Fas mediates apoptosis and oxidant-induced cell death in cultured hRPE cells

Investigative Ophthalmology and Visual Science

Volumn 41, Issue 3, 2000, Pages 645-655

  Jiang, Shunai ^a   Wu, Mei Whey H ^a   Sternberg Jr , Paul ^a   Jones, Dean P ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; DNA; FAS ANTIGEN; OXIDIZING AGENT; TERT BUTYL HYDROPEROXIDE;

APOPTOSIS; ARTICLE; CELL KILLING; CHROMATIN CONDENSATION; DNA CLEAVAGE; HUMAN; MOLECULAR INTERACTION; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACETYLCYSTEINE; ANNEXIN A5; ANTIGENS, CD95; APOPTOSIS; BLOTTING, WESTERN; CELL DEATH; CELLS, CULTURED; FAS LIGAND PROTEIN; FLOW CYTOMETRY; FLUORESCEIN-5-ISOTHIOCYANATE; GLUTATHIONE; HUMANS; MEMBRANE GLYCOPROTEINS; MICROSCOPY, CONFOCAL; PIGMENT EPITHELIUM OF EYE; RECOMBINANT PROTEINS; TERT-BUTYLHYDROPEROXIDE; UP-REGULATION;

EID: 0034066522     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Young RW, Bok D, Participation of the retinal pigment epithelium in the rod outer segment renewal process. J Cell Biol. 1969;42: 392-403.
2. Young RW. Pathology of age-related macular degeneration. Surv Ophthalmol. 1987;31:291-306.
3. Cai J, Wu M, Nelson KC, Sternberg PJr, Jones DP. Oxidant-induced apoptosis in cultured human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1999;40:959-966.
4. McConkey DJ, Zhiotovsky B, Orrenius S. Apoptosis-molecular mechanism and biomedical implications. Mol Aspects Med. 1996; 17:1-110.
5. Osborne NN, Cazevieille C, Pergande G, Wood HP. Induction of apoptosis in cultured human retinal pigment epithelial cells is counteracted by flupirtine. Invest Ophthalmol Vis Sci. 1997;38: 1390-1400.
6. Buchi ER, Szczesny PJ. Necrosis and apoptosis in neuroretina and pigment epithelium after diffuse photodynamic action in rats: a light and electron microscopic study. Jpn J Ophthalmol. 1996;40: 1-11.
7. Harris MS, Sakamoto T, Kimura H, et al. Hypericin inhibits cell growth and induces apoptosis in retinal pigment epithelial cells: possible involvement of protein kinase C. Curr Eye Res. 1996;15: 255-262.
8. Hinton DR, He S, Lopez PF. Apoptosis in surgically excised choroidal neovascular membranes in age-related macular degeneration. Arch Ophthalmol. 1998;116:203-209.
9. Nagata S. Apoptosis by death receptor. Cell. 1997;88:355-365.
10. Chinnaiyan AM, Dixit VM. Portrait of an executioner: the molecular mechanism of Fas/APO-1-induced apoptosis. Semin Immunol. 1997;9:69-76.
11. Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TA. CD95-induced apoptosis as a mechanism of immune privilege. Science. 1995;270:1189-1192.
12. Stuart PM, Griffith TS, Usui N, Pepose J, Yu X, Ferguson TA. CD95 ligand (FasL)-induced apoptosis in necessary for corneal allograft survival. J Clin Invest. 1997;99:396-402.
13. Esser P, Heimann K, Abts H, Fontana A, Weller M. CD95 (Fas/ APO-1) antibody-mediated apoptosis of human retinal pigment epithelial cells. Biochem Biophys Res Commun. 1995;213:1026-1034.
14. Hug H, Strand S, Grambihler A, et al. Reactive oxygen intermediates are involved in the induction of CD95 ligand mRNA expression by cytostatic drugs in hepatoma cells. J Biol Chem. 1997;272: 28191-28193.
15. Bauer MKA, Vogt M, Los M, Siegel J, Wesselborg S, Schulze-Osthoff K. Role of reactive oxygen intermediates in activation-induced CD95 (Apo-1/Fas) ligand expression. J Biol Chem. 1998; 273:8048-8055.
16. Kasahara Y, Iwai K, Yachie A, et al. Involvement of reactive oxygen intermediates in spontaneous and CD95 (Fas/APO-1)-mediated apoptosis of neutrophils. Blood. 1997;89:1748-1753.
17. Kohno T, Yamada Y, Hata T, et al. Relation of oxidative stress and glutathione synthesis to CD95(Fas/APO-1)-mediated apoptosis of adult T cell leukemia. J Immunol. 1996;156:4722-4728.
18. Sternberg P Jr, Davidson PC, Jones DP, Hagen TM, Reed RL, Drews-Botsch C. Protection of retinal pigment epithelium from oxidative injury by glutathione and precursors. Invest Ophthalmol Vis Sci. 1993;34:3661-3668.
19. Panayiotids P, Ganeshaguru K, Foroni L, Hoffbrand AV. Expression and function of FAS antigen in B chronic lymphocytic leukemia and hairy cell leukemia. Leukemia. 1995;9:1227-1232.
20. Boshell M, McLeod J, Walker L, Hall N, Patel Y, Sansom D, Effects of antigen presentation on superantigen-induced apoptosis mediated by Fas/Fas ligand interactions in human T cells. Immunology. 1996;87:586-592.
21. Wong H, Anderson WD, Cheng T, Riabowol KT. Monitoring mRNA expression by polymerase chain reaction: the "primer-dropping" methods. Anal Biochem. 1994;223:251-258.
22. Raynal P, Pollard HB. Annexin: the problem of assessing the biological role for a gene family of multifunctional calcium and phospholipid-binding protein. Biochim Biophys Acta. 1994:1197:63-93.
23. Sata M, Walsh K. Oxidized LDL activates Fas-mediated endothelial cell apoptosis. J Clin Invest. 1998;102:1682-1689.
24. Nelson KC, Kurtz JC, Newman ML, et al. Effect of dimethylfumarate on glutathione in cultured human retinal pigment epithelial cells. 1999;40:1927-1935.
25. Tsang NCK, Penfold PL, Snitch PJ, Billson F. Serum levels of antioxidants and age-related macular degeneration. Doc Ophthalmol 1992;81:387-400.
26. Brunk UT, Wihlmarik U, Wrigstad A, Roberg K, Nilsson S-E. Accumulation of lipofuscin within retinal pigment epithelial cells results in enhanced sensitivity to phosphooxidation. Gerentology. 1995;41:201-212.
27. Samiec PS, Drews-Botsch C, Flagg EW, et al. Glutathione in human plasma: decline in association with aging, age-related macular degeneration, and diabetes. Free Radic Biol Med. 1998;24:699-704.
28. Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl-2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 1998;94:481-490.
29. Li H, Zhu H, Xu C-J, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 1998;94:491-501.
30. Weis M, Schlegel J, Kass GE, et al. Cellular events in Fas/APO-1-mediated apoptosis in JURKAT T lymphocytes. Exp Cell Res. 1995; 219:609-708.
31. Ugarte M, Osborne NN. The localization of endogenous zinc and the in vitro effect of exogenous zinc on the GABA immunoreactivity and formation of reactive oxygen species in the retina. Gen Pharmacol. 1998;30:297-303.
32. Perry DK, Smyth MJ, Stennicke HR, et al. Zinc is a potent inhibitor of the apoptotic protease, caspase-3: a novel target for zinc in the inhibition of apoptosis. J Biol Chem. 1997;272:18530-18533.
33. Cohen JJ, Duke RC. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J Immunol. 1984;132:38-42.
34. Cai J, Yang J, Jones DP. Mitochondrial control of apoptosts: the role of cytochrome c. Biochim Biophys Acta. 1998;1366:139-150.
35. Martinez-Lorenzo MJ, Alava MA, Anel A, Pineiro A, Naval J. Release of preformed Fas ligand in soluble form is the major factor for activation-induced death of Jurkat T cells. Immunology. 1996;89:511-517.
36. Brown SB, Savill J. Phagocytosis triggers macrophage release of Fas ligand and induces apoptosis of bystander leukocytes. J Immunol. 1999;162:480-485.
37. Hodge S, Novembre FJ, Whetter L, Gelbard HA, Dewhurst S. Induction of Fas ligand expression by an acutely lethal simian immunodeficiency virus, SIVsmmPBj 14. Virology. 1998;252:354-363.
38. Kayagaki N, Kawasaki A, Ebata T, et al. Metalloproteinase-mediated release of human Fas ligand. J Exp Med. 1995;182:1777-1783.
39. Liversidge J, Dawson R, Hoey S, McKay D, Grabowski P, Forrester JV. CD59 and CD48 expressed by rat retinal pigment epithelial cells are major ligands for the CD2-mediated alternative pathway of T cell activation. J Immunol. 1996;156:3696-3703
40. Sarks SH. Aging and degeneration in the macular region: a clinicopathological study. Br J Ophthalmol. 1976;60:324-341.
41. Hasegawa D, Kojima S, Tatsumi E, et al. Elevation of the serum Fas ligand in patients with hemophagocytic syndrome and Diamond-Blackfan anemia. Blood. 1998;91:2793-2799.
42. Tanaka M, Suda T, Haze K, et al. Fas ligand in human serum. Nat Med. 1996;2:317-322.
43. Shiota G, Oyama K, Noguchi N, Takano Y, Kitaoka S, Kawasaki H. Clinical significance of serum soluble Fas ligand in patients with acute self-limited and fulminant hepatitis. Res Commun Mol Patbol Pharmacot. 1998;101:3-12.
44. Jorgensen A, Wiencke AK, la Cour M, et al. Human retinal pigment epithelial cell-induced apoptosis in activated T cells. Invest Ophthalmol Vis Sci. 1998;39:1590-1599.