Pick's disease: Hyperphosphorylated tau protein segregates to the somatoaxonal compartment

Acta Neuropathologica

Volumn 92, Issue 6, 1996, Pages 588-596

  Probst, A ^a   Tolnay, M ^a   Langui, D ^a   Goedert, M ^b   Spillantini, M G ^b  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Axons; Pick's disease; Tau protein

Indexed keywords

ANTIBODY; SERINE; TAU PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; CASE REPORT; CONTROLLED STUDY; DENDRITE; DENTATE GYRUS; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; NERVE CELL; NEUROFIBRILLARY TANGLE; NEUROPIL; PICK PRESENILE DEMENTIA; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

AGED; AXONS; DEMENTIA; DENTATE GYRUS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; NEURAL PATHWAYS; NEURITES; PHOSPHORYLATION; TAU PROTEINS; TISSUE DISTRIBUTION;

EID: 0029850476     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050565     Document Type: Article

References (32)

1. Bancher C, Brunner C, Lassmann H, Budka H, Jellinger K, Wiche G, Seitelberger F, Grundke-Iqbal I, Iqbal K, Wisniewski HM (1989) Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease. Brain Res 477:90-99
2. Binder LI, Frankfurter A, Rebhun LI (1985) The distribution of tau in the mammalian central nervous system. J Cell Biol 101: 1371-1378
3. Braak E, Braak H (1994) A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol 87:554-567
4. Braak H, Braak E, Grundke-Iqbal I, Iqbal K (1986) Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neurosci Lett 65:351-355
5. Catala I, Ferrer I, Calofré E, Fabregues I (1988) Decreased numbers of dendritic spines on cortical pyramidal neurons in dementia. A quantitative Golgi study on biopsy samples. Human Neurobiol 6:255-259
6. Cochran EJ, Fox JH, Mufson EJ (1994) Severe panencephalic Pick's disease with Alzheimer's disease like neuropil threads and synaptophysin immunoreactivity. Acta Neuropathol 88: 479-484
7. Ferrer I, Guionnet N, Cruz-Sanchez F, Tunon T (1990) Neuronal alterations in patients with dementia: a Golgi study on biopsy samples. Neurosci Lett 114:11-16
8. Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA (1989) Multiple isoforms of human microtubule associated protein tau: sequences and location in neurofibrillary tangles of Alzheimer's disease. Neuron 2:519-526
9. Goedert M, Jakes R, Crowther RA, Cohen P, Vanmechelen E, Vandermeeren P, Cras P (1994) Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein. Biochem J 301:872-877
10. Goedert M, Jakes R, Vanmechelen E (1995) Monoclonal antibody AT8 recognizes tau protein phosphorylated at both serine 202 and threonine 205. Neurosci Lett 189:167-170
11. Goetz J, Probst A, Spillantini MG, Schäfer Th, Jakes R, Bürki K, Goedert M (1995) Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. EMBO J 14: 1304-1313
12. Greenberg SG, Davies P, Schein JD, Binder LI (1992) Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau. J Biol Chem 267:564-569
13. Hof PR, Bouras C, Perl P, Morrison JH (1994) Quantitative neuropathologic analysis of Pick's disease cases: cortical distribution of Pick bodies and coexistence with Alzheimer's disease. Acta Neuropathol 87:115-124
14. Iwatsubo T, Hasegawa M, Ihara Y (1994) Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics. Acta Neuropathol 88: 129-136
15. Kato S, Nakamura H (1990) Presence of two different fibril subtypes in Pick bodies: an immunoelectron microscopic study. Acta Neuropathol 81:125-129
16. Love S, Saitoh T, Quij S, Cole GM, Terry RD (1988) Alz 50, ubiquitin and tau immunoreactivity of neurofibrillary tangles, Pick bodies and Lewy bodies. J Neuropathol Exp Neurol 47: 393-405
17. Love S, Burrola P, Terry RD, Wiley CA (1989) Immunoelectron microscopy of Alzheimer and Pick brain tissue labelled with the monoclonal antibody Alz 50. Neuropathol Appl Neurobiol 15:223-231
18. Mercken M, Vandermeeren M, Lübke U, Six J, Boons J, Vaan de Voorde A, Martin JJ, Gheuens J (1992) Monoclonal antibodies with selective specificity for Alzheimer tau are directed against phosphatase-sensitive epitopes. Acta Neuropathol 84: 265-272
19. Munoz-Garcia D, Ludwin SK (1984) Classic and generalized variants of Pick's disease: a clinicopathological, ultrastructural and immunochemical comparative study. Ann Neurol 16:467-480
20. Murayama S, Mori H, Ihara Y, Tomonaga M (1990) Immunocytochemical and ultrastructural studies of Pick's disease. Ann Neurol 27:394-405
21. Nakamura Y, Takeda M, Yoshimi K, Hattori H, Hariguchi S, Hashimoto S, Nishimura T (1994) Involvement of clathrin light chains in the pathology of Pick's disease. Neurosci Lett 180: 25-28
22. Otvos L, Feiner L, Lang E, Szendrei G, Goedert M, Lee VM-Y (1994) Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404. J Neurosci Res 39:669-673
23. Perry G, Stewart D, Friedmann R, Manetto V, Autilio-Gambetti L, Gambetti P (1987) Filaments of Pick's body contain altered cytoskeletal elements. Am J Pathol 127:559-567
24. Probst A, Anderton B, Ulrich J, Kohler R, Kahan J, Heitz PU (1983) Pick's disease: An immunocytochemical study of neuronal changes. Monoclonal antibodies show that Pick bodies share antigenic determinants with neurofibrillary tangles and neurofilaments. Acta Neuropathol (Berl) 60:175-182
25. Seubert P, Mawal-Dewan M, Barbour R, Jakes R, Goedert M, Johnson GVW, Literski JM, Schenk D, Lieberburg I, Trojanowski JQ, Lee VM-Y (1995) Detection of phosphorylated Ser 262 in fetal tau, adult tau and paired helical filament-tau. J Biol Chem 270:18917-18922
26. Su JH, Cummings BJ, Cotman CW (1994) Early phosphorylation of tau in Alzheimer's disease occurs at Ser-202 and is perferentially within neurites. Neuro Report 5:2358-2362
27. Szendrei GI, Lee VM-Y, Otvos L (1993) Recognition of the minimal epitope of monoclonal antibody tau-1 depends on the presence of a phosphate group but not on its location. J Neurosci Res 34:243-249
28. Ulrich J, Haugh M, Anderton BH, Probst A, Lautenschlager C, His B (1987) Alzheimer dementia and Pick's disease: neurofibrillary tangles and Pick bodies are associated with identical phosphorylated neurofilament epitopes. Acta Neuropathol 73:240-246
29. Wechsler AF, Berity MA, Rosenschein S, Friede I, Scheibel AB (1982) Pick's disease. A clinical, computed tomographic and histological study with Golgi impregnation observations. Arch Neurology 39:287-290
30. Williams HW (1935) The peculiar cells of Pick's disease. Their pathogenesis and distribution in disease. Arch Neurol Psychiatry 34:508-519
31. Yamagushi H, Nakazato Y, Shoji M, Ihara Y, Hirai S (1990) Ultrastructure of the neuropil threads in the Alzheimer brain: their dendritic origin and the accumulation in the senile plaques. Acta Neuropathol 80:368-374
32. Yashuhara O, Matsuo A, Tooyama I, Kimura H, McGeer EG, McGeer PL (1994) Pick's disease immunohistochemistry: new alterations and Alzheimer's disease comparison. Acta Neuropathol 89:322-330