Bioenergetics of immune functions: Fundamental and therapeutic aspects

Immunology Today

Volumn 21, Issue 4, 2000, Pages 194-199

  Buttgereit, Frank ^a   Burmester, Gerd Rüdiger ^a   Brand, Martin D ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

21 AMINOSTEROID; ADENOSINE TRIPHOSPHATE; AMIODARONE; ANTIARRHYTHMIC AGENT; AURANOFIN; CHARYBDOTOXIN; CHLOROQUINE; CYCLOSPORIN A; DITHRANOL; GLIBENCLAMIDE; GLIQUIDONE; GLUCOCORTICOID; INDOMETACIN; LAZAROID; MARGATOXIN; METHYLPREDNISOLONE; NONSTEROID ANTIINFLAMMATORY AGENT; POTASSIUM CHANNEL BLOCKING AGENT; SULFONYLUREA; TACROLIMUS;

AGING; ANTIBODY PRODUCTION; ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; BIOENERGY; CELL DEATH; CELL ENERGY; CELL FUNCTION; CELL GROWTH; CELL MIGRATION; CELL VOLUME; CYTOKINESIS; CYTOTOXICITY; DRUG MECHANISM; DRUG TARGETING; ENERGY CONSUMPTION; ENERGY METABOLISM; ENERGY RESOURCE; HUMAN; IMMUNITY; IMMUNOCOMPETENT CELL; IMMUNOTHERAPY; ION TRANSPORT; LYMPHOCYTE ACTIVATION; PHAGOCYTOSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0034177660     PISSN: 01675699     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0167-5699(00)01593-0     Document Type: Article

References (46)

1. Saraste M. Oxidative phosphorylation at the fin de siècle. Science. 283:1999;1488-1493.
2. 2 improves energetics and decreases lethality. J. Surg. Res. 56:1994;537-542.
3. Karlsson H., Nässberger L. In vitro metabolic inhibition of the human lymphocyte: influence on the expression of interleukin-2 receptors. Immunol. Cell. Biol. 70:1992;309-313.
4. Sanchez-Alcazar J.A.et al. Down-regulation of tumor necrosis factor receptors by blockade of mitochondrial respiration. J. Biol. Chem. 270:1995;23944-23950.
5. Buttgereit F., Brand M.D. A hierarchy of ATP-consuming processes in mammalian cells. Biochem. J. 312:1995;163-167.
6. Brown G.C. Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochem. J. 284:1992;1-13.
7. Richter C. Oxidative damage to mitochondrial DNA and its relationship to ageing. Int. J. Biochem. Cell. Biol. 27:1995;647-653.
8. Mazzeo R.S. The influence of exercise and aging on immune function. Med. Sci. Sports Exerc. 26:1994;586-592.
9. Leist M.et al. Intracellular adenosine triphosphate (ATP) concentration. a switch in the decision between apoptosis and necrosis J. Exp. Med. 185:1997;1481-1486.
10. Buttgereit F.et al. ConA induced changes in energy metabolism of rat thymocytes. Bioscience Rep. 12:1992;381-386.
11. Berney S.M., Atkinson T.P. Phosphatidylinositol hydrolysis in freshly isolated human T lymphocytes. J. Immunol. Methods. 186:1995;71-77.
12. Wells A.L.et al. Myosin VI is an actin-based motor that moves backwards. Nature. 401:1999;505-508.
13. Bianchi E.et al. Through and beyond the wall. late steps in leukocyte transendothelial migration Immunol. Today. 18:1997;586-591.
14. Culic O.et al. Energy turnover of vascular endothelial cells. Am. J. Physiol. 273:1997;205-213.
15. Groettrup M.et al. Peptide antigen production by the proteasome. complexity provides efficiency Immunol. Today. 17:1996;429-435.
16. York I.A., Rock K.L. Antigen processing and presentation by the class I major histocompatibility complex. Annu. Rev. Immunol. 14:1996;369-396.
17. Authier F.et al. Endosomal proteolysis of internalized proteins. FEBS Lett. 389:1996;55-60.
18. Seligmann B. Kleinzeller A., Grinstein S., Rotstein O.D. Current Topics in Membranes and Transport. 1990;103-125 Academic Press.
19. Lewis R.S., Cahalan R.S. Potassium and calcium channels in lymphocytes. Annu. Rev. Immunol. 13:1995;623-653.
20. Togashi K.et al. Characterization of a series of vacuolar type H(1)-ATPase inhibitors on CTL-mediated cytotoxicity. Immunol. Lett. 55:1997;139-144.
21. Ferrari D.et al. Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65. J. Cell Biol. 139:1997;1635-1643.
22. Lammas D.A.et al. ATP-induced killing of mycobacteria by human macrophages is mediated by purinergic P2Z(P2X7) receptors. Immunity. 7:1997;433-444.
23. Di Virgilio F. The P2Z purinoceptor. an intriguing role in immunity, inflammation and cell death Immunol. Today. 16:1995;524-528.
24. Redegeld F.A.et al. Phosphorylation of T-lymphocyte plasma membrane-associated proteins by ectoprotein kinases: implications for a possible role for ectophosphorylation in T-cell effector functions. Biochim. Biophys. Acta. 1328:1997;151-165.
25. Buttgereit F.et al. A new hypothesis of modular glucocorticoid actions. steroid treatment of rheumatic diseases revisited Arthritis Rheum. 41:1998;761-767.
26. Boumpas D.T.et al. Glucocorticoid therapy for immune-mediated diseases. basic and clinical correlates Ann. Intern. Med. 119:1993;1198-1208.
27. Buttgereit F.et al. The effects of methylprednisolone on oxidative phosphorylation in Concanavalin-A-stimulated thymocytes. Top-down elasticity analysis and control analysis. Eur. J. Biochem. 223:1994;513-519.
28. + ions into concanavalin A-stimulated thymocytes. Biochem. J. 326:1997;329-332.
29. Buttgereit F.et al. Equivalent doses and relative drug potencies for nongenomic glucocorticoid effects. Biochem. Pharmacol. 58:1999;363-368.
30. Seki M.et al. Apoptosis of lymphocytes induced by glucocorticoids and relationship to therapeutic efficacy in patients with systemic lupus erythematosus. Arthritis Rheum. 41:1998;823-830.
31. Migita K.et al. Apoptosis induction in human peripheral blood T lymphocytes by high-dose steroid therapy. Transplantation. 63:1997;583-587.
32. Distelhorst W., Dubyak G. Role of calcium in glucocorticosteroid-induced apoptosis of thymocytes and lymphoma cells. resurrection of old theories by new findings Blood. 91:1998;731-734.
33. Chvatchko Y.et al. The involvement of an ATP-gated ion channel, P(2X1), in thymocyte apoptosis. Immunity. 5:1996;275-283.
34. Kroemer G.et al. Mitochondrial control of apoptosis. Immunol. Today. 18:1997;44-51.
35. Buttgereit F.et al. Effects of methylprednisolone and 21-aminosteroids on mitogen-induced interleukin-6 and tumor necrosis factor-alpha production in human peripheral blood mononuclear cells. J. Pharm. Exp. Ther. 275:1995;850-853.
36. Spapen H.et al. Potential therapeutic value of lazaroids in endotoxemia and other forms of sepsis. Shock. 8:1997;321-327.
37. Karlsson H.et al. Energy levels in resting and mitogen-stimulated human lymphocytes during treatment with FK506 or cyclosporin A in vitro. Biochim. Biophys. Acta. 1319:1997;301-310.
38. Horigome A.et al. Tacrolimus-induced apoptosis and its prevention by interleukins in mitogen-activated human peripheral-blood mononuclear cells. Immunopharmacology. 39:1998;21-30.
39. Koo G.C.et al. Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo. J. Immunol. 158:1997;5120-5128.
40. + channels. Proc. Natl. Acad. Sci. U. S. A. 96:1999;10917-10921.
41. Fuchs J.et al. The antipsoriatic compound anthralin influences bioenergetic parameters and redox properties of energy transducing membranes. J. Invest. Dermatol. 94:1990;71-76.
42. Deepalakshmi P.D.et al. Effect of chloroquine on rat liver mitochondria. Indian J. Exp. Biol. 32:1994;797-799.
43. Anderson R.et al. Auranofin inactivates phosphofructokinase in human neutrophils, leading to depletion of intracellular ATP and inhibition of superoxide generation and locomotion. Mol. Pharmacol. 40:1991;427-434.
44. Somasundaram S.et al. Mitochondrial damage. a possible mechanism of the 'topical' phase of NSAID induced injury to the rat intestine Gut. 41:1997;344-353.
45. Yasuda S.U.et al. Amiodarone-induced lymphocyte toxicity and mitochondrial function. J. Cardiovasc. Pharmacol. 28:1996;94-100.
46. Somogyi J.et al. Interference of the sulphonylurea antidiabeticum gliquidone with mitochondrial bioenergetics in the rat under in vitro conditions. Acta Physiol. Hung. 83:1995;299-312.