Conclusive evidence for distinct transporters for 5-hydroxytryptamine and noradrenaline in pulmonary endothelial cells of the rat

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 353, Issue 4, 1996, Pages 423-430

  Paczkowski, Natalii J ^a   Vuocolo, Helen E ^a   Bryan Lluka, Lesley J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

5 Hydroxytryptamine; 5 Hydroxytryptamine transporter; Endothelial cells; Noradrenaline; Rat lungs; Uptake1

Indexed keywords

7 METHYLTRYPTAMINE; CITALOPRAM; COCAINE; DESIPRAMINE; FLUOXETINE; IMIPRAMINE; NISOXETINE; NORADRENALIN; OXAPROTILINE; PAROXETINE; SEROTONIN; TRYPTAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CATECHOLAMINE UPTAKE; DRUG TRANSPORT; FEMALE; ISOTOPE LABELING; LUNG FUNCTION; MALE; NONHUMAN; RAT;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC UPTAKE INHIBITORS; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; CITALOPRAM; DESIPRAMINE; FEMALE; LUNG; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; NOREPINEPHRINE; RATS; RATS, WISTAR; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS;

EID: 0029872382     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Amara SG, Kuhar MJ (1993) Neurotransmitter transporters: recent progress. Ann Rev Neurosci 16:73-93
2. Blakely RD, Berson HE, Fremeau RT, Caron MG, Peek MM, Prince HK, Bradley CC (1991) Cloning and expression of a functional serotonin transporter from rat brain. Nature 354:66-70
3. 3H-desipramine to the neuronal noradrenaline carrier of rat phaeochromocytoma cells (PC-12 cells). Naunyn-Schmiedeberg's Arch Pharmacol 334:403-411
4. Bryan-Lluka LJ, O'Donnell SR (1991) Isolated perfused lungs of guinea-pig, in contrast with rat, lack an uptake process for noradrenalinc. Pulm Pharmacol 4:146-150
5. Bryan-Lluka LJ, O'Donnell SR (1992) Dopamine and adrenaline, but not isoprenaline, are substrates for uptake and metabolism in isolated perfused lungs of rats. Naunyn Schmiedeberg's Arch Pharmacol 346:20-26
6. 1 in noradrenergic neurones. Naunyn Schmiedeberg's Arch Pharmacol 345:319-326
7. 50) of an enzymatic reaction. Biochem Pharmacol 22:3099-3108
8. Geigy JR (1962) In: Diem K (ed) Documenta Geigy Scientific Tables, 6th edn. Geigy Australia Pty Ltd, Pharmaceuticals Division, Sydney, Australia, pp 54-55 and 160-165
9. Gillis CN, Iwasawa Y (1972) Technique for measurement of norepinephrine and 5-hydroxytryptamine uptake by rabbit lungs. J Appl Physiol 33:404-408
10. Gillis CN, Roth JA (1977) The fate of biogenic monoamines in perfused rabbit lung. Br J Pharmacol 59:585-590
11. Gillis CN, Greene NM, Cronau LH, Hammond GL (1972) Pulmonary extraction of 5-hydroxytryptamine and norepinephrine before and after cardiopulmonary bypass in man. Circ Res 30: 666-674
12. Hoffman BJ, Mezey E, Brownstein MJ (1991) Cloning of a serotonin transporter affected by antidepressants. Science 254:579-580
13. Hughes J, Gillis CN, Bloom FE (1969) The uptake and disposition of d1-norepinephrine in perfused rat lung. J Pharmacol Exp Ther 169:237-248
14. Hyttel J (1982) Citalopram pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog Neuro-Psychopharmacol Biol Psychiatry 6:277-295
15. Iwasawa Y, Gillis CN (1974) Pharmacological analysis of norepinephrine and 5-hydroxytryptamine removal from the pulmonary circulation: differentiation of uptake sites for each amine. J Pharmacol Exp Ther 188:386-393
16. Iwasawa Y, Gillis CN, Aghajanian G (1973) Hypothermic inhibition of 5-hydroxytryptamine and norepinephrine uptake by lung: Cellular location of amines after uptake. J Pharmacol Exp Ther 186:498-507
17. 14C-5-hydroxytryptamine in isolated perfused rat lungs. J Pharmacol Exp Ther 183:341-355
18. Lesch K-P, Wolozin BL, Murphy DL, Riederer P (1993) Primary structure of the human platelet serotonin uptake site: identity with the human brain serotonin transporter. J Neurochem 60:2319-2322
19. 3H-1-norepinephrine by isolated perfused rat lungs. Circ Res 35:670-680
20. Paczkowski NJ, Bryan-Lluka LJ (1993) Different transporters for uptake of 5-hydroxytryptamine and noradrenaline into rat pulmonary endothelial cells. Clin Exp Pharmacol Physiol Suppl 1:55
21. Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS, Ganapathy V, Blakely RD (1993) Antidepressant-and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 90:2542-2546
22. Richelson E, Pfenning M (1984) Blockade by antidepressants and related compounds of biogenic amine uptake into rat brain synaptosomes: most antidepressants selectively block norepinephrine uptake. Eur J Pharmacol 104:277-286
23. Russell WJ, Frewin DB, Jonsson JR (1982) Pulmonary extraction of catecholamines in critically ill patients. Anaesth Intens Care 10:319-323
24. Snedecor GW, Cochran WG (1989) Statistical methods, 8th edn. Iowa State University Press, Ames, USA
25. 3H uptake by pulmonary endothelial cells. J Cell Biol 54:456-467
26. Wölfel R, Graefe K-H (1992) Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter. Naunyn-Schmiedeberg's Arch Pharmacol 345:129-136