Apoptosis of lymphocytes induced by glucocorticoids and relationship to therapeutic efficacy in patients with systemic lupus erythematosus

Arthritis and Rheumatism

Volumn 41, Issue 5, 1998, Pages 823-830

  Seki, Manami ^a,b   Ushiyama, Chifuyu ^a   Seta, Noriyuki ^a   Abe, Kaori ^a   Fukazawa, Toru ^a   Asakawa, Junichi ^a   Takasaki, Yoshinari ^a   Hashimoto, Hiroshi ^a  

^a JUNTENDO UNIVERSITY   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; FAS ANTIGEN; GLUCOCORTICOID; MONOCLONAL ANTIBODY;

ADOLESCENT; ADULT; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMETRY; DISEASE ACTIVITY; GENE EXPRESSION; HUMAN; LYMPHOCYTE DIFFERENTIATION; MONONUCLEAR CELL; PREDICTION; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; TREATMENT PLANNING;

EID: 0031969165     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(199805)41:5<823::aid-art8>3.0.co;2-%23     Document Type: Article

References (31)

1. Takahashi T, Tanaka M, Barannan CI, Jenkins NA, Copeland NG, Suda T, et al. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 1994;76:969-76.
2. Katsumata M, Siegel R, Louie D. Differential effects of Bcl-2 on T and B cells in transgenic mice. Proc Natl Acad Sci U S A 1992;89:1376-80.
3. McDonnell DG, Deane N, Platt FM. Bcl-2 immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 1989;57:79-88.
4. Strasser A, Whittingham S, Vaux DL, Bath ML, Adams JM, Cory S, et al. Enforced Bcl-2 expression in B lymphoid cells prolongs antibody responses and autoimmune disease. Proc Natl Acad Sci USA 1991;88:8661-5.
5. Emlen W, Niebur J, Kadera R. Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus. J Immunol 1994;152:3685-92.
6. Schwartzman RA, Cidlowski JA. Apoptosis: the biochemistry and molecular biology of programmed cell death. Endocrinol Rev 1993;14:133-51.
7. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-7.
8. Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH, and the Committee on Prognosis Studies in SLE. Derivation of the SLEDAI: a disease activity index for lupus patients. Arthritis Rheum 1992;35:630-40.
9. Klumper E, Pieters R, Veerman AJP, Huismans DR, Loonen AH, Hahlen K, et al. In vitro cellular drug resistance in children with relapsed/refractory acute lymphoblastic leukemia. Blood 1995;86: 3861-8.
10. Sellins K, Cohen J. Gene induction by γ-irradiation leads to DNA fragmentation in lymphocytes. J Immunol 1987;139:3199-206.
11. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning: a laboratory manual. 2nd ed. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory; 1989.
12. Brunetti M, Martelli N, Clasante A, Piantelli M, Musiani P, Aiello FB. Spontaneous and glucocorticoid-induced apoptosis in human mature T lymphocytes. Blood 1994;86:4199-205.
13. Aringer M, Wintersberger W, Steiner CW, Kiener H, Presterl E, Jaeger U, et al. High levels of bcl-2 protein in circulating T lymphocytes, but not B lymphocytes, of patients with systemic lupus erythematosus. Arthritis Rheum 1994;37:1423-30.
14. Shwartzman R, Cidlowski J. Glucocorticoid-induced apoptosis of lymphoid cells. Int Arch Allergy Immunol 1994;105:347-54.
15. Kam J, Szefler S, Surs W, Sher E, Leung D. Combination IL2 and IL4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoid. J Immunol 1993;151:3460-6.
16. Cupps T, Fauci A. Corticosteroid mediated immunoregulation in man. Immunol Rev 1982;65:133-5.
17. Ranelleti F, Maggiano N, Aiello F, Carbone A, Larocca L, Musiani P, et al. Glucocorticoid receptors and corticosensitivity of human thymocytes at discrete stages of intrathymic differentiation. J Immunol 1987;138:440-5.
18. Kumagai S. Apoptosis and SLE. J Clin Exp Med 1996;176:314-9.
19. Nieto MA, Gonzalez A, Diaz-Espada F, Lopez-Rivas A. Apoptosis in human thymocytes after treatment with glucocorticoids. Clin Exp Immunol 1992;88:341-4.
20. Tuosuto L, Cundari E, Gilardini MM, Picollera E. Analysis of susceptibility of mature human T lymphocytes to dexamethasone-induced apoptosis. Eur J Immunol 1994;24:1061-5.
21. Lorenz H-M, GrÜnke M, Hieronymus T, Herrmann M, Kühnel A, Manger B, et al. In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases. Arthritis Rheum 1997;40:306-17.
22. Osako S, Hara M, Harigai M, Fukazawa C, Kashiwazaki S. Expression and function of Fas antigen and bcl-2 in human systemic lupus erythematosus lymphocytes. Clin Immunol Immunopathol 1994;73:109-14.
23. Rose LM, Latchman DS, Isenberg DA. Bcl-2 expression is unaltered in unfractionated peripheral blood mononuclear cells in patients with systemic lupus erythematosus. Br J Rheumatol 1995;34:314-20.
24. Cheng J, Zhou T, Liu C, Shapiro J, Brauer M, Kiefer M, et al. Identification of a soluble form of the Fas molecule that protects cells from Fas-mediated apoptosis. Science 1994;263:1759-61.
25. Migliorati G, Nicoletti J, Pagliacci MC, Adamio LD, Riccardi C. Interleukin-2 induces apoptosis in mouse thymocytes. Cell Immunol 1993;146:52-61.
26. Lenardo MJ. Interleukin-2 programs mouse γ β lymphocytes for apoptosis. Nature 1991;353:858-61.
27. Nieto MA, Gonzalez A, Lopez-Rivas A, Diaz-Espada F, Gambon F. Interleukin-2 protects against anti-CD3-induced cell death in human medullary lymphocytes. J Immunol 1990;145:1364-8.
28. Nieto MA, Lopez-Rivas A. Interleukin-2 protects T lymphocytes from glucocorticoid-induced DNA fragmentation and cell death. J Immunol 1989;143:4166-70.
29. Zubiaga AM, Munoz E, Huber BT. Interleukin(IL)-4 and IL2 rescue Th cell subsets from glucocorticoid-induced apoptosis. J Immunol 1992;149:107-12.
30. Felix M, Irum RC. IL-2 rescues antigen-specific T cells from radiation or dexamethasone-induced apoptosis. J Immunol 1996; 156:515-22.
31. Rebollo A, Pitton C, Garcia A, Gomez J, Silvia A. A role for the intermediate affinity IL-2R in the protection against glucocorticoid-induced apoptosis. Immunology 1995;84:388-95.