Melanocortins and feeding behavior

Biomedicine and Pharmacotherapy

Volumn 54, Issue 3, 2000, Pages 129-134

  Vergoni, A V ^a   Schioth H B ^b,c   Bertolini, A ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UPPSALA UNIVERSITY   (Sweden)

^c Melacure Therapeutics AB   (Sweden)

Author keywords

ACTH; Feeding; Melanocortins; Stress; MSH

Indexed keywords

MELANOCORTIN; MELANOCORTIN RECEPTOR;

ANOREXIA; FEEDING BEHAVIOR; HORMONAL REGULATION; HORMONE RELEASE; HYPOTHALAMUS; LATERAL BRAIN VENTRICLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; STARVATION; STRESS;

EID: 0034175921     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0753-3322(00)89045-9     Document Type: Article

References (56)

1. Adan RA, Gispen WH. Brain melanocortin receptors: From cloning to function. Peptides 1997; 18 : 1279-87.
2. Antelman SM, Szechtman H. Tail pinch induces eating in sated rats which appears to depend on nigrostriatal dopamine. Science 1975; 189 : 731-3.
3. Assenmacher I, Barbanel G, Gailet S, Givalois L, Ixart G, Malaval F, et al. Central regulation of ACTH release in stress. Ann NY Acad Sci 1995; 771 : 41-54.
4. Atcheson JB, Tyler FH. Circadian rythm: Man and animals. In: Blasatko H, Sayers G, Smith AD, eds. Handbook of Physiology. Vol 6. Adrenal glands. Washington DC: American Physiological Society; 1975. p. 127-45.
5. Bertolini A, Guarini S, Rompianesi E, Ferrari W. α-MSH and other ACTH fragments improve cadiovascular function and survival in experimental hemorrhagic shock. Eur J Pharmacol 1986; 139 : 19-26.
6. Bertolini A, Poggioli R, Vergoni AV. Cross-species comparison of the acth-induced behavioral syndrome. Ann NY Acad Sci 1988; 525 : 114-29.
7. Chen W, Kelly MA, Opitz-Araya X, Thomas RE, Low MJ, Cone RD. Exocrine gland dysfunction in mc5-r-deficient mice: Evidence for coordinated regulation of exocrine gland function by melanocortin peptides. Cell 1997; 91 : 789-98.
8. Chhajlani V, Muceniece R, Wikberg JES. Molecular cloning of a novel human melanocortin receptor. Biochem Piophys Res Commun 1993; 195 : 866-73.
9. De Wied D, Jolles J. Neuropeptides derived from pro-opiocortin: Behavioral, physiological and neurochemical effects. Physiol Rev 1982; 62 : 976-1059.
10. Donohoe TP. Stress-induced anorexia: Implications for anorexia nervosa. Life Sci 1984; 34 : 203-18.
11. Duhl DMJ, Vrieling H, Miller KA, Wolff GL, Barsh GS. Neomorphic agouti mutations in obese yellow mice. Nat Genet 1994; 8 : 59-65.
12. Eberle AN. The Melanotropins: Chemistry, Physiology and Mechanisms of Action. Basel: Karger; 1988.
13. Fan W, Boston BA, Kestrson RA, Hruby VJ, Cone RD. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 1997; 385 : 165-8.
14. Ferrari W, Floris E, Paulesu F. Su di una particolare, imponente sintomatologia prodotta nel cane dall'acth iniettato nella cisterna magna. Boll Soc It Biol Sper 1955; 31 : 862-4.
15. Gantz I, Konda Y, Tashiro T, Shimoto Y, Miwa H, Munzert G, et al. Molecular cloning of a novel melanocortin receptor. J Biol Chem 1993; 268 : 8246-50.
16. Gantz I, Miwa H, Konda Y, Shimoto Y, Tashiro T, Watson SJ, et al. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J Biol Chem 1993; 268 : 15174-9.
17. Gillmann MA, Lichtigfeld E. The opioid system and anorexia nervosa. Am J Psychiat 1983; 140 : 371-2.
18. Gold PW, Gwirtsman H, Avgerinos PC, Nieman LK, Gallucci WT, Kaye WH, et al. Abnormal hypothalamic-pituitary-adrenal function in anorexia nervosa: Pathophysiological mechanisms in underweight and weight-corrected patients. New Engl J Med 1986; 314 : 1335-42.
19. Grignaschi G, Mantelli B, Samanin R. The hypophagic effect of restraint stress in rats can be mediated by 5-HT2 receptors in the paraventricular nucleus of the hypothalamus. Neurosci Lett 1993; 152 : 103-6.
20. Haslam C, Stevens R, Donohoe TP. The influence of cyproheptadine on immobilization and oestradiol benzoate induced anorexia in ovariectomized rats. Psychopharmacology 1987; 93 : 201-6.
21. Holland JCB, Rowland J, Plumb M. Psychological aspects of anorexia in cancer patients. Cancer Res 1977; 37 : 2425-8.
22. Hotta M, Shibasaki T, Masuda A, Imaki T, Demura H, Ling N, et al. The response of plasma adrenocorticotropin and cortisol to corticotropin-releasing hormone (CRH) and cerebrospinal fluid immunoreactive CRH in anorexia nervosa patients. J Clin Endocrinol Metab 1986; 62 : 319-24.
23. Huszar D, Lynch CA, Faurchild-Huntress V, Dumore JH, Fang Q, Berkemeyer LR, et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997; 88 : 131-41.
24. Kask A, Mutulis F, Muceniece R, Pahkla R, Mutule I, Wikberg JE, et al. Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): Evaluation in vitro and in vivo. Endocrinology 1998; 139 : 5006-14.
25. Kask A, Pahkla R, Irs A, Rago L, Wikberg JE, Schioth HB. Long-term administration of MC4 receptor antagonist HS014 causes hyperphagia and obesity in rats. Neuroreport 1999; 10 : 707-11.
26. Kask A, Rago L, Mutulis F, Pahkla R, Wikberg JE, Schioth HB. Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats. Biochem Biophys Res Commun 1998; 245 : 90-3.
27. Krahn DD, Gosnell BA, Grace M, Levine AS. CRF antagonist partially reverses CRF- And stress-induced effects on feeding. Brain Res Bull 1986; 17 : 285-9.
28. Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 1998; 19 : 155-7.
29. Lu D, Willard D, Patel IR, Kadwell S, Overton L, Kost T, et al. Agouti protein is an antagonist of the melanocyte-stimulating hormone receptor. Nature 1994; 371 : 799-802.
30. Marsh DJ, Hollopeter G, Huszar D, LaufeR R, Yagaloff KA, Fisher SL, et al. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet 1999; 21 : 119-22.
31. Michaud EJ, Bultman SJ, Klebig ML, Van Vugt MJ, Stubbs LJ, Russell LB, et al. A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation. Proc Natl Acad Sci USA 1994; 91 : 2562-6.
32. Morley JE, Levine AS, Rowland NE. Stress induced eating. Life Sci 1983; 32 : 2169-82.
33. Morley JE, Levine AS, Willenbring ML. Stress-induced feeding disorders. In: Carruba MO, Blundell JE, eds. Pharmacology of Eating Disorders: Theorethical and Clinical DevelopMents. New York: Raven Press; 1986. p. 71-83.
34. Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD. Localization of the melanocortin-4 receptor (MC4-R) in endocrine and autonomie control circuits in the brain. Mol endocrinol 1994; 8 : 1298-308.
35. Mountjoy KG, Robbins LS, Mortrud MT, Cone RD. The cloning of a family of genes that encodes the melanocortin receptors. Science 1992; 257 : 1248-51.
36. O'Donohue TL, Dorsa DM. The opiomelanotropinergic neuronal and endocrine systems. Peptides 1982; 3 : 353-95.
37. Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, et al. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 1997; 278 : 135-8.
38. Pare WP. Stress and consummatory behavior in the albino rat. Psychol Rev 1965; 16 : 399-405.
39. Parker EM. The role of central neuropeptide, neurotransmitter and hormonal systems in the regulation of body weight. Neurotransmissions 1999; 15 : 3-11.
40. Poggioli R, Arletti R, Vergoni AV, Castelli M, Bertolini A. ACTH-(1-24) antagonizes the cholestatic and constipating effects of morphine. Arch Int Pharmacodyn Ther 1988; 293 : 265-72.
41. Poggioli R, Vergoni AV, Bertolini A. ACTH-(1-24) and α-MSH antagonize feeding behavior stimulated by kappa opiate agonists. Peptides 1986; 7 : 843-8.
42. Schiöth HB, Muceniece R, Larsson M, Wikberg JES. The melanocortin 1, 3, 4 or 5 receptors do not have a binding epitope for ACTH beyond the sequence of α-MSH. J Endocrinology 1997; 155 : 73-8.
43. Schiöth HB, Muceniece R, Wikberg JES, Chhajlani V. Characterisation of melanocortin receptor subtypes by radioligand binding analysis. Eur J Pharmacol 1995; 288 : 311-7.
44. Schiöth HB, Mutulis F, Muceniece R, Prusis P, Wikberg JE. Discovery of novel melanocortin 4 receptor selective MSH analogues. Br J Pharmacol 1998; 124 : 75-82.
45. Shibasaki T, Yamauchi N, Kato Y, Masuda A, Imaki T, Hotta M, et al. Involvement of corticotropin-releasing factor in restraint stress-induced anorxia and reversion of the anorexia by somatostatin in the rat. Life Sci 1988; 43 : 1103-10.
46. Shimizu N, Oomura Y, Kai Y. Stress-induced anorexia in rats mediated by serotonergic mechanisms in the hypothalamus. Physiol Behav 1989; 46 : 835-41.
47. Skuladdotir GV, Jonsson L, Skarphedinsson JO, Mutulis F, Muceniece R, Raine A, et al. Long-term orexigenic effect of a novel melanocortin 4 receptor selective antagonist. Br J Pharmacol 1999; 126 : 27-34.
48. Slochower J. Emotional labeling and overeating in obese and normal-weight individuals. Psychosom Med 1976; 38 : 131-9.
49. Troop NA, Treasure JL. Psychosocial factors in the onset of eating disorders: Responses to life-events and difficulties. Br J Med Psychol 1997; 70 : 373-85.
50. Vaisse C, Clement K, Guy-Grand B, Froguel P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet 1998; 20 : 113-4.
51. Vergoni AV, Bertolini A, Wikberg JE, Schiöth HB. Differential influence of a selective melanocortin MC4 receptor antagonist on melanocortin-induced behavioral effects in rats. Eur J PharMacol 1998; 362 : 95-101.
52. Vergoni AV, Bertolini A, Wikberg JES, Schiöth HB. Corticotropin-releasing factor (CRF)-induced anorexia is not influenced by a melanocortin 4 receptor blockage. Peptides 1999; 20 : 509-13.
53. Vergoni AV, Bertolini A, Wikberg JES, Schiöth HB. Selective melanocortin MC4 receptor blockage reduces immobilization stress-induced anorexia in rats. Eur J Pharmacol 1999; 369 : 11-5.
54. Vergoni AV, Poggioli R, Bertolini A. Corticotropin inhibits food intake in rats. Neuropeptides 1986; 7 : 153-8.
55. Vergoni AV, Poggioli R, Marrama D, Bertolini A. Inhibition of feeding by ACTH-(1-24): Behavioral and pharmacological aspects. Eur J Pharmacol 1990; 179 : 347-55.
56. Yeo GS, Farooqi IS, Aminian S, Halsall DJ, Stanhope RG, O'Rahilly S. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Genet 1998; 20 : 111-2.