Equivalent doses and relative drug potencies for non-genomic glucocorticoid effects: A novel glucocorticoid hierarchy

Biochemical Pharmacology

Volumn 58, Issue 2, 1999, Pages 363-368

  Buttgereit, Frank ^a   Brand, Martin D ^b   Burmester, Gerd Rüdiger ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

ATP consuming processes; Equivalent doses; Genomic glucocorticoid effects; Non genomic glucocorticoid effects; Relative drug potencies; Thymocytes

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BETAMETHASONE; CONCANAVALIN A; CORTILEN SOLUBILE; DEXAMETHASONE; GLUCOCORTICOID; METHYLPREDNISOLONE; METYPRED; PREDNISOLONE; PREDNYLIDENE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL RESPIRATION; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVITY; FEMALE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; THYMOCYTE;

EID: 0033566281     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00090-8     Document Type: Article

References (22)

1. Buttgereit F., Wehling M., Burmester G.R. A new hypothesis of modular glucocorticoid actions. Glucocorticoid treatment of rheumatic diseases revisited. Arthritis Rheum. 41:1998;761-767.
2. Boumpas D.T., Chrousos G.P., Wilder R.L., Cupps T.R., Balow J.W. Glucocorticoid therapy for immune-mediated diseases Basic and clinical correlates . Ann Intern Med. 119:1993;1198-1208.
3. Barnes P.J., Karin M. Nuclear factor-κB-a pivotal transcription factor in chronic inflammatory diseases. New Engl J Med. 336:1997;1066-1071.
4. Wehling M. Specific, nongenomic steroid action. Annu Rev Physiol. 59:1997;365-393.
5. + into concanavalin A-stimulated thymocytes. Biochem J. 326:1997;329-332.
6. Buttgereit F., Grant A., Müller M., Brand M.D. The effects of methylprednisolone on oxidative phosphorylation in concanavalin A-stimulated thymocytes Top-down elasticity analysis and control analysis . Eur J Biochem. 223:1994;513-519.
7. Buttgereit F., Brand M.D. A hierarchy of ATP-consuming processes in mammalian cells. Biochem J. 312:1995;163-167.
8. Hardman JG, Goodman Gilman A and Limbird LE (Eds.) The Pharmacological Basis of Therapeutics, 9th Edn. McGraw-Hill, New York, 1996.
9. Kaiser H and Kley HK, Cortisontherapie-Corticoide in Therapie und Praxis (10. Auflage). Georg Thieme Verlag, Stuttgart, 1997.
10. Buttgereit F., Brand M.D., Müller M. Effects of methylprednisolone on the energy metabolism of quiescent and concanavalin A-stimulated thymocytes of the rat. Bioscience Rep. 13:1993;41-52.
11. Martens M.E., Peterson P.L., Lee C.P. In vitro effects of glucocorticoid on mitochondrial energy metabolism. Biochim Biophys Acta. 1058:1991;152-160.
12. Barile L., Lavalle C. Transverse myelitis in systemic lupus erythematosus-the effect of iv pulse methylprednisolone and cyclophosphamide. J Rheumatol. 19:1992;370-372.
13. Youssef P.P., Haynes D.R., Triantafillou S., Parker A., Gamble J.R., Roberts-Thomson P.J., Ahern M.J., Smith M.D. Effects of pulse methylprednisolone on inflammatory mediators in peripheral blood, synovial fluid, and synovial membrane in rheumatoid arthritis. Arthritis Rheum. 40:1997;1400-1408.
14. Guillevin L., Lhote F. Distinguishing polyarteritis nodosa from microscopic polyangiitis and implications for treatment. Curr Opin Rheumatol. 7:1995;20-24.
15. Dalakas M.C. Current treatment of inflammatory myopathies. Curr Opin Rheumatol. 6:1994;595-601.
16. Hall E.D. The neuroprotective pharmacology of methylprednisolone. J Neurosurg. 76:1992;13-22.
17. Bracken M.B., Shepard J.M., Collins W.F., Holford T.R., Young W., Baskin D.S., Eisenberg H.M., Flamm E., Leo-Summers L., Maroon J., Marshall L.F., Perot P.L., Piepmeier J., Sonntag V.K.H., Wagner F.C., Wilberger J.L., Winn H.R., Young W. Methylprednisolone or naloxone treatment after acute spinal cord injury 1-year follow-up data . J Neurosurg. 76:1992;23-31.
18. Tada E., Matsumoto K., Kinoshita K., Furuta T., Ohmoto T. The protective effect of dexamethasone against radiation damage induced by interstitial irradiation in normal monkey brain. Neurosurgery. 41:1997;209-217.
19. Du Plessis J.J. High-dose dexamethasone therapy in head injury A patient group that may benefit from therapy . Br J Neurosurg. 6:1992;145-147.
20. Gasperini C., Pozzilli C., Bastianello S., Koudriavtseva T., Galgani S., Millefiorini E., Paolillo A., Horsfield M.A., Bozzao L., Fieschi C. Effect of steroids on Gd-enhancing lesions before and during recombinant beta interferon 1a treatment in relapsing remitting multiple sclerosis. Neurology. 50:1998;403-406.
21. Droogan A.G., Crockard A.D., McMillan S.A., Hawkins S.A. Effects of intravenous methylprednisolone therapy on leukocyte and soluble adhesion molecule expression in MS. Neurology. 50:1998;224-229.
22. Filipovic S.R., Drulovic J., Stojsavljevic N., Levic Z. The effects of high-dose intravenous methylprednisolone on event-related potentials in patients with multiple sclerosis. J Neurol Sci. 152:1997;147-153.