Recombinant human interleukin-11 directly promotes megakaryocytopoiesis in vitro

Blood

Volumn 90, Issue 10, 1997, Pages 3893-3902

  Weich, Nadine S ^a   Wang, Anlai ^b   Fitzgerald, Michael ^b   Neben, Tamlyn Yee ^b   Donaldson, Debra ^b   Giannotti, Joann ^b   Yetz Aldape, Joanne ^b   Leven, Robert M ^b   Turner, Katherine J ^b  

^a PFIZER INC   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 11; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; ONCOSTATIN M; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL PROLIFERATION; COLONY FORMATION; DISEASE SEVERITY; GENE EXPRESSION; IMMUNOBLOTTING; MEGAKARYOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; THROMBOCYTE FUNCTION; THROMBOCYTE TRANSFUSION;

EID: 0030828578     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.10.3893     Document Type: Article

References (41)

1. Turner KJ, Neben S, Weich N, Schaub RG, Goldman SJ: The role of recombinant interleukin-11 in megakaryocytopoiesis. Stem Cells 14:53, 1996 (suppl 1)
2. Goldman SJ: Preclinical biology of interleukin 11: A multifunctional hematopoietic cytokine with potent thrombopoietic activity. Stem Cells 13:462, 1995
3. Gordon MS, McCaskill-Stevens WJ, Battiato LA, Loesch D, Breeden E, Hoffman R, Beach KJ, Kuca B, Kaye J, Sledge GW: A phase I trial of recombinant interleukin-11 (Neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy. Blood 87:3615, 1996
4. Orazi A, Cooper RJ, Tong J, Gordon MS, Battiato L, Sledge GW, Kaye JA, Kahsai M, Hoffman R: Effects of recombinant human interleukin-11 (Neumega™ rhIL-11 growth factor) on megakaryocytopoiesis in human bone marrow. Exp Hematol 24:1289, 1996
5. Tepler I, Elias L, Smith II JW, Hussein M, Rosen G, Chang AYC, Moore JO, Gordon MS, Kuca B, Beach KJ, Loewy, JW, Garnick MB, Kaye JA: A randomized placebo-controlled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy. Blood 87:3607, 1996
6. Issacs C, Robert N, Loewy J, Kaye JA: Neumega* (rhIL-11) prevents platelet transfusions in up to 4 cycles of dose-intense chemotherapy in women with breast cancer. Blood 86:448a, 1996 (abstr, suppl 1)
7. Neben TY, Loebelenz J, Hayes L, McCarthy K, Stoudemire J, Schaub R, Goldman SJ: Recombinant human interleukin-11 stimulates megakaryocytopoiesis and increases peripheral platelets in normal and splenectomized mice. Blood 81:901, 1993
8. Yonemura Y, Kawakita M, Masuda T, Fujimoyo K, Takatsuki K: Effect of recombinant human interleukin-11 on rat megakaryocytopoiesis and thrombopoiesis in vivo: Comparative study with interleukin-1. Br J Haematol 84:16, 1993
9. Schlerman FJ, Bree AG, Kaviani MD: Thrombopoietic activity of recombinant human interleukin-11 (rhIL-11) in normal and myeiosuppressed nonhuman primates. Stem Cells 14:517, 1996
10. Leonard JP, Neben TY, Kozitza MK, Quinto CM, Goldman SJ: Constant subcutaneous infusion of rhIL-11 in mice: Efficient delivery enhances biological activity. Exp Hematol 24:270, 1996
11. Leonard JP, Quinto CM, Kozitza MK, Neben TY, Goldman SJ: Recombinant human interleukin-11 stimulates multilineage hematopoietic recovery in mice after a myelosuppressive regimen of sublethal irradiation and carboplatin. Blood 83:1499, 1994
12. - cells and synergizes with stem cell factor, interleukin-3, and granulocyte-macrophage colony-stimulating factor. Exp Hematol 21:1688, 1993
13. Yonemura Y, Kawakita M, Masuda T, Fujimoto K, Kato K, Takatsuki K: Synergistic effects of interleukin 3 and interleukin 11 on murine megakaryopoiesis in serum-free culture. Exp Hematol 20:1011, 1992
14. Bruno E, Briddell RA, Cooper RJ, Hoffman R: Effects of recombinant interleukin 11 on human megakaryocyte progenitor cells. Exp Hematol 19:378, 1991
15. Burstein SA, Mei RL, Henthorn J, Friese P, Turner K: Leukemia inhibitory factor and interleukin-11 promote the maturation of murine and human megakaryocytes in vitro. J Cell Physiol 153:305, 1992
16. Teramura M, Kobayashi S, Hoshino S, Oshimi K, Mizoguchi H: Interleukin-11 enhances human megakaryocytopoiesis in vitro. Blood 79:327, 1992
17. Taga T, Yoshida K, Hirota H, Kishimoto T: Physiological and pathological role of gp130, a common signal transducer for the IL-6 family of cytokines, in Ikehav S, Takaku F, Good RA (eds): Bone Marrow Transplantation. Tokyo, Japan, Springer-Verlag, 1996, p 101
18. Cherel M, Sorel M, Lebeau B, Dubois S, Moreau JF, Bataille R, Minvielle S, Jacques Y: Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11. Blood 86:2534, 1995
19. Yang YC, Yin T: Interleukin (IL)-11-mediated signal transduction. Ann NY Acad Sci 762:31, 1995
20. Stahl N, Farruggella, Boulton TG, Zhong Z, Darnell JE, Yancopoulos GD: Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267:1349, 1995
21. Bruno E, Briddell R, Hoffman R: Effect of recombinant and purified hematopoietic growth factors on human megakaryocyte colony formation. Exp Hematol 16:371, 1988
22. Miller AD, Rosman GJ: Improved retroviral vectors for gene transfer and expression. Biotechniques 7:980, 1989
23. Paul SR, Bennett F, Calvetti JA, Kelleher K, Wood CR, O'Hara RM, Leary AC, Sibley B, Clark SC, Williams DA, Yang YC: Molecular cloning of a cDNA encoding interleukin-11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc Natl Acad Sci USA 87:7512, 1990
24. Brady G, Barbara M, Iscove NN: Representative in vitro cDNA amplification from individual hemopoietic cells and colonies. Methods Mol Cell Biol 2:17, 1990
25. Berardi AC, Wang A, Levine JD, Lopez P, Scadden DT: Functional isolation and characterization of human hematopoietic stem cells. Science 267:104, 1995
26. Leven RM, Rodriguez A: lmmunomagnetic bead isolation of megakaryocytes from guinea-pig bone marrow: Effect of recombinant interleukin-6 on size, ploidy and cytoplasmic fragmentation. Br J Haemtol 77:267, 1991
27. Laemmli UK: Cleavage of structural proteins during the assembly of the head of the bacteriophage T4. Nature 227:680, 1970
28. Methia N, Louache F, Vainchenker W, Wendung F: Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 82:1395, 1993
29. Lutticken C, Wegenka UM, Yuan J, Buschmann J, Schindler C, Zierniecki A, Harpur AG, Wilks AF, Yasukawa K, Taga T, Kishimoto T, Barbieri G, Pellegrini S, Sendtner M, Heinrich PC, Horn F: Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science 263:89, 1994
30. Kaushansky K, Broudy VC, Lin N, Jorgensen MJ, McCarty J, Fox N, Zucker-Franklin D, Lofton-Day C: Thrombopoietin. the Mpl ligand, is essential for full megakaryocyte development. Proc Natl Acad Sci USA 92:3234, 1995
31. Broudy VC, Lin NL, Fox N, Taga T, Saito M, Kaushansky K: Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit. Blood 88:2026, 1996
32. Carver-Moore K, Broxmeyer HE, Luoh SM, Cooper S, Peng J, Burstein SA, Moore MW, de Sauvage FJ: Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice. Blood 88:803. 1996
33. Ku H, Yonemura Y, Kaushansky K, Ogawa M: Thrombopoietin, the ligand for the mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 87:4544, 1996
34. Fourcin M, Chevalier S, Lebrun JJ, Kelly P, Pouplard A, Wijdenes J, Gascan H: Involvement of gp130/interleukin-6 receptor transducing component in interleukin-11 receptor. Eur J Immunol 24:277, 1994
35. Hilton DJ, Hilton AA, Raicevic A, Rakar S, Harrison-Smith M, Gough NM, Begley CG, Metcalf D, Nicola NA, Willson TA: Cloning of a murine IL-11 receptor α-chain: Requirement of gp130 for high affinity binding and signal transduction. EMBO J 13:4765, 1994
36. Baumann H, Wang Y, Morella KK, Lai CF, Dams H, Hilton DJ, Hawley RG, Mackiewicz A: Complex of the soluble IL-11 receptor and IL-11 acts as IL-6 type cytokine in hepatic and nonhepatic cells. J Immunol 157:284, 1996
37. Ihle JN: Cytokine receptor signalling. Nature 377:591, 1995
38. Schiinder C, Darnell JE Jr: Transcriptional responses to polypeptide ligands: The Jak-Stat pathway. Annu Rev Biochem 64:621, 1995
39. Navarro S, Debili N, Le Couedic JP, Klein B, Breton-Gorius J, Doly J, Vainchenker W: Interleukin-6 and its receptor are expressed by human megakaryocytes: In vitro effects on proliferation and endoreplication. Blood 77:461, 1991
40. Zucker-Franklin D, Petursson S: Thrombocytopoiesis-analysis by membrane tracer and freeze-fracture studies on fresh human and cultured mouse megakaryocytes. J Cell Biol 99:390, 1984
41. Chang M, Suen Y, Meng G, Buzby JS, Bussel J, Shen V, van de Ven C, Cairo MS: Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: Insight into the regulation of platelet production. Blood 88:3354, 1996