Cytokines and cachexia

Nutrition

Volumn 13, Issue 9, 1997, Pages 763-770

  Matthys, Patrick ^a   Billiau, Alfons ^b  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b NONE

Author keywords

Animal models; Cachexia; Cancer; Cytokines; Infections

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CYTOKINE; CYTOKINE ANTIBODY; GAMMA INTERFERON; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; TUMOR NECROSIS FACTOR;

ANOREXIA; CACHEXIA; CANCER; GENE EXPRESSION; HUMAN; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNITY; INFECTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SECOND MESSENGER; WEIGHT REDUCTION;

ANIMALIA;

EID: 0030868324     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(97)00185-8     Document Type: Article

References (80)

1. Langstein HN, Norton JA. Mechanisms of cachexia. Nutr Cancer 1991;5:103
2. Norton JA, Peacock JL, Morrison SD. Cancer cachexia. Crit Rev Oncol Hematol 1987;7:289
3. Gold J. Proposed treatment of cancer by inhibition of gluconeogenesis. Oncology 1968;22:185
4. Inculet RI, Peacock JL, Gorschboth CM, et al. Gluconeogenesis in the tumor-influenced rat hepatocyte: importance of tumor burden, lactate, insulin, and glucagon. J Natl Cancer Inst 1987;79:1039
5. Tisdale MJ. Cancer cachexia. Br J Cancer 1991;63:337
6. Mordes JP, Rossini AA. A tumor-induced anorexia in the Wistar rat. Science 1981;213:565
7. Norton JA, Moley JF, Green MW, Carson RE, Morrison SD. Parabiotic transfer of cancer anorexia/cachexia in male rats. Cancer Res 1985;45:5547
8. Kitada S, Hays EF, Mead JF. A lipid mobilizing factor in serum of tumor-bearing mice. Lipids 1980;15:168
9. Masuno H, Yamasaki N, Okuda H. Purification and characterization of a lipolytic factor (toxohormone-L) from cell-free fluid of ascites sarcoma 180. Cancer Res 1981;41:284
10. Kondo Y, Sato K, Ueyama Y, et al. Serum sialyltransferase and liver catalase activity in cachectic nude mice bearing a human malignant melanoma. Cancer Res 1981;41:2912
11. Mori M, Yamaguchi K, Honda S, et al. Cancer cachexia syndrome developed in nude mice bearing melanoma cells producing leukemia-inhibitory factor. Cancer Res 1991;51:6656
12. Beck SA, Tisdale MJ. Production of lipolytic and proteolytic factors by a murine tumor-producing cachexia in the host. Cancer Res 1987;47:5919
13. Todorov P, Cariuk P, McDevitt T, et al. Characterization of a cancer cachetic factor. Nature 1996;379:739
14. Strassmann G, Fong M, Kenney JS, et al. Evidence for the involvement of interleukin 6 in experimental cancer cachexia. J Clin Invest 1992;89:1681
15. Tisdale MJ. Cancer cachexia. Anti-Cancer Drugs 1993;4:115
16. Shenouda G, Labateya M, Souhami L, et al. Elevated serum cytokines in patients with malignancy and weight loss. Int J Oncol 1993;2:115
17. Coodley GO, Loveless MO, Merrill TM. The HIV wasting syndrome: a review. J Acquired Immune Deficiency Synd 1994;7:681
18. Weinroth SE, Parenti DM, Simon GL. Wasting syndrome in AIDS: pathophysiologic mechanisms and therapeutic approaches. Infect Agents Dis 1995;4:76
19. Roubenoff R, Roubenoff RA, Ward LM, et al. Rheumatoid cachexia: depletion of lean body mass in rheumatoid arthritis. Possible association with tumor necrosis factor. J Rheumatol 1992;19:1505
20. Roubenoff R, Roubenoff RA, Cannon JG, et al. Rheumatoid cachexia. Cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation. J Clin Invest 1994;93:2379
21. Levine DS. Immune modulating therapies for idiopathic inflammatory bowel diseases. Adv Pharmacol 1994;25:171
22. Tilg H. The role of cytokines in the pathophysiology of chronic liver diseases. Int J Clin Lab Res 1993;23:179
23. Difrancia M, Barbier D, Mege JL, et al. Tumor necrosis factor-α levels and weight loss in chronic obstructive pulmonary disease. Am J Resp Crit Care Med 1993;150:1453
24. Rouzer CA, Cerami A. Hypertriglyceridemia associated with Trypanosoma brucei infection in rabbits. Role of defective triglyceride removal. Mol Biochem Parasitol 1980;2:31
25. Kawakami M, Cerami A. Studies of endotoxin-induced decrease in lipoprotein lipase activity. J Exp Med 1981;154:631
26. Beutler B, Mahoney J, Le Trang N, et al. Purification of cachectin, a lipoprotein-lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells. J Exp Med 1985;161:984
27. Tracey KJ. Tumor-necrosis factor-alpha. In: A. Thomson, ed. The Cytokine Handbook, 2nd. ed. London: Academic Press, 1994:289
28. Tracey KJ, Wei H, Manogue KR, et al. Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation. J Exp Med 1988;167:1211
29. Fong Y, Moldawer LL, Marano M, et al. Cachectin/TNF or IL-1α induces cachexia with redistribution of body proteins. Am J Physiol 1989;256:R659
30. Mahony SM, Tisdale MJ. Induction of weight loss and metabolic alterations by human recombinant tumour necrosis factor. Br J Cancer 1988;58:345
31. Plata-Salaḿan CR, Oomura Y, Kai Y. Tumor necrosis factor and interleukin-1β: suppression of food intake by direct action in the central nervous system. Brain Res 1988;448:106
32. Socher SM, Friedman A, Martinez D. Recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice. J Exp Med 1988;167:1957
33. Stovroff MC, Fraker DL, Swedenborg JA, et al. Cachectin/tumor necrosis factor: a possible mediator of cancer anorexia in the rat. Cancer Res 1988;48:4567
34. Oliff A, Defeo-Jones D, Boyer M, et al. Tumors secreting human TNF-cachectin induce cachexia in mice. Cell 1987;50:555
35. Tracey KJ, Morgello S, Koplin B, et al. Metabolic effects of cachectin/tumor necrosis factor are modified by site of production. J Clin Invest 1990;86:2014
36. Cheng J, Turksen K, Yu Q-C, et al. Cachexia and graft-vs.-host-disease-type skin-changes in keratin promoter-driven TNFα transgenic mice. Genes Dev 1992;6:144
37. Sherry BA, Gelin J, Fong Y, et al. Anti-cachectin/tumor necrosis factor-α antibodies attenuate development of cachexia in tumor models. FASEB J 1989;3:1956
38. Gelin J, Moldawer LL, Lonnroth C, et al. Role of endogenous tumor necrosis factor α and interleukin 1 for experimental tumor growth and the development of cancer cachexia. Cancer Res 1991;51:415
39. Langstein HN, Doherty GM, Fraker DL, et al. The roles of γ-interferon and tumor necrosis factor α in an experimental rat model of cancer cachexia. Cancer Res 1991;51:2302
40. Yoneda T, Alsina MA, Chavez JB, et al. Evidence that tumor necrosis factor plays a pathogenetic role in the paraneoplastic syndromes of cachexia, hypercalcemia, and leukocytes in a human tumor in nude mice. J Clin Invest 1991;87:977
41. Costelli P, Carbo N, Tessitore L, et al. Tumor necrosis factor-α mediates changes in tissue protein turnover in a rat cancer cachexia model. J Clin Invest 1993;92:2783
42. Truyens C, Torrico F, Angelo-Barrios A, et al. The cachexia associated with Trypanosoma cruzi acute infection in mice is attenuated by anti-TNF-α, but not by anti-IL-6 or anti-IFN-γ antibodies. Parasite Immunol 1995;17:561
43. Dinarello CA. Interleukin-1. In: A. Thomson, ed. The Cytokine Handbook, 2nd ed. Academic Press, 1994:31
44. Grunfeld C, Feingold KR. The metabolic effects of tumor necrosis factor and other cytokines. Biotherapy 1991;3:143
45. Otterness IG, Golden HW, Brissette WH, et al. Effects of continously administered murine interleukin-1α: tolerance development and granuloma formation. Infect Immun 1989;57:2742
46. Moldawer LL, Georgieff M, Lundholm K. Interleukin-1, tumor necrosis factor-alpha (cachectin) and the pathogenesis of cancer cachexia. Clin Physiol 1987;7:263
47. Hellerstein MK, Meydani SN, Meydani M, et al. Interleukin-1 induced anorexia in the rat. Influence of prostaglandins. J Clin Invest 1989;84:228
48. Yang Z-J, Koseki M, Meguid MM, et al. Synergistic effect of rhTNF-α and rhIL-1α in inducing anorexia in rats. Am J Physiol 1994;267:R1056
49. Uehara A, Sekiya C, Takasugi Y, et al. Anorexia induced by interleukin 1: involvement of corticotropin-releasing factor. Am J Physiol 1989;257:R613
50. Plata-Salaḿan CR, Borkoksi JP. Chemokines/intercrines and central regulation of feeding. Am J Physiol 1994;266:R1711
51. Sonti G, Ilyin SE, Plata-Salaman CR. Anorexia induced by cytokine interactions at pathophysiological concentrations. Am J Physiol 1996;270:R1394
52. Plata-Salaḿan CR. Anorexia during acute and chronic disease. Nutrition 1996;12:69
53. Strassmann G, Masui Y, Chizzonite R, et al. Mechanisms of experimental cancer cachexia. Local involvement of IL-1 in colon-26 tumor. J Immunol 1993;150:2341
54. Strassmann G, Jacob CO, Evans R, et al. Interaction between mononuclear phagocytes and colon-26 carcinoma and its relevance to IL-6-mediated cancer cachexia. J Immunol 1992;148:3674
55. Hirano T. Interleukin-6. In: A. Thomson, ed. The Cytokine Handbook, 2nd ed. Academic Press, 1994:31
56. Greenberg AS, Nordan RP, McIntosh J, et al. Interleukin 6 reduces lipoprotein lipase activity in adipose tissue of mice in vivo and in 3T3-L1 adipocytes: a possible role for innterleukin 6 in cancer cachexia. Cancer Res 1992;52:4113
57. Tsujinaka T, Fujita J, Ebisui C, et al. Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice. J Clin Invest 1996;97:244
58. Black K, Garrett R, Mundy GR. Chinese hamster ovary cells transfected with the murine interleukin-6 gene cause hypercalcemia as well as cachexia, leukocytosis and thrombocytosis in tumor-bearing nude mice. Endocrinology 1991;28:2657
59. Fujimoto-Ouchi K, Tamura S, Mori K, et al. Establishment and characterization of cachexia-inducing and -non-inducing clones of murine colon 26 carcinoma. Int J Cancer 1995;61:522
60. Soda K, Kawakami M, Kashii A, et al. Manifestations of cancer cachexia induced by colon 26 adenocarcinoma are not fully ascribable to interleukin-6. Int J Cancer 1995;62:332
61. Yasumoto K, Mukaida N, Harada A, et al. Molecular analysis of the cytokine network involved in cachexia in colon 26 adenocarcinoma-bearing mice. Cancer Res 1995;55:921
62. Metcalf D, Gearing DP. Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor. Proc Natl Acad Sci USA 1989;86:5948
63. Iseki H, Kajimura N, Ohue C, et al. Cytokine production in five tumor cell lines with activity to induce cancer cachexia syndrome in nude mice. Jpn J Cancer Res 1995;86:562
64. Henderson JT, Seniuk NA, Richardson PM, et al. Systemic administration of ciliary neurotrophic factor induces cachexia in rodents. J Clin Invest 1994;93:2632
65. Henderson JT, Mullen BJM, Roder JC. Physiological effects of CNTF-induced wasting. Cytokine 1996;8:784
66. Espat NJ, Auffenberg T, Rosenberg JJ, et al. Ciliary neurotrophic factor is catabolic and shares with IL-6 the capacity to induce an acute phase response. Am J Physiol 1996;271:R185
67. Fantuzzi G, Benigni F, Sironi M, et al. Ciliary neurotrophic factor (CNTF) induces serum amyloid A, hypoglycaemia and anorexia, and potentiates IL-1 induced corticosterone and IL-6 production in mice. Cytokine 1995;7:150
68. Billiau A. Interferon-γ: biology and role in pathogenesis. Adv Immunol 1996;62:61
69. Patton JS, Shepard HM, Wilking H, et al. Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells. Proc Natl Acad Sci USA 1986;83:8313
70. Kurzrock R, Rohde MF, Quesada JR, et al. Recombinant γ-interferon induces hypertriglyceridemia and inhibits postheparin lipase activity in cancer patients. J Exp Med 1986;164:1093
71. Grégoire F, De Broux N, Hauser N, et al. Interferon-γ and interleukin-1β inhibit adipoconversion in cultured rodent preadipocytes. J Cell Physiol 1992;151:300
72. Memon RA, Feingold KR, Moser AH, et al. In vivo effects of interferon-α and interferon-γ on lipolysis and ketogenesis. Endocrinology 1992;131:1695
73. Matthys P, Dijkmans R, Proost P, et al. Severe cachexia in mice inoculated with interferon-γ-producing tumor cells. Int J Cancer 1991;49:77
74. Matthys P, Heremans H, Opdenakker G, et al. Anti-interferon-γ antibody treatment, growth of Lewis lung tumours in mice and tumour-associated cachexia. Eur J Cancer 1991;27:182
75. Plata-Salaḿan CR. Interferons and central regulation of feeding. Am J Physiol 1992;263:R1222
76. Plata-Salaḿan CR. Anorexia induced by activators of the signal transducer of gp 130. NeuroReport 1996;7:841
77. Matthys P, Mitera T, Heremans H, et al. Anti-interferon-γ and anti-IL-6 antibodies affect Staphylococcal enterotoxin B-induced weight loss, hypoglycemia, and cytokine release in D-galactosamine-sensitized and unsensitized mice. Infect Immun 1994;63:1158
78. Matthys P, Dillen C, Proost P, et al. Modification of the anti-CD3-induced cytokine release syndrome by anti-IFN-γ or anti-IL-6 antibody treatment: protective effects and biphasic changes in blood cytokine levels. Eur J Immunol 1993;23:2209
79. Nabel GJ, Grunfeld C. Calories lost-another mediator of cancer cachexia? Nat Med 1996;2:397
80. Grunfeld C, Zhao C, Fuller J, et al. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. A role for leptin in the anorexia of infection. J Clin Invest 1996;97:2152