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Volumn 74, Issue 2-3, 2000, Pages 231-237

Metabotropic glutamate receptors: A structural view point

Author keywords

3D homology model; Amino terminal domain; Metabotropic glutamate receptors; Neuroprotective agents

Indexed keywords

4 CARBOXY 2 METHYLPHENYLGLYCINE; GLUTAMIC ACID; GLYCINE DERIVATIVE; IONOTROPIC RECEPTOR; LIGAND; METABOTROPIC RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

EID: 0034078074     PISSN: 00316865     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-6865(99)00055-2     Document Type: Conference Paper
Times cited : (8)

References (26)
  • 1
    • 0024464164 scopus 로고
    • Bacterial periplasmic binding protein tertiary structures
    • Adams M.D., Oxender D.L. Bacterial periplasmic binding protein tertiary structures. J. Biol. Chem. 264:1989;15739-15742.
    • (1989) J. Biol. Chem. , vol.264 , pp. 15739-15742
    • Adams, M.D.1    Oxender, D.L.2
  • 2
    • 0032923165 scopus 로고    scopus 로고
    • Antagonist pharmacology of metabotropic glutamate receptors coupled to phospholipase D activation in adult rat hippocampus: Focus on (2R,1′S,2′R,3′S)-2-(2′-carboxy-3′- phenylcyclopropyl)glycine versus 2,3-dihydroxyphenylglycine
    • Albani Torregrossa S., Attucci S., Marinozzi M., Pellicciari R., Moroni F., Pellegrini-Giampietro D.E. Antagonist pharmacology of metabotropic glutamate receptors coupled to phospholipase D activation in adult rat hippocampus: focus on (2R,1′S,2′R,3′S)-2-(2′-carboxy-3′- phenylcyclopropyl)glycine versus 2,3-dihydroxyphenylglycine. Mol. Pharmacol. 55:1999;699-707.
    • (1999) Mol. Pharmacol. , vol.55 , pp. 699-707
    • Albani Torregrossa, S.1    Attucci, S.2    Marinozzi, M.3    Pellicciari, R.4    Moroni, F.5    Pellegrini-Giampietro, D.E.6
  • 3
    • 0032578635 scopus 로고    scopus 로고
    • Structure of a glutamate-receptor ligand-binding core in complex with kainate
    • Armstrong N., Sun Y., Chen G.Q., Gouaux E. Structure of a glutamate-receptor ligand-binding core in complex with kainate. Nature. 395:1998;913-917.
    • (1998) Nature , vol.395 , pp. 913-917
    • Armstrong, N.1    Sun, Y.2    Chen, G.Q.3    Gouaux, E.4
  • 4
    • 0033046392 scopus 로고    scopus 로고
    • Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): Comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors
    • Bruno V., Battaglia G., Kingston A., O'Neill M.J., Catania M.V., Di Grezia R., Nicoletti F. Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors. Neuropharmacology. 38:1999;199-207.
    • (1999) Neuropharmacology , vol.38 , pp. 199-207
    • Bruno, V.1    Battaglia, G.2    Kingston, A.3    O'Neill, M.J.4    Catania, M.V.5    Di Grezia, R.6    Nicoletti, F.7
  • 5
    • 0030995878 scopus 로고    scopus 로고
    • Pharmacology and functions of metabotropic glutamate receptors
    • Conn P.J., Pin J.-P. Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol. 37:1997;205-237.
    • (1997) Annu. Rev. Pharmacol. Toxicol. , vol.37 , pp. 205-237
    • Conn, P.J.1    Pin, J.-P.2
  • 6
    • 0029819599 scopus 로고    scopus 로고
    • Homology modeling of metabotropic glutamate receptors (mGluRs). Structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists
    • Costantino G., Pellicciari R. Homology modeling of metabotropic glutamate receptors (mGluRs). Structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists. J. Med. Chem. 39:1996;3998-4006.
    • (1996) J. Med. Chem. , vol.39 , pp. 3998-4006
    • Costantino, G.1    Pellicciari, R.2
  • 7
    • 0033614956 scopus 로고    scopus 로고
    • Pharmacophore models of group I and group II metabotropic glutamate receptor agonists. Analysis of conformational, steric, and topological parameters affecting potency and selectivity
    • Costantino G., Macchiarulo A., Pellicciari R. Pharmacophore models of group I and group II metabotropic glutamate receptor agonists. Analysis of conformational, steric, and topological parameters affecting potency and selectivity. J. Med. Chem. 42:1999;2816-2827.
    • (1999) J. Med. Chem. , vol.42 , pp. 2816-2827
    • Costantino, G.1    MacChiarulo, A.2    Pellicciari, R.3
  • 10
    • 0033529055 scopus 로고    scopus 로고
    • Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: A different environment but similar recognition of an extended glutamate conformation
    • Jullian N., Brabet I., Pin J.-P., Acher F.C. Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation. J. Med. Chem. 42:1999;1546-1555.
    • (1999) J. Med. Chem. , vol.42 , pp. 1546-1555
    • Jullian, N.1    Brabet, I.2    Pin, J.-P.3    Acher, F.C.4
  • 11
    • 0030991790 scopus 로고    scopus 로고
    • Molecular determinants of agonist discrimination by NMDA receptor subunits: Analysis of the glutamate binding site on the NR2B subunit
    • Laube B., Hirai H., Sturgess M., Betz H., Kuhse J. Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit. Neuron. 18:1997;493-503.
    • (1997) Neuron , vol.18 , pp. 493-503
    • Laube, B.1    Hirai, H.2    Sturgess, M.3    Betz, H.4    Kuhse, J.5
  • 13
    • 0026093312 scopus 로고
    • Sequence and expression of a metabotropic glutamate receptor
    • Masu M., Tanabe Y., Tsuchida K., Shigemoto R., Nakanishi S. Sequence and expression of a metabotropic glutamate receptor. Nature. 349:1991;760-765.
    • (1991) Nature , vol.349 , pp. 760-765
    • Masu, M.1    Tanabe, Y.2    Tsuchida, K.3    Shigemoto, R.4    Nakanishi, S.5
  • 14
    • 0025221685 scopus 로고
    • A family of glutamate receptor genes: Evidence for the formation of heteromultimeric receptors with distinct channel properties
    • Nakanishi N., Schneider N.A., Axel R. A family of glutamate receptor genes: evidence for the formation of heteromultimeric receptors with distinct channel properties. Neuron. 5:1990;569-581.
    • (1990) Neuron , vol.5 , pp. 569-581
    • Nakanishi, N.1    Schneider, N.A.2    Axel, R.3
  • 15
    • 0022639103 scopus 로고
    • Coupling of inositol phospholipid metabolism with excitatory amino acid recognition sites in rat hippocampus
    • Nicoletti F., Meek J.L., Iadarola M.J., Chuang D.M., Roth B.L., Costa E. Coupling of inositol phospholipid metabolism with excitatory amino acid recognition sites in rat hippocampus. J. Neurochem. 46:1986;40-46.
    • (1986) J. Neurochem. , vol.46 , pp. 40-46
    • Nicoletti, F.1    Meek, J.L.2    Iadarola, M.J.3    Chuang, D.M.4    Roth, B.L.5    Costa, E.6
  • 17
    • 0027171026 scopus 로고
    • Leucine/isoleucine/valine-binding protein contracts upon binding of ligand
    • Olah G.A., Trakhanov S., Trewhella J., Quiocho F.A. Leucine/isoleucine/valine-binding protein contracts upon binding of ligand. J. Biol. Chem. 268:1993;16241-16247.
    • (1993) J. Biol. Chem. , vol.268 , pp. 16241-16247
    • Olah, G.A.1    Trakhanov, S.2    Trewhella, J.3    Quiocho, F.A.4
  • 18
    • 0032032919 scopus 로고    scopus 로고
    • The macro- And microarchitectures of the ligand binding domains of glutamate receptors
    • Paas Y. The macro- and microarchitectures of the ligand binding domains of glutamate receptors. Trends Neurosci. 21:1998;117-122.
    • (1998) Trends Neurosci. , vol.21 , pp. 117-122
    • Paas, Y.1
  • 20
    • 0030014882 scopus 로고    scopus 로고
    • (S)-(+)-2-(3′-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist
    • Pellicciari R., Raimondo M., Marinozzi M., Natalini B., Costantino G., Thomsen C. (S)-(+)-2-(3′-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist. J. Med. Chem. 39:1996;2874-2876.
    • (1996) J. Med. Chem. , vol.39 , pp. 2874-2876
    • Pellicciari, R.1    Raimondo, M.2    Marinozzi, M.3    Natalini, B.4    Costantino, G.5    Thomsen, C.6
  • 21
    • 0033566221 scopus 로고    scopus 로고
    • (2R, 1′S,2′R,3′S)-2-(2′-carboxy-3′-phenylcyclopropyl) glycine (PCCG-13), the first potent and selective competitive antagonist of PLD-Coupled metabotropic glutamate receptors. Asymmetric synthesis and preliminary biological properties
    • Pellicciari R., Marinozzi M., Costantino G., Natalini B., Pellegrini-Giampietro D.E., Moroni F. (2R, 1′S,2′R,3′S)-2-(2′-carboxy-3′-phenylcyclopropyl) glycine (PCCG-13), the first potent and selective competitive antagonist of PLD-Coupled metabotropic glutamate receptors. Asymmetric synthesis and preliminary biological properties. J. Med. Chem. 42:1999;2716-2720.
    • (1999) J. Med. Chem. , vol.42 , pp. 2716-2720
    • Pellicciari, R.1    Marinozzi, M.2    Costantino, G.3    Natalini, B.4    Pellegrini-Giampietro, D.E.5    Moroni, F.6
  • 22
    • 0028284466 scopus 로고
    • Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells
    • Shigemoto R., Abe T., Nomura S., Nakanishi S., Hirano T. Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells. Neuron. 12:1994;1245-1255.
    • (1994) Neuron , vol.12 , pp. 1245-1255
    • Shigemoto, R.1    Abe, T.2    Nomura, S.3    Nakanishi, S.4    Hirano, T.5
  • 23
    • 0022370635 scopus 로고
    • Glutamate stimulates inositol phosphate formation in striatal neurones
    • Sladeczek F., Pin J.-P., Recasens M., Bockaert J., Weiss S. Glutamate stimulates inositol phosphate formation in striatal neurones. Nature. 317:1985;717-719.
    • (1985) Nature , vol.317 , pp. 717-719
    • Sladeczek, F.1    Pin, J.-P.2    Recasens, M.3    Bockaert, J.4    Weiss, S.5
  • 24
    • 0028559605 scopus 로고
    • Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins
    • Stern-Bach Y., Bettler B., Hartley M., Sheppard P.O., O'Hara P.J., Heinemann S.F. Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins. Neuron. 13:1994;1345-1357.
    • (1994) Neuron , vol.13 , pp. 1345-1357
    • Stern-Bach, Y.1    Bettler, B.2    Hartley, M.3    Sheppard, P.O.4    O'Hara, P.J.5    Heinemann, S.F.6
  • 25
    • 0032465939 scopus 로고    scopus 로고
    • Antagonists for group I mGluRs attenuate excitotoxic neuronal death in cortical cultures
    • Strasser U., Lobner D., Behrens M.M., Canzoniero L.M., Choi D.W. Antagonists for group I mGluRs attenuate excitotoxic neuronal death in cortical cultures. Eur. J. Neurosci. 10:1998;2848-2855.
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 2848-2855
    • Strasser, U.1    Lobner, D.2    Behrens, M.M.3    Canzoniero, L.M.4    Choi, D.W.5
  • 26
    • 0027282265 scopus 로고
    • Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination
    • Takahashi K., Tsuchida K., Tanabe Y., Masu M., Nakanishi S. Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination. J. Biol. Chem. 268:1993;19341-19345.
    • (1993) J. Biol. Chem. , vol.268 , pp. 19341-19345
    • Takahashi, K.1    Tsuchida, K.2    Tanabe, Y.3    Masu, M.4    Nakanishi, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.