β-Amyloid peptide blocks the fast-inactivating K+ current in rat hippocampal neurons

Biophysical Journal

Volumn 70, Issue 1, 1996, Pages 296-304

  Good, Theresa A ^a   Smith, Dean O ^b,d   Murphy, Regina M ^a,c  

^a University of Wisconsin Madison   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c NONE   (United States)

^d UNIVERSITY OF HAWAII   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN;

ANIMAL CELL; ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CONTROLLED STUDY; HIPPOCAMPUS; NERVE CELL CULTURE; NEWBORN; NONHUMAN; POTASSIUM CURRENT; RAT; VOLTAGE CLAMP;

ANIMALIA;

EID: 0029670616     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(96)79570-X     Document Type: Article

References (43)

1. Arispe, N., H. B. Pollard, and E. Rojas. 1993. Giant multilevel cation channels formed by Alzheimer disease amyloid β-protein [AβP-(1-40)] in bilayer membranes. Proc. Natl. Acad. Sci. USA. 90:10573-10577.
2. + channel blocker - involves non-NMDA receptor activation. Neurochem. Int. 24: 81-90.
3. --induced depolarization and NMDA treatment. Neuron. 12:87-95.
4. 2+ influx induced by β-amyloid peptide 25-35 in cultured hippocampal neurons results from network excitation. J. Neurobiol. 26:325-338.
5. Burdick, D., B. Soreghan, M Kwon, J. Kosmoski, M. Knauer, A. Henschen, J. Yates, C. Cotman, and C Glabe. 1992. Assembly and aggregation properties of synthetic Alzheimer's A4/β amyloid peptide analogs. J. Biol. Chem. 267:546-554.
6. Busciglio, J., J. Yeh, and B. A. Yankner. 1993. β-Amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins. J Neurochem. 61:1565-1568.
7. Cotman, C. W., C. J. Pike, and A. Copani. 1992. β-Amyloid neurotoxicity: a discussion of in vitro findings. Neurobiol. Aging. 13:587-590.
8. + channels. Science. 264:276-279.
9. Ficker, E., and U. Heinemann. 1992 Slow and fast transient potassium currents in cultured rat hippocampal cells. J. Physiol. 445:431-455
10. Franklin, J. L., and E. M. Johnson, Jr. 1994. Elevated intracellular calcium blocks programmed neuronal death. Ann. N.Y. Acad. Sci. 747:195-204.
11. Fraser, P. E., J. T. Nguyen, H. Inouye, W. K. Surewicz, D. J. Selkoe, M. B Podlisny, and D. A. Kirschner. 1992. Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid β-protein. Biochemistry. 31:10716-10723.
12. Games, D., D. Adams, R. Alessandrini, R. Barbour, P. Berthelette, C. Blackwell, T. Carr, J. Clemens, T. Donaldson, F. Gillespie, T. Guido, S. Hagopian, K. Johnson-Wood, K. Khan, M. Lee, P. Leibowitz, I. Lieberburg, S. Little, E. Masliah, L. McConlogue, M. Montoya-Zavala, L Mucke, L. Paganini, E. Penniman, M. Power, D. Schenk, P. Seubert B. Snyder, F. Soriano, H. Tan, H. Vitale, S. Wadsworth, B. Wolozin, and J. Zhao. 1995. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature. 373:523-527.
13. + channels from Leiurus quinquestriatus var. nebraeus venom. Biochemistry. 33:6834-6839.
14. Giordano, T., J. B. Pan, L. M. Monteggia, T. F. Holzman, S. W. Snyder, G. Krafft, H. Ghanbari, and N. W. Kowall. 1994. Similarities between β amyloid peptides 1-40 and 40-1: effects on aggregation, toxicity in vitro, and injection in young and aged rats. Exp. Neurol. 125:175-182.
15. Good, T. A., and R. M. Murphy. 1995. Aggregation-state dependent binding of β-amyloid peptide to protein and lipid components of rat cortical homogenates. Biochem. Biophys. Res. Commun. 207:209-215.
16. Gorevic, P. D., T. T. Casey, W. J. Stone, C. R. DiRaimondo, F. C. Prelli, and B. Frangione. 1985. Beta-2-microglobulin is an amyloidogenic protein in man. J. Clin. Invest. 76:2425-2429.
17. Gorevic, P. D., E. M. Castano, R. Sarma, and B. Frangione. 1987. Ten to fourteen residue peptides of Alzheimer's disease protein are sufficient for amyloid fibril formation and its characteristic X-ray diffraction pattern. Biochem. Biophys. Res. Commun. 147:854-862.
18. Halliwell, J. V., I. B. Othman, A. Pelchen-Matthews, and J. O. Dolly. 1986. Central action of dendrotoxin: selective reduction of a transient K conductance in hippocampus and binding to localized acceptors. Proc. Natl. Acad. Sci. USA. 83:493-497.
19. Hensley, K., J. M. Carney, M. P. Mattson, M. Aksenova, M. Harris, J. F. Wu, R A. Floyd, and D. A. Butterfield. 1994. A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. Proc. Natl. Acad. Sci. USA. 91:3270-3274.
20. Hurst, R. S., A. E. Busch, M. P. Kavanaugh, P. B. Osborne, R. A. North, and J. P. Adelman. 1991. Identification of amino acid residues involved in dendrotoxin block of rat voltage-dependent potassium channels. Mol. Pharmacol. 40:572-576.
21. 2+ accumulation in hippocarnpal pyramidal neurons based on fluorescence imaging measurements. J. Neurophysiol. 71:1065-1077.
22. Johnson, B A., and E. E. Sugg. 1992. Determination of the 3-dimensional structure of iberiotoxin in solution by H-1 nuclear magnetic resonance spectroscopy. Biochemistry. 31:8151-8159.
23. Kirschner, D. A., H. Inouye, L. K. Duffy, A. Sinclair, M. Lind, and D. J. Selkoe. 1987. Synthetic peptide homologous to β protein from Alzheimer disease forms amyloid-like fibrils in vitro. Proc. Natl. Acad. Sci. USA. 84:6953-6957.
24. Koh, J.-Y., L. L. Yang, and C. W. Cotman. 1990. β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res. 533:315-320.
25. Loo, D. T., A. Copani, C. J. Pike, E. R. Whittemore, A. J. Walencewicz, and C. W. Cotman. 1993. Apoptosis is induced by β-amyloid in cultured central nervous system neurons. Proc. Natl. Acad. Sci. USA. 90: 7951-8055.
26. 2+ deregulation, and cytoskeletal pathology. Neurobiol. Aging. 16: 187-198.
27. Mattson, M. P., B. Cheng, D. Davis, K. Bryant, I. Lieberburg, and R. E. Rydel. 1992. β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12:376-389.
28. Mattson, M. P., K. P. Tomaselli, and R. E. Rydel. 1993. Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF. Brain Res. 621:35-49.
29. May, P. C., L. N. Boggs, and K. S. Fuson. 1993. Neurotoxicity of human amylin in rat primary hippocampal cultures: similarity to Alzheimer's disease amyloid-β neurotoxicity. J. Neurochem. 61:2330-2333.
30. Moran, P. M., L. S. Higgins, B. Cordell, and P. C. Moser. 1995. Agerelated learning deficits in transgenic mice expressing the 751-amino acid isoform of human β-amyloid precursor protein. Proc. Natl. Acad. Sci. USA. 92:5431-5435.
31. + channel. Neuron. 9:307-313.
32. Pike, C. J., D. Burdick, A. F. Walencewicz, C. G. Glabe, and C. W. Cotman. 1993 Neurodegeneration induced by β-amyloid peptides in vitro: the role of peptide assembly state. J. Neurosci. 13:1676-1687.
33. Shen, C.-L., and R. M. Murphy. 1995. Solvent effects on self-assembly of β-amyloid peptide. Biophys. J. 69:640-651.
34. Shen, C.-L., G. L. Scott, F. Merchant, and R. M. Murphy. 1993. Light scattering analysis of fibril growth from the ami no-terminal fragment β(1-28)-Of β-amyloid peptide. Biophys. J. 65:2383-2395.
35. Siesjo, B. K. 1994. Calcium-mediated processes in neuronal degeneration. Ann. N.Y. Acad. Sci. 747:140-161.
36. Simmons, M. A., and C. R. Schneider. 1993. Amyloid β peptides act directly on single neurons. Neurosci. Lett. 150:133-136.
37. Skarzynski, T. 1992. Crystal structure of α-dendrotoxin from the green mamba venom and its comparison with the structure of bovine pancreatic trypsin inhibitor. J. Mol. Biol. 224:671-683.
38. + channel blocker. Biochemistry. 32:5692-5697.
39. Tennent, G. A., L. B. Lovat, and M B. Pepys. 1995. Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis. Proc. Natl. Acad. Sci. USA. 92: 4299-4303.
40. Trussell, L. O., and M. B. Jackson. 1987. Dependence of an adenosine-activated potassium current on a GTP-binding protein in mammalian central neurons. J. Neurosci. 7:3306-3316.
41. 2+ channel blockers attenuate β-amyloid peptide toxicity to cortical neurons in culture. J. Neurochem. 62:372-375.
42. Whitson, J. S., and S. H. Appel. 1995. Neurotoxicity of Aβ amyloid protein in vitro is not altered by calcium channel blockade. Neurobiol. Aging. 16:5-10.
43. Yankner, B. A., L. K. Duffy, and D. A. Kirschner. 1990. Neurotrophic and neurotoxic effects of amyloid β-protein: reversal by tachykinin neuropeptides. Science. 250:279-282.