Increased appetite augments hypothalamic NPY Y1 receptor gene expression: Effects of anorexigenic ciliary neurotropic factor

Regulatory Peptides

Volumn 75-76, Issue , 1998, Pages 391-395

  Xu, B ^a   Kalra, P S ^a   Moldawer, L L ^a   Kalra, S P ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

CNTF; mRNA; NPY; NPY Y1 receptor; NPY Y5 receptor; Rat

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; MESSENGER RNA; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y5 RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APPETITE; ARTICLE; BODY WEIGHT; DIET RESTRICTION; FOOD INTAKE; HYPOTHALAMUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANOREXIA; APPETITE; CILIARY NEUROTROPHIC FACTOR; DOWN-REGULATION; FASTING; GENE EXPRESSION; HYPOTHALAMUS; MALE; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROPEPTIDE Y; RNA, MESSENGER;

EID: 0032566814     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(98)00093-7     Document Type: Article

References (24)

1. Kalra SP Appetite and body weight regulation: is it all in the brain? Neuron. 19:1997;227-230.
2. Clark JT, Kalra PS, Kalra SP Neuropeptide Y stimulate feeding but inhibits sexual behavior in rats. Endocrinology. 117:1985;2435-2442.
3. Kalra SP, Dube MG, Kalra PS Continuous intraventricular infusion of neuropeptide Y evokes episodic food intake in satiated female rats: effects of adrenalectomy and cholecystokinin. Peptides. 9:1988;723-728.
4. Zarjevski N, Cusin I, Vettor R, Rohner-Jeanrenaud F, Jeanrenaud B Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology. 133:1993;1753-1758.
5. Kalra SP, Dube MG, Sahu A, Phelps A, Kalra PS Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc Natl Acad Sci USA. 88:1991;10931-10935.
6. Sahu A, Kalra PS, Kalra SP Food deprivation and ingestion-induced reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus. Peptides. 9:1988;83-86.
7. White JD, Kershaw M Increased hypothalamic neuropeptide Y expression following food deprivation. Mol Cell Neurosci. 1:1990;41-48.
8. Brady LS, Smith MA, Gold PW, Herkenham M Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats. Neuroendocrinology. 52:1992;441-447.
9. Dube MG, Xu B, Crowley WR, Kalra PS, Kalra SP Evidence that neuropeptide Y is a physiological signal for normal food intake. Brain Res. 646:1994;341-344.
10. Daniels AJ, Heyer D, Spaltenstein A. Peptide antagonists of neuropeptide Y: design, structure and pharmacological characterization. In: Grundemar L, Bloom SR, (Eds.). Neuropeptide Y and drug development. New York: Academic Press, 1997:127-55.
11. Kanatani A, Ishihara A, Asahi S, Tanaka T, Ozaki S, Ihara S Potent neuropeptide Y Y1 receptor antagonist, 1229U91: blockade of neuropeptide Y-induced physiological food intake. Endocrinology. 137:1996;3177-3182.
12. Hofbauer KG, Schaffhauser AO, Batzl-Hartmann C, Stricker-Krograd A, Whitebread S, Cumin F, Rigollier P, Yamaguchi Y, Chisie M, Levens N, Schilling W, Walker MW, Gerald C, Rueeger H, Criscione L Antisense oligonucleotides targeted against the NPY Y5 receptor and a selective Y5 receptor antagonist inhibit food intake in rodents (abstract). Regul Pept. 71:1997;211.
13. Espat NJ, Auffenberg T, Rogy M, Martin D, Fang CH, Hesselgren PO, Copeland EM, Moldawer LL Ciliary neurotropic factor is catabolic and shares with IL-6 the capacity to induce an acute phase response. Am J Physiol. 271:1996;R185-R190.
14. Plata-Salaman CR, Sonti-Gayatri S, Borkoski JP, Wilson CD, Eferench-Mullen JMH Anorexia induced by chronic central administration of cytokines at estimated pathophysiological concentrations. Physiol Behav. 60:1996;867-875.
15. Kalra S.P., Xu B., Dube M.G., Moldawer L.L., Martin D., Kalra P.S. Leptin and ciliary neurotropic factor (CNTF) inhibit fasting-induced suppression of LH release: role of neuropeptide Y. Neurosci Lett. 240(1):1998;45-49.
16. Xu B, Dube MG, Kalra PS, Farmerie WG, Kaibara A, Moldawer LL, Kalra SP Anorectic effects of the cytokine, ciliary neurotropic factor, are mediated by hypothalamic neuropeptide Y: comparison with leptin. Endocrinology. 139:1998;466-473.
17. Blomqvist AG, Herzog H Y-receptor subtypes - how many more? Trends Neurosci. 20:1997;294-298.
18. Gerald C, Walker MW, Criscione L, Gustafson EL, Batzl-Hartmann C, Smith KE, Vaysse P, Durkin MM, Laz TMet al. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature. 382:1996;168-171.
19. Grundemar L. Multiple receptors and multiple actions. In: Grundemar L, Bloom SR, editors. Neuropeptide Y and drug development. New York: Academic Press, 1997:1-14.
20. Kalra P.S., Dube M.G., Xu B., Farmerie W.G., Kalra S.P. Neuropeptide Y (NPY) Y1 receptor mRNA is upregulated in association with transient hyperphagia and body weight gain: evidence for a hypothalamic site for concurrent development of leptin resistance. J Neuroendocrinol. 10:1998;43-49.
21. Dumont Y, Jacques D, St-Pierre J-A, Quirion R. Neuropeptide Y receptor types in mammalian brain: species differences and status in the human central nervous system. In: Grundemar L, Bloom SR, editors. Neuropeptide Y and drug development. New York: Academic Press, 1997:57-86.
22. Dube MG, Sahu A, Phelps CP, Kalra PS, Kalra SP Neuropeptide Y (NPY) concentration is decreased in the paraventricular nucleus (PVN) of rats exhibiting excessive weight gain produced by ventromedial hypothalamic (VMH) lesions (abstract). Soc Neurosci. 18:1992;937.
23. Kalra PS, Dube MG, Xu B, Kalra SP Increased receptor sensitivity to neuropeptide Y in the hypothalamus may underlie transient hyperphagia and body weight gain. Regul Pept. 72:1997;121-130.
24. Schaffhauser AO, Stricker-Krongrad A, Brunner L, Cumin F, Gerald C, Whitebread S, Criscione L, Hofbauer KG Inhibition of food intake by neuropeptide Y Y5 receptor antisense oligodeoxynucleotides. Diabetes. 46:1997;1792-1798.