Expression of biologically active human insulin-like growth factor-I following intramuscular injection of a formulated plasmid in rats

Human Gene Therapy

Volumn 8, Issue 15, 1997, Pages 1785-1795

  Alila, Hector ^a  

^a GeneMedicine Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE; MESSENGER RNA; NERVE GROWTH FACTOR; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE THERAPY; IMMUNOREACTIVITY; MALE; MOTONEURON; NERVE REGENERATION; NONHUMAN; PLASMID; RAT;

ANIMALIA;

EID: 0030726175     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.15-1785     Document Type: Article

References (9)

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2. ACSADI, G., JIAO, S.S., JANI, A., DUKE, D., WILLIAMS, P., CHONG, W., and WOLFF, J.A. (1991). Direct gene transfer and expression into rat heart in vivo. New Biol. 3, 71-81.
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6. CARONI, P., and GRANDES, P. (1990). Nerve sprouting in innervated adult skeletal muscle induced by exposure to elevated levels of insulin-like growth factors. J. Cell Biol. 110, 1307-1317.
7. CARONI, P., and SCHNEIDER, C. (1994). Signaling by insulin-like growth factors in paralyzed skeletal muscle: rapid induction of IGF1 expression in muscle fibers and prevention of interstitial cell proliferation by IGF-BP5 and IGF-BP4. J. Neurosci. 14, 3378-3388.
8. COLEMAN, M.E., DEMAYO, F., YIN, K.C., LEE, H.M., GESKE, R., MONTGOMERY, C., and SCHWARTZ, R.J. (1995). Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice. J. Biol. Chem. 270, 12109-12116.
9. WOLFF, J.A., LUDTKE, J.J., ACSADI, G., WILLIAMS, P., and JANIA. (1992). Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle. Hum. Mol. Genet. 1, 363-369.