Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells

Clinical Cancer Research

Volumn 6, Issue 3, 2000, Pages 924-932

  Motwani, Monica ^a   Li, Xiao Kui ^a   Schwartz, Gary K ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN B1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR; FLAVOPIRIDOL; PACLITAXEL; PROTEIN P21; PROTEIN P53;

ARTICLE; CANCER CELL; CARCINOGENESIS; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DIVISION; CHEMOPROPHYLAXIS; GENE ACTIVATION; GENE ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; MITOSIS SPINDLE; POLYPLOIDY; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CDC2 PROTEIN KINASE; CDC2-CDC28 KINASES; CYCLIN B; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASES; DNA REPLICATION; ENZYME INHIBITORS; FLAVONOIDS; G1 PHASE; HUMANS; MICROTUBULES; NOCODAZOLE; PHOSPHORYLATION; PIPERIDINES; POLYPLOIDY; PROTEIN-SERINE-THREONINE KINASES; RETINOBLASTOMA PROTEIN; TUMOR CELLS, CULTURED;

EID: 0034019911     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Hartwell, L. Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cell. Cell, 71: 543-546, 1992.
2. Hartwell, L. H, and Kastan, M. B. Cell cycle control and cancer. Science (Washington DC), 266: 1821-1828, 1994.
3. Hartwell, L. H, and Weinert, T. A. Checkpoints: controls that ensure the order of cell cycle events. Science (Washington DC), 246: 629-634, 1989.
4. Gorbsky, G. J. Cell cycle checkpoints: arresting progress in mitosis. Bioessays, 19: 193-197, 1997.
5. Hoyt, M. A., Totis, L, and Roberts, B. T. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell, 66: 507-517, 1991.
6. Murray, A. W. Creative blocks: cell cycle checkpoints and feedback controls. Nature (Lond.), 359: 569-604, 1992.
7. Cross, S. M., Sanchez, C. A, Morgan, C. A., Schimke, M. K., Ramel, S., Idzerda, R. L., Raskind, W. H., and Reid, B. J. A p53-dependent mouse spindle checkpoint. Science (Washington DC), 267: 1353-1356, 1995.
8. 1 arrest. Cancer Res., 58: 396-401, 1998.
9. Lanni, J. S., and Jacks, T. Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol. Cell. Biol., 18: 1055-1064, 1998.
10. Minn, A. I., Boise, L. H., and Thompson, C. B. Expression of Bcl-xL and loss of p53 can cooperate a cell cycle checkpoint induced by mitotic spindle damage. Genes Dev., 10: 2621-2631, 1996.
11. Waf1/Cip1 inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption. Mol. Cell. Biol., 19: 204-215, 1999.
12. Gu, Y., Turck, C. W., and Morgan, D. O. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature (Lond.), 366: 707-710, 1993.
13. 1 cyclin-dependent kinases. Cell, 75: 805-816, 1993.
14. Chellappan, S. P., Hiebert, S., Mudryj, M., Horowitz, J. M., and Kevins, J. R. The E2F transcription factor is a cellular target for the RB protein. Cell, 65: 1053-1061, 1991.
15. Heibert, S. W., Chellappan, S., Horowitz, J. M., and Nevins, J. R. The interaction of RB with E2F coincides with inhibition of the transcriptional activity of E2F. Genes Dev., 6: 177-185, 1992.
16. Helin, K., Harlow, E., and Fattaey, A. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma gene. Mol. Cell Biol., 13: 6501-6508, 1993.
17. Serrano, M., Hannon, G. J., and Beach, D. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/Cdk4. Nature (Lond.), 366: 704-707, 1993.
18. Bischoff, F. Z., Yim, S. O., Pathak, S., Grant, S., Siciliano, M. J., Giovanella, B. C., Strong, L. C., and Tainsky, M. A. Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization. Cancer Res., 50: 7979-7984, 1990.
19. Shackney, S. E., Smith, C. A., Miller, B. W., Burholt, D. R., Murtha, K., Giles, H. R., Ketterer, D. M., and Pollice, A. A. Model for the genetic evolution of human solid tumors. Cancer Res., 49: 3344-3354, 1989.
20. Galipeau, P. C., Cowan, D. S., Sanchez, C. A., Barrett, M. T., Emond, M. J., Levine, D. J., Rabinovitch, P. S., and Reid, B. J. 17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus. Proc. Natl. Acad. Sci., 93: 7081-7084, 1996.
21. Levine, D. J., Sanchez, C. A., Rabinovitch, P. S., and Reid, B. J. Formation of tetraploid intermediate is associated with the development of cells with more than four centrioles in the elastase-simian virus 40 tumor antigen transgenic mouse model of pancreatic cancer. Proc. Natl. Acad. Sci. USA, 88: 6427-6431, 1991.
22. Ornitz, D. M., Hammer, R. E., Messing, A., Palmiter, R. D., and Brinster, R. L. Pancreatic neoplasia induced by SV40 T antigen expression in acinar cells of transgenic mice. Science (Washington DC), 238: 188-193, 1987.
23. Senderowicz, A. M., Headlee, D., Stinson, S. F., Lush, R. M., Kalil, K., Villalba, L., Hill, K., Steinberg, S. M., Figg, W. D., Tompkins, A., Arbuck, S. G., and Sausville, E. A. Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms. J. Clin. Oncol., 16: 2986-2999, 1998.
24. 1 arrest with inhibition of cyclin-dependent kinase CDK2 and CDK4 in human breast carcinoma cells. Cancer Res., 56: 2973-2978, 1996.
25. Losiewicz, M. D., Carlson, B. A., Kaur, G., Sauville, E. A., and Worland, P. J. Potent inhibition of cdc2 kinase activity by the flavonoid L86-8275. Biochem. Biophys. Res. Commun., 201: 589-595, 1994.
26. Kaur, G., Steuer-Stevenson, M., Sebers, S., Worland, P., Sedlacek, H., Myers, C., Czech, J., Naik, R., and Sausville, E. A. Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275. J. Natl. Cancer Inst., 84: 1736-1740, 1992.
27. Schwartz, G. K., Farsi, K., Maslak, P., Kelsen, D. P., and Spriggs, D. Potentiation of apoptosis by flavopiridol in mitomycin-C-treated gastric and breast cancer cells. Clin. Cancer Res., 3: 1467-1472, 1997.
28. Bible, K. C., and Kaufmann, S. H. Cytotoxic synergy between Flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: the importance of sequence of administration. Cancer Res., 57: 3375-3380, 1997.
29. Motwani, M., Delhorey, T. M., and Schwartz, G. K. Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel treated human gastric and breast cancer cells. Clin. Cancer Res., 5: 1876-1883, 1999.
30. Schwartz, G. K., Kaubisch, A., Saltz, L., Ilson, D., O'Reily, E., Barazzuol, J., Endres, S., Saltz, M., Tong, W., Spriggs, D., and Kelsen, D. P. Phase I trial of sequential paclitaxel and the cyclin dependent kinase inhibitor flavopiridol. Proc. Am. Soc. Clin. Oncol., 18: 614, 1999.
31. Vandre, D. D., and Borisy, G. G. Anaphase onset and dephosphorylation of mitotic phosphoproteins occur concomitantly. J. Cell Sci., 94: 245-258, 1989.
32. 1 phase of the human cell cycle. Science (Washington DC), 257: 1689-1694, 1992.
33. 1 phase progression: cycling on cue. Cell, 79: 551-555, 1994.
34. 1-S phase protein kinase. Science (Washington DC), 257: 1958-1961, 1992.
35. 1-to-S phase transition. Mol. Cell. Biol., 15: 2612-2624, 1995.
36. Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell, 81: 323-330, 1995.
37. Nurse, P. Universal control mechanism regulating onset of M-phase. Nature (Lond.), 344: 503-508, 1990.
38. Waldmann, T., Lengauer, C., Kinzler, K. W., and Vogelstein, B. uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p2L Nature (Lond.), 381: 713-716, 1996.
39. Carlson, B., Lahusen, T., Singh, S., Loaiza-Perez, A., M., Worland, P. J., Pestell, P. J., Albanese, C., Sausville, E. A., and Senderowicz, A. M. Down-regulation of cyclin D1 by transcriptional repression in Mcf-7 human breast carcinoma cells induced by flavopiridol. Cancer Res., 15: 4634-4641, 1999.
40. 2-M cell cycle control in human mammary epithelial cells. Cancer Res., 57: 3351-3355, 1997.
41. 2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol. Cell, 3: 389-395, 1999.