Description and targeted deletion of 5' hypersensitive site 5 and 6 of the mouse β-globin locus control region

Blood

Volumn 92, Issue 11, 1998, Pages 4394-4403

  Bender, M A ^b   Reik, Andreas ^b   Close, Jennie ^b   Telling, Agnes ^b   Epner, Elliot ^b   Fiering, Steven ^b   Hardison, Ross ^b   Groudine, Mark ^a  

^a USA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN;

ANIMAL CELL; ARTICLE; CHICKEN; ERYTHROID CELL; GENE EXPRESSION; GENE LOCUS; GENE MAPPING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; TRANSCRIPTION REGULATION;

EID: 0032402123     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.11.4394.423k48_4394_4403     Document Type: Article

References (49)

1. Stamatoyannopoulos G, Nienhaus AW: Hemoglobin switching, in Stamatoyannopoulos G, Nienhaus AW, Majerus PW, Varmus H (eds): The Molecular Basis of Blood Diseases. Philadelphia, PA, Saunders, 1994, p 107
2. Taramelli R, Kioussis D, Vanin E, Bartram K, Groffen J, Hurst J, Grosveld FG: γδβ-thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human beta-globin cluster. Nucleic Acids Res 14:7017, 1986
3. Driscoll MC, Dobkin CS, Alter BP: Gamma delta beta-thalassemia due to a de novo mutation deleting the 5′ β-globin gene activation-region hypersensitive sites. Proc Natl Acad Sci USA 86: 7470, 1989
4. Curtin P, Pirastu M, Kan YW, Gobert-Jones JA, Stephens AD, Lehmann H: A distant gene deletion affects β-globin gene function in an atypical γδβ-thalassemia. J Clin Invest 76:1554, 1985
5. Dhar V, Nandi A, Schildkraut CL, Skoultchi AI: Erythroid-specific nuclease-hypersensitive sites flanking the human β-globin domain. Mol Cell Biol 10:4324, 1990
6. Forrester WC, Thompson C, Elder JT, Groudine M: A developmentally stable chromatin structure in the human β-globin gene cluster. Proc Natl Acad Sci USA 83:1359, 1986
7. Jimenez G, Griffiths SD, Ford AM, Greaves MF, Enver T: Activation of the β-globin locus control region precedes commitment to the erythroid lineage. Proc Natl Acad Sci USA 89:10618, 1992
8. Tuan D, Solomon W, Li Q, London IM: The "β-like-globin" gene domain in human erythroid cells. Proc Natl Acad Sci USA 82:6384, 1985
9. Zafarana G, Raguz S, Pruzina S, Grosveld F, Meijer D: The regulation of human β-globin gene expression: The analysis of hypersensitive site 5 (HS5) in the LCR, in Stamatoyannapoulas G (ed): Molecular Biology of Hemoglobin Switching. Andover, Hants, UK, Intercept, 1995, p 39
10. Townes TM, Behringer RR: Human globin locus activation region (LAR): Role in temporal control. Trends Genet 6:219, 1990
11. Grosveld F, Antoniou M, Berry M, De Boer E, Dillon N, Ellis J, Fraser P, Hanscombe O, Hurst J, Imam A, Lindenbaum M, Philipsen S, Pruzina S, Strouboulis J, Raguz-Bolognesi S, Talbot D: The regulation of human globin gene switching. Philos Trans R Soc Lond-Series B Biol Sci 339:183, 1993
12. Aladjem MI, Groudine M, Brody LL, Dieken ES, Fournier RE, Wahl GM, Epner EM: Participation of the human β-globin locus control region in initiation of DNA replication. Science 270:815, 1995
13. Forrester WC, Epner E, Driscoll MC, Enver T, Brice M, Papayannopoulou T, Groudine M: A deletion of the human β-globin locus activation region causes a major alteration in chromatin structure and replication across the entire β-globin locus. Genes Dev 4:1637, 1990
14. Hardison R, Slightom JL, Gumucio DL, Goodman M, Stojanovic N, Miller W: Locus control regions of mammalian β-globin gene clusters: Combining phylogenetic analyses and experimental results to gain functional insights. Gene 205:73, 1997
15. Kieffer LJ, Van L, Hanke JH, Kavathas PB: Appropriate developmental expression of human CDS beta in transgenic mice. J Immunol 159:4907, 1997
16. Porcu S, Kitamura M, Witkowska E, Zhang Z, Mutero A, Lin C, Chang J, Gaensler KM: The human β globin locus introduced by YAC transfer exhibits a specific and reproducible pattern of developmental regulation in transgenic mice. Blood 90:4602, 1997
17. Fiering S, Epner E, Robinson K, Zhuang Y, Telling A, Hu M, Martin DI, Enver T, Ley TJ, Groudine M: Targeted deletion of 5′HS2 of the murine β-globin LCR reveals that it is not essential for proper regulation of the β-globin locus. Genes Dev 9:2203, 1995
18. Hug BA, Wesselschmidt RL, Fiering S, Bender MA, Epner E, Groudine M, Ley TJ: Analysis of mice containing a targeted deletion of β-globin locus control region 5′ hypersensitive site 3. Mol Cell Biol 16:2906, 1996
19. Chung JH, Whiteley M, Felsenfeld G: A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell 74:505, 1993
20. Jackson JD, Petrykowska H, Philipsen S, Miller W, Hardison R: Role of DNA sequences outside the cores of DNase hypersensitive sites (HSs) in functions of the β-globin locus control region. Domain opening and synergism between HS2 and HS3. J Biol Chem 271:11871, 1996
21. Li Q, Stamatoyannopoulos G: Hypersensitive site 5 of the human β locus control region functions as a chromatin insulator. Blood 84:1399, 1994
22. Yu J, Bock JH, Slightom JL, Villeponteau B: A 5′ β-globin matrix-attachment region and the polyoma enhancer together confer position-independent transcription. Gene 139:139, 1994
23. Slightom JL, Bock JH, Tagle DA, Gumucio DL, Goodman M, Stojanovic N, Jackson J, Miller W, Hardison R: The complete sequences of the galago and rabbit β-globin locus control regions: Extended sequence and functional conservation outside the cores of DNase hypersensitive sites. Genomics 39:90, 1997
24. Jarman AP, Higgs DR: Nuclear scaffold attachment sites in the human globin gene complexes. EMBO J 7:3337, 1988
25. Orkin SH: Regulation of globin gene expression in erythroid cells. Eur J Biochem 231:271, 1995
26. Reitman M, Felsenfeld G: Developmental regulation of topoisomerase II sites and DNase I-hypersensitive sites in the chicken β-globin locus. Mol Cell Biol 10:2774, 1990
27. Hebbes TR, Clayton AL, Thorne AW, Crane-Robinson C: Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken β-globin chromosomal domain. EMBO J 13:1823, 1994
28. Chung JH, Bell AC, Felsenfeld G: Characterization of the chicken β-globin insulator. Proc Natl Acad Sci USA 94:575, 1997
29. Huang XQ, Hardison RC, Miller W: A space-efficient algorithm for local similarities. Comput Appl Biosci 6:373, 1990
30. Hardison R, Chao KM, Adamkiewicz M, Price D, Jackson J, Zeigler T, Stojanovic N, Miller W: Positive and negative regulatory elements of the rabbit embryonic β-globin gene revealed by an improved multiple alignment program and functional analysis. DNA Sequence 4:163, 1993
31. Chao KM, Hardison RC, Miller W: Recent developments in linear-space alignment methods: A survey. J Computl Biol 1:271, 1994
32. Hardison RC, Oeltjen J, Miller W: Long human-mouse sequence alignments reveal novel regulatory elements: A reason to sequence the mouse genome. Genome Res 7:959, 1997
33. Nagy A, Moens C, Ivanyi E, Pawling J, Gertsenstein M, Hadjantonakis A-K, Pirity M, Rossant J: Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles. Curr Biol 8:661, 1998
34. Jimenez G, Gale KB, Enver T: The mouse β-globin locus control region: Hypersensitive sites 3 and 4. Nucleic Acids Res 20:5797, 1992
35. Baron MH: Transcriptional control of globin gene switching during vertebrate development. Biochim Biophys Acta 1351:51, 1997
36. Motohashi H, Shavit JA, Igarashi K, Yamamoto M, Engel JD: The world according to Maf. Nucleic Acids Res 25:2953, 1997
37. Kataoka K, Noda M, Nishizawa M: Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun. Mol Cell Biol 14:700, 1994
38. Perkins AC, Sharpe AH, Orkin SH: Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature 375:318, 1995
39. Nuez B, Michalovich D, Bygrave A, Ploemacher R, Grosveld F: Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature 375:316, 1995
40. Fiering S, Kim CG, Epner EM, Groudine M: An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: Analysis of the β-globin locus control region. Proc Natl Acad Sci USA 90:8469, 1993
41. Kim CG, Epner EM, Forrester WC, Groudine M: Inactivation of the human β-globin gene by targeted insertion into the β-globin locus control region. Genes Dev 6:928, 1992
42. Fiering SN, Bender MA, Groudine M: Analysis of mammalian cis-regulatory DNA elements by homologous recombination. Methods Enzymol 1999 (in press)
43. von der Ahe D, Pearson D, Nakagawa J, Rajput B, Nagamine Y: Multiple nuclear factors interact with promoter sequences of the urokinase-type plasminogen activator gene. Nucleic Acids Res 16:7527, 1988
44. Epner E, Reik A, Cimbora D, Telling A, Bender MA, Fiering S, Kennedy M, Keller G, Groudine M: The β-globin LCR is not required for an open chromatin structure or low level transcription of the mouse β-globin locus. Mol Cell 1998 (in press)
45. Sutherland HG, Martin DI, Whitelaw E: A globin enhancer acts by increasing the proportion of erythrocytes expressing a linked transgene. Mol Cell Biol 17:1607, 1997
46. Robertson G, Garrick D, Wilson M, Martin DI, Whitelaw E: Age-dependent silencing of globin transgenes in the mouse. Nucleic Acids Res 24:1465, 1996
47. Lakso M, Pichel JG, Gorman JR, Sauer B, Okamoto Y, Lee E, Alt FW, Westphal H: Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sciences USA 93:5860, 1996
48. Schwenk F, Baron U, Rajewsky K: A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res 23:5080, 1995
49. Martin DI, Fiering S, Groudine M: Regulation of β-globin gene expression: Straightening out the locus. Curr Opin Genet Dev 6:488, 1996