Abnormal early TCR/CD3-mediated signaling events of a snRNP- autoreactive lupus T cell clone

Clinical Immunology and Immunopathology

Volumn 88, Issue 3, 1998, Pages 305-310

  Liossis, Stamatis Nick C ^a   Hoffman, Robert W ^b   Tsokos, George C ^a,c  

^a Uniformed Services University of the Health Sciences   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

Antigen receptor; Autoantigen; Signal transduction; SnRNP; Systemic lupus erythematosus

Indexed keywords

AUTOANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MONOCLONAL ANTIBODY CD3; OKT 3; SMALL NUCLEAR RIBONUCLEOPROTEIN; T LYMPHOCYTE RECEPTOR;

ARTICLE; B LYMPHOCYTE; CALCIUM TRANSPORT; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOCYTE CLONE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

EID: 0032169879     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1998.4569     Document Type: Article

References (17)

1. Weiss A., Littman D. R. Signal transduction by lymphocyte antigen receptors. Cell. 76:1994;263-274.
2. DeFranco A. L. The complexity of signaling pathways activated by the BCR. Curr. Opin. Immunol. 9:1997;296-308.
3. Sloan-Lancaster J., Allen P. M. Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14:1996;1-27.
4. Tsokos G. C. Overview of cellular immune function in systemic lupus erythematosus. Systemic Lupus Erythematosus. 1998;Academic Press, New York. p. 17-54.
5. Vassilopoulos D., Kovacs B., Tsokos G. C. TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus. J. Immunol. 155:1995;2269-2281.
6. Liossis S. N., Kovacs B., Dennis G., Kammer G. M., Tsokos G. C. B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events. J. Clin. Invest. 98:1996;2549-2557.
7. Liossis S. N., Ding X. Z., Dennis G. J., Tsokos G. C. Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. J. Clin. Invest. 101:1998;1448-1457.
8. Pettersson I., Hinterberger M., Mimori T., Gottleib E., Steitz J. A. The structure of mammalian small nuclear ribonucleoproteins: Identification of multiple protein and anti-Sm autoantibodies. J. Biol. Chem. 259:1984;5907-5914.
9. Pettersson I., Wang G., Smith E. I., Wigzell H., Hedfors E., Horn J., Sharp G. C. The use of immunoblotting and immunoprecipitation of (U) small nuclear ribonucleoproteins in the analysis of sera of patients with mixed connective tissue disease and systemic lupus erythematosus: A cross-sectional, longitudinal study. Arthritis Rheum. 29:1986;986-996.
10. Holyst M. M., Hill D. L., Hoch S. O., Hoffman R. W. Analysis of human T cell and B cell responses against U small nuclear ribonucleoprotein 70-kd, B, and D polypeptides among patients with systemic lupus erythematosus and mixed connective tissue disease. Arthritis Rheum. 40:1997;1493-1503.
11. Hoffman R. W., Takeda Y., Sharp G. C., Lee D. R., Hill D. L., Kaneoka H., Caldwell C. W. Human T cell clones reactive against U-small nuclear ribonucleoprotein autoantigens from connective tissue disease patients and healthy individuals. J. Immunol. 151:1993;6460-6469.
12. June C. H., Fletcher M. C., Ledbetter J. A., Samelson L. E. Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation. J. Immunol. 144:1990;1591-1599.
13. Jensen W. A., Pleiman C. M., Beaufils P., Wegener A.-M. K., Malissen B., Cambier J. C. Qualitatively distinct signaling through T cell antigen receptor subunits. Eur. J. Immunol. 27:1997;707-716.
14. Kammer G. M., Khan I., Malemud C. Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes. J. Clin. Invest. 94:1994;422-430.
15. Inghirami G., Simon J., Balow J. E., Tsokos G. C. Activated T lymphocytes in the peripheral blood of patients with systemic lupus erythematosus induce B cells to produce immunoglobulin. Clin. Exp. Rheumatol. 6:1988;269-276.
16. Osborne M. A., Zenner G., Lubinus M., Zhang X., Songyang Z., Cantley L. C., Majerus P., Burn P., Kochan J. P. The inositol 5-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation. J. Biol. Chem. 271:1996;29271-29278.
17. Ono M., Bolland S., Tempst P., Ravetch J. V. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcγRIIB. Nature. 383:1996;263-266.