Tacrolimus-induced apoptosis and its prevention by interleukins in mitogen-activated human peripheral-blood mononuclear cells

Immunopharmacology

Volumn 39, Issue 1, 1998, Pages 21-30

  Horigome, Atsushi ^a   Hirano, Toshihiko ^a   Oka, Kitaro ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Apoptosis; Cyclosporine; Glucocorticoid; Human peripheral blood mononuclear cell; Interleukin; Tacrolimus

Indexed keywords

CELL DNA; CYCLOSPORIN A; CYTOKINE; GLUCOCORTICOID; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; MITOGENIC AGENT; PREDNISOLONE; TACROLIMUS;

ADULT; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DNA DEGRADATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOMODULATION; LEUKOCYTE ACTIVATION; MONONUCLEAR CELL; NORMAL HUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

APOPTOSIS; CELLS, CULTURED; DNA FRAGMENTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-1; INTERLEUKIN-2; INTERLEUKIN-4; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MITOGENS; TACROLIMUS;

EID: 0031839346     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-3109(97)00094-5     Document Type: Article

References (42)

1. Ashwell, J.D., 1994. Lymphocyte programmed cell death. In: Snow, E.C. (Ed.), Handbook of B- and T-lymphocytes. Academic Press, San Diego, CA, pp. 63-89.
2. Auphan N., DiDonato J.A., Rosette C., Helmberg A., Karin M. Immunosuppression by glucocorticoids: Inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science. 270:1995;286-290.
3. Bickel M., Tsuda H., Amstad P., Evequoz V., Mergenhagen S.E., Wahl S.M., Pluznik D.H. Differential regulation of colony-stimulating factors and interleukin 2 production by cyclosporin A. Proc. Natl. Acad. Sci. USA. 84:1987;3274-3277.
4. Bierer B.E. Biology of cyclosporin A and FK506. Prog. Clin. Biol. Res. 390:1994;203-223.
5. Bowes L.G., Dumble L.J., Clunie G.J., Francis D.M., Macdonald I.M., Kincaid S.P. Increased risk of rejection in renal transplant recipients with in vitro cyclosporin-resistant lymphoid responses. Transplant. Proc. 21:1989;1470-1471.
6. Brunetti M., Martelli N., Colasante A., Piantelli M., Musiani P., Aiello F.B. Spontaneous and glucocorticoid-induced apoptosis in human mature T-lymphocytes. Blood. 86:1995;4199-4205.
7. Chen-Woan M., Zerbe T.R., Zeevi A., Kaufman C., Mallick C., Warty V.J., Griffith B.P., Kormos R.L., Armitage J., Duquesnoy R.J. Diminished lymphocyte growth from endomyocardial biopsies from cardiac transplant patients on FK 506 immunosuppression. Transplant. Proc. 23:1991;2941-2942.
8. Collins M.K., Marvel J., Malde P., Lopez R.A. Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents. J. Exp. Med. 176:1992;1043-1051.
9. Conti P., Reale M., Panara M.R., Barbacane R.C., Bongrazio M., Dempsey R.A. Human recombinant interleukin-1 receptor antagonist inhibits lymphocyte blastogenesis induced by concanavalin A. Restorative effect of hrIL-1. FEBS Lett. 286:1991;137-141.
10. Francis D.M., Dumble L.J., Bowes L., Clunie G.J., Macdonald I.M. Adverse influence of recipient lymphoid resistance to in vitro immunosuppression on the outcome of kidney transplants. Transplantation. 46:1988;853-857.
11. Frantz B., Nordby E.C., Bren G., Steffan N., Paya C.V., Kincaid R.L., Tocci M.J., O'Keefe S.J., O'Neill E.A. Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B. EMBO J. 13:1994;861-870.
12. Fruman D.A., Mather P.E., Burakoff S.J., Bierer B.E. Correlation of calcineurin phosphatase activity and programmed cell death in murine T-cell hybridomas. Eur. J. Immunol. 22:1992;2513-2517.
13. Goto T., Kino T., Hatanaka H., Okuhara M., Kohsaka M., Aoki H., Imanaka H. FK 506: Historical perspectives. Transplant. Proc. 23:1991;2713-2717.
14. Granelli-Piperno A., Andrus L., Steinman R.M. Lymphokine and nonlymphokine mRNA levels in stimulated human T-cells. Kinetics, mitogen requirements, and effects of cyclosporin A. J. Exp. Med. 163:1986;922-937.
15. Hirano T., Oka K., Kawashima E., Akiba M. Effects of synthetic and naturally occurring flavonoids on mitogen-induced proliferation of human peripheral-blood lymphocytes. Life Sci. 45:1989;1407-1411.
16. Hirano T., Oka K., Sakurai E., Tamaki T., Kozaki M. Impaired prednisolone sensitivities of the endocrine system and peripheral-blood lymphocytes are closely related to clinical incidence in renal transplantation. J. Pharm. Pharmacol. 43:1991;569-573.
17. Hirano T., Oka K., Takeuchi H., Sakurai E., Matsuno N., Tamaki T., Kozaki M. Clinical significance of glucocorticoid pharmacodynamics assessed by antilymphocyte action in kidney transplantation. Marked difference between prednisolone and methylprednisolone. Transplantation. 57:1994;1341-1348.
18. Hirano T., Oka K., Tamaki T. Gramicidin as a potential immunosuppressant for organ transplantation: Suppression of human lymphocyte blastogenesis in vitro and prolongation of heart allograft survival in the rat. J. Pharmacol. Exp. Ther. 273:1995;223-229.
19. Horigome A., Hirano T., Oka K., Takeuchi H., Sakurai E., Kozaki K., Matsuno N., Nagao T., Kozaki M. Glucocorticoid and cyclosporine induce apoptosis in mitogen-activated human peripheral mononuclear cells. Immunopharmacology. 37:1997;87-94.
20. Huss R., Hoy C.A., Ottinger H., Grosse-Wilde H., Deeg H.J. Cyclosporine-induced apoptosis in CD4+ T-lymphocytes and computer-simulated analysis: Modeling a treatment scenario for HIV infection. Res. Immunol. 146:1995;101-108.
21. Jiang H., Suguo H., Takahara S., Takano Y., Li D., Kameoka H., Moutabarrik A., Kokado Y., Ishibashi M., Okuyama A., Sonoda T. Combined immunosuppressive effect of FK 506 and other immunosuppressive agents on PHA- and CD3-stimulated human lymphocyte proliferation in vitro. Transplant. Proc. 23:1991;2933-2936.
22. Kang X.X., Hirano T., Oka K., Sakurai E., Tamaki T., Kozaki M. Role of altered prednisolone-specific lymphocyte sensitivity in chronic renal failure as a pharmacodynamic marker of acute allograft rejection after kidney transplantation. Eur. J. Clin. Pharmacol. 41:1991;417-423.
23. Kawauchi M., Van A.G., Alonso D.B.J., Gundry S.R., Bailey L.L., Nehlsen C.S. Flow cytometric analysis of lymphocyte populations in FK 506-treated newborn goats. Transplant. Proc. 23:1991;2970-2971.
24. Keicho N., Sawada S., Kitamura K., Yotsumoto H., Takaku F. Effects of an immunosuppressant, FK506, on interleukin 1 alpha production by human macrophages and a macrophage-like cell line, U937. Cell. Immunol. 132:1991;285-294.
25. Kronke M., Leonard W.J., Depper J.M., Arya S.K., Wong-Staal F., Gallo R.C., Waldman T.A., Greene W.C. Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc. Natl. Acad. Sci. USA. 81:1984;5214-5218.
26. Langhoff E., Ladefoged J., Jakobsen B.K., Platz P., Ryder L.P., Svejgaard A., Thaysen J.H. Recipient lymphocyte sensitivity to methylprednisolone affects cadaver kidney graft survival. Lancet. 1:1986;1296-1297.
27. Liu J., Farmer J.J., Lane W.S., Friedman J., Weissman I., Schreiber S.L. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 66:1991;807-815.
28. Manger B., Weiss A., Weyand C., Goronzy J., Stobo J.D. T-cell activation: Differences in the signals required for IL 2 production by nonactivated and activated T-cells. J. Immunol. 135:1985;3669-3673.
29. Manson J.C., Symons J.A., Di G.F., Poole S., Duff G.W. Autoregulation of interleukin 1 production. Eur. J. Immunol. 19:1989;261-265.
30. Masy E., Labalette H.M., Dessaint J.P. Individual susceptibility to cyclosporine: Possible involvement of the CD28/CD80 (B7/BB1) pathway. Transplant. Proc. 26:1994;2846-2848.
31. Migita K., Eguchi K., Kawabe Y., Tsukada T., Mizokami A., Nagataki S. FK506 augments activation-induced programmed cell death of T-lymphocytes in vivo. J. Clin. Invest. 96:1995;727-732.
32. Nieto M.A., Lopez R.A. IL-2 protects T-lymphocytes from glucocorticoid-induced DNA fragmentation and cell death. J. Immunol. 143:1989;4166-4170.
33. Reisman L., Lin W.G., Martinelli G.P. Modulation of interleukin-1 secretion by immunosuppressive drugs, alone and in combination. Transplant. Immunol. 3:1995;45-99.
34. Sawada S., Suzuki G., Kawase Y., Takaku F. Novel immunosuppressive agent, FK506. In vitro effects on the cloned T-cell activation. J. Immunol. 139:1987;1797-1803.
35. Shi Y.F., Sahai B.M., Green D.R. Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes. Nature. 339:1989;625-626.
36. Sigal N.H., Lin C.S., Siekierka J.J. Inhibition of human T-cell activation by FK 506, rapamycin and cyclosporine A. Transplant. Proc. 23:1991;1-5.
37. Staruch M.J., Sigal N.H., Dumont F.J. Differential effects of the immunosuppressive macrolides FK-506 and rapamycin on activation-induced T-cell apoptosis. Int. J. Immunopharmacol. 13:1991;677-685.
38. Tocci M.J., Matkovich D.A., Collier K.A., Kwok P., Dumont F., Lin S., Degudicibus S., Siekierka J.J., Chin J., Hutchinson N.I. The immunosuppressant FK506 selectively inhibits expression of early T-cell activation genes. J. Immunol. 143:1989;718-726.
39. Tuosto L., Cundari E., Montani M.S., Piccolella E. Analysis of susceptibility of mature human T-lymphocytes to dexamethasone-induced apoptosis. Eur. J. Immunol. 24:1994;1061-1065.
40. Walker P.R., Kwast W.J., Gourdeau H., Leblanc J., Neugebauer W., Sikorska M. Relationship between apoptosis and the cell cycle in lymphocytes: Roles of protein kinase C, tyrosine phosphorylation and AP1. Exp. Cell. Res. 207:1993;142-151.
41. Zhao Y., Tozawa Y., Iseki R., Mukai M., Iwata M. Calcineurin activation protects T-cells from glucocorticoid-induced apoptosis. J. Immunol. 154:1995;6346-6354.
42. Zubiaga A.M., Munoz E., Huber B.T. IL-4 and IL-2 selectively rescue Th cell subsets from glucocorticoid-induced apoptosis. J. Immunol. 149:1992;107-112.