Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania

Lancet

Volumn 351, Issue 9114, 1998, Pages 1477-1482

  Fawzi, Wafaie W ^a   Msamanga, Gernard I ^b   Spiegelman, Donna ^a   Urassa, Ernest J N ^b   McGrath, Nuala ^a   Mwakagile, Davis ^b   Antelman, Gretchen ^a   Mbise, Roger ^b   Herrera, Guillermo ^c   Kapiga, Saidi ^b   Willett, Walter ^a   Hunter, David J ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; MULTIVITAMIN; PLACEBO; RETINOL;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE COURSE; DOUBLE BLIND PROCEDURE; FEMALE; FETUS DEATH; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LOW BIRTH WEIGHT; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; NUTRITIONAL STATUS; PREGNANCY; PREGNANCY COMPLICATION; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SMALL FOR DATE INFANT; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TANZANIA; VERTICAL TRANSMISSION; VITAMIN INTAKE;

EID: 0032537366     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(98)04197-X     Document Type: Article

References (27)

1. 1 UNAIDS. Report on the global HIV/AIDS epidemic: December 1997. Geneva, Switzerland: UNAIDS, Jan 28, 1998.
2. 2 Gray RH, Wawer MJ, Serwadda D, et al. Population-based study of fertility in women with HIV-1 infection in Uganda. Lancet 1998; 351: 98-103.
3. 3 Urassa EJN, Kilewo C, Mtavangu SR, Mhalu FS, Mbena E, Biberfeld G. The role of HIV infection in pregnancy wastage in Dar es Salaam, Tanzania. J Obstet Gynaecol Central Afr 1992; 10: 70-72.
4. 4 Abrams EJ, Matheson PB, Thomas PA, et al. Neonatal predictors of infection status and early death among 332 infants at risk of HIV-1 infection monitored prospectively from birth. Pediatrics 1995; 96:451-58.
5. 5 Nair P, Alger L, Hines S, Seiden S, Hebel R, Johnson JP. Maternal and neonatal characteristics associated with HIV infection in infants of seropositive women. J Acquir Immune Defic Syn 1993; 6: 298-302.
6. 6 Taha TET, Dallabetta GA, Canner JK, et al. The effect of human immunodeficiency virus infection on birthweight, and infant and child mortality in urban Malawi. Int J Epidemiol 1995; 24: 1022-28.
7. 7 McCormick MC. The contribution of low birth weight to infant mortality and childhood mortality. N Engl J Med 1985; 312: 82-90.
8. 8 Semba RD, Graham NMH, Caiaffa WT, Clement L, Vlahov D. Increased mortality associated with vitamin A deficiency during human immunodeficiency virus type-1 infection. Arch Intern Med 1993; 153: 2149-54.
9. 9 Tang AM, Graham NMH, Saah AJ. Effects of micronutrient intake on survival in human immunodeficiency virus type 1 infection. Am J Epidemiol 1996; 143: 1244-56.
10. 10 Tang AM, Graham NMH, Ranjit KC, Saah AJ. Low serum vitamin B-12 concentrations are associated with faster human immunodeficiency virus type 1 (HIV-1) disease progression J Nutr 1997; 127: 345-51.
11. 11 Semba RD, Miotti PG, Chipangwi JD, et al. Infant mortality and vitamin A deficiency during human immunodeficiency virus infection. Clin Infect Dis 1995; 21: 966-72.
12. 12 Dushimimana A, Graham NM, Humphrey JH, et al. Maternal vitamin Alevels and HIV-related birth outcome in Rwanda. Amsterdam, the Netherlands: Programs and abstracts of the Eighth International Conference on AIDS/Third STD World Conference, 1992; July 19-24 (abstr).
13. 13 Dacie JV, Lewis SM. Practical haematology. London: Longman group, 1991.
14. 14 Lyamuya EF, Kagoma C, Mbena EC, et al. Evaluation of FACScount, TRAx CD4 and Dynabeads methods for CD4 lymphocyte determination. J Immunol Methods 1996; 195: 103-112.
15. 15 Brenner WE, Edelman DA, Hendricks CH. A standard of fetal growth for the United States of America. Am J Obstet Gynecol 1993; 168: 1197-1205.
16. 16 Wei LJ, Johnson WE. Combining dependent tests with incomplete repeated measurements. Biometrika 1985; 72: 359-64.
17. 17 The European Collaborative Study and the Swiss HIV Pregnancy Cohort. Immunological markers in HIV-infected pregnant women. AIDS 1997; 11: 1859-65.
18. 18 Scholl TO, Hediger ML, Bendich A, Schall JI, Smith WK, Krueger PM. Use of multivitamin/mineral prenatal supplements: influence on the outcome of pregnancy. Am J Epidemiol 1997; 146: 134-41.
19. 19 Rolschau J, Date J, Kristoffersen K. Folic acid supplement and intrauterine growth. Acta Obstet Gynecol Scand 1979; 58: 343-46.
20. 20 Royston E. The prevalence of nutritional anemia in women in developing countries: a critical review of available information. World Health Stat Q 1982; 35: 5-91.
21. 21 Concorde Coordinating Committee. Concorde: MRC/ANRS randomized double-blind controlled trial of immediate and deferred zidovudine in symptom-free HIV infection. Lancet 1994; 343: 871-81.
22. 22 De Gruttola V, Gelman R, Lagakos SW. The uses of CD4 lymphocyte count to evaluate therapy for HIV disease. In: Finkelstein DM, Schoenfield DA, eds. AIDS clinical trials. New York: Wiley-Liss, 1995: 129-42.
23. 23 Filteau SM, Morris SS, Abbott RA, et al. Influence of morbidity on serum retinol of children in a community-based study in northern Ghana. Am J Clin Nutr 1993; 58: 192-197.
24. 24 Coodley GO, Nelson HD, Loveless MO, Folk C. β-carotene in HIV infection. J Acquir Immune Defic Syn 1993; 6: 272-276.
25. 25 Coodley GO, Coodley MK, Lusk R, et al. ß-carotene in HIV infection: an extended evaluation. AIDS 1996; 10: 967-73.
26. 26 Rothman KJ, Moore LL, Singer MR, Nguyen USADT, Mannino S, Milunsky A. Teratogenicity of high vitamin A intake. N Engl J Med 1995; 333: 1369-73.
27. 27 Beach RS, Mantero-Atienza E, Shor-Posner G, et al. Specific nutrient abnormalities in asymptotic HIV-1 infection.AIDS 1992; 6: 701-08.