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Volumn 5, Issue 5, 1998, Pages 343-349

Mechanisms of thrombosis in hyperhomocysteinemia

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; HOMOCYSTEINE; PROTHROMBIN; VITAMIN B GROUP;

EID: 0031718236     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-199809000-00007     Document Type: Review
Times cited : (72)

References (79)
  • 1
    • 0029029934 scopus 로고
    • Plasma homocyst(e)ine or homocysteine?
    • Mudd SH, Lew HL: Plasma homocyst(e)ine or homocysteine? N Engl J Med 1995, 333:325.
    • (1995) N Engl J Med , vol.333 , pp. 325
    • Mudd, S.H.1    Lew, H.L.2
  • 3
    • 0030709337 scopus 로고    scopus 로고
    • Homocyst(e)ine and coronary artery disease: Clinical evidence and genetic and metabolic background
    • Moghadasian MH, Mcmanus BM, Frohlich JJ: Homocyst(e)ine and coronary artery disease: clinical evidence and genetic and metabolic background. Arch Intern Med 1997, 157:2299-2308.
    • (1997) Arch Intern Med , vol.157 , pp. 2299-2308
    • Moghadasian, M.H.1    Mcmanus, B.M.2    Frohlich, J.J.3
  • 4
    • 0030929483 scopus 로고    scopus 로고
    • Hyperhomocysteinemia: Detection, risk assessment, and treatment
    • Dennis VW, Nurko S, Robinson K: Hyperhomocysteinemia: detection, risk assessment, and treatment. Curr Opin Nephrol Hypertens 1997, 6:483-488.
    • (1997) Curr Opin Nephrol Hypertens , vol.6 , pp. 483-488
    • Dennis, V.W.1    Nurko, S.2    Robinson, K.3
  • 5
    • 0030968144 scopus 로고    scopus 로고
    • The role of vitamins in the pathogenesis and treatment of hyperhomocyst(e)inaemia
    • Ubbink JB: The role of vitamins in the pathogenesis and treatment of hyperhomocyst(e)inaemia. J Inher Metabol Dis 1997, 20:316-325.
    • (1997) J Inher Metabol Dis , vol.20 , pp. 316-325
    • Ubbink, J.B.1
  • 6
    • 0030911174 scopus 로고    scopus 로고
    • Disorders of homocysteine metabolism
    • Fowler B: Disorders of homocysteine metabolism. J Inher Metabol Dis 1997, 20:270-285.
    • (1997) J Inher Metabol Dis , vol.20 , pp. 270-285
    • Fowler, B.1
  • 7
    • 0030762686 scopus 로고    scopus 로고
    • Hyperhomocysteinemia in end-stage renal disease: Prevalence, etiology, and potential relationship to arteriosclerotic outcomes
    • Bostom AG, Lathrop L: Hyperhomocysteinemia in end-stage renal disease: prevalence, etiology, and potential relationship to arteriosclerotic outcomes. Kidney Int 1997, 52:10-20.
    • (1997) Kidney Int , vol.52 , pp. 10-20
    • Bostom, A.G.1    Lathrop, L.2
  • 8
    • 0030888183 scopus 로고    scopus 로고
    • Homocyst(e)ine: An important risk factor for atherosclerotic vascular disease
    • Duell PB, Malinow MR: Homocyst(e)ine: an important risk factor for atherosclerotic vascular disease. Curr Opin Lipidol 1997, 8:28-34.
    • (1997) Curr Opin Lipidol , vol.8 , pp. 28-34
    • Duell, P.B.1    Malinow, M.R.2
  • 10
    • 0014545138 scopus 로고
    • Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis
    • McCully KS: Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol 1969, 56:111-128.
    • (1969) Am J Pathol , vol.56 , pp. 111-128
    • McCully, K.S.1
  • 13
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: Probable benefits of increasing folic acid intakes
    • Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG: A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA 1995, 274:1049-1057.
    • (1995) JAMA , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.A.2    Omenn, G.S.3    Motulsky, A.G.4
  • 14
    • 1842331509 scopus 로고    scopus 로고
    • Plasma homocysteine as a risk factor for vascular disease: The European Concerted Action Project
    • Graham IM, Daly LE, Refsum HM, Robinson K, Brattström LE, Ueland PM, et al.: Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project. JAMA 1997, 277:1775-1781.
    • (1997) JAMA , vol.277 , pp. 1775-1781
    • Graham, I.M.1    Daly, L.E.2    Refsum, H.M.3    Robinson, K.4    Brattström, L.E.5    Ueland, P.M.6
  • 15
    • 1842370239 scopus 로고    scopus 로고
    • Plasma homocysteine levels and mortality in patients with coronary artery disease
    • Nygård O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE: • Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997, 337:230-236. This prospective study of patients with angiographically confirmed coronary artery disease demonstrates that elevated plasma homocyst(e)ine concentration is a strong, graded risk factor for mortality.
    • (1997) N Engl J Med , vol.337 , pp. 230-236
    • Nygård, O.1    Nordrehaug, J.E.2    Refsum, H.3    Ueland, P.M.4    Farstad, M.5    Vollset, S.E.6
  • 17
    • 0027156287 scopus 로고
    • Elevated total plasma homocysteine, a risk factor for thrombosis: Relation to coagulation and fibrinolytic parameters
    • Bienvenu T, Ankri A, Chadefaux B, Montalescot G, Kamoun P: Elevated total plasma homocysteine, a risk factor for thrombosis: relation to coagulation and fibrinolytic parameters. Thromb Res 1993, 70:123-129.
    • (1993) Thromb Res , vol.70 , pp. 123-129
    • Bienvenu, T.1    Ankri, A.2    Chadefaux, B.3    Montalescot, G.4    Kamoun, P.5
  • 19
    • 0028853921 scopus 로고
    • Prevalence of moderate hyperhomocysteinemia in patients with early-onset venous and arterial occlusive disease
    • Fermo I, Vigano'D'Angelo S, Paroni R, Mazzola G, Calori G, D'Angelo A: Prevalence of moderate hyperhomocysteinemia in patients with early-onset venous and arterial occlusive disease. Ann Intern Med 1995, 123:747-753.
    • (1995) Ann Intern Med , vol.123 , pp. 747-753
    • Fermo, I.1    Vigano'D'angelo, S.2    Paroni, R.3    Mazzola, G.4    Calori, G.5    D'Angelo, A.6
  • 21
    • 0029116984 scopus 로고
    • Plasma homocysteine levels in patients with deep venous thrombosis
    • Amundsen T, Ueland PM, Waage A: Plasma homocysteine levels in patients with deep venous thrombosis. Arterioscler Thromfa Vasc Biol 1995, 15:1321-1323.
    • (1995) Arterioscler Thromfa Vasc Biol , vol.15 , pp. 1321-1323
    • Amundsen, T.1    Ueland, P.M.2    Waage, A.3
  • 24
    • 0030953866 scopus 로고    scopus 로고
    • Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism
    • Ridker PM, Hennekens CH, Selhub J, Miletich JP, Malinow MR, Stampfer • MJ: Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism. Circulation 1997, 95:1777-1782. In this large, prospective cohort analysis from the Physicians Health Study, apparently healthy men with hyperhomocysteinemia had increased risk of idiopathic venous thromboembolism. The risk of venous thromboembolism among men with coexistent hyperhomocysteinemia and the factor V Leiden mutation was far greater than the sum of the individual risks associated with either abnormality alone.
    • (1997) Circulation , vol.95 , pp. 1777-1782
    • Ridker, P.M.1    Hennekens, C.H.2    Selhub, J.3    Miletich, J.P.4    Malinow, M.R.5    Stampfer, M.J.6
  • 26
    • 0030971062 scopus 로고    scopus 로고
    • Homocysteine and thrombotic disease
    • D'Angelo A, Selhub J: Homocysteine and thrombotic disease. Blood 1997, 90:1-11.
    • (1997) Blood , vol.90 , pp. 1-11
    • D'Angelo, A.1    Selhub, J.2
  • 27
    • 2442544086 scopus 로고    scopus 로고
    • High plasma concentrations of activated protein C in patients with deep venous thrombosis and hyperhomocysteinemia
    • Cattaneo M, Martinelli I, Faioni E, Franchi F, Zighetti ML, Mannucci PM: High plasma concentrations of activated protein C in patients with deep venous thrombosis and hyperhomocysteinemia. Br J Haematol 1996, 93(suppl 2):8.
    • (1996) Br J Haematol , vol.93 , Issue.2 SUPPL. , pp. 8
    • Cattaneo, M.1    Martinelli, I.2    Faioni, E.3    Franchi, F.4    Zighetti, M.L.5    Mannucci, P.M.6
  • 28
    • 0026486960 scopus 로고
    • Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein(a) to fibrin: A potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism
    • Harpel PC, Chang VT, Borth W: Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein(a) to fibrin: a potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism. Proc Natl Acad Sci U S A 1992, 89:10193-10197.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 10193-10197
    • Harpel, P.C.1    Chang, V.T.2    Borth, W.3
  • 29
    • 0027288252 scopus 로고
    • Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor
    • Hajjar KA: Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor. J Clin Invest 1993, 91:2873-2879.
    • (1993) J Clin Invest , vol.91 , pp. 2873-2879
    • Hajjar, K.A.1
  • 30
    • 0027531427 scopus 로고
    • Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen
    • Stamler JS, Osborne JA, Jaraki O, Rabbani LE, Mullins M, Singel D, Loscalzo J: Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest 1993, 91:308-318.
    • (1993) J Clin Invest , vol.91 , pp. 308-318
    • Stamler, J.S.1    Osborne, J.A.2    Jaraki, O.3    Rabbani, L.E.4    Mullins, M.5    Singel, D.6    Loscalzo, J.7
  • 31
    • 0027247803 scopus 로고
    • Abnormally high thromboxane biosynthesis in homozygous homocystinuria: Evidence for platelet involvement and probucol-sensitive mechanism
    • Di Minno G, Davi G, Margaglione M, Cirillo F, Grandone E, Ciabattoni G, et al.: Abnormally high thromboxane biosynthesis in homozygous homocystinuria: evidence for platelet involvement and probucol-sensitive mechanism. J Clin Invest 1993, 92:1400-1406.
    • (1993) J Clin Invest , vol.92 , pp. 1400-1406
    • Di Minno, G.1    Davi, G.2    Margaglione, M.3    Cirillo, F.4    Grandone, E.5    Ciabattoni, G.6
  • 32
    • 0030728675 scopus 로고    scopus 로고
    • Acute methionine load-induced hyperhomocysteinemia enhances platelet aggregation thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats
    • Durand P, Lussiercacan S, Blache D: Acute methionine load-induced •• hyperhomocysteinemia enhances platelet aggregation thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats. FASEB J 1997, 11:1157-1168. In a rat model, acute methionine load-induced hyperhomocysteinemia was associated with increased platelet aggregation, increased tissue factor activity in peritoneal macrophages, and increased plasma concentration of lipid peroxidation products.
    • (1997) FASEB J , vol.11 , pp. 1157-1168
    • Durand, P.1    Lussiercacan, S.2    Blache, D.3
  • 33
    • 1842411860 scopus 로고    scopus 로고
    • Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase
    • Upchurch GR, Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keaney •• JF, Loscalzo J: Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem 1997, 272:17012-17017. Treatment of bovine aortic endothelial cells with homocysteine resulted in decreased nitric oxide production and decreased glutathione peroxidase activity. These findings suggest that homocysteine may promote oxidative inactivation of nitric oxide by impairing the endothelial cell's ability to detoxify hydrogen peroxide.
    • (1997) J Biol Chem , vol.272 , pp. 17012-17017
    • Upchurch, G.R.1    Welch, G.N.2    Fabian, A.J.3    Freedman, J.E.4    Johnson, J.L.5    Keaney, J.F.6    Loscalzo, J.7
  • 34
    • 0030015522 scopus 로고    scopus 로고
    • Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia
    • Lentz SR, Sobey CG, Piegors DJ, Bhopatkar MY, Faraci FM, Malinow MR, •• Heistad DD: Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia. J Clin Invest 1996, 98:24-29. The first study to demonstrate that moderate hyperhomocysteinemia is associated with impaired endothelium-dependent vasodilatation.
    • (1996) J Clin Invest , vol.98 , pp. 24-29
    • Lentz, S.R.1    Sobey, C.G.2    Piegors, D.J.3    Bhopatkar, M.Y.4    Faraci, F.M.5    Malinow, M.R.6    Heistad, D.D.7
  • 35
    • 0031040293 scopus 로고    scopus 로고
    • Activated protein C resistance due to a common factor V gene mutation is a major risk factor for venous thrombosis
    • Zöller B, Hillarp A, Berntorp E, Dahlbäck B: Activated protein C resistance due to a common factor V gene mutation is a major risk factor for venous thrombosis. Annu Rev Med 1997, 48:45-58.
    • (1997) Annu Rev Med , vol.48 , pp. 45-58
    • Zöller, B.1    Hillarp, A.2    Berntorp, E.3    Dahlbäck, B.4
  • 36
    • 0027255291 scopus 로고
    • Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not in their heterozygous parents
    • Celermajer DS, Sorensen K, Ryalls M, Robinson J, Thomas O, Leonard JV, Deanfield JE: Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not in their heterozygous parents. J Am Coll Cardiol 1993, 22:854-858.
    • (1993) J Am Coll Cardiol , vol.22 , pp. 854-858
    • Celermajer, D.S.1    Sorensen, K.2    Ryalls, M.3    Robinson, J.4    Thomas, O.5    Leonard, J.V.6    Deanfield, J.E.7
  • 37
    • 0031018333 scopus 로고    scopus 로고
    • Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans
    • Tawakol A, Omland P, Gerhard M, Wu JT, Creager MA: •• Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation 1997, 95:1119-1121. Impaired endothelium-dependent vasodilatation was demonstrated in humans with chronic moderate hyperhomocysteinemia.
    • (1997) Circulation , vol.95 , pp. 1119-1121
    • Tawakol, A.1    Omland, P.2    Gerhard, M.3    Wu, J.T.4    Creager, M.A.5
  • 38
    • 0030876147 scopus 로고    scopus 로고
    • Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans
    • Woo KS, Chook P, Lolin YI, Cheung ASP, Chan LT, Sun YY, et al.: • Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans. Circulation 1997, 96:2542-2544. Another recent study demonstrating that moderate hyperhomocysteinemia is associated with impaired endothelium-dependent vasodilatation in humans.
    • (1997) Circulation , vol.96 , pp. 2542-2544
    • Woo, K.S.1    Chook, P.2    Lolin, Y.I.3    Cheung, A.S.P.4    Chan, L.T.5    Sun, Y.Y.6
  • 39
    • 0030917545 scopus 로고    scopus 로고
    • Putative mechanisms for vascular damage by homocysteine
    • Bellamy MF, Mcdowell IFW: Putative mechanisms for vascular damage by homocysteine. J Inher Metabol Dis 1997, 20:307-315.
    • (1997) J Inher Metabol Dis , vol.20 , pp. 307-315
    • Bellamy, M.F.1    Mcdowell, I.F.W.2
  • 40
    • 7844248116 scopus 로고    scopus 로고
    • Experimental induction of moderate hyperhomocyst(e)inemia rapidly produces endothelial dysfunction in healthy humans
    • Kanani P, Sinkey CA, Knapp HR, Haynes WG: Experimental induction of moderate hyperhomocyst(e)inemia rapidly produces endothelial dysfunction in healthy humans [abstract]. Circulation 1997, 96:I-420.
    • (1997) Circulation , vol.96
    • Kanani, P.1    Sinkey, C.A.2    Knapp, H.R.3    Haynes, W.G.4
  • 44
    • 0030783147 scopus 로고    scopus 로고
    • Homocysteine as a modulator of platelet-derived growth factor action in vascular smooth muscle cells: A possible role for hydrogen peroxide
    • Nishio E, Watanabe Y: Homocysteine as a modulator of platelet-derived • growth factor action in vascular smooth muscle cells: a possible role for hydrogen peroxide. Br J Pharmacol 1997, 122:269-274. Experiments with cultured rat vascular smooth muscle cells demonstrated that homocysteine promotes cell proliferation and decreases glutathione peroxidase activity. This study suggests that homocysteine may stimulate growth of vascular smooth muscle through oxidative mechanisms.
    • (1997) Br J Pharmacol , vol.122 , pp. 269-274
    • Nishio, E.1    Watanabe, Y.2
  • 45
    • 0030789201 scopus 로고    scopus 로고
    • Homocysteine signal cascade: Production of phospholipids, activation of protein kinase C, and the induction of c-fos and c-myb in smooth muscle cells
    • Dalton ML, Gadson PF, Wrenn RW, Rosenquist TH: Homocysteine signal •• cascade: production of phospholipids, activation of protein kinase C, and the induction of c-fos and c-myb in smooth muscle cells. FASEB J 1997, 11:703-711. Experiments with cultured smooth muscle cells suggest that homocysteine promotes cell proliferation through activation of a receptor-mediated signal transduction pathway.
    • (1997) FASEB J , vol.11 , pp. 703-711
    • Dalton, M.L.1    Gadson, P.F.2    Wrenn, R.W.3    Rosenquist, T.H.4
  • 47
    • 17344368557 scopus 로고    scopus 로고
    • Homocysteine as a risk factor for vascular disease: Enhanced collagen production and accumulation by smooth muscle cells
    • Majors A, Ehrhart LA, Pezacka EH: Homocysteine as a risk factor for • vascular disease: enhanced collagen production and accumulation by smooth muscle cells. Arterioscler Thromb Vasc Biol 1997, 17:2074-2081. This study found that homocysteine increased cell growth and collagen production in cultured rabbit aortic smooth muscle cells.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 2074-2081
    • Majors, A.1    Ehrhart, L.A.2    Pezacka, E.H.3
  • 48
    • 0031965641 scopus 로고    scopus 로고
    • Homocysteine-induced nitric oxide production in vascular smooth-muscle cells by NF-kB-dependent transcriptional activation of Nos2
    • Welch GN, Upchurch GR Jr, Farivar RS, Pigazzi A, Vu K, Brecher P, et al.: • Homocysteine-induced nitric oxide production in vascular smooth-muscle cells by NF-kB-dependent transcriptional activation of Nos2. Proc Assoc Am Physicians 1998, 1:22-31. Homocysteine produced increased expression of the inducible nitric oxide synthase gene in cultured rat aortic smooth muscle cells. This suggests that hyperhomocysteinemia may induce or potentiate inflammatory responses in the vessel wall.
    • (1998) Proc Assoc Am Physicians , vol.1 , pp. 22-31
    • Welch, G.N.1    Upchurch Jr., G.R.2    Farivar, R.S.3    Pigazzi, A.4    Vu, K.5    Brecher, P.6
  • 49
    • 0030604041 scopus 로고    scopus 로고
    • Involvement of N-methyl-D-aspartate receptor and free radical in homocysteine-mediated toxicity on rat cerebellar granule cells in culture
    • Kim W, Pae YS: Involvement of N-methyl-D-aspartate receptor and free radical in homocysteine-mediated toxicity on rat cerebellar granule cells in culture. Neurosci Lett 1996, 216:117-120.
    • (1996) Neurosci Lett , vol.216 , pp. 117-120
    • Kim, W.1    Pae, Y.S.2
  • 50
    • 0030915272 scopus 로고    scopus 로고
    • Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor
    • Lipton SA, Kim WK, Choi YB, Kumar S, D'Emilia DM, Rayudu PV, et al.: •• Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proc Natl Acad Sci U S A 1997, 94:5923-5928. An important study demonstrating that homocysteine is an agonist for the N-methyl-D-aspartate (NMDA) receptor. This property of homocysteine may contribute to neurotoxicity associated with stroke, and also may mediate some of the effects of homocysteine on vascular cells
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 5923-5928
    • Lipton, S.A.1    Kim, W.K.2    Choi, Y.B.3    Kumar, S.4    D'Emilia, D.M.5    Rayudu, P.V.6
  • 51
    • 0030610779 scopus 로고    scopus 로고
    • Homocysteine and vascular dysfunction
    • Lentz SR: Homocysteine and vascular dysfunction. Life Sci 1997, 61:1205-1215.
    • (1997) Life Sci , vol.61 , pp. 1205-1215
    • Lentz, S.R.1
  • 52
    • 0030188563 scopus 로고    scopus 로고
    • The oxidant stress of hyperhomocyst(e)inemia
    • Loscalzo J: The oxidant stress of hyperhomocyst(e)inemia. J Clin Invest 1996, 98:5-7.
    • (1996) J Clin Invest , vol.98 , pp. 5-7
    • Loscalzo, J.1
  • 53
    • 0027103736 scopus 로고
    • Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity: A potential rapid mechanism for modulation of coagulation
    • Glaser CB, Morser J, Clarke JH, Blasko E, McLean K, Kuhn I, et al.: Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity: a potential rapid mechanism for modulation of coagulation. J Clin Invest 1992, 90:2565-2573.
    • (1992) J Clin Invest , vol.90 , pp. 2565-2573
    • Glaser, C.B.1    Morser, J.2    Clarke, J.H.3    Blasko, E.4    McLean, K.5    Kuhn, I.6
  • 54
    • 0022552919 scopus 로고
    • Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine
    • Starkebaum G, Harlan JM: Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine. J Clin Invest 1986, 77:1370-1376.
    • (1986) J Clin Invest , vol.77 , pp. 1370-1376
    • Starkebaum, G.1    Harlan, J.M.2
  • 55
    • 0023094333 scopus 로고
    • Oxidation of low density lipoprotein by thiol compounds leads to its recognition by the acetyl LDL receptor
    • Parthasarathy S: Oxidation of low density lipoprotein by thiol compounds leads to its recognition by the acetyl LDL receptor. Biochim Biophys Acta 1987, 917:337-340.
    • (1987) Biochim Biophys Acta , vol.917 , pp. 337-340
    • Parthasarathy, S.1
  • 56
    • 0023664723 scopus 로고
    • The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells
    • Heinecke JW, Rosen H, Suzuki LA, Chait A: The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells. J Biol Chem 1987, 262:10098-10103.
    • (1987) J Biol Chem , vol.262 , pp. 10098-10103
    • Heinecke, J.W.1    Rosen, H.2    Suzuki, L.A.3    Chait, A.4
  • 57
    • 0028329986 scopus 로고
    • Lipid peroxidation and homocysteine induced toxicity
    • Jones BG, Rose FA, Tudball N: Lipid peroxidation and homocysteine induced toxicity. Atherosclerosis 1994, 105:165-170.
    • (1994) Atherosclerosis , vol.105 , pp. 165-170
    • Jones, B.G.1    Rose, F.A.2    Tudball, N.3
  • 58
    • 0029891753 scopus 로고    scopus 로고
    • Effect of homocysteine on copper ion-catalyzed, azo compound-initiated, and mononuclear cell-mediated oxidative modification of low density lipoprotein
    • Halvorsen B, Brude I, Drevon CA, Nysom J, Ose L, Christiansen EN, Nenseter MS: Effect of homocysteine on copper ion-catalyzed, azo compound-initiated, and mononuclear cell-mediated oxidative modification of low density lipoprotein. J Lipid Res 1996, 37:1591-1600.
    • (1996) J Lipid Res , vol.37 , pp. 1591-1600
    • Halvorsen, B.1    Brude, I.2    Drevon, C.A.3    Nysom, J.4    Ose, L.5    Christiansen, E.N.6    Nenseter, M.S.7
  • 60
    • 0027468536 scopus 로고
    • Circulating lipid hydroperoxide levels in human hyperhomocysteinemia: Relevance to development of arteriosclerosis
    • Dudman NPB, Wilcken DEL, Stocker R: Circulating lipid hydroperoxide levels in human hyperhomocysteinemia: relevance to development of arteriosclerosis. Arterioscler Thromb 1993, 13:512-516.
    • (1993) Arterioscler Thromb , vol.13 , pp. 512-516
    • Dudman, N.P.B.1    Wilcken, D.E.L.2    Stocker, R.3
  • 61
  • 62
    • 0030763280 scopus 로고    scopus 로고
    • Hyperhomocysteinemia following oral methionine load is associated with increased lipid peroxidation
    • Domagala TB, Libura M, Szczeklik A: Hyperhomocysteinemia following oral • methionine load is associated with increased lipid peroxidation. Thromb Res 1997, 87:411-416. This study found that methionine load-induced hyperhomocysteinemia was associated with increased lipid peroxidation in human volunteers.
    • (1997) Thromb Res , vol.87 , pp. 411-416
    • Domagala, T.B.1    Libura, M.2    Szczeklik, A.3
  • 63
    • 0029928653 scopus 로고    scopus 로고
    • Pro-thrombotic effects of a folic acid deficient diet in rat platelets and macrophages related to elevated homocysteine and decreased n-3 polyunsaturated fatty acids
    • Durand P, Prost M, Blache D: Pro-thrombotic effects of a folic acid deficient diet in rat platelets and macrophages related to elevated homocysteine and decreased n-3 polyunsaturated fatty acids. Atherosclerosis 1996, 121:231-243.
    • (1996) Atherosclerosis , vol.121 , pp. 231-243
    • Durand, P.1    Prost, M.2    Blache, D.3
  • 64
    • 0031055681 scopus 로고    scopus 로고
    • Lipid peroxidation induced in vivo by hyperhomocysteinaemia in pigs
    • Young PB, Kennedy S, Molloy AM, Scott JM, Weir DG, Kennedy DG: Lipid • peroxidation induced in vivo by hyperhomocysteinaemia in pigs. Atherosclerosis 1997, 129:67-71. Elevated levels of lipid peroxidation products are demonstrated in cardiac tissue in a pig model of severe hyperhomocysteinemia.
    • (1997) Atherosclerosis , vol.129 , pp. 67-71
    • Young, P.B.1    Kennedy, S.2    Molloy, A.M.3    Scott, J.M.4    Weir, D.G.5    Kennedy, D.G.6
  • 65
    • 0023032002 scopus 로고
    • Methionine metabolism in mammals: Adaptation to methionine excess
    • Finkelstein JD, Martin JJ: Methionine metabolism in mammals: adaptation to methionine excess. J Biol Chem 1986, 261:1582-1587.
    • (1986) J Biol Chem , vol.261 , pp. 1582-1587
    • Finkelstein, J.D.1    Martin, J.J.2
  • 66
    • 0026533906 scopus 로고
    • The pathogenesis of homocysteinemia: Interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine
    • Selhub J, Miller JW: The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine. Am J Clin Nutr 1992, 55:131-138.
    • (1992) Am J Clin Nutr , vol.55 , pp. 131-138
    • Selhub, J.1    Miller, J.W.2
  • 67
    • 0030610589 scopus 로고    scopus 로고
    • Inhibition of growth and p21(ras) methylation in vascular endothelial cells by homocysteine but not cysteine
    • Wang H, Yoshizumi M, Lai KH, Tsai JC, Perrella MA, Haber E, Lee ME: •• Inhibition of growth and p21(ras) methylation in vascular endothelial cells by homocysteine but not cysteine. J Biol Chem 1997, 272:25380-25385. This interesting study found that homocysteine, but not cysteine, inhibited DNA synthesis and decreased methylation of the guanine nucleotide binding protein Ras in cultured endothelial cells.
    • (1997) J Biol Chem , vol.272 , pp. 25380-25385
    • Wang, H.1    Yoshizumi, M.2    Lai, K.H.3    Tsai, J.C.4    Perrella, M.A.5    Haber, E.6    Lee, M.E.7
  • 71
    • 0022472013 scopus 로고
    • Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator
    • Rodgers GM, Kane WH: Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator. J Clin Invest 1986, 77:1909-1916.
    • (1986) J Clin Invest , vol.77 , pp. 1909-1916
    • Rodgers, G.M.1    Kane, W.H.2
  • 72
    • 0025190042 scopus 로고
    • Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells
    • Rodgers GM, Conn MT: Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells. Blood 1990, 75:895-901.
    • (1990) Blood , vol.75 , pp. 895-901
    • Rodgers, G.M.1    Conn, M.T.2
  • 73
    • 0026345948 scopus 로고
    • Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine
    • Lentz SR, Sadler JE: Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. J Clin Invest 1991, 88:1906-1914.
    • (1991) J Clin Invest , vol.88 , pp. 1906-1914
    • Lentz, S.R.1    Sadler, J.E.2
  • 74
    • 0026773724 scopus 로고
    • An atherogenic stimulus homocysteine inhibits cofactor activity of thrombomodulin and enhances thrombomodulin expression in human umbilical vein endothelial cells
    • Hayashi T, Honda G, Suzuki K: An atherogenic stimulus homocysteine inhibits cofactor activity of thrombomodulin and enhances thrombomodulin expression in human umbilical vein endothelial cells. Blood 1992, 79:2930-2936.
    • (1992) Blood , vol.79 , pp. 2930-2936
    • Hayashi, T.1    Honda, G.2    Suzuki, K.3
  • 75
    • 0027472128 scopus 로고
    • Homocysteine inhibits von Willebrand factor processing and secretion by preventing transport from the endoplasmic reticulum
    • Lentz SR, Sadler JE: Homocysteine inhibits von Willebrand factor processing and secretion by preventing transport from the endoplasmic reticulum. Blood 1993, 81:683-689.
    • (1993) Blood , vol.81 , pp. 683-689
    • Lentz, S.R.1    Sadler, J.E.2
  • 76
    • 0027250615 scopus 로고
    • Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells
    • Fryer RH, Wilson BD, Gubler DB, Fitzgerald LA, Rodgers GM: Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells. Arterioscler Thromb 1993, 13:1327-1333.
    • (1993) Arterioscler Thromb , vol.13 , pp. 1327-1333
    • Fryer, R.H.1    Wilson, B.D.2    Gubler, D.B.3    Fitzgerald, L.A.4    Rodgers, G.M.5
  • 77
    • 0027319970 scopus 로고
    • Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells
    • Nishinaga M, Ozawa T, Shimada K: Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells. J Clin Invest 1993, 92:1381-1386.
    • (1993) J Clin Invest , vol.92 , pp. 1381-1386
    • Nishinaga, M.1    Ozawa, T.2    Shimada, K.3
  • 78
    • 0027755295 scopus 로고
    • Effects of homocysteine and related compounds on prostacyclin production by cultured human vascular endothelial cells
    • Wang J, Dudman NPB, Wilcken DEL: Effects of homocysteine and related compounds on prostacyclin production by cultured human vascular endothelial cells. Thromb Haemost 1993, 70:1047-1052.
    • (1993) Thromb Haemost , vol.70 , pp. 1047-1052
    • Wang, J.1    Dudman, N.P.B.2    Wilcken, D.E.L.3
  • 79
    • 0029860742 scopus 로고    scopus 로고
    • Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis: GRP78/BiP and novel genes
    • Kokame K, Kato H, Miyata T: Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis: GRP78/BiP and novel genes. J Biol Chem 1996, 271:29659-29665.
    • (1996) J Biol Chem , vol.271 , pp. 29659-29665
    • Kokame, K.1    Kato, H.2    Miyata, T.3


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