Effect of dietary inducer dimethylfumarate on glutathione in cultured human retinal pigment epithelial cells

Investigative Ophthalmology and Visual Science

Volumn 40, Issue 9, 1999, Pages 1927-1935

  Nelson, Kasey C ^a   Carlson, Joanne L ^a   Newman, Melanie L ^a   Sternberg Jr , Paul ^a   Jones, Dean P ^a   Kavanagh, Terrance J ^b   Diaz, Dolores ^b   Cai, Jiyang ^a   Wu, Mei ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; FUMARIC ACID; GLUTATHIONE; TERT BUTYL HYDROPEROXIDE; VISUAL PIGMENT;

ANTIOXIDANT ACTIVITY; ARTICLE; CATALYSIS; DETOXIFICATION; DIETARY INTAKE; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; MAMMAL CELL; NORTHERN BLOTTING; OXIDATIVE PHOSPHORYLATION; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA MACULA DEGENERATION; STEADY STATE; WESTERN BLOTTING;

AMINOACYLTRANSFERASES; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FUMARATES; GLUTATHIONE; HUMANS; OXIDATIVE STRESS; PIGMENT EPITHELIUM OF EYE; RNA, MESSENGER; TERT-BUTYLHYDROPEROXIDE;

EID: 0032857578     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. National Advisory Eye Council, Report of the Retinal and Choroidal Disease Panel. Vision Research - A National Plan: 1983-87. Bethesda, MD: US Dept of Health and Human Services, National Institutes of Health; 1984. Publication; 83-2471.
2. Klein R, Klein B, Linton KLP. Prevalence of age-related maculopathy: the Beaver Dam study. Ophthalmology. 1992;99: 933-943.
3. Snodderly DM. Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins. Am J Clin Nutr. 1995;62(Suppl):1448S-1461S.
4. Sternberg P Jr, Davidson PC, Jones DP, Hagen TM, Reed RL, Drews-Botsch C. Protection of retinal pigment epithelium from oxidative injury by glutathione and precursors. Invest Ophthalmol Vis Sci. 1993;34:3661-3668.
5. Flagg EW, Coates RJ, Eley JW, et al. Dietary glutathione intake in humans and the relationship between intake and plasma total glutathione level. Nutr Cancer. 1994;21:33-46.
6. Prochaska HJ, Fernandes CL. Elevation of serum phase II enzymes by anticarcinogenic enzyme inducers: markers for a chemoprotected state? Carcinogenesis. 1993;14:2441-2445.
7. Spencer SR, Wilczak CA, Talalay P. Induction of glutathione transferases and NAD(P)H:quinone reductase by fumaric acid derivatives in rodent cells and tissues. Cancer Res. 1990;50:7871-7875.
8. Prochaska HJ, Rubinson L, Yeh Y, Baron P, Polsky B. Elevation of glutathione levels by phase II enzyme inducers: lack of inhibition of human immunodeficiency virus type 1 replication in chronically infected monocytoid cells. Mol Pharmacol. 1994;45:916-921.
9. Fitzhugh OG, Nelson AA. The comparative chronic toxicities of fumaric, tartaric, oxalic and maleic acids. J Am Pharm Assoc Sci Ed. 1947;36:217-219.
10. Levey S., Lasichak AG, Brimi R, et al. A study to determine the toxicity of fumaric acid. J Am Pharm Assoc Sci Ed. 1946;35:298-304.
11. Locke A, Locke RB, Schlesinger H, Carr H. The comparative toxicity and cathartic efficiency of disodium tartrate and fumarate and magnesium fumarate for the mouse and rabbit. J Am Pharm Assoc Sci Ed. 1942;31:12-14.
12. Altmeyer PJ, Matthes U, Pawlak F, et al. Antipsoriatic effect of fumaric acid derivatives: results of a multicenter double-blind study in 100 patients. J Am Acad Dermatol. 1994;30:977-981.
13. Nieboer C, de Hoop D, van Loenen AC, Langendijk PNJ, van Dijk E. Systemic therapy with fumaric acid derivatives: new possibilities in treatment of psoriasis. J Am Acad Dermatol. 1989;20:601-608.
14. Nieboer C, de Hoop D, Langendijk PNJ, van Loenen AC, Gubbels J. Fumaric acid therapy in psoriasis: a double-blind comparison between fumaric acid compound therapy and monotherapy with dimethylfumaric acid ester. Dermatologica. 1990;181:33-37.
15. Flood MT, Gouras P, Kyeldbye H. Growth characteristics and ultrastructure of human retinal pigment epithelium in vitro. Invest Ophthalmol Vis Sci. 1980;19:1309.
16. Jones DP, Carlson JL, Samiec PS, et al. Glutathione measurement in human plasma: evaluation of sample collection, storage and derivatization conditions for analysis of dansyl derivatives by HPLC. Clin Chim Acta. 1998;275:175-184.
17. LeBel CP, Bondy, SC. Sensitive and rapid quantitation of oxygen reactive species formation in rat synaptosomes. Neurochem Int. 1990;17:435-440.
18. Fernandez-Checa JC, Kaplowitz N. The use of monochlorobimane to determine hepatic GSH levels and synthesis. Anal Biochem. 1990;190:212-219.
19. Cai J, Wu M, Nelson KC, Sternberg P Jr, Jones DP. Oxidant induced apoptosis in cultured human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1999;40:959-966.
20. Scanlon JM, Reynolds, IJ. Effects of oxidants and glutamate receptor activation on mitochondrial membrane potential in rat forebrain neurons. J Neurochem. 1998;71:2392-2400.
21. Hoyt KR, Gallagher AJ, Hastings TG, Reynolds IJ. Characterization of hydrogen peroxide toxicity in cultured rat forebrain neurons. Neurochem Res. 1997;22:333-340.
22. Talalay P. Mechanisms of induction of enzymes that protect against chemical carcinogenesis. Adv Enzyme Regul. 1989;28:237-250.
23. Talalay P, DeLong MJ, Prochaska HJ. Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis. Proc Natl Acad Sci USA. 1988; 85:8261-8265.
24. Cai J, Huang ZZ, Lu SC. Differential regulation of γ-glutamylcysteine synthetase heavy and light subunit gene expression. Biochem J. 1997;326:167-172.
25. Trian L, Shi MM, Forman HJ. Increased transcription of the regulatory subunit of γ-glutamylcysteine synthetase in rat lung epithelial L2 cells exposed to oxidative stress or glutathione depletion. Arch Biochem Biophys. 1997;342:126-133.
26. Sekhar KR, Long M, Long J, Xu ZQ, Summar ML, Freeman ML. Alteration of transcriptional and post-transcriptional expression of γ-glutamylcysteine synthetase by diethyl maleate. Radiat Res. 1997;147:592-597.
27. Yao K, Godwin AK, Johnson SW, Ozols RF, O'Dwyer PJ, Hamilton TC. Evidence for altered regulation of γ-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines. Cancer Res. 1995;55: 4367-4374.
28. Winkler BS, Giblin FJ. Glutathione oxidation in retina: effects on biochemical and electrical activities. Exp Eye Res. 1983;36:287-297.
29. Meister A. On the antioxidant effects of ascorbic acid and glutathione. Biochem Pharmacol. 1992;44:1905-1915.
30. Nicolas MG, Fujiki K, Murayama K, et al. Studies on the mechanisms of early onset macular degeneration in cynomolgus monkeys, II: suppression of metallothionein synthesis in the retina in oxidative stress. Exp Eye Res. 1996;62:399-408.
31. Ueda T, Ueda T, Armstrong D. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res. 1996;28:184-192.
32. Brunk UT, Wihlmark U, Wrigstad A, Roberg K, Nilsson S-E. Accumulation of lipofuscin within retinal pigment epithelial cells resuits in enhanced sensitivity to photo-oxidation. Gerontology: 1995;41:201-212.
33. Olin KL, Morse LS, Murphy C, et al. Trace element status and free radical defense in elderly Rhesus Macaques (Macaca mulatta) with macular drusen. Proc Soc Exp Biol Med. 1995;208:370-377.
34. Age-Related Eye Disease Study. Manual of Procedures. Bethesda, MD: National Eye Institute, 1992.
35. Landrum JT, Bone RA, Kilburn MD. The macular pigment: a possible role in protection from age-related macular degeneration. Adv Pharmacol. 1997;38:537-556.
36. Curcio CA, Medeiros NE, Millican CL. Photoreceptor loss in age-related macular degeneration. Invest Ophthalmol Vis Sci. 1996; 37:1236-1249.
37. del Priore LV, Kaplan HJ. Pathogenesis of AMD. Ophthalmology. 1995;102:1125.
38. Friedman E, Kuwabara T. The retinal pigment epithelium, IV: the damaging effects of radiant energy. Arch Ophthalmol. 1968;80: 265-279.
39. Noell WK, Walker VS, Kang BS, Berman S. Retinal damage by light in rats. Invest Ophthalmol. 1966;5:450-473.
40. Olsen TW, Sternberg P Jr, Reed R, Jones DP. A model for light toxicity of cultured human retinal pigment epithelium. Graefes Arch Clin Exp Ophthalmol. 1997;235:111-117.
41. Woo KI, Lee J. The effects of ascorbic acid on free radical injury in cultured retinal pigment epithelial cells. Korean J Ophthalmol. 1995;9:19-25.
42. Davidson PC, Sternberg P Jr, Jones DP, Reed RL. Synthesis and transport of glutathione by cultured human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1994;35:2843-2849.
43. Gupta E, Olopade OI, Ratain MJ, et al. Pharmacokinetics and pharmacodynamics of oltipraz as a chemopreventive agent. Clin Cancer Res. 1995;1:1133-1138.
44. Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C and E, and advanced age-related macular degeneration. JAMA. 1994;272:1413-1420.
45. Goldberg J, Flowerdew G, Smith E, Brody JA, Tso MOM. Factors associated with age-related macular degeneration: an analysis of data from the first national health and nutrition examination survey. Am J Epidemiol. 1988;128:700-710.