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1
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0033597438
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Transcriptional coregulators in development
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PID: 10213677, COI: 1:CAS:528:DyaK1MXislykuro%3D
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Mannervik M, Nibu Y, Zhang H, Levine M: Transcriptional coregulators in development. Science 1999, 284:606–609. DOI: 10.1126/science.284.5414.606
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(1999)
Science
, vol.284
, pp. 606-609
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Mannervik, M.1
Nibu, Y.2
Zhang, H.3
Levine, M.4
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2
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17144458786
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Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia
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PID: 9486655, COI: 1:CAS:528:DyaK1cXhtlCisrs%3D, This paper demonstrates that recruitment of histone deacetylase is critical for the transforming potential of APL fusion proteins; the differential effects of RA on the stability of the PML-RARa versus PLZF-RARa corepressor complex correlates with the retinoic acid-responsiveness of t(15;17) versus t(11;17) APLs
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Grignani F, De Matteis S, Nervi C, et al.: Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. Nature 1998, 391:815–818. This paper demonstrates that recruitment of histone deacetylase is critical for the transforming potential of APL fusion proteins; the differential effects of RA on the stability of the PML-RARa versus PLZF-RARa corepressor complex correlates with the retinoic acid-responsiveness of t(15;17) versus t(11;17) APLs. DOI: 10.1038/35901
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(1998)
Nature
, vol.391
, pp. 815-818
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Grignani, F.1
De Matteis, S.2
Nervi, C.3
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3
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0032538429
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Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6
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PID: 9765306, COI: 1:CAS:528:DyaK1cXntVSgsLs%3D
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Wong CW, Privalsky ML: Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6. J Biol Chem 1998, 273:27695–27702. DOI: 10.1074/jbc.273.42.27695
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(1998)
J Biol Chem
, vol.273
, pp. 27695-27702
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Wong, C.W.1
Privalsky, M.L.2
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4
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0031723957
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Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO
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PID: 9819405, COI: 1:CAS:528:DyaK1cXnvVKltbk%3D
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Gelmetti V, Zhang J, Fanelli M, et al.: Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. Mol Cell Biol 1998, 18:7185–7191.
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(1998)
Mol Cell Biol
, vol.18
, pp. 7185-7191
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Gelmetti, V.1
Zhang, J.2
Fanelli, M.3
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5
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0031791875
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PML is essential for multiple apoptotic pathways
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PID: 9806545, COI: 1:CAS:528:DyaK1cXntFKqurw%3D
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Wang ZG, Ruggero D, Ronchetti S, et al.: PML is essential for multiple apoptotic pathways. Nat Genet 1998, 20:266–272. DOI: 10.1038/3030
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(1998)
Nat Genet
, vol.20
, pp. 266-272
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Wang, Z.G.1
Ruggero, D.2
Ronchetti, S.3
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6
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0031724804
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ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors
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PID: 9819404, COI: 1:CAS:528:DyaK1cXnvVKltbg%3D, The study demonstrates the interaction of ETO with the corepressors mSin3 and N-CoR and provides a model for how AML1/ETO can repress transcription of AML-1 targets
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Lutterbach B, Westendorf JJ, Linggi B, et al.: ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors. Mol Cell Biol 1998, 18:7176–7184. The study demonstrates the interaction of ETO with the corepressors mSin3 and N-CoR and provides a model for how AML1/ETO can repress transcription of AML-1 targets.
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(1998)
Mol Cell Biol
, vol.18
, pp. 7176-7184
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Lutterbach, B.1
Westendorf, J.J.2
Linggi, B.3
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7
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0032873462
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Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein
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PID: 10490596, COI: 1:CAS:528:DyaK1MXmtlamtbY%3D
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Fenrick R, Amann JM, Lutterbach B, et al.: Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein. Mol Cell Biol 1999, 19:6566–6574.
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(1999)
Mol Cell Biol
, vol.19
, pp. 6566-6574
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Fenrick, R.1
Amann, J.M.2
Lutterbach, B.3
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8
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0032546017
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Role of the histone deacetylase complex in acute promyelocytic leukaemia
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PID: 9486654, COI: 1:CAS:528:DyaK1cXhtlCisr4%3D, This study describes the importance of the PML-RARa and PLZF-RARa/histone deacetylase (HDAC) complex the development of APL. Inhibitors of histone deacetylase dramatically potentiate retinoid-induced differentiation
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Lin RJ, Nagy L, Inoue S, et al.: Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature 1998, 391:811–814. This study describes the importance of the PML-RARa and PLZF-RARa/histone deacetylase (HDAC) complex in the development of APL. Inhibitors of histone deacetylase dramatically potentiate retinoid-induced differentiation. DOI: 10.1038/35895
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(1998)
Nature
, vol.391
, pp. 811-814
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Lin, R.J.1
Nagy, L.2
Inoue, S.3
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9
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0031244521
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Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs
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PID: 9667866, COI: 1:CAS:528:DyaK2sXnt12mtL4%3D
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Hassig CA, Schreiber SL: Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs. Curr Opin Chem Biol 1997, 1:300–308. DOI: 10.1016/S1367-5931(97)80066-X
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(1997)
Curr Opin Chem Biol
, vol.1
, pp. 300-308
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Hassig, C.A.1
Schreiber, S.L.2
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10
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13044268455
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Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha
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PID: 10339585, COI: 1:CAS:528:DyaK1MXksFKktrw%3D, The study shows the leukemogenic potential of the PLZF-RARa and NPM-RARa fusion genes vivo using a transgenic mice model
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Cheng GX, Zhu XH, Men XQ, et al.: Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha. Proc Natl Acad Sci USA 1999, 96:6318–6323. The study shows the leukemogenic potential of the PLZF-RARa and NPM-RARa fusion genes in vivo using a transgenic mice model. DOI: 10.1073/pnas.96.11.6318
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(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 6318-6323
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Cheng, G.X.1
Zhu, X.H.2
Men, X.Q.3
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11
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0031924709
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Knocking in and out genes and trans genes: the use of the engineered mouse to study normal and aberrant hemopoiesis
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PID: 9565156, COI: 1:CAS:528:DyaK1cXivFSkt7k%3D
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Pandolfi PP: Knocking in and out genes and trans genes: the use of the engineered mouse to study normal and aberrant hemopoiesis. Semin Hematol 1998, 35:136–148.
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(1998)
Semin Hematol
, vol.35
, pp. 136-148
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Pandolfi, P.P.1
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12
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0032487923
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Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide
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Soignet SL, Maslak P, Wang ZG, et al.: Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide. N Engl J Med 998, 339:1341–1348.
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N Engl J Med
, vol.998
, Issue.339
, pp. 1341-1348
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Soignet, S.L.1
Maslak, P.2
Wang, Z.G.3
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13
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0029616633
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The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B
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PID: 8545124, COI: 1:CAS:528:DyaK28XlvF2gtg%3D%3D
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Frank R, Zhang J, Uchida H, et al.: The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B. Oncogene 1995, 11:2667–2674.
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(1995)
Oncogene
, vol.11
, pp. 2667-2674
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Frank, R.1
Zhang, J.2
Uchida, H.3
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14
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0028925282
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The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation
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PID: 7891692, COI: 1:CAS:528:DyaK2MXksFWjtr0%3D
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Meyers S, Lenny N, Hiebert SW: The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation. Mol Cell Biol 1995, 15:1974–1982.
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(1995)
Mol Cell Biol
, vol.15
, pp. 1974-1982
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Meyers, S.1
Lenny, N.2
Hiebert, S.W.3
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15
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0033607165
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The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor
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PID: 10536006, COI: 1:CAS:528:DyaK1MXnt1yqtrk%3D
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Lutterbach B, Hou Y, Durst KL, Hiebert SW: The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor. Proc Natl Acad Sci U S A 1999, 96:12822–12827. DOI: 10.1073/pnas.96.22.12822
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(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 12822-12827
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Lutterbach, B.1
Hou, Y.2
Durst, K.L.3
Hiebert, S.W.4
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16
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0030445949
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The AML1/ETO fusion protein activates transcription of BCL-2
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PID: 8943060, COI: 1:CAS:528:DyaK28Xnt1GksL8%3D
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Klampfer L, Zhang J, Zelenetz AO, et al.: The AML1/ETO fusion protein activates transcription of BCL-2. Proc Natl Acad Sci USA 1996, 93:14059–14064. DOI: 10.1073/pnas.93.24.14059
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(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 14059-14064
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Klampfer, L.1
Zhang, J.2
Zelenetz, A.O.3
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17
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0033522234
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The t(8;21) fusion protein, AML1/ETO, transforms NIH3T3 cells and activates AP-1
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PID: 10208431, COI: 1:CAS:528:DyaK1MXitVarsbo%3D
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Frank RC, Sun X, Berguido FJ, et al.: The t(8;21) fusion protein, AML1/ETO, transforms NIH3T3 cells and activates AP-1. Oncogene 1999, 18:1701–1710. DOI: 10.1038/sj.onc.1202459
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(1999)
Oncogene
, vol.18
, pp. 1701-1710
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Frank, R.C.1
Sun, X.2
Berguido, F.J.3
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18
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0032578394
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Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/ Groucho corepressors
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PID: 9751710, COI: 1:CAS:528:DyaK1cXmsV2iur0%3D
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Levanon D, Goldstein RE, Bernstein Y, et al.: Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/ Groucho corepressors. Proc Natl Acad Sci U S A 1998, 95:11590–11595. DOI: 10.1073/pnas.95.20.11590
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(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 11590-11595
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Levanon, D.1
Goldstein, R.E.2
Bernstein, Y.3
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19
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0032573465
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TLE, the human homolog of groucho, interacts with AML1 and acts as a repressor of AML1-induced transactivation
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PID: 9837750, COI: 1:CAS:528:DyaK1cXnvF2gsb4%3D
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Imai Y, Kurokawa M, Tanaka K, et al.: TLE, the human homolog of groucho, interacts with AML1 and acts as a repressor of AML1-induced transactivation. Biochem Biophys Res Commun 1998, 252:582–589. DOI: 10.1006/bbrc.1998.9705
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(1998)
Biochem Biophys Res Commun
, vol.252
, pp. 582-589
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Imai, Y.1
Kurokawa, M.2
Tanaka, K.3
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20
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9044231364
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The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription
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PID: 8657108, COI: 1:CAS:528:DyaK28XhvVahtbs%3D
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Hiebert SW, Sun W, Davis JN, et al.: The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription. Mol Cell Biol 1996, 16:1349–1355.
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(1996)
Mol Cell Biol
, vol.16
, pp. 1349-1355
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Hiebert, S.W.1
Sun, W.2
Davis, J.N.3
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21
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0033611582
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Three distinct domains in TEL-AML1 are required for transcriptional repression of the IL-3 promoter
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PID: 10023677, COI: 1:CAS:528:DyaK1MXhsVyit7g%3D
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Uchida H, Downing JR, Miyazaki Y, et al.: Three distinct domains in TEL-AML1 are required for transcriptional repression of the IL-3 promoter. Oncogene 1999, 18:1015–1022. DOI: 10.1038/sj.onc.1202383
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(1999)
Oncogene
, vol.18
, pp. 1015-1022
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Uchida, H.1
Downing, J.R.2
Miyazaki, Y.3
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22
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0031685620
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TGF-beta signal transduction
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PID: 9759503, COI: 1:CAS:528:DyaK1cXlsFOmsbY%3D
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Massague J: TGF-beta signal transduction. Annu Rev Biochem 1998, 67:753–791. DOI: 10.1146/annurev.biochem.67.1.753
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(1998)
Annu Rev Biochem
, vol.67
, pp. 753-791
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Massague, J.1
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23
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0032400836
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The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells
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PID: 9834202, COI: 1:CAS:528:DyaK1cXnslylsro%3D
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Kurokawa M, Mitani K, Imai Y, et al.: The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells. Blood 1998, 92:4003–4012.
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(1998)
Blood
, vol.92
, pp. 4003-4012
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Kurokawa, M.1
Mitani, K.2
Imai, Y.3
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24
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0032474868
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The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3
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PID: 9665135, COI: 1:CAS:528:DyaK1cXksVOrtro%3D
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Kurokawa M, Mitani K, Irie K, et al.: The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3. Nature 1998, 394:92–96. DOI: 10.1038/27945
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(1998)
Nature
, vol.394
, pp. 92-96
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Kurokawa, M.1
Mitani, K.2
Irie, K.3
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25
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0033559746
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Biallelic and heterozygous point mutations in the runt domain of the AML1/ PEBP2alphaB gene associated with myeloblastic leukemias
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PID: 10068652, COI: 1:CAS:528:DyaK1MXhvFSmtL4%3D
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Osato M, Asou N, Abdalla E, et al.: Biallelic and heterozygous point mutations in the runt domain of the AML1/ PEBP2alphaB gene associated with myeloblastic leukemias. Blood 1999, 93:1817–1824.
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(1999)
Blood
, vol.93
, pp. 1817-1824
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Osato, M.1
Asou, N.2
Abdalla, E.3
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26
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0032830638
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Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia
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PID: 10508512, COI: 1:CAS:528:DyaK1MXmtlOhtbw%3D, This is the first example of the role of haploinsufficiency (due to genetic mutations within the AML1 gene) a familial predisposition to developing leukemia
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Song WJ, Sullivan MG, Legare RD, et al.: Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet 1999, 23:166–175. This is the first example of the role of haploinsufficiency (due to genetic mutations within the AML1 gene) in a familial predisposition to developing leukemia. DOI: 10.1038/13793
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(1999)
Nat Genet
, vol.23
, pp. 166-175
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Song, W.J.1
Sullivan, M.G.2
Legare, R.D.3
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27
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0027373893
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Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia
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PID: 8351518, COI: 1:CAS:528:DyaK3sXmtVSku7w%3D
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Liu P, Tarle SA, Hajra A, et al.: Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Science 1993, 261:1041–1044. DOI: 10.1126/science.8351518
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Science
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, pp. 1041-1044
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Liu, P.1
Tarle, S.A.2
Hajra, A.3
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28
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0032985363
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Molecular insights into PEBP2/ CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta
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PID: 10404215, COI: 1:CAS:528:DyaK1MXksVenuro%3D
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Goger M, Gupta V, Kim WY, et al.: Molecular insights into PEBP2/ CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta. Nat Struct Biol 1999, 6:620–623. DOI: 10.1038/10664
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(1999)
Nat Struct Biol
, vol.6
, pp. 620-623
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Goger, M.1
Gupta, V.2
Kim, W.Y.3
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29
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0031945625
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Secondary acute leukemia and myelodysplastic syndrome with 11q23 abnormalities. EU Concerted Action 11q23 Workshop
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PID: 9593290, COI: 1:STN:280:DyaK1c3lsVWhsA%3D%3D
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Secker-Walker LM, Moorman AV, Bain BJ, Mehta AB: Secondary acute leukemia and myelodysplastic syndrome with 11q23 abnormalities. EU Concerted Action 11q23 Workshop. Leukemia 1998, 12:840–844. DOI: 10.1038/sj.leu.2401021
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(1998)
Leukemia
, vol.12
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Secker-Walker, L.M.1
Moorman, A.V.2
Bain, B.J.3
Mehta, A.B.4
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30
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0032188805
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The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children’s Leukaemia Working Parties
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PID: 9746770, COI: 1:CAS:528:DyaK1cXmsVKnsrw%3D
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Grimwade D, Walker H, Oliver F, et al.: The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children’s Leukaemia Working Parties. Blood 1998, 92:2322–2333.
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Blood
, vol.92
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Grimwade, D.1
Walker, H.2
Oliver, F.3
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31
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0031918022
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General report on the European Union Concerted Action Workshop on 11q23, London, UK, May 1997
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PID: 9593280, COI: 1:STN:280:DyaK1c3lsVWisA%3D%3D
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Secker-Walker LM: General report on the European Union Concerted Action Workshop on 11q23, London, UK, May 1997. Leukemia 1998, 12:776–778. DOI: 10.1038/sj.leu.2401011
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(1998)
Leukemia
, vol.12
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Secker-Walker, L.M.1
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32
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13144281720
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The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/ SNF complex
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PID: 9539705, COI: 1:CAS:528:DyaK1cXis1Ohtrc%3D
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Rozenblatt-Rosen O, Rozovskaia T, Burakov D, et al.: The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/ SNF complex. Proc Natl Acad Sci U S A 1998, 95:4152–4157. DOI: 10.1073/pnas.95.8.4152
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(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 4152-4157
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Rozenblatt-Rosen, O.1
Rozovskaia, T.2
Burakov, D.3
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33
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0032168459
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MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis
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PID: 9724755, COI: 1:CAS:528:DyaK1cXlvFWgtLs%3D
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Yu BD, Hanson RD, Hess JL, et al.: MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis. Proc Natl Acad Sci U S A 1998, 95:10632–10636. DOI: 10.1073/pnas.95.18.10632
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(1998)
Proc Natl Acad Sci U S A
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Yu, B.D.1
Hanson, R.D.2
Hess, J.L.3
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34
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0033168716
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The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis
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PID: 10393173, COI: 1:CAS:528:DyaK1MXksFKlsbk%3D
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Dobson CL, Warren AJ, Pannell R, et al.: The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis. EMBO J 1999, 18:3564–3574. DOI: 10.1093/emboj/18.13.3564
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EMBO J
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, pp. 3564-3574
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Dobson, C.L.1
Warren, A.J.2
Pannell, R.3
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35
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0033546189
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Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53
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PID: 10358050, COI: 1:CAS:528:DyaK1MXjvVGktLc%3D
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Shinobu N, Maeda T, Aso T, et al.: Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53. J Biol Chem 1999, 274:17003–17010. DOI: 10.1074/jbc.274.24.17003
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J Biol Chem
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Shinobu, N.1
Maeda, T.2
Aso, T.3
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36
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0031984414
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Rearrangement of ALL1 (MLL) in acute myeloid leukemia with normal cytogenetics
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PID: 9426057, COI: 1:CAS:528:DyaK1cXitVGmtg%3D%3D
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Caligiuri MA, Strout MP, Lawrence D, et al.: Rearrangement of ALL1 (MLL) in acute myeloid leukemia with normal cytogenetics. Cancer Res 1998, 58:55–59.
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Cancer Res
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Caligiuri, M.A.1
Strout, M.P.2
Lawrence, D.3
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37
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0032170594
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Partial tandem duplications of the MLL gene are detectable in peripheral blood and bone marrow of nearly all healthy donors
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PID: 9716602, COI: 1:CAS:528:DyaK1cXls1Shs7w%3D
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Schnittger S, Wormann B, Hiddemann W, Griesinger F: Partial tandem duplications of the MLL gene are detectable in peripheral blood and bone marrow of nearly all healthy donors. Blood 1998, 92:1728–1734.
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Blood
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Schnittger, S.1
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Hiddemann, W.3
Griesinger, F.4
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38
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0029555913
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Unidirectional and bidirectional protein traffic across membranes
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