Activation of a Rel-A/CEBP-β-related transcription factor heteromer by PGG-glucan in a murine monocytic cell line

Journal of Cellular Biochemistry

Volumn 77, Issue 2, 2000, Pages 221-233

  Adams, David S ^a,e   Nathans, Robin ^b,d   Pero, Stephanie C ^a   Sen, Ami ^a   Wakshull, Eric ^b,c  

^a WORCESTER POLYTECHNIC INSTITUTE   (United States)

^b Alpha Beta Technology Inc   (United States)

^c Collaborative Group Ltd ^*  (United States)

^d Hematech LLC   (United States)

^e Worcester Polytechnic Institute   (United States)

Author keywords

BMC2.3 cells; Immunomodulator; Signal transduction

Indexed keywords

BETAFECTIN; CCAAT ENHANCER BINDING PROTEIN BETA;

ANIMAL CELL; ARTICLE; CELL LINE; LEUKOCYTE ACTIVATION; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BASE SEQUENCE; BETA-GLUCANS; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE; DNA PROBES; DNA-BINDING PROTEINS; GLUCANS; MACROMOLECULAR SUBSTANCES; MICE; MONOCYTES; NF-KAPPA B; NUCLEAR PROTEINS; PROTEIN KINASE C; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTORS;

ANIMALIA; MURINAE;

EID: 0034122994     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(20000501)77:2<221::AID-JCB6>3.0.CO;2-V     Document Type: Article

References (71)

1. Adams DS, Pero SC, Petro JB, Nathans R, Mackin WM, Wakshull E. 1997. PGG-Glucan activates NF-κB-like and NF-IL-6-like transcription factor complexes in a murine monocytic cell line. J Leukoc Biol 62:865-873.
2. Akira S, Kishimoto T. 1997. NF-IL-6 and NF-κB in cytokine gene regulation. Adv Immunol 65:1-46.
3. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, Shibuya M, Fukami Y. 1987. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262:5592-5595.
4. An MR, Hsieh CC, Reisner PD, Rabek JP, Scott SG, Kuninger DT, Papaconstantinou J. 1996. Evidence for post-transcriptional regulation of C/EBP-α and C/EBP-β isoform expression during the lipopolysaccharide-mediated acute-phase response. Mol Cell Biol 16:2295-2306.
5. Baldwin AS. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol 14:649-683.
6. Barnes PJ, Karin M. 1997. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336:1066-1071.
7. Bleicher P, Mackin W. 1995. Betafectin PGG-Glucan: a novel carbohydrate immunomodulator with anti-infective properties. J Biotech Healthcare 2:207-222.
8. Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF, Young PR, Lee JC. 1995. SB203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 364:229-233.
9. Czop JK, Austen KF. 1985. A β-glucan inhibitable receptor on human monocytes: its identity with the phagocytic receptor for particulate activators of the alternative complement pathway. J Immunol 134:2588-2593.
10. Czop JK, Kay J. 1991. Isolation and characterization of β-glucan receptors on human mononuclear phagocytes. J Exp Med 173:1511-1520.
11. Diaz-Meco M, Dominguez I, Sanz I, Dent P, Lozano J, Municio M, Berra E, Hay R, Sturgill T, Moscot J. PKC-ζ induces phosphorylation and inativation of IκB-α in vitro. EMBO J 13:2842-2848.
12. DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M. 1997. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388:548-554.
13. Diehl JA, Hannink M. 1994. Identification of a C/EBP-Rel complex in avian lymphoid cells. Mol Cell Biol 14:6635-6646.
14. Fujihara M, Connolly N, Ito N, Suzuki T. 1994. Properties of protein kinase C isoforms (beta II, epsilon, and zeta) in a macrophage cell line (J774) and their roles in LPS-induced nitric oxide production. J Immunol 152:1898-1906.
15. + exchange activity during phagocytosis in human neutrophils: role of Fc receptors and tyrosine kinases. J Cell Biol 132:1037-1052.
16. Geng Y, Zhang B, Lotz M. 1993. Protein tyrosine kinase activation is required for LPS induction of cytokines in human blood monocytes. J Immunol 151:6692-6700.
17. Ghosh S, Baltimore D. 1990. Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB. Nature 344:678-682.
18. Glaser KB, Sung A, Bauer J, Weichman BM. 1993. Regulation of eicosanoid biosynthesis in the macrophage: involvement of protein tyrosine phosphorylation and modulation by selective protein tyrosine kinase inhibitors. Biochem Pharmacol 45:711-721.
19. Goldman R. 1988. Characteristics of the β-glucan receptor of murine macrophages. Exp Cell Res 174:481-490.
20. Harler MB, Wakshull E, Filardo EJ, Albina JE, Reichner JS. 1999. Promotion of neutrophil chemotaxis through differential regulation of β1 and β2 integrins. J Immunol 162:6792-6799.
21. Hiemstra PS, Annema A, Schippers EF, vanFurth R. 1992. Pertussis toxin partially inhibits phagocytosis of immunoglobulin G-opsonized Staphylococcus aureus by human granulocytes but does not affect intracellular killing. Infect Immun 60:202-205.
22. Hsieh CC, Xiong W, Xie Q, Rabek JP, Scott SG, An MR, Reisner PD, Kuninger DT, Papaconstantinou J. Effects of age on the post-transcriptional regulation of CCAAT/ enhancer binding protein alpha and CCAAT/enhancer binding protein beta isoform synthesis in control and LPS-treated livers. Mol Biol Cell 9:1479-1494.
23. Iwasaki T, Uehara Y, Graves L, Rachie N, Bomsztyk K. 1992. Herbimycin-A blocks IL-1-induced NF-κB DNA-binding activity in lymphoid cell lines. FEBS Lett 298:240-244.
24. Katz S, Kowenz-Leutz E, Muller C, Meese K, Ness SA, Leutz A. 1993. The NF-M transcription factor is related to C/EBP-β and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells. EMBO J 12:1321-1332.
25. Kernodle DS, Gates H, Kaiser AB. 1998. Prophylactic anti-infective activity of PGG-Glucan in a guinea pig model of staphylococcal wound infection. Antimicrob Agents Chemother 42:545-549.
26. Konopski Z, Smedsrod B, Seljelid R, Eskeland T. 1994. A novel mmunomodulator soluble aminated β-1,3-D-glucan: binding characteristics to mouse peritoneal macrophages. Biochim Biophys Acta 1221:61-65.
27. Krappmann D, Scheidereit C. 1997. NF-κB and signal transduction. Regulation of NF-κB activity by IκBα and IκBβ stability. Immunobiology 198:3-13.
28. Kunsch C, Ruben SM, Rosen CA. 1992. Selection of optimal κB/Rel DNA-binding motifs: interaction of both subunits of NF κB with DNA is required for transcriptional activation. Mol Cell Biol 12:4412-4421.
29. LeClair KP, Blanar MA, Sharp PA. 1992. The p50 subunit of NF-κB associates with the NF-IL-6 transcription factor. Proc Natl Acad Sci USA 89:8145-8149.
30. Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, McNulty D, Blumenthal MJ, Heys JR, Landvatter SW. 1994. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372:739-746.
31. Lekstrom-Himes J, Xanthopoulos KG. 1998. Biological role of the CCAAT/Enhancer-binding protein family of transcription factors. J Biol Chem 273:28545-28548.
32. Lenardo MJ, Baltimore D. 1989. NF-κB: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 58:227-229.
33. Liang J, Melican D, Cafro L, Palace G, Fisette L, Armstrong R, Patchen ML. 1998. Enhanced clearance of a multiple antibiotic resistant Staphylococcus aureus in rats treated with PGG-Glucan is associated with increased leukocyte counts and increased neutrophil oxidative burst activity. Int J Immunopharmacol 20:595-614.
34. Lozano J, Berra E, Municio MM, Diaz MT, Dominguez I, Sanz L, Moscat J. 1994. PKC zeta isoform is critical for κB-dependent promoter activation by sphingomyelinase. J Biol Chem 269:19200-19202.
35. Lyman CA, Simons ER, Melnick DA, Diamond RD. 1988. Induction of signal transduction in human neutrophils by Candida albicans hyphae: the role of pertussis toxinsensitive guanosine triphosphate-binding proteins. J Infect Dis 158:1056-1064.
36. Mahoney CW, Shuman J, McKnight SL, Chen H, Huang K. 1992. Phosphorylation of CCAAT-enhancer binding protein by protein kinase C attenuates site selective DNA binding. J Biol Chem 267:19396-19403.
37. Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li JW, Young DB, Barbosa M, Mann M, Manning A, Rao A. 1997. IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation. Science 278:860-866.
38. Metz R, Ziff E. 1991. cAMP stimulates the C/EBP-related transcription factor NF-IL-6 to translocate to the nucleus and induce c-fos transcription. Genes Dev 5:1754-1766.
39. Michalek M, Melican D, Brunke-Reese D, Langevin M, Lemerise K, Galbraith W, Patchen M, Mackin W. 1998. Activation of rat macrophages by Betafectin PGG-Glucan requires crosslinking of membrane receptors distinct from complement receptor three CR3. J Leukoc Biol 64:337-344.
40. Muller A, Rice PJ, Ensley HE, Coogan PS, Kalbfleisch JH, Kelley JL, Love EJ, Portera CA, Ha T, Browder IW, Williams DL. 1996. Receptor binding and internalization of a water-soluble (1,3)-β-D-glucan biological response modifier in two monocyte/macrophage cell lines. J Immunol 156:3418-3425.
41. Natsuka S, Isshiki H, Akira S, Kishimoto T. 1991. Augmentation of haptoglobin production in Hep3B cell line by a nuclear factor NF-IL-6. FEBS Lett 291:58-62.
42. Onderonk AB, Cisneros RL, Hinkson, P, Ostroff GR. 1992. Anti-infective effect of poly-β1-6-glucotriosyl-β1-3-glucopyranose glucan in vivo. Infect Immun 60:1642-1647.
43. Parry G, Mackman N. 1998. NF-κB mediated transcription in human monocytic cells and endothelial cells. Trends Cardiovasc Med 8:138-142.
44. Patchen ML, Vaudrain T, Correira H, Martin T, Reese D. 1998a. In vitro and in vivo hematopoietic activities of Betafectin PGG-Glucan. Exp Hematol 26:1247-1254.
45. Patchen, ML, Liang J, Vaudrain T, Martin T, Melican D, Zhong S, Stewart M, Quesenberry PJ. 1998b. Mobilization of peripheral blood progenitor cells by PGG-Glucan alone and in combination with granulocyte colony-stimulating factor. Stem Cells 16:208-217.
46. Pierce RA, Sandefur S, Doyle GAR, Welgus HG. 1996. Monocytic cell type-specific transcriptional induction of collagenase. J Clin Invest 97:1890-1899.
47. Platanias LC, Colamonici OR. 1992. Interferon-α induces rapid tyrosine phosphorylation of the α subunit of its receptor. J Biol Chem 267:24053-24057.
48. Plevy SE, Gemberling JHM, Hsu S, Dorner AJ, Smale ST. 1997. Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and rel proteins. Mol Cell Biol 17:4572-4588.
49. Poutsiaka DD, Mengozzi M, Vannier E, Sinha B, Dinarello CA. 1993. Crosslinking of the β-glucan receptor on human monocytes results in interleukin-1 receptor antagonist but not interleukin-1 production. Blood 82:3695-3700.
50. 2. J Biol Chem 269:19480-19487.
51. Ray A, Hannink M, Ray BK. 1995. Concerted participation of NF-κB and C/EBP heteromer in LPS induction of serum amyloid A gene expression in liver. J Biol Chem 270:7365-7374.
52. Ruocco MR, Chen X, Ambrosino C, Dragonetti E, Liu W, Mallardo M, DeFalco G, Palmieri C, Franzoso G, Quinto I, Venuta S, Scala G. 1996. Regulation of HIV-1 long terminal repeats by interaction of C/EBP (NF-IL-6) and NF-κB/Rel transcription factors. J Biol Chem 271: 22479-22486.
53. Sears RC, Sealy L. 1994. Multiple forms of C/EBP-β bind the EFII enhancer sequence in the Rous sarcoma virus long terminal repeat. Mol Cell Biol 14:4855-4871.
54. Shattock RJ, Friedland JS, Griffin GE. 1994. Phagocytosis of Mycobacterium tuberculosis modulates human immunodeficiency virus replication in muman monocytic cells. J Gen Virol 75:849-856.
55. Stashenko P, Wang CY, Riley E, Wu Y, Ostroff G, Niederman R. 1995. Reduction of infection-stimulated periapical bone resorption by the biological response modifier PGG-Glucan. J Dent Res 74:323-330.
56. Stein B, Cogswell PC, Baldwin AS Jr. 1993. Functional and physical associations between NF-κB and C/EBP family members: a rel domain-bZIP interaction. Mol Cell Biol 13:3964-3974.
57. Sweet MJ, Hume DA. 1996. Endotoxin signal transduction in macrophages. J Leukoc Biol 60:8-26.
58. Szabo T, Kadish JL, Czop JK. 1995. Biochemical properties of the ligand-binding 20-kDa subunit of the β-glucan receptors on human mononuclear phagocytes. J Biol Chem 270:2145-2151.
59. Tamaoki T, Nakano H. 1990. Potent and specific inhibitors of PKC of microbial origin. BioTechnology 8:732-735.
60. Tapper H, Sundler R. 1995. Protein kinase C and intracellular pH regulate zymosan-induced lysosomal enzyme secretion in macrophages. J Leukoc Biol 58:485-494.
61. Thornton BP, Vetvicka V, Pitman M, Goldman RC, Ross GD. 1996. Analysis of the sugar specificity and molecular location of the β-glucan-binding lectin site of complement receptor type 3 (CD11b/CD18). J Immunol 156: 1235-1246.
62. Tran-Thi TA, Decker K, Baeuerle PA. 1995. Differential activation of transcription factors NF-κB and AP-1 in rat liver macrophages. Hepatology 22:613-619.
63. Turner NC, Wood LJ. 1994. Superoxide generation by guinea-pig peritoneal macrophages is inhibited by rolipram, staurosporine, and mepacrine in an agonist-dependent manner. Cell Signal 6:923-931.
64. 2-dependent and -independent mechanisms. Biochem Pharmacol 41: 1449-1454.
65. Uckun FM, Schieven GL, Tuel-Ahlgren LM, Dibirdik I, Myers DE, Ledbetter JA, Song CW. 1993. Tyrosine phosphorylation is a mandatory proximal step in radiation-induced activation of the PKC signaling pathway in human B-lymphocyte precursors. Proc Natl Acad Sci USA 90:252-256.
66. Wakshull E, Brunke-Reese D, Lindermuth J, Fisette L, Nathans R, Crowley JJ, Tufts JC, Zimmerman J, Mackin W, Adams, DS. 1999. PGG-Glucan, a soluble β-glucan, enhances the oxidative burst response, microbial activity, and increases an NF-κB-like factor in human PMN. Evidence for a unique β-glucan receptor. Immunopharmacology 41:89-107.
67. Wedel A, Ziegler-Heitbrock HW. 1995. The C/EBP family of transcription factors. Immunobiology 193:171-185.
68. Williams SC, Cantwell CA, Johnson PF. 1991. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev 5:1553-1567.
69. Williams SC, Baer M, Dillner AJ, Johnson PF. 1995. CRP2 (C/EBP-β) contains a bipartite regulatory domain that controls transcriptional activation, DNA binding and cell specificity. EMBO J 14:3170-3183.
70. Yoshimoto T, Kojima K, Funakoshi T, Endo Y, Fujita T, Nariuchi H. 1996. Molecular cloning and characterization of murine IL-12 genes. J Immunol 156:1082-1088.
71. Zimmerman JW, Lindermuth J, Fish PA, Paklace GP, Stevenson TT, DeMong DE. 1998. A novel carbohydrate-glycosphingolipid interaction between a β-(1-3)-glucan immunomodulator, PGG-Glucan, and lactosylceramide of human leukocytes. J Biol Chem 273:22014-22020.