Ciliary neurotrophic factor stimulates the expression of glial fibrillary acidic protein by brain astrocytes in vivo

Journal of Comparative Neurology

Volumn 369, Issue 4, 1996, Pages 543-551

  Clatterbuck, Richard E ^a   Price, Donald L ^a   Koliatsos, Vassilis E ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

brain injury; cytokines; glia; inflammation; trophic factors

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CYTOKINE; GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN INJURY; CONTROLLED STUDY; GENE EXPRESSION; MALE; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; PROMOTER REGION; RAT;

ANIMALS; ASTROCYTES; BASE SEQUENCE; BRAIN; BRAIN CHEMISTRY; CILIARY NEUROTROPHIC FACTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAVENTRICULAR; MALE; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; STIMULATION, CHEMICAL; THALAMUS;

EID: 0029899834     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9861(19960610)369:4<543::AID-CNE5>3.0.CO;2-4     Document Type: Article

References (60)

1. Adler, R., K.B. Landa, M. Manthorpe, and S. Varon (1979) Cholinergic neuronotrophic factors: Intraocular distribution of trophic activity for ciliary neurons. Science 204:1434-1436.
2. Adler, R. (1993) Ciliary neurotrophic factor as an injury factor. Curr. Opin. Neurobiol. 3:785-789.
3. Akira, S., Y. Nishio, M. Inoue, X-J. Wang, S. Wei, T. Matsusaka, K. Yoshida, T. Sudo, M. Naruto, and T. Kishimoto (1994) Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77:63-71.
4. Bailey, K., M. Hofer, A. Hohn, J. Leibrock, and Y-A. Barde (1991) Neurotrophins: A group of structurally related proteins supporting the survival of neurons. In D.L. Price, H. Thoenen and A.J. Aguayo (eds): Neurodegenerative Disorders: Mechanisms and Prospects for Therapy. Chicheater: John Wiley & Sons, pp. 145-156.
5. Balcarek, J.M., and N.J. Cowan (1985) Structure of the mouse glial fibrillary acidic protein gene: Implications for the evolution of the intermediate filament multigene family. Nucleic Acids Res. 13:5527-5543.
6. Banati, R.B., J. Gehrmann, P. Schubert, and G.W. Kreutzberg (1993) Cytotoxicity of microglia. GLIA 7.111-118.
7. Barres, B.A., R. Schmid, M. Sendnter, and M.C. Raff (1993) Multiple extracellular signals are required for long-term oligodendrocyte survival. Development 118:283-295.
8. Besnard, F., M. Brenner, Y. Nakatani, R. Chao, H.J. Purohit, and E. Freese (1991) Multiple interacting sites regulate astrocyte-specific transcription of the human gene for glial fibrillary acidic protein. J. Biol. Chem. 266:18877-18883.
9. Bonni, A., D.A. Frank, C. Schindler, and M.E. Greenberg (1993) Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus. Science 262:1575-1579.
10. Clatterbuck, R.E., D.L. Price, and V.E. Koliatsos (1993a) Ciliary neurotrophic factor prevents retrograde neuronal death in the adult central nervous system. Proc. Natl. Acad. Sci. USA 90:2222-2226.
11. Clatterbuck, R.E., D.L. Price, and V.E. Koliatsos (1993b) Evidence that the effects of ciliary neurotrophic factor (CNTF) in the central nervous system (CNS) are mediated via astrocytes. Soc. Neurosci. Abstr. 19:1299
12. Clatterbuck, R.E., D.L. Price, and V.E. Koliatsos (1994) Further characterization of the effects of brain-derived neurotrophic factor and ciliary neurotrophic factor on axotomized neonatal and adult mammalian motor neurons. J. Comp. Neurol. 342.45-56.
13. Curtis, R., Y. Zhu, R.M. Lindsay, and P.S. DiStefano (1992) Axonal retrograde transport of CNTF; modulation by prior nerve injury and soluble CNTF receptor. Soc. Neurosci. Abstr. 18:617
14. Curtis, R., K.M. Adryan, Y. Zhu, P.J. Harkness, R.M. Lindsay, and P.S. DiStefano (1993) Retrograde axonal transport of ciliary neurotrophic factor is increased by peripheral nerve injury. Nature 365:253-255.
15. Davis, S., T.H. Aldrich, D.M. Valenzuela, V. Wong, M.E. Furth, S.P. Squinto, and G.D. Yancopoulos (1991) The receptor for ciliary neurotrophic factor. Science 253:59-63.
16. Davis, S., T.H. Aldrich, N.Y. Ip, N. Stahl, S. Scherer, T. Farruggella, P.S. DiStefano, R. Curtis, N. Panayotatos, H. Gascan, S. Chevalier, and G.D. Yancopoulos (1993a) Released form of CNTF receptor a component as a soluble mediator of CNTF responses. Science 259:1736-1739.
17. Davis, S., T.H. Aldrich, N. Stahl, L. Pan, T. Taga, T. Kishimoto, N.Y. Ip, and G.D. Yancopoulos (1993b) LIFRβ and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Science 260:1805-1808.
18. Giulian, D., J. Woodward, D.G. Young, J.F. Krebs, and L.B. Lachman (1988) Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization. J. Neurosci. 8:2485-2490.
19. Giulian, D., B. Johnson, J.F. Krebs, J.K. George, and M. Tapscott (1991) Microglial mitogens are produced in the developing and injured mammalian brain. J. Cell Biol. 112:323-333.
20. Giulian, D. (1993) Reactive glia as rivals in regulating neuronal survival. GLIA 7:102-110.
21. Giulian, D., K. Vaca, and M. Corpuz (1993) Brain glia release factors with opposing actions upon neuronal survival. J Neurosci. 13:29-37.
22. Giulian, D., and L.B. Lachman (1985) Interleukin-1 stimulation of astroglial p4roliferation after brain injury. Science 228:497-499.
23. Graeber, M.B., and G.W. Kreutzberg (1986) Astrocytes increase in glial fibrillary acidic protein during retrograde changes of facial motor neurons. J. Neurocytol. 15:363-373.
24. Graeber, M.B., and G.W. Kreutzberg (1988) Delayed astrocyte reaction following facial nerve axotomy. J. Neurocytol. 17:209-220.
25. Hagg, T., D. Quon, J. Higaki, and S. Varon (1992) Ciliary neurotrophic factor prevents neuronal degeneration and promotes low affinity NGF receptor expression in the adult rat CNS. Neuron 8:145-158.
26. Hagg, T., S. Varon, and J-C. Louis 11993) Ciliary neurotrophic factor (CNTF) promotes low-affinity nerve growth factor receptor and CD4 expression by rat CNS microglia. J. Neuroimmunol. 48:177-188.
27. Hagg, T., and S. Varon (1993) Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo. Proc. Natl. Acad. Sci. USA 90:6315-6319.
28. Helgren, M.E., B. Friedman, M. Kennedy, K. Mullholland, A. Messer, V. Wong, and R.M. Lindsay (1992) Ciliary neurotrophic factor (CNTF) delays motor impairments in the mnd mouse, a genetic model of motor neuron disease. Soc. Neurosci. Abstr. 18:618
29. Henderson, J.T., N.A. Seniuk, P.M. Richardson, J. Gauldie, and J.C. Roder (1994) Systemic administration of ciliary neurotrophic factor induces cachexia in rodents. J. Clin. Invest. 93:2632-2638.
30. Hughes, S.M., L.E. Lillien, M.C. Raff, H. Rohrer, and M. Sendtner (1988) Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture. Nature 335:70-73.
31. Ip, N.Y., S.H. Nye, T.G. Boulton, S. Davis, T. Taga, Y. Li, S.J. Birren, K. Yasukawa, T. Kishimoto, D.J. Anderson, N. Stahl, and G.D. Yancopoulos (1992) CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell 69:1121-1132.
32. Ip, N.Y., J. McClain, N.X. Barrezueta, T.H. Aldrich, L. Pan, Y. Li, S.J. Wiegand, B. Friedman, S. Davis, and G.D. Yancopoulos (1993a) The a component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development. Neuron 10:89-102.
33. Ip, N.Y., S.J. Wiegand, J. Morse, and J.S. Rudge (1993b) Injury-induced regulation of ciliary neurotrophic factor mRNA in the adult rat brain. Eur. J. Neurosci. 5:25-33.
34. Koliatsos, V.E., M.D. Applegate, C.A. Kitt, L.C. Walker, M.R. DeLong, and D.L. Price (1989) Aberrant phosphorylation of neurofilaments accompanies transmitter-related changes in rat septal neurons following transection of the fimbria-fornix. Brain Res. 482:205-218.
35. Laping, N.J., B. Teter, N.R. Nichols, I. Rozovsky, and C.E. Finch (1994) Glial fibrillary acidic protein: regulation by hormones, cytokines, and growth factors. Brain Pathol. 1:259-275.
36. Lillien, L.E., M. Sendtner, H. Rohrer, S.M. Hughes, and M.C. Raff (1988) Type-2 astrocyte development in rat brain cultures is initiated by a CNTF-like protein produced by type-1 astrocytss. Neuron 1:485-494.
37. Louis, J-C., E. Magal, S. Takayama, and S. Varon (1993) CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death. Science 259:689-692.
38. Lu, B., M. Yokoyama, C.F. Dreyfus, and I.B. Black (1991) NGF gene expression in actively growing brain glia. J. Neurosci. 11:318-326.
39. Lütticken, C., U.M. Wegenka, J. Yuan, J. Buschmann, C. Schindler, A. Ziemiecki, A.G. Harpur, A.F. Wilks, K. Yasukawa, T. Taga, T. Kishimoto, G. Barbieri, S. Pellegrini, M. Sendtner, P.C. Heinrich, and H. Friedemann (1994) Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science 263:89-92.
40. Masiakowski, P., H. Liu, C. Radziejewski, F. Lottspeich, W. Oberthuer, V. Wong, R.M. Lindsay, M.E. Furth, and N. Panayotatos (1991) Recombinant human and rat ciliary neurotrophic factors. J. Neurochem. 57:1003-1012.
41. Masu, Y., E. Wolf, B. Holtmann, M. Sendtner, G. Brem, and H. Thoenen (1993) Disruption of the CNTF gene results in motor neuron degeneration. Nature 365:27-32.
42. Mignatti, P., T. Morimoto, and D.B. Rifkin (1992) Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum-golgi complex. J. Cell. Physiol. 151:81-93.
43. Mitsumoto, H., K. Ikeda, T. Holmlund, T. Greene, J.M. Cedarbaum, V. Wong, and R.M. Lindsay (1994a) The effects of ciliary neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease. Ann. Neurol. 36:142-148.
44. Mitsumoto, H., K. Ikeda, B. Klinkosz, J.M. Cedarbaum, V. Wong, and R.M. Lindsay (1994b) Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF. Science 265:1107-1110.
45. Muesch, A., E. Hartmann, K. Rohde, A. Rubartelli, R. Sitia, and T.A. Rapoport (1990) A novel pathway for secretory proteins? Trends Biol. Sci. 15:86-88.
46. Murray, M., S-D. Wang, M.E. Goldberger, and P. Levitt (1990) Modification of astrocytes in the spinal cord following dorsal root or peripheral nerve lesions. Exp. Neurol. 110:248-257.
47. Paxinos, G., and C. Watson (1986) The Rat Brain in Stereotaxic Coordinates. Sydney: Academic Press.
48. Penfield, W. (1965) Cytology and Cellular Pathology of the Nervous System. New York: Hafner Publishing.
49. Rudge, J.S., R.F. Alderson, E. Pasnikowski, J. McClain, N.Y. Ip, and R.M. Lindsay (1992) Expression of ciliary neurotrophic factor and the neurotrophins - nerve growth factor, brain-derived neurotrophic factor and neurotrophin 3 - in cultured rat hippocampal astrocytes. Eur. J. Neurosci.4:459-471.
50. Rudge, J.S., Y. Li, E.M. Pasnikowski, K. Mattsson, L. Pan, G.D. Yancopoulos, S.J. Wiegand, R.M. Lindsay, and N.Y. Ip (1994) Neurotrophic factor receptors and their signal transduction capabilities in rat astrocytes. Eur. J. Neurosci. 6:693-705.
51. Sendtner, M., G.W. Kreutzberg, and H. Thoenen (1990) Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy. Nature 345:440-441.
52. Sendtner, M., H. Schmalbruch, K.A. Stöckli, P. Carroll, G.W. Kreutzberg, and H. Thoenen (1992) Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy. Nature 358:502-504.
53. Shapiro, L., X-X. Zhang, R.G. Rupp, S.M. Wolff, and C.A. Dinarello (1993) Ciliary neurotrophic factor is an endogenous pyrogen. Proc. Natl. Acad. Sci. USA 90:8614-8618.
54. Squinto, S.P., T.H. Aldrich, R.M. Lindsay, D.M. Morrissey, N. Panayotatos, S.M. Bianco, M.E. Furth, and G.D. Yancopoulos (1990) Identification of functional receptors for ciliary neurotrophic factor on neuronal cell lines and primary neurons. Neuron 5:757-766.
55. Stahl, N., T.G. Boulton, T. Farruggella, N.Y. Ip, S. Davis, B.A. Witthuhn, F.W. Quelle, O. Silvennoinen, G. Barbieri, S. Pellegrini, J.N. Ihle, and G.D. Yancopoulos (1994) Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor components. Science 263:92-95.
56. Stöckli, K.A., L.E. Lillien, M. Näher-Noé, G. Breitfeld, R.A. Hughes, M.C. Raff, H. Thoenen, and M. Sendtner (1991) Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain. J. Cell Biol. 115:447-459.
57. Thoenen, H. (1991) The changing scene of neurotrophic factors. Trends Neurosci. 14:165-170.
58. Thomas, W.E. (1992) Brain macrophages: Evaluation of microglia and their functions. Brain Res. Rev. 17:61-74.
59. Yoshida, K., and F.H. Gage (1992) Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines. Brain Res. 569:14-25.
60. Yoshida, T., M. Satoh, Y. Nakagaito, H. Kuno, and M. Takeuchi (1993) Cytokines affecting survival and differentiation of an astrocyte progenitor cell line. Dev. Brain Res. 76:147-150.