Steinman. 1990. The T lymphocyte in experimental allergic encephalomyclitis. Annu. Rev. Immunol. 8:579.
2. Oldstone, M. B. A. 1990. Molecular mimicry and autoimmune disease. Cell 50:819.
3. Wucherpfennig, K. W., and J. L. Strominger. 1995. Molecular mimicry in T cell mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80:695.
4. Brocke, S., A. Gaur, C. Piercy, A. Gautam, K. Gijbels, C. G. Fathman, and L. Steinman. 1993. Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen. Nature 365:642.
5. Steinman, L. 1996. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 85:299.
6. Miller, S. D., C. I., Vanderlugt, W. S. Begolka, W. Pao, R. L. Yauch, K. I., Neville, Y. Katz-Levy, A. Carrizosa, and B. S. Kim. 1997. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading. Nat. Med. 3:1133.
7. Hemmer, B., B. T. Fleckenstein, M. Vergelli, G. Jung, H. McFarland, R. Martin, and K.-H. Wiesmüller. 1997. Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone. J. Exp. Med. 185:1651.
8. Kersh, G. J., and P. M. Allen. 1996. Essential flexibility in the T-cell recognition of antigen. Nature 380:495.
9. Rammensee, H.-G., T. Friede, and S. Stevanovic. 1995. MHC ligands and peptide motifs: first listing. Immunogenetics 41:178.
10. Stern, L. J., J. H. Brown, T. S. Jardetzky, R. Urban, J. L. Strominger, and D. C. Wiley. 1994. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368:215.
11. Jardetzky, T. S., J. H. Brown, J. C. Gorga, L. J. Stern, R. G. Urban, J. L. Strominger, and D. C. Wiley. 1996. Crystallographic analysis of endogenous peptides associated with HLA-DR1 suggests a common, polyproline II-like conformation for bound peptides. Proc. Natl. Acad. Sci. USA 93:734.
12. Garboczi, D. N., P. Ghosh, U. Utz, Q. R. Fan, W. E. Biddison, and D. C. Wiley. 1996. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384:134.
13. Garcia, K. C., M. Degano, R. L. Stanfield, A. Brunmark, M. R. Jackson, P. A. Peterson, L. Teyton, and I. A. Wilson. 1996. An αβ T cell receptor structure at 2.5Å and its orientation in the TCR-MHC complex. Science 274:209.
14. Garboczi, D. N., U. Utz, P. Ghosh, A. Seth, J. Kim, E. A. VanTienhoven, W. E. Biddison, and D. C. Wiley. 1996. Assembly, specific binding, and crystallization of a human TCR-αβ with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2. J. Immunol. 157:5403.
15. Wucherpfennig, K. W., A. Sette, S. Southwood, C. Oseroff, M. Matsui, J. L. Strominger, and D. A. Hafler. 1994. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J. Exp. Med. 179:279.
16. Wucherpfennig, K. W., J. Zhang, C. Witek, M. Matsui, Y. Modabber, K. Ota, and D. A. Hafler. 1994. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J. Immunol. 150:5581.
17. Kalandadze, A., M. Galleno, L. Foncerrado, J. L. Strominger, and K. W. Wucherpfennig. 1996. Expression of HLA-DR2 molecules: replacement of the hydrophobic transmembrane region by a leucine zipper dimerization motif allows the assembly and secretion of soluble DR αβ heterodimers. J. Biol. Chem. 271:20156.
18. Wucherpfennig, K. W., D. A. Hafler, and J. L. Strominger. 1995. Structure of human T cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T cell receptors on HLA-DR2/peptide complexes. Proc. Natl. Acad. Sci. USA 92:8896.
19. Spielman, R. S., and N. Nathenson. 1982. The genetics of susceptibility to multiple sclerosis. Epidemiol. Rev. 4:45.
20. Hillert, J., T. Kall, M. Vrethem, S. Fredrikson, M. Ohlson, and O. Olerup. 1994. The HLA-Dw2 haplotype segregates closely with multiple sclerosis in multiplex families. J. Neuroimmunol. 50:95.
21. The Multiple Sclerosis Study Group. 1996. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. Nat. Genet. 13:469.
22. Smith, K. J., J. Pyrdol, L. Gauthier, D. C. Wiley, and K. W. Wucherpfennig. Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein. J. Exp. Med. 188:1511.
23. Hammer, J., E. Bono, F. Gallazzi, C. Belunis, Z. Nagy, and F. Sinigaglia. 1994. Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning. J. Exp. Med. 180:2353.
24. Bhardwaj, V., V. Kumar, H. M. Geysen, and E. E. Sercarz. 1993. Degenerate recognition of a dissimilar antigenic peptide by myelin basic protein-reactive T cells. J. Immunol. 151:5000.
25. Evavold, B. D., J. Sloan-Lancaster, K. J. Wilson, J. B. Rothbard, and P. M. Allen. 1995. Specific T cell recognition of minimally homologous peptides: evidence for multiple endogenous ligands. Immunity 2:655.
26. Hausmann, S., and K. W. Wucherpfennig. 1997. Activation of autoreactive T cells by peptides from human pathogens. Curr. Opin. Immunol. 9:831.
27. Koop, B. F., L. Rowen, K. Wang, C. L. Kuo, D. Seto, J. A. Lenstra, S. Howard, W. Shan, P. Deshpande, and L. Hood. 1994. The human T-cell receptor TCRAC/ TCRDC (Ca/Cd) region: organization, sequence, and evolution of 97.6 kb of DNA. Genomics 19:478.