Expression of elongation factor-1α and S1 in young and old human skeletal muscle

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 52, Issue 5, 1997, Pages

  Welle, Stephen ^a,b   Thornton, Charles ^a   Bhatt, Kirti ^a,b   Krym, Matthew ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

^b Monroe Community Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELONGATION FACTOR 1ALPHA; MESSENGER RNA; NUCLEASE S1;

ADULT; AGED; AGING; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MUSCLE BIOPSY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RNA ANALYSIS; SKELETAL MUSCLE; VASTUS LATERALIS MUSCLE;

ANIMALIA;

EID: 0030821555     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/52A.5.B235     Document Type: Article

References (6)

1. Blazejowski, C.A.; Webster, G.C. Effect of age on peptide chain initiation and elongation in preparations from brain, liver, kidney, and skeletal muscle of the C57B1/6J mouse. Mech. Ageing Dev. 25:323-333; 1984.
2. Cavallius, J.; Rattan, S.I.S; Clark, B.F.C. Changes in activity and amount of active elongation factor la in aging and immortal human fibroblast cultures. Exp. Gerontol. 21:149-157; 1986.
3. Condeelis, J. Elongation factor 1α, translation and the cytoskeleton. Trends Biol. Sci. 20:169-170; 1995.
4. Fabian, T.J.; Johnson, T.E. Identification of genes that are differentially expressed during aging in Caenorhabditis elegans. J. Gerontol Biol. Sci. 50A:B245-B253; 1995.
5. Gabius, H J.; Engelhardt, R; Deerberg, F.; Cramer, F. Age-related changes in different steps of protein synthesis of liver and kidney of rats. FEES Lett. 160:115-118; 1983.
6. Gonen, H.; Smith, C.E.; Siegel, N.R.; Kahana, C.; Merrick, W.C.; Chakraburtty, K.; Schwartz, A.L.; Ciechanover, A. Protein synthesis elongation factor EF-1α is essential for ubiquitin-dependent degradation of certain N-acetylated proteins and may be substituted for by the bacterial elongation factor EF-Tu. Proc. Natl. Acad. Sci. USA 91: 7648-7652; 1994.