Regulation of apoptosis in the prostate gland by androgenic steroids

Trends in Endocrinology and Metabolism

Volumn 10, Issue 2, 1999, Pages 47-54

  Buttyan, Ralph ^a   Shabsigh, Ahmad ^a   Perlman, Harris ^a   Colombel, Marc ^b  

^a New York Presbyterian Columbia University Medical Center   (United States)

^b HOSPICES CIVILS DE LYON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; FAS ANTIGEN; PROTEIN BCL 2; PROTEIN P53;

ADULTHOOD; ANDROGEN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; BLOOD FLOW; CASTRATION; CONTROLLED STUDY; EMBRYO DEVELOPMENT; GENE ACTIVITY; HORMONE METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROSTATE; PROSTATE EPITHELIUM; REVIEW;

EID: 0033034290     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(98)00104-0     Document Type: Review

References (64)

1. Kumar V.L., Majumder P.K. Prostate gland: structure, functions and regulation. Int. Urol. Nephrol. 27:1995;231-243.
2. Buttyan, R., Zhang, X., Dorai, T. and Olsson, C.A. (1997) Anti-apoptosis genes and the development of hormone-resistant prostate cancer. In: Prostate: Basic and Clinical Aspects (Rajesh Naz, ed.), CRC Press, pp 201-216.
3. Kyprianou N., Tu H., Jacobs S.C. Apoptotic versus proliferative activities in human benign prostatic hyperplasia. Hum. Pathol. 27:1996;668-675.
4. Wilson, J.D. (1996) Role of dihydrotestosterone in androgen action. Prostate 6 (Suppl.), 88-92.
5. Chang C.et al. Androgen receptor: an overview. Crit. Rev. Eukaryot. Gene Expr. 5:1995;97-125.
6. Iwarmura M., Abrahamsson P.A., Benning C.M., Cockett A.T., di Sant'Agnese P.A. Androgen receptor immunostaining and its tissue distribution in formalin-fixed, paraffin-embedded sections after microwave treatment. J. Histochem. Cytochem. 42:1994;783-788.
7. Prins G.S., Birch L., Greene G.L. Androgen receptor localization in different cell types of the adult rat prostate. Endocrinology. 129:1991;3187-3199.
8. Lee C., Sensibar J.A., Dudek S.M., Hiipakka R.A., Liao S.T. Prostatic ductal system in rats: regional variation in morphological and functional activities. Biol. Reprod. 43:1990;1079-1086.
9. Sonnenschein C., Olea N., Pasanen M.E., Soto A.M. Negative controls of cell proliferation: human prostate cancer cells and androgens. Cancer Res. 49:1989;3474-3481.
10. Webber M.M., Bello D., Kleinman H.K., Wartinger D.D., Williams D.E., Rhim J.S. Prostate specific antigen and androgen receptor induction and characterization of an immortalized adult human prostatic epithelial cell line. Carcinogenesis. 17:1996;1641-1646.
11. Huggins C., Hodges C.V. Studies on prostate cancer: I. The effects of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res. 1:1941;293-298.
12. Bruchovsky N., Lesser B., van Doorne E. Hormonal effects on cell proliferation in rat prostate. Vitam. Horm. 33:1975;61-102.
13. Lee C. Physiology of castration-induced regression in rat prostate. Prog. Clin. Biol. Res. 75A:1981;145-159.
14. Kyprianou N., Isaacs J.T. Activation of programmed cell death in the rat ventral prostate after castration. Endocrinology. 122:1988;552-562.
15. Kerr J.F.R., Searle J. Deletion of cells by apoptosis during castration-induced involution of the rat prostate. Virchows Arch. B Cell Pathol. 13:1973;87-102.
16. English H.F., Drago J.R., Santen R.J. Cellular response to androgen depletion and repletion in the rat prostate; autoradiography and morphometric analysis. Prostate. 7:1985;41-51.
17. Sanford M.L., Searle J.W., Kerr J.F.R. Successive waves of apoptosis in the rat prostate after repeated withdrawal of testosterone stimulation. Pathology. 16:1984;406-410.
18. Berges R.R., Furuya Y., Remington L., English H.F., Jacks T., Isaacs J.T. Cell proliferation, DNA repair, and p53 function are not required for the programmed death of prostatic glandular cells induced by androgen ablation. Proc. Natl. Acad. Sci. U. S. A. 90:1993;8910-8914.
19. Sensibar J.A.et al. Prostatic ductal system in rats: regional variation in localization of an androgen-repressed gene product, sulfated glycoprotein-2. Endocrinology. 128:1991;2091-2102.
20. Lee, C. (1996) Role of androgen in prostate growth and regression: stromal-epithelial interaction. Prostate 6 (Suppl.), 52-56.
21. Colombel M., Buttyan R. Hormonal control of apoptosis: the rat ventral prostate gland as a model system. Methods Cell Biol. 46:1995;369-385.
22. Montpetit M.L., Tenniswood M.P. Separation of mature rat ventral prostate epithelial and fibroblast cells. Prostate. 15:1989;315-325.
23. 2+-dependent endonuclease as an early event in castration-induced prostatic cell death. Prostate. 13:1988;103-117.
24. English H.F., Kyprianou N., Isaacs J.T. Relationship between DNA fragmentation and apoptosis in the programmed cell death in the rat prostate following castration. Prostate. 15:1989;233-350.
25. Gavereli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:1992;493-501.
26. Rauch F., Polzar B., Stephan H., Zanotti S., Paddenberg R., Mannherz H.G. Androgen ablation leads to an upregulation and intranuclear accumulation of deoxynuclease I in rat prostate epithelial cells paralleling their apoptotic elimination. J. Cell Biol. 137:1997;909-923.
27. Zhang X., DeCarli A., Buttyan R. Internucleosomal DNA fragmentation is not obligatory for castration-induced rat ventral prostate cell apoptosis in vivo. Cell Death Differ. 4:1997;304-310.
28. Kyprianou N., Isaacs J.T. Expression of transforming growth factor-beta in the rat ventral prostate during castration-induced programmed cell death. Mol. Endocrinol. 3:1989;1515-1522.
29. Martikainen P., Kyprianou N., Isaacs J.T. Effect of transforming growth factor-beta 1 on proliferation and death of rat prostatic cells. Endocrinology. 127:1990;2963-2968.
30. Nishi N., Oya H., Matsumoto K., Nakamura T., Miyanka H., Wada F. Changes in gene expression of growth factors and their receptors during castration-induced involution and androgen-induced regrowth of rat prostates. Prostate. 28:1996;139-152.
31. Kennedy W.A., Buttyan R., Garcia-Montes E., D'Agati V., Olsson C.A., Sawczuk I.S. Epidermal growth factor suppresses renal tubular apoptosis following ureteral obstruction. Urology. 49:1997;973-980.
32. Suzuki A., Matsuzawa A., Iguchi T. Downregulation of bcl-2 is the first step of fas-mediated apoptosis of male reproductive tract. Oncogene. 13:1996;31-37.
33. Buttyan R., Zakeri Z., Lockshin R.A., Wolgemuth D. Cascade induction of c-fos, c-myc and heat shock 70 K transcripts during regression of the rat ventral prostate gland. Mol. Endocrinol. 2:1988;650-657.
34. Marti A., Jehn B., Costello E., Keon N., Ke G., Martin F., Jaggi R. Protein kinase A and AP-1 (c-fos/Jun D) are induced during apoptosis of mammary epithelial cells. Oncogene. 9:1994;1213-1223.
35. Feng Z., Joos H.J., Vallan C., Muhlbauer R., Altermatt H.J., Jaggi R. Apoptosis during castration-induced regression of the prostate is fos dependent. Oncogene. 17:1998;2593-2600.
36. Yin X.M., Oltvai Z.N., Korsmeyer S.J. BH1 and BH2 domains of bcl-2 are required for inhibition of apoptosis and heterodimerization with bax. Nature. 369:1994;321-323.
37. Yang E., Korsmeyer S.J. Molecular thanatopsis: a discourse on the bcl-2 family and cell death. Blood. 88:1996;386-401.
38. Reed J.C.et al. Bcl-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J. Cell. Biochem. 60:1996;23-32.
39. Perlman H.R., Zhang X., Chen M-W., Walsh K., Buttyan R. Differential expression of bax and bcl-2 in the rat ventral prostate gland after castration: an elevated bax/bcl-2 ratio corresponds with the onset of prostate epithelial cell apoptosis. Cell Death Differ. 6:1999;48-54.
40. Oltvai Z., Milliman C.L., Korsmeyer S.J. Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell. 74:1993;609-619.
41. Korsmeyer S.J., Shutter J.R., Veis D.J., Merry D.E., Oltvai Z. Bcl-2/Bax: a rheostat that regulates an antioxidant pathway and cell death. Semin. Cancer Biol. 4:1993;327-332.
42. McDonnell T.J.et al. Expression of the protooncogene bcl-2 in the prostate and its association with the emergence of androgen-independent prostate cancer. Cancer Res. 52:1992;6940-6944.
43. Colombel M.et al. Detection of the apoptosis-suppressing oncoprotein bcl-2 in hormone refractory human prostate cancers. Am. J. Pathol. 143:1993;390-400.
44. Krajewska M.et al. Immunohistochemical analysis of bcl-2, bax, bcl-X and mcl-1 expression in prostate cancers. Am. J. Pathol. 148:1996;1567-1576.
45. Raffo A., Perlman H., Chen M-W., Day M., Buttyan R. Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo. Cancer Res. 55:1996;4438-4445.
46. Dorai T., Olsson C.A., Katz A.E., Buttyan R. Development of a hammerhead ribozyme against bcl-2. I. Preliminary evaluation of a potential gene therapeutic agent for hormone-refractory human prostate cancer. Prostate. 32:1997;246-258.
47. Morgan S.E., Kastan M.B. p53 and ATM: cell cycle, cell death and cancer. Adv. Cancer Res. 71:1997;1-25.
48. Colombel M., Olsson C.A., Ng P-Y., Buttyan R. Hormone-regulated apoptosis results from reentry of differentiated prostate cells into a defective cell cycle. Cancer Res. 52:1992;4313-4319.
49. Zhang X., DeCarll A., Buttyan R. Internucleosomal DNA fragmentation is not obligatory for castration-induced rat ventral prostate apoptosis in vivo. Cell Death Differ. 4:1997;304-310.
50. Colombel M.C.et al. Androgen-suppressed apoptosis is modified in p53 deficient mice. Oncogene. 10:1995;1269-1274.
51. Rennie P.S., Bouffard R., Bruchovsky N., Cheng H. Increased activity of plasminogen activators during involution of the rat ventral prostate. Biochem. J. 221:1984;171-178.
52. Sensibar J.A., Liu X.X., Patai B., Alger B., Lee C. Characterization of castration-induced cell death in the rat prostate by immunohistochemical localization of cathepsin D. Prostate. 16:1990;263-276.
53. Guenette R.S., Mooibroek M., Wong K., Wong P., Tenniswood M. Cathepsin B, a cysteine protease implicated in metastatic progression, is also expressed during regression of the rat prostate and mammary glands. Eur. J. Biochem. 226:1994;311-321.
54. Powell W.C., Domann F.E. Jr., Mitchen J.M., Matrisian L.M., Nagle R.B., Bowden G.T. Matrilysin expression in the involuting rat ventral prostate. Prostate. 29:1996;159-168.
55. Mitmaker B., Baytner S., Wang E. Temporal relationships of statin and termin expression in the ventral lobe of rat prostate following castration. Eur. J. Histochem. 37:1993;295-301.
56. Montpetit M.L., Lawless K.R., Tenniswood M. Androgen-repressed messages in the rat ventral prostate. Prostate. 8:1986;25-36.
57. Briehl M.M., Miesfeld R.L. Isolation and characterization of transcripts induced by androgen withdrawal and apoptotic cell death in the rat ventral prostate. Mol. Endocrinol. 5:1991;1381-1388.
58. Hsieh J.T., Lin S.H. Androgen regulation of cell adhesion molecule gene expression in rat prostate during organ degeneration. C-CAM belongs to a class of androgen-repressed genes associated with enriched stem/amplifying cell population after prolonged castration. J. Biol. Chem. 269:1994;3711-3716.
59. Sells S.F.et al. Expression and function of the leucine zipper protein Par-4 in apoptosis. Mol. Cell. Biol. 17:1997;3823-3832.
60. Lekas E., Johansson M., Widmark A., Bergh A., Damber J-E. Decrement of blood flow precedes the involution of the ventral prostate in the rat after castration. Urol. Res. 25:1997;309-314.
61. Shabsigh A.et al. Rapid reduction in blood flow to the rat ventral prostate gland after castration: preliminary evidence that androgens influence prostate size by regulating blood flow to the prostate gland and prostate endothelial cell survival. Prostate. 36:1998;201-206.
62. Gobe G.C., Axelson R.A., Searle J.W. Cellular events in experimental unilateral ischemic renal atrophy and in regeneration after contralateral nephrectomy. Lab. Invest. 63:1990;770-779.
63. Schumer M.et al. Morphological biochemical and molecular evidence of apoptosis during the reperfusion phase following brief periods of renal ischemia. Am. J. Pathol. 140:1992;831-838.
64. Franck-Lissbrant I., Haggstrom S., Damber J-E., Bergh A. Testosterone stimulates angiogenesis and vascular regrowth in the ventral prostate in castrated rats. Endocrinology. 139:1998;451-456.