Combinatorial solid-phase synthesis of balanol analogues

Tetrahedron Letters

Volumn 37, Issue 46, 1996, Pages 8439-8442

  Nielsen, John ^a   Lyngsø, Lars O ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BALANOL; BALANOL DERIVATIVE; PROTEIN KINASE C INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS;

EID: 0030580364     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01913-2     Document Type: Article

References (18)

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18. 3, -3-F, respectively 6, 7, 7 and 7 balanol-structures were identified as distinct peaks in the LC-UV/MS analyses. The remaining five balanol analogues containing either one of the isomeric building blocks 1-amino-propan-2-ol or 3-amino-propan-1-ol were missing due to yet unclarified reasons (precipitation or co-elution in HPLC are likely possibilities). Further studies will be performed using non-isomeric structures to facilitate LC-MS identification, preferably in combination with a non-UV based HPLC detection system.