IL-11 activates human endothelial cells to resist immune-mediated injury

Journal of Immunology

Volumn 164, Issue 7, 2000, Pages 3837-3846

  Mahboubi, Keyvan ^a   Biedermann, Barbara C ^a,c   Carroll, Joseph M ^b   Pober, Jordan S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

^c Medinische Universitatsklinik   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLYCOPROTEIN GP 130; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE; ONCOSTATIN M; RECOMBINANT INTERLEUKIN 11; TUMOR NECROSIS FACTOR;

ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME REGULATION; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOTOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

EID: 0034176004     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.7.3837     Document Type: Article

References (53)

1. Weich, N. S., A. Wang, M. Fitzgerald, T. Y. Neben, D. Donaldson, J. Giannotti, J. Yetz-Aldape, R. M. Leven, and K. J. Turner. 1997. Recombinant human interleukin-11 directly promotes megakaryocytopoiesis in vitro. Blood 90:3893.
2. Orazi, A., R. J. Cooper, J. Tong, M. S. Gordon, L. Battiato, G. W. Sledge, Jr., J. A. Kaye, M. Kahsai, and R. Hoffman. 1996 Effects of recombinant human interleukin-11 (Neumega rhIL-11 growth factor) on megakaryocytopoiesis in human bone marrow. Exp. Hematol. 24:1289.
3. de Haan, G., B. Dontje, C. Engel, M. Loeffler, and W. Nijhof. 1995. In vivo effects of interleukin-11 and stem cell factor in combination with erythropoietin in the regulation of erythropoiesis. Br J. Haematol. 90:783.
4. Kaye, J. A. 1996. Clinical development of recombinant human interleukin-11 to treat chemotherapy-induced thrombocytopenia. Curr. Opin. Hematol. 3:209.
5. Du, X., Q. Liu, Z. Yang, A. Orazi, F. J. Rescorla, J. L. Grosfeld, and D. A. Williams. 1997. Protective effects of interleukin-11 in a murine model of ischemic bowel necrosis. Am. J. Physiol. 272:G545.
6. Orazi, A., X. Du, Z. Yang, M. Kashai, and D. A. Williams. 1996. Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation. Lab. Invest. 75:33.
7. Keith, J. C., Jr., L. Albert, S. T. Sonis, C. J. Pfeiffer, and R. G. Schauh. 1994. IL-11, a pleiotropic cytokine: exciting new effects of IL-11 on gastrointestinal mucosal biology. Stem Cells 12(Suppl. 1):79.
8. Qiu, B. S., C. J. Pfeiffer, and J. C. Keith, Jr. 1996. Protection by recombinant human interleukin-11 against experimental TNB- induced colitis in rats. Dig. Dis. Sci. 41:1625.
9. Hill, G. R., K. R. Cooke, T. Teshima, J. M. Crawford, J. C. Keith, Jr., Y. S. Brinson, D. Bungard, and J. L. Ferrara. 1998. Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic hone marrow transplantation. J. Clin. Invest. 102:115.
10. Redlich, C. A., X. Gao, S. Rockwell, M. Kelley, and J. A. Elias. 1996. IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury. J. Immunol. 157:1705.
11. Waxman, A. B., O. Einarsson, T. Seres, R. G. Knickelbein, J. B. Warshaw, R. Johnston, R. J. Homer, and J. A. Elias. 1998. Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation. J. Clin. Invest. 101:1970.
12. Leng, S. X., and J. A. Elias. 1997. Interleukin-11 inhibits macrophage interleukin-12 production. J. Immunol. 159:2161.
13. Trepicchio, W. L., L. Wang, M. Bozza, and A. J. Domer. 1997. IL-11 regulates macrophage effector function through the inhibition of nuclear factor-κB. J. Immunol. 159:5661.
14. Trepicchio, W. L., M. Bozza, G. Pedneault, and A. J. Dorner. 1996. Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production. J. Immunol. 157: 3627.
15. Taga, T., and T. Kishimoto. 1997. Gp130 and the interleukin-6 family of cytokines. Annu. Rev. Immunol. 15:797.
16. Zhang, X. G., J. J. Gu, Z. Y. Lu, K. Yasukawa, G. D. Yancopoulos, K. Turner, M. Shoyab, T. Taga, T. Kishimoto, R. Bataille, et al. 1994. Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130. J. Exp. Med. 179:1337.
17. Yang, Y. C., and T. Yin. 1995. Interleukin (IL)-11-mediated signal transduction. Ann. NY Acad. Sci. 762:31.
18. Nandurkar, H. H., D. J. Hilton, P. Nathan, T. Willson, N. Nicola, and C. G. Begley. 1996. The human IL-II receptor requires gp130 for signalling: demonstration by molecular cloning of the receptor. Oncogene 12:585.
19. Miyatake, T., K. Sato, K. Takigami, N. Koyamada, W. W. Hancock, H. Bazin, D. Latinne, F. H. Bach, and M. P. Soares. 1998. Complement-fixing elicited antibodies are a major component in the pathogenesis of xenograft rejection. J. Immunol. 160:4114.
20. Yin, T., K. Yasukawa, T. Taga, T. Kishimoto, and Y. C. Yang. 1994. Identification of a 130-kilodalton tyrosine-phosphorylated protein induced by interleukin-11 as JAK2 tyrosine kinase, which associates with gp130 signal transducer. Exp. Hematol. 22:467.
21. Wang, X. Y., D. K. Fuhrer, M. S. Marshall, and Y. C. Yang. 1995. Interleukin-11 induces complex formation of Grb2, Fyn, and JAK2 in 3T3L1 cells. J. Biol. Chem. 270:27999.
22. Lutticken, C., U. M. Wegenka, J. Yuan, J. Buschmann, C. Schindler, A. Ziemiecki, A. G. Harpur, A. F. Wilks, K. Yasukawa, T. Taga, et al. 1994. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp 130. Science 263:89.
23. Hemmann, U., C. Gerhartz, B. Heesel. J. Sasse, G. Kurapkat, J. Grotzinger, A. Wollmer, Z. Zhong, J. E. Darnell, Jr., L. Graeve, et al. 1996. Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation. J. Biol. Chem. 271:12999.
24. Zhong, Z., Z. Wen, and J. E. Darnell, Jr. 1994. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264:95.
25. Ihle, J. N. 1996. STATs: signal transducers and activators of transcription. Cell 84:331.
26. Akira, S. 1997. IL-6-regulated transcription factors. Int. J. Biochem. Cell Biol. 29:1401.
27. Zhang, X., J. Blenis, H. C. Li, C. Schindler, and S. Chen-Kiang. 1995. Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science 267:1990.
28. Boulton, T. G., Z. Zhong, Z. Wen, J. E. Darnell, Jr., N. Stahl, and G. D. Yancopoulos. 1995. STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase Proc. Natl. Acad. Sci. USA 92:6915.
29. Adunyah, S. E., G. C. Spencer, R. S. Cooper, J. A. Rivero, and K. Ceesay. 1995. Interleukin-11 induces tyrosine phosphorylation, and c-jun and c-fos mRNA expression in human K562 and U937 cells. Ann. NY Acad. Sci. 766:296.
30. Yin, T., and Y. C. Yang. 1994. Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells. J. Biol. Chem. 269:3731.
31. Pober, J. S., and R. S. Cotran. 1990. The role of endothelial cells in inflammation. Transplantation 50:537.
32. Gimbrone, M. A., Jr. 1976. Culture of vascular endothelium. Prog. Hemost. Thromb. 3:1.
33. Thornton, S. C., S. N. Mueller, and E. M. Levine. 1983. Human endothelial cells: use of heparin in cloning and long-term serial cultivation. Science 222:623.
34. Karmann, K., W. Min, W. C. Fanslow, and J. S. Pober. 1996. Activation and homologous desensitization of human endothelial cells by CD40 ligand, tumor necrosis factor, and interleukin 1. J. Exp. Med. 184:173.
35. Min, W., S. Ghosh, and P. Lengyel. 1996. The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-κB, c-Fos, and c-Jun activities. Mol. Cell. Biol. 16:359.
36. Biedermann, B. C., and J. S. Pober. 1998. Human endothelial cells induce and regulate cytolytic T cell differentiation. J. Immunol. 161:4679.
37. Biedermann, B. C., and J. S. Pober. 1999. Human vascular endothelial cells favor clonal expansion of unusual alloreactive cytolytic T lymphocytes. J. Immunol. 162:7022.
38. Sierra-Honigmann, M. R., A. K. Nath, C. Murakami, G. Garcia-Cardena, A. Papapetropoulos, W. C. Sessa, L. A. Madge, J. S. Scheduler, M. B. Schwabb, P. J. Polverini, et al. 1998. Biological action of leptin as an angiogenic factor. Science 281:1683.
39. Faris, M., B. Ensoli, N. Kokot, and A. E. Nel. 1998. Inflammatory cytokines induce the expression of basic fibroblast growth factor (bFGF) isoforms required for the growth of Kaposi's sarcoma and endothelial cells through the activation of AP-1 response elements in the bFGF promoter. AIDS 12:19.
40. Brown, T. J., J. M. Rowe, J. W. Liu, and M. Shoyab. 1991. Regulation of IL-6 expression by oncostatin M. J. Immunol. 147:2175.
41. Modur, V., M. J. Feldhaus, A. S. Weyrich, D. L. Jicha, S. M. Prescott, G. A. Zimmerman, and T. M. McIntyre. 1997. Oncostatin M is a proinnammatory mediator: in vivo effects correlate with endothelial cell expression of inflammatory cytokines and adhesion molecules. J. Clin. Invest. 100:158.
42. Yao, L., J. Pan, H. Setiadi, K. D. Patel, and R. P. McEver. 1996. Interleukin 4 or oncostatin M induces a prolonged increase in P-selectin mRNA and protein in human endothelial cells. J. Exp. Med. 184:81.
43. Cherel, M., M. Sorel, B. Lebeau, S. Dubois, J. F. Morcau, R. Bataille, S. Minvielle, and Y. Jacques. 1995. Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11. Blood 86:2534.
44. Frasca, D., C. Pioli, F. Guidi, S. Pucci, M. Arbitrio, G. Leter, and G. Doria. 1996. IL-11 synergizes with IL-3 in promoting the recovery of the immune system after irradiation [see comments]. Int. Immunol. 8:1651.
45. Schieven, G. L., J. C. Kallestad, T. J. Brown, J. A. Ledbetter, and P. S. Linsley. 1992. Oncostatin M induces tyrosine phosphorylation in endothelial cells and activation of p62yes tyrosine kinase. J. Immunol. 149:1676.
46. Ghosh, S., M. J. May, and E. B. Kopp. 1998. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16: 225.
47. Wang, C. Y., M. W. Mayo, R. G. Korneluk, D. V. Goeddel, and A. S. Baldwin, Jr. 1998. NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c- IAP2 to suppress caspase-8 activation. Science 281:1680.
48. Van Antwerp, D. J., S. J. Martin, I. M. Verma, and D. R. Green. 1998. Inhibition of TNF-induced apoptosis by NF-κB. Trends Cell Biol. 8:107.
49. Collins, T., M. A. Read, A. S. Neish, M. Z. Whitley, D. Thanos, and T. Maniatis. 1995. Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers. FASEB J. 9:899.
50. Johnson, D. R., I. Douglas, A. Jahnke, S. Ghosh, and J. S. Pober. 1996. A sustained reduction in IκB-β may contribute to persistent NF-βB activation in human endothelial cells. J. Biol. Chem. 271:16317.
51. Renne, C., K. J. Kallen, J. Mullberg, T. Jostock, J. Grotzinger, and S. Rose-John. 1998. A new type of cytokine receptor antagonist directly targeting gp130. J. Biol. Chem. 273:27213.
52. Auguste, P., C. Guillet, M. Fourcin, C. Olivier, J. Veziers, A. Pouplard-Barthelaix, and H. Gascan. 1997. Signaling of type II oncostatin M receptor. J. Biol. Chem. 272:15760.
53. Romano, M., M. Sironi, C. Toniatti, N. Polentarutti, P. Fruscella, P. Ghezzi, R. Faggioni, W. Luini, V. van Hinsbergh, S. Sozzani, et al. 1997. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 6:315.