Cadmium-induced apoptosis in the urogenital organs of the male rat and its suppression by chelation

Journal of Toxicology and Environmental Health

Volumn 52, Issue 2, 1997, Pages 149-168

  Yan, Heping ^a   Carter, Clint E ^a   Xu, Cunyong ^b   Singh, Pramod K ^b   Jones, Mark M ^b   Johnson, Joyce E ^b   Dietrich, Mary S ^b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CADMIUM; CHELATING AGENT; DNA FRAGMENT; SUCCIMER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CHELATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDIDYMIS; HISTOPATHOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTATE; RAT; SEMINAL VESICLE; UROGENITAL SYSTEM;

ANIMALS; APOPTOSIS; BIOTIN; CADMIUM CHLORIDE; CHELATING AGENTS; CHROMATIN; DNA FRAGMENTATION; DNA NUCLEOTIDYLEXOTRANSFERASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIDIDYMIS; INJECTIONS, INTRAPERITONEAL; KIDNEY; MALE; MUTAGENS; PROSTATE; RATS; RATS, WISTAR; SEMINAL VESICLES; SUCCIMER; URIDINE TRIPHOSPHATE; URINARY BLADDER; UROGENITAL SYSTEM;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0030931841     PISSN: 00984108     EISSN: None     Source Type: Journal    
DOI: 10.1080/00984109708984058     Document Type: Article

References (30)

1. Ansari, B., Coates, P. J., Greenstein, B. D., and Hall, P. A. 1993. In situ end-labelling detects DNA strand breaks in apoptosis and other physiological and pathological states. J. Pathol. 170:1-8.
2. Arends, M. J., and Wyllie, A. H. 1991. Apoptosis: Mechanisms and roles in pathology. Int. Rev. Exp. Pathol. 32:223-254.
3. Arends, M.D., Morris, R. G., and Wyllie, A. H. 1990. Apoptosis. The role of the endonuclease. Am. 1. Pathol. 136:593-608.
4. Azzouzi, B. E., Tsangaris, C. T., Pellegrini, Y. M., Benveniste, J., and Thomas, Y. 1994. Cadmium induces apoptosis in human T cell line. Toxicology 88:127-139.
5. Cohen, J. J., Duke, R. C., Chervenak, R., Sellins, K. S., and Olson, L. K. 1985. DNA fragmentation in targets of CTL: An example of programmed cell death in the immune system. Adv. Exp. Med. Biol. 184:493-508.
6. Duvall, E., and Wyllie, A. H. 1986. Death and the cell. Immunol. Today 17:115-119.
7. Elmes, M. E. 1977. Apoptosis in the small intestine of zinc-deficient and fasted rats. J. Pathol. 123:219-223.
8. Elmes, M. E., and Jones, J. G. 1980. Ultrastructural studies of Paneth cell apoptosis in zinc deficient rats.Cell Tissue Res. 8:57-63.
9. Fujita, N., Kataoka, S., Naito, M., Heike, Y., Boku, N., Nakajima, M., and Tauruo, T. 1993. Suppression of T-lymphoma cell apoptosis by monocolonal antibodies raised against cell surface adhesion molecules. Cancer Res. 53:5022-5027.
10. Gunn, S. A., Gould, T. C., and Anderson, W. A. D. 1968. Selectivity of organ response to cadmium injury and various protective measures. J. Pathol. Bacteriol. 96:89-96.
11. Ishido, M., Homma, S. T., Leung, P. S., and Tohyama, C. 1995. Cadmium-induced DNA fragmentation is inhibitable by zinc in porcine kidney LLC-PK, cells. Life Sci. 56:PL351-PL356.
12. Jones, M. M., Singh, P. K., Gale, G. R., Smith, A. B., and Atkins, L. M. 1992. Cadmium mobilization in vivo by intraperitoneal or oral administration of monoalkyl esters of meso-2,3-dimercaptosuccinic acid in the mouse. Pharmacol. Toxicol. 70:336-343.
13. Kojima, S., Sugimura, Y., Hirukawa, H., Kiyozumi, M., Shimada, H., and Funakoshi, T. 1992. Effects of dithiocarbamates on testicular toxicity in rats caused by acute exposure to cadmium. Toxicol. Appl. Pharmacol. 116:24-29.
14. Laskey, J. W., Rehnberg, G. L., Laws, S. C., and Hein, J. F. 1984. Reproductive effects of low acute doses of cadmium chloride in adult male rats. Toxicol. Appl. Pharmacol. 73:250-255.
15. Leist, M., Gartner, T., Bohlinger, I., Tiegs, G., and Wendel, A. 1994. Application of the cell death detection ELISA for the detection of tumor necrosis factor-induced DNA fragmentation in murine models of inflammatory organ failure. Biochim. Boehringer Mannheim. 11:20-22.
16. Leist, M., Gartner, T., Ganter, F., Jilg, S., and Wendel, A. 1995. Activation of the 55 KDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis and nitrite release. J. Immunol. 154:1307-1316.
17. 2*-dependent endonuclease in apoptosis. Biochem. Biophys. Res. Commun. 190:1097-1103.
18. McCabe, M. J., Jr., Jiang, S. A., and Orrenius, S. 1993. Chelation of intracellular zinc triggers apoptosis in mature thymocytes. Lab. Invest. 69:101-110.
19. Mogil, R. J., Shi, Y., Bissonnette, R. P., Bromley, P., Yamaguchi, I., and Green, D. R. 1994. Role of DNA fragmentation in T cell activation-induced apoptosis in vivo. I. Immunol. 152:1674-1683.
20. Nordberg, G. F. 1975. Effects of long-term cadmium exposure on the seminal vesicles of mice. J. Reprod. Fertil. 45:165-167.
21. Oldereid, N. B., Thomassen, Y., Attramadal, A., Olaisen, B., and Purvis, K. 1993. Concentrations of lead, cadmium and zinc in the tissues of reproductive organs of men. J. Reprod Fertil. 99:421-425.
22. Raff, M. C. 1992. Social controls on cell survival and cell death. Nature 356:397-400.
23. Tanimoto, A., Hamada, T., and Koide, O. 1993. Cell death and regeneration of renal proximal tubular cells in rats with subchronic cadmium intoxication. Toxicol. Pathol. 21:341-352.
24. Tasende, M. S. G., Gale, G. R., Smith, A. B., Jones, M. M., and Singh, P. K. 1992. Monoisoamyl meso-2,3-dimercaptosuccinate: Interaction with metallothionein-bound cadmium in vitro and evidence of active transport into renal and hepatic cells in vivo. Res. Commun. Chem. Pathol. Pharmacol. 76:323-339.
25. Tilly, J. L., and Hsueh, A. J. W. 1993. Microscale autoradiographic method for the qualitative and quantitative analysis of apoptotic DNA fragmentation. J. Cell. Pharmacol. 154:519-526.
26. Umansky, S. R. 1982. The genetic program of cell death. Hypothesis and some applications. J. Theor. Biol. 97:591-602.
27. Walker, N. I., Harmor, B. V., Cobe, G. C., and Kerr, D. F. R. 1988. Patterns of cell death. Methods Arch. Exp. Pathol. 13:18-54.
28. Wyllie, A. H. 1980. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284:555-556.
29. Xu, C., Holscher, M. A., Jones, M. M., and Singh, P. K. 1995. Effect of monoisoamyl meso-2,3-dimercaptosuccinate on the pathology of acute cadmium intoxication. J. Toxicol. Environ. Health 45:261-277.
30. Xu, C., Johnson, J. E., Singh, P. K., Jones, M. M., Yan, H., and Carter, C. E. 1996. In vivo studies of cadmium-induced apoptosis in testicular tissue of the rat and its modulation by a chelating agent. Toxicology 107:1-8.