Expression, induction and regulation of the cytochrome P450 monooxygenase system in the rat glioma C6 cell line

Brain Research

Volumn 784, Issue 1-2, 1998, Pages 276-283

  Geng, Jun ^a   Strobel, Henry W ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZ[A]ANTHRACENE; CYTOCHROME P450; MESSENGER RNA; PHENOBARBITAL; POLYTHYMIDYLIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN TUMOR; CARCINOGENESIS; CONTROLLED STUDY; ENZYME INDUCTION; GLIOMA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; TUMOR CELL LINE;

ANIMALS; BLOTTING, NORTHERN; BRAIN NEOPLASMS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLIOMA; HALF-LIFE; ISOENZYMES; MALE; MICROSOMES; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; RNA, NEOPLASM; TUMOR CELLS, CULTURED;

EID: 0032536328     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01346-2     Document Type: Article

References (41)

1. R. Ahlgren, M. Warner, J.-A. Gustaffson, Cloning of a rat P450 26-hydroxylase cDNA, comparison of tissue distribution with rat P450scc, in: M. Ingelman-Sundberg, J.A. Gustaffson, S. Orrenius, (Eds.), Drug Metabolizing Enzymes: Genetics, Regulation and Toxicology, Karolinska Institute, Stockholm, 1990, 161 pp.
2. Bartsch H., Montesona R. Mutagenic and carcinogenic effects of vinyl chloride. Mutat. Res. 32:1975;92-113.
3. Bergh A.F., Strobel H.W. Reconstitution of the brain mixed function oxidase system: purification of NADPH-cytochrome P450 reductase and partial purification of cytochrome P450 from whole rat brain. J. Neurochem. 59(2):1992;575-581.
4. De Waziers I., Garlatti M., Bouguet J., Beaune P.H., Barouki R. Insulin downregulates cytochrome P450 2B and 2E expression at the post-transcriptional level in the rat hepatoma cell line. Mol. Pharmacol. 47(3):1995;474-479.
5. Decker C.J., Parker R. A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation. Genes and Dev. 7:1993;1632-1643.
6. Geng J., Strobel H.W. Identification of cytochromes P450 1A2, 2A1, 2C7, 2E1 in rat glioma C6 cell line by RT-PCR and specific restriction enzyme digestion. Biochem. Biophys. Res. Commun. 197(3):1993;1179-1184.
7. Geng J., Strobel H.W. Identification of inducible mixed function oxidase system in rat glioma C6 cell line. J. Neurochem. 65(2):1995;554-563.
8. Gonzalez F.J. Molecular genetics of the P-450 super family. Pharmacol. Ther. 45:1990;1-38.
9. Guengerich F.P., Mason P.S., Scott W.T., Fox T.R., Watanabe P.G. Role of 2-haloethylene oxides and 2-haloacetaldehydes derived from vinyl chloride and vinyl bromide in irreversible binding to protein and DNA. Cancer Res. 41:1981;4391-4398.
10. Guengerich F.P., Mason P.S. Immunological comparison of hepatic and extrahepatic cytochromes P-450. Mol. Pharmacol. 15(1):1979;154-164.
11. Kapitulnik J., Gelboin H.V., Guengerich F.P., Jacobowitz D.M. Immunohistochemical localization of cytochrome P450 in rat brain. Neuroscience. 20:1987;829-833.
12. R. Katakura, T. Yoshimoto, Epidemiology and statistical analysis of gliomas, in: J.S. (Ed.), Treatment of Glioma, Springer, Berlin, 1988, pp. 3-16.
13. Kohler C., Erikson L.G., Hansson T., Warner M., Gustafsson J.-A. Immunohistochemical localization of cytochrome P450 in the rat brain. Neurosci. Lett. 84:1988;109-144.
14. Le Goascogne C., Robel P., Gouezou M., Sananes N., Baulieu E.E., Waterman M. Neurosteroids: cytochrome P-450scc in rat brain. Science. 237(4819):1987;1212-1215.
15. Liao C.L., Eng L.F., Herman M.M., Bench K.G. Glial fibrillary acidic protein-solubility characteristics, relation to cell growth phase and cellular localization in rat C6 glioma cells: an immunoradiometric and immunohistologic study. J. Neurochem. 30:1978;1181-1186.
16. Lu A.Y., Junk K.W., Coon M.J. Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components. J. Biol. Chem. 244(13):1969;3714-3721.
17. McManus M.E., Burgess W.M., Veronese M.E., Huggett A., Quattrochi L.C., Tukey R.H. Metabolism of 2-acetylaminofluoere and benzo(a)pyrene and activation of food derived heterocyclic amine mutagens by human cytochrome P450. Cancer Res. 50:1991;3367-3376.
18. Naftolin F. Brain aromatization of androgens. J. Reprod. Med. 39(4):1994;257-261.
19. Naslund B.M., Glaumann H., Warner M., Gustafsson J.-A., Hansson T. Cytochrome P450 b and c in the rat brain and pituitary gland. Mol. Pharmacol. 33:1988;31-37.
20. Newaz S.N., Fang W.F., Strobel H.W. Metabolism of the carcinogen 1,2-dimethylhydrazine by isolated human colon microsomes and human colon tumor cells in culture. Cancer. 52(5):1983;794-798.
21. Perry R.P., Kelly D.E. Inhibition of RNA synthesis by actinomycin D: characteristic dose-response of different RNA species. J. Cell. Physiol. 76:1970;127-139.
22. Price T., Aitken J., Simpson E.R. Relative expression of aromatase cytochrome P450 in human fetal tissues as determined by competitive polymerase chain reaction amplification. J. Clin. Endocrinol. Metab. 74:1992;879-883.
23. Primus R.J., Jacobs A.A., Gallager D.W. Developmental profile of polyadenylated and non-polyadenylated GABAA receptor subunit mRNAs. Mol. Brain Res. 14:1992;179-185.
24. Ravindranath V., Anandatheerthavarada H.K., Shankar S.K. Xenobiotic metabolism in human brain-presence of cytochrome P-450 and associated mono-oxygenases. Brain Res. 496(1)(2):1989;331-335.
25. Rouet P., Alexandrov K., Markovits P., Frayssinet C., Dansette P.M. Metabolism of benzo[a]pyrene by brain microsomes of fetal and adult rats and mice. Induction by 5,6 benzoflavone, comparison with liver and lung microsomal activities. Carcinogenesis. 2(9):1981;919-926.
26. Sachs A.B. Messenger RNA degradation in eukaryotes. Cell. 74:1993;413-421.
27. Sachs A.B., Deardorff J.A. Translation initiation requires the PAB-dependent poly(A) ribonuclease in yeast. Cell. 70:1992;961-973.
28. Saito T., Strobel H.W. Purification to homogeneity and characterization of a form of cytochrome P-450 with high specificity for benzo[alpha]pyrene from beta-naphthoflavone-pretreated rat liver microsomes. J. Biol. Chem. 256(2):1981;984-988.
29. J. Sambrook, E.F. Fritsch, T. Maniatis, Molecular Cloning, 2nd edn., Cold Spring Harbor Lab. Press, 1989.
30. Shen S., Strobel H.W. Role of lysine and arginine residues of cytochrome P450 in the interaction between cytochrome P4502B1 and NADPH-cytochrome P450 reductase. Arch. Biochem. Biophys. 304(1):1993;257-265.
31. Snider B.J., Morrison-Bogorad M. Brain non-adenylated mRNAs. Brain Res. Rev. 17:1992;263-282.
32. Srivastava S.P., Seth P.K., Mukhtar H. 7-Ethoxycoumarin O-de-ethylase activity in rat brain microsomes. Biochem. Pharmacol. 32(23):1983;3657-3660.
33. Steward A.R., Wrighton S.A., Pasco D.S., Fagan J.B., Li D., Guzelian P.S. Synthesis and degradation of 3-methylcholanthrene inducible cytochromes P-450 and their mRNAs in primary monolayer cultures of adult rat hepatocytes. Arch. Biochem. Biophys. 241:1985;494-508.
34. Strobel H.W., Kawashima H., Geng J., Sequeira D., Bergh A., Hodgson A.V., Wang H., Shen S. Expression of multiple forms of brain cytochrome P450. Toxicol. Lett. 82 83:1995;639-643.
35. Tierney D.J., Haas A.L., Koop D.R. Degradation of cytochrome P450 2E1: selective loss after labialization of the enzyme. Arch. Biochem. Biophys. 293:1992;9-16.
36. Tyndale R.F., Sunahara R., Inaba T., Kalow W., Gonzalea F.J., Niznik H.B. Neuronal cytochrome P450 IID1 (Debrisoquine/Sparteine-type): potent inhibition of activity by (-)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP 2D6. Mol. Pharmacol. 40:1991;63-68.
37. Warner M., Kohler C., Hansson T., Gustafsson J.-A. Regional distribution of cytochrome P-450 in the rat brain: spectral quantitation and contribution of P-450 b, e, and P450 c, d. J. Neurochem. 50:1988;1057-1065.
38. Warner M., Gustafsson J.-A. Cytochrome P450 in the brain: neuroendocrine functions. Front. Neuroendocrinol. 16(3):1995;224-236.
39. Warner M., Tollet P., Stromstedt M., Carlstrom K., Gustafsson J.-A. Endocrine regulation of cytochrome P-450 in the rat brain and pituitary gland. J. Endocrinol. 122(1):1989;341-349.
40. Waxweiler R.J., Stringer W., Wagoner J.K., Jones J., Falk H., Carter C. Neoplastic risk among workers exposed to vinyl chloride. Ann. NY Acad. Sci. 159:1976;337-359.
41. White T.B., Hammond D.K., Vasquez H., Strobel H.W. Expression of two cytochromes P450 involved in carcinogen activation in a human colon cell line. Mol. Cell. Biochem. 102(1):1991;61-69.