메뉴 건너뛰기




Volumn 92, Issue 11, 1998, Pages 4003-4012

The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-β-mediated growth inhibition of myeloid cells

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; ZINC FINGER PROTEIN;

EID: 0032400836     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.11.4003.423a56_4003_4012     Document Type: Article
Times cited : (94)

References (87)
  • 2
    • 0026327483 scopus 로고
    • Translocation (3;21)(q26; q22) in secondary leukemia
    • Schneider NR, Bowman WP, Frenkel EP: Translocation (3;21)(q26; q22) in secondary leukemia. Ann Genet 34:256, 1991
    • (1991) Ann Genet , vol.34 , pp. 256
    • Schneider, N.R.1    Bowman, W.P.2    Frenkel, E.P.3
  • 3
    • 0028069226 scopus 로고
    • Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia
    • Mitani K, Ogawa S, Tanaka T, Miyoshi H, Kurokawa M, Mano H, Yazaki Y, Ohki M, Hirai H: Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. EMBO J 13:504, 1994
    • (1994) EMBO J , vol.13 , pp. 504
    • Mitani, K.1    Ogawa, S.2    Tanaka, T.3    Miyoshi, H.4    Kurokawa, M.5    Mano, H.6    Yazaki, Y.7    Ohki, M.8    Hirai, H.9
  • 4
    • 0030658039 scopus 로고    scopus 로고
    • Oncogenic transcription factors in the human acute leukemias
    • Look AT: Oncogenic transcription factors in the human acute leukemias. Science 278:1059, 1997
    • (1997) Science , vol.278 , pp. 1059
    • Look, A.T.1
  • 6
    • 0027184229 scopus 로고
    • Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α
    • Ogawa E, Inuzuka M, Maruyama M, Satake M, Naito FM, Ito Y, Shigesada K: Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α. Virology 194:314, 1993
    • (1993) Virology , vol.194 , pp. 314
    • Ogawa, E.1    Inuzuka, M.2    Maruyama, M.3    Satake, M.4    Naito, F.M.5    Ito, Y.6    Shigesada, K.7
  • 7
    • 0027256023 scopus 로고
    • Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor
    • Wang S, Wang Q, Crute BE, Melnikova IN, Keller SR, Speck NA: Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol 13:3324, 1993
    • (1993) Mol Cell Biol , vol.13 , pp. 3324
    • Wang, S.1    Wang, Q.2    Crute, B.E.3    Melnikova, I.N.4    Keller, S.R.5    Speck, N.A.6
  • 8
    • 0027158441 scopus 로고
    • The role of viral enhancer "core" motif-related sequences in regulating T cell receptor-gamma and -delta gene expression
    • Hsiang YH, Spencer D, Wang S, Speck NA, Raulet DH: The role of viral enhancer "core" motif-related sequences in regulating T cell receptor-gamma and -delta gene expression. J Immunol 150:3905, 1993
    • (1993) J Immunol , vol.150 , pp. 3905
    • Hsiang, Y.H.1    Spencer, D.2    Wang, S.3    Speck, N.A.4    Raulet, D.H.5
  • 9
    • 0027383818 scopus 로고
    • Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: The runt homology domain is required for DNA binding and protein-protein interactions
    • Meyers S, Downing JR, Hiebert SW: Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: The runt homology domain is required for DNA binding and protein-protein interactions. Mol Cell Biol 13:6336, 1993
    • (1993) Mol Cell Biol , vol.13 , pp. 6336
    • Meyers, S.1    Downing, J.R.2    Hiebert, S.W.3
  • 10
    • 0028066779 scopus 로고
    • PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBFβ proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells
    • Nuchprayoon I, Meyers S, Scott LM, Suzow J, Hiebert S, Friedman AD: PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBFβ proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. Mol Cell Biol 14:5558, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 5558
    • Nuchprayoon, I.1    Meyers, S.2    Scott, L.M.3    Suzow, J.4    Hiebert, S.5    Friedman, A.D.6
  • 11
    • 0027395118 scopus 로고
    • The murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type restricted transcription factor, myeloid nuclear factor l (MyNF1)
    • Suzow J, Friedman AD: The murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type restricted transcription factor, myeloid nuclear factor l (MyNF1). Mol Cell Biol 13:2141, 1993
    • (1993) Mol Cell Biol , vol.13 , pp. 2141
    • Suzow, J.1    Friedman, A.D.2
  • 12
    • 0031092629 scopus 로고    scopus 로고
    • AML1A and AML1B can transactivate the human IL-3 promoter
    • Uchida H, Zhang J, Nimer SD: AML1A and AML1B can transactivate the human IL-3 promoter. J Immunol 158:2251, 1997
    • (1997) J Immunol , vol.158 , pp. 2251
    • Uchida, H.1    Zhang, J.2    Nimer, S.D.3
  • 13
    • 0030024112 scopus 로고
    • CCAAT enhancer-binding protein (C/EBP) and AML1 (CBFα2) synergistically activate the macrophage colony-stimulating factor receptor promoter
    • Zhang DE, Hetherington CJ, Shapiro LH, Chen HM, Look AT, Tenen DC: CCAAT enhancer-binding protein (C/EBP) and AML1 (CBFα2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol Cell Biol 16:1231, 1994
    • (1994) Mol Cell Biol , vol.16 , pp. 1231
    • Zhang, D.E.1    Hetherington, C.J.2    Shapiro, L.H.3    Chen, H.M.4    Look, A.T.5    Tenen, D.C.6
  • 14
    • 0028837972 scopus 로고
    • An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms
    • Tanaka T, Tanaka K, Ogawa S, Kurokawa M, Mitani K, Nishida J, Shibata Y, Yazaki Y, Hirai H: An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms. EMBO J 14:341, 1995
    • (1995) EMBO J , vol.14 , pp. 341
    • Tanaka, T.1    Tanaka, K.2    Ogawa, S.3    Kurokawa, M.4    Mitani, K.5    Nishida, J.6    Shibata, Y.7    Yazaki, Y.8    Hirai, H.9
  • 16
    • 0023678897 scopus 로고
    • Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines
    • Morishita K, Parker DS, Mucenski ML, Jenkins NA, Copeland NG, Ihle JN: Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell 54:831, 1988
    • (1988) Cell , vol.54 , pp. 831
    • Morishita, K.1    Parker, D.S.2    Mucenski, M.L.3    Jenkins, N.A.4    Copeland, N.G.5    Ihle, J.N.6
  • 17
    • 0025287710 scopus 로고
    • Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: Sequence of cDNAs and structure of alternatively spliced transcripts
    • Morishita K, Parganas E, Douglass EC, Ihle JN: Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts. Oncogene 5:963, 1990
    • (1990) Oncogene , vol.5 , pp. 963
    • Morishita, K.1    Parganas, E.2    Douglass, E.C.3    Ihle, J.N.4
  • 22
    • 0028065441 scopus 로고
    • Expression of EVI1 in myelodysplastic syndromes and other hématologic malignancies without 3q26 translocations
    • Russell M, List A, Greenberg P, Woodward S, Glinsmann B, Parganas E, Ihle J, Taetle R: Expression of EVI1 in myelodysplastic syndromes and other hématologic malignancies without 3q26 translocations. Blood 84:1243, 1994
    • (1994) Blood , vol.84 , pp. 1243
    • Russell, M.1    List, A.2    Greenberg, P.3    Woodward, S.4    Glinsmann, B.5    Parganas, E.6    Ihle, J.7    Taetle, R.8
  • 24
    • 0030048617 scopus 로고    scopus 로고
    • Molecular analysis of Evil, a zinc finger oncogene involved in myeloid leukemia
    • Lopingco MC, Perkins AS: Molecular analysis of Evil, a zinc finger oncogene involved in myeloid leukemia. Curr Top Microbiol Immunol 211:211, 1996
    • (1996) Curr Top Microbiol Immunol , vol.211 , pp. 211
    • Lopingco, M.C.1    Perkins, A.S.2
  • 25
    • 0031040314 scopus 로고    scopus 로고
    • The Evi-1 proto-oncogene encodes a transcriptional repressor activity associated with transformation
    • Bartholomew C, Kilbey A, Clark AM, Walker M: The Evi-1 proto-oncogene encodes a transcriptional repressor activity associated with transformation. Oncogene 14:569,1997
    • (1997) Oncogene , vol.14 , pp. 569
    • Bartholomew, C.1    Kilbey, A.2    Clark, A.M.3    Walker, M.4
  • 26
    • 0027983769 scopus 로고
    • Evi-1 raises AP-1 activity and stimulates c-fos promoter transactivation with dependence on the second zinc finger domain
    • Tanaka T, Nishida J, Mitani K, Ogawa S, Yazaki Y, Hirai H: Evi-1 raises AP-1 activity and stimulates c-fos promoter transactivation with dependence on the second zinc finger domain. J Biol Chem 269:24020, 1994
    • (1994) J Biol Chem , vol.269 , pp. 24020
    • Tanaka, T.1    Nishida, J.2    Mitani, K.3    Ogawa, S.4    Yazaki, Y.5    Hirai, H.6
  • 27
    • 0029091464 scopus 로고
    • The AML1/Evi-1 fusion protein in the t(3;21) translocation exhibits transforming activity on Rat1 fibroblasts with dependence on the Evi-1 sequence
    • Kurokawa M, Ogawa S, Tanaka T, Mitani K, Yazaki Y, Witte ON, Hirai H: The AML1/Evi-1 fusion protein in the t(3;21) translocation exhibits transforming activity on Rat1 fibroblasts with dependence on the Evi-1 sequence. Oncogene 11:833, 1995
    • (1995) Oncogene , vol.11 , pp. 833
    • Kurokawa, M.1    Ogawa, S.2    Tanaka, T.3    Mitani, K.4    Yazaki, Y.5    Witte, O.N.6    Hirai, H.7
  • 28
    • 0026599120 scopus 로고
    • Expression of the Evi-1 zinc finger gene in 32Dc13 myeloid cells blocks granulocytic differentiation in response to granulocyte colony-stimulating factor
    • Morishita K, Parganas E, Matsugi T, Ihle JN: Expression of the Evi-1 zinc finger gene in 32Dc13 myeloid cells blocks granulocytic differentiation in response to granulocyte colony-stimulating factor. Mol Cell Biol 12:183, 1992
    • (1992) Mol Cell Biol , vol.12 , pp. 183
    • Morishita, K.1    Parganas, E.2    Matsugi, T.3    Ihle, J.N.4
  • 29
    • 0027267480 scopus 로고
    • Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene
    • Kreider BL, Orkin SH, Ihle JN: Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene. Proc Natl Acad Sci USA 90:6454, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6454
    • Kreider, B.L.1    Orkin, S.H.2    Ihle, J.N.3
  • 30
    • 0025222517 scopus 로고
    • The transforming growth factor-β family
    • Massagué J: The transforming growth factor-β family. Annu Rev Cell Biol 6:597, 1990
    • (1990) Annu Rev Cell Biol , vol.6 , pp. 597
    • Massagué, J.1
  • 32
    • 0028180315 scopus 로고
    • The TGF-β superfamily: New members, new receptors, and new genetic tests of function in different organisms
    • Kingsley DM: The TGF-β superfamily: New members, new receptors, and new genetic tests of function in different organisms. Gen Dev 8:133, 1994
    • (1994) Gen Dev , vol.8 , pp. 133
    • Kingsley, D.M.1
  • 33
    • 0028940853 scopus 로고
    • Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster
    • Sekelsky JJ, Newfeld SJ, Raftery LA, Chartoff EH, Gelbart WM: Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139:1347, 1995
    • (1995) Genetics , vol.139 , pp. 1347
    • Sekelsky, J.J.1    Newfeld, S.J.2    Raftery, L.A.3    Chartoff, E.H.4    Gelbart, W.M.5
  • 34
    • 0030265714 scopus 로고    scopus 로고
    • Intracellular signalling: The mad way to do it
    • Derynck R, Zhang Y: Intracellular signalling: the mad way to do it. Curr Biol 6:1226, 1996
    • (1996) Curr Biol , vol.6 , pp. 1226
    • Derynck, R.1    Zhang, Y.2
  • 35
    • 0030604542 scopus 로고    scopus 로고
    • TGFβ signaling: Receptors, transducers, and Mad proteins
    • Massagué J: TGFβ signaling: receptors, transducers, and Mad proteins. Cell 85:947, 1996
    • (1996) Cell , vol.85 , pp. 947
    • Massagué, J.1
  • 36
    • 0029842713 scopus 로고    scopus 로고
    • MAD-related proteins in TGFβ signaling
    • Wrana JL, Attisano L: MAD-related proteins in TGFβ signaling. Trends Genet 12:493, 1996
    • (1996) Trends Genet , vol.12 , pp. 493
    • Wrana, J.L.1    Attisano, L.2
  • 37
    • 0029829230 scopus 로고    scopus 로고
    • A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway
    • Baker JC, Harland RM: A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. Gen Dev 10:1880, 1996
    • (1996) Gen Dev , vol.10 , pp. 1880
    • Baker, J.C.1    Harland, R.M.2
  • 39
    • 0029834067 scopus 로고    scopus 로고
    • Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
    • Lagna G, Hata A, Hemmati BA, Massagué J: Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways. Nature 383:832, 1996
    • (1996) Nature , vol.383 , pp. 832
    • Lagna, G.1    Hata, A.2    Hemmati, B.A.3    Massagué, J.4
  • 40
    • 0030300115 scopus 로고    scopus 로고
    • MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling
    • Macias-Silva M, Abdollah S, Hoodless PA, Pirone R, Attisano L, Wrana JL: MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87:1215, 1996
    • (1996) Cell , vol.87 , pp. 1215
    • Macias-Silva, M.1    Abdollah, S.2    Hoodless, P.A.3    Pirone, R.4    Attisano, L.5    Wrana, J.L.6
  • 41
    • 0029786212 scopus 로고    scopus 로고
    • Receptor-associated Mad homologues synergize as effectors of the TGF-β response
    • Zhang Y, Feng X, We R, Derynck R: Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature 383:168, 1996
    • (1996) Nature , vol.383 , pp. 168
    • Zhang, Y.1    Feng, X.2    We, R.3    Derynck, R.4
  • 43
    • 0030872367 scopus 로고    scopus 로고
    • Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
    • Kim J, Johnson K, Chen HJ, Carroll S, Laughon A: Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388:304, 1997
    • (1997) Nature , vol.388 , pp. 304
    • Kim, J.1    Johnson, K.2    Chen, H.J.3    Carroll, S.4    Laughon, A.5
  • 44
    • 0029802485 scopus 로고    scopus 로고
    • A transcriptional partner for MAD proteins in TGF-β signalling
    • Chen X, Rubock MJ, Whitman M: A transcriptional partner for MAD proteins in TGF-β signalling. Nature 383:691, 1996
    • (1996) Nature , vol.383 , pp. 691
    • Chen, X.1    Rubock, M.J.2    Whitman, M.3
  • 48
    • 0032031511 scopus 로고    scopus 로고
    • The AML1/ETO(MTG8) and AML1/Evi-1 leukemia-associated chimeric oncoproteins accumulate PEBP2β(CBFβ) in the nucleus more efficiently than wild-type AML1
    • Tanaka K, Tanaka T, Kurokawa M, Imai Y, Ogawa S, Mitani K, Yazaki Y, Hirai H: The AML1/ETO(MTG8) and AML1/Evi-1 leukemia-associated chimeric oncoproteins accumulate PEBP2β(CBFβ) in the nucleus more efficiently than wild-type AML1. Blood 91:1688, 1998
    • (1998) Blood , vol.91 , pp. 1688
    • Tanaka, K.1    Tanaka, T.2    Kurokawa, M.3    Imai, Y.4    Ogawa, S.5    Mitani, K.6    Yazaki, Y.7    Hirai, H.8
  • 49
    • 0023850352 scopus 로고
    • SRα promoter: An efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat
    • Takebe Y, Seiki M, Fujisawa J, Hoy P, Yokota K, Arai K, Yoshida M, Arai N: SRα promoter: An efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol Cell Biol 8:466, 1988
    • (1988) Mol Cell Biol , vol.8 , pp. 466
    • Takebe, Y.1    Seiki, M.2    Fujisawa, J.3    Hoy, P.4    Yokota, K.5    Arai, K.6    Yoshida, M.7    Arai, N.8
  • 53
    • 0027367937 scopus 로고
    • Signaling activity of transforming growth factor β type II receptors lacking specific domains in the cytoplasmic region
    • Wieser R, Attisano L, Wrana JL, Massagué J: Signaling activity of transforming growth factor β type II receptors lacking specific domains in the cytoplasmic region. Mol Cell Biol 13:7239, 1993
    • (1993) Mol Cell Biol , vol.13 , pp. 7239
    • Wieser, R.1    Attisano, L.2    Wrana, J.L.3    Massagué, J.4
  • 55
    • 0028359376 scopus 로고
    • Type I receptors specify growth-inhibitory and transcrip- Tional responses to transforming growth factor β and activin
    • Carcamo J, Weis FM, Ventura F, Wieser R, Wrana JL, Attisano L, Massagué J: Type I receptors specify growth-inhibitory and transcrip- tional responses to transforming growth factor β and activin. Mol Cell Biol 14:3810, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 3810
    • Carcamo, J.1    Weis, F.M.2    Ventura, F.3    Wieser, R.4    Wrana, J.L.5    Attisano, L.6    Massagué, J.7
  • 56
    • 0028894025 scopus 로고
    • Disruption of transforming growth factor β signaling by a mutation that prevents transphosphorylation within the receptor complex
    • Carcamo J, Zentella A, Massagué J: Disruption of transforming growth factor β signaling by a mutation that prevents transphosphorylation within the receptor complex. Mol Cell Biol 15:1573, 1995
    • (1995) Mol Cell Biol , vol.15 , pp. 1573
    • Carcamo, J.1    Zentella, A.2    Massagué, J.3
  • 57
    • 0023162479 scopus 로고
    • Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells
    • Ohta M, Greenberger JS, Anklesaria P, Bassols A. Massagué J: Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells. Nature 329:539, 1987
    • (1987) Nature , vol.329 , pp. 539
    • Ohta, M.1    Greenberger, J.S.2    Anklesaria, P.3    Bassols, A.4    Massagué, J.5
  • 58
    • 0024333776 scopus 로고
    • Selection of lineage-restricted cell lines immortalized at different stages of hematopietic differentiation from murine cell line 32D
    • Migliaccio G, Migliaccio AR, Kreide BL, Rovera G. Adamson JW: Selection of lineage-restricted cell lines immortalized at different stages of hematopietic differentiation from murine cell line 32D. J Cell Biol 109:833, 1989
    • (1989) J Cell Biol , vol.109 , pp. 833
    • Migliaccio, G.1    Migliaccio, A.R.2    Kreide, B.L.3    Rovera, G.4    Adamson, J.W.5
  • 61
    • 0024412752 scopus 로고
    • Transcriptional repression of eukaryotic promoters
    • Levine M, Manley JL: Transcriptional repression of eukaryotic promoters. Cell 59:405, 1989
    • (1989) Cell , vol.59 , pp. 405
    • Levine, M.1    Manley, J.L.2
  • 64
    • 0032101178 scopus 로고    scopus 로고
    • Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type I gene
    • Dennler S, Itoh S, Vivien D, ten Dijke P, Huet S, Gaulthier J-M: Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type I gene. EMBO J 17:3091, 1998
    • (1998) EMBO J , vol.17 , pp. 3091
    • Dennler, S.1    Itoh, S.2    Vivien, D.3    Ten Dijke, P.4    Huet, S.5    Gaulthier, J.-M.6
  • 66
    • 0030926004 scopus 로고    scopus 로고
    • Mechanism of TGFβ receptor inhibition by FKBP12
    • Chen Y-G, Fang L, Massagué J: Mechanism of TGFβ receptor inhibition by FKBP12. EMBO J 16:3866, 1997
    • (1997) EMBO J , vol.16 , pp. 3866
    • Chen, Y.-G.1    Fang, L.2    Massagué, J.3
  • 67
    • 0027055598 scopus 로고
    • Transforming growth factor β 1 (TGF β 1) reduces cellular levels of p34cdc2, and this effect is abrogated by adenovirus independently of the E1A-associated pRB binding activity
    • Abraham SE, Carter MC, Moran E: Transforming growth factor β 1 (TGF β 1) reduces cellular levels of p34cdc2, and this effect is abrogated by adenovirus independently of the E1A-associated pRB binding activity. Mol Biol Cell 3:655, 1992
    • (1992) Mol Biol Cell , vol.3 , pp. 655
    • Abraham, S.E.1    Carter, M.C.2    Moran, E.3
  • 71
    • 0024549531 scopus 로고
    • Interacting cytokines regulate in vitro human megakaryocytopoiesis
    • Bruno E, Miller ME, Huffman R: Interacting cytokines regulate in vitro human megakaryocytopoiesis. Blood 73:671, 1989
    • (1989) Blood , vol.73 , pp. 671
    • Bruno, E.1    Miller, M.E.2    Huffman, R.3
  • 72
    • 0026565511 scopus 로고
    • Transforming growth factor β inhibits megakaryocyte growth and endomitosis
    • Kuter DJ, Gminski DM, Rosenberg RD: Transforming growth factor β inhibits megakaryocyte growth and endomitosis. Blood 79:619, 1992
    • (1992) Blood , vol.79 , pp. 619
    • Kuter, D.J.1    Gminski, D.M.2    Rosenberg, R.D.3
  • 73
    • 0030240711 scopus 로고    scopus 로고
    • Overexpression of EVI-1 in blast crisis of chronic myeloid leukemia
    • Carapeti M, Goldman JM, Cross NC: Overexpression of EVI-1 in blast crisis of chronic myeloid leukemia. Leukemia 10:1561, 1996
    • (1996) Leukemia , vol.10 , pp. 1561
    • Carapeti, M.1    Goldman, J.M.2    Cross, N.C.3
  • 74
    • 0021929667 scopus 로고
    • Clinical correlations of the 3q21;q26 cytogenetic anomaly. A leukemic or myelodysplastic syndrome with preserved or increased platelet production and lack of response to cytotoxic drug therapy
    • Pintado T, Ferro MT, San RC, Mayayo M, Larana JG: Clinical correlations of the 3q21;q26 cytogenetic anomaly. A leukemic or myelodysplastic syndrome with preserved or increased platelet production and lack of response to cytotoxic drug therapy. Cancer 55:535, 1985
    • (1985) Cancer , vol.55 , pp. 535
    • Pintado, T.1    Ferro, M.T.2    San, R.C.3    Mayayo, M.4    Larana, J.G.5
  • 82
    • 0029759540 scopus 로고    scopus 로고
    • Allelic loss and mutational analysis of the DPC4 gene in esophageal adenocarcinoma
    • Barrett MT, Schutte M, Kern SE, Reid BJ: Allelic loss and mutational analysis of the DPC4 gene in esophageal adenocarcinoma. Cancer Res 56:4351, 1996
    • (1996) Cancer Res , vol.56 , pp. 4351
    • Barrett, M.T.1    Schutte, M.2    Kern, S.E.3    Reid, B.J.4
  • 84
    • 0031034503 scopus 로고    scopus 로고
    • Evidence that loss of chromosome 18q is associated with tumor progression
    • Frank CJ, McClatchey KD, Devaney KO, Carey TE: Evidence that loss of chromosome 18q is associated with tumor progression. Cancer Res 57:824, 1997
    • (1997) Cancer Res , vol.57 , pp. 824
    • Frank, C.J.1    McClatchey, K.D.2    Devaney, K.O.3    Carey, T.E.4
  • 85
    • 0030825516 scopus 로고    scopus 로고
    • Mutations increasing autoinhibition inactivate tumor suppressors Smad2 and Smad4
    • Hata A, Lo RS, Wotton D, Lagna G, Massagué J: Mutations increasing autoinhibition inactivate tumor suppressors Smad2 and Smad4. Nature 388:82, 1997
    • (1997) Nature , vol.388 , pp. 82
    • Hata, A.1    Lo, R.S.2    Wotton, D.3    Lagna, G.4    Massagué, J.5
  • 86
    • 0030974042 scopus 로고    scopus 로고
    • Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4
    • Wu R-Y, Zhang Y. Feng X-H, Derynck R: Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol Cell Biol 17:2521, 1997
    • (1997) Mol Cell Biol , vol.17 , pp. 2521
    • Wu, R.-Y.1    Zhang, Y.2    Feng, X.-H.3    Derynck, R.4
  • 87
    • 0032521421 scopus 로고    scopus 로고
    • The Smad5 gene is involved in the intracellular signaling pathways that mediate the inhibitory effects of transforming growth factor-β on human hematopoiesis
    • Bruno E, Horrigan SK, Van Den Berg D, Rozler E, Fitting PR, Moss ST, Westbrook C, Hoffman R: The Smad5 gene is involved in the intracellular signaling pathways that mediate the inhibitory effects of transforming growth factor-β on human hematopoiesis. Blood 91:1917, 1998
    • (1998) Blood , vol.91 , pp. 1917
    • Bruno, E.1    Horrigan, S.K.2    Van den Berg, D.3    Rozler, E.4    Fitting, P.R.5    Moss, S.T.6    Westbrook, C.7    Hoffman, R.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.