Agonist peptide from a cytotoxic T-lymphocyte epitope of human carcinoembryonic antigen stimulates production of TC1-type cytokines and increases tyrosine phosphorylation more efficiently than cognate peptide

International Journal of Cancer

Volumn 85, Issue 6, 2000, Pages 829-838

  Salazar, Elena ^a   Zaremba, Sam ^a   Arlen, Philip M ^a   Tsang, Kwong Y ^a   Schlom, Jeffrey ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Lab of Tumor Immunology and Biology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA;

AMINO ACID SUBSTITUTION; ARTICLE; CANCER IMMUNOLOGY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DOSE RESPONSE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

CARCINOEMBRYONIC ANTIGEN; CELL LINE; CYTOKINES; CYTOTOXICITY TESTS, IMMUNOLOGIC; CYTOTOXICITY, IMMUNOLOGIC; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMMUNODOMINANT EPITOPES; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-4; OLIGOPEPTIDES; PEPTIDES; PHOSPHORYLATION; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, CYTOTOXIC; TYROSINE;

EID: 0034012202     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(20000315)85:6<829::AID-IJC16>3.0.CO;2-K     Document Type: Article

References (43)

1. + T cell lines from patients immunized with ras oncogene-derived peptides reflecting codon 12 mutations. Cell. Immunol., 182, 137-151 (1997).
2. ALTERS, S.E., GADEA, J.R., SORICH, M., O'DONOGHUE, G., TALIB, S. and PHILIP, R., Dendritic cells pulsed with CEA peptide induce CEA-specific CTL with restricted TCR repertoire. J. Immunother., 21, 17-26 (1998).
3. BOYUM, A., A one-stage procedure for isolation of granulocytes and lymphocytes from human blood; general sedimentation properties of white blood cells in a 1g gravity field. Scand. J. Clin. Lab. Invest. (Suppl.), 97, 51-76 (1968).
4. CHEN, Y., KUCHROO, V.K., INOBE, J., HAFLER, D.A. and WEINER, H.L., Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science, 265, 1237-1240 (1994).
5. CONRY, R.M., SALEH, M.N., SCHLOM, J. and LOBUGLIO, A.F., Human immune response to carcinoembryonic antigen tumor vaccines. J. Immunother., 18, 137 (1995).
6. CROWE, P.D., BOEHME, S.A, WONG, T., GAUR, A., SIDNEY, J., SETTE, A. and CONLON, P.J., Differential signaling and hierarchical response thresholds induced by an immunodominant peptide of myelin basic protein and an altered peptide ligand in human T cells. Hum. Immunol., 59, 679-689 (1998).
7. DE MAGISTRIS, M.T., ALEXANDER, J., COGGESHALL, M., ALTMAN, A., GAETA, F.C.A., GREY, H.M. and SETTE, A., Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell, 68, 625-634 (1992).
8. DRESSEL, A., CHIN, J.L., SETTE, A., GAUSLING, R., HOLLSBERG, P. and HÄFLER, D.A., Autoantigen recognition by human CD8 T cell clones. Enhanced agonist response induced by altered peptide ligands. J. Immunol., 159, 4943-4951 (1997).
9. EVAVOLD, B.D. and ALLEN, P.M. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science, 252, 1308-1310 (1991).
10. EVAVOLD, B.D., SLOAN-LANCASTER, J. and ALLEN, P.M., Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands. Immunol. Today, 14, 602-609 (1993).
11. FAGERBERG, J., SAMANI, A., YI, Q., STRIGARD, K., RYDEN, U., WAHREN, B. and MELLSTEDT, H., Recombinant carcinoembryonic antigen and granulocyte macrophage colony-stimulating factor for active immunization of colorectal carcinoma patients. J. Immunother., 19, 461 (1996).
12. FOON, K.A., CHAKRABORTY, M., JOHN, W.I., SHERRAFT, A., KOHLER, H. and BHATTACHARYA-CHATTERJEE, M., Immune response to the carcinoembryonic antigen in patients treated with an anti-idiotype antibody vaccine. J. clin. Invest., 96, 334-342 (1995).
13. GOLD, P. and FREEDMAN, S.O., Demonstration of tumor-specific antigens in human colonic carcinoma by immunological tolerance and absorption technique. J. exp. Med., 121, 439-462 (1965).
14. HEMMER, B., FLECKENSTEIN, B.T., VERGELLI, M., JUNG, G., MCFARLAND, H.F., MARTIN, R. and WEISMULLER, K.H., Identification of high-potency microbial and self ligands for a human autoreactive class II restricted T-cell clone. J. exp. Med., 185, 1651-1659 (1997).
15. HEMMER, B., STEFANOVA, I., VERGELLI, M., GERMAIN, R.N. and MARTIN, R., Relationships among TCR ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells. J. Immunol., 160, 5807-5814 (1998).
16. HOLLSBERG, P., WEBER, W.E.J., DANGOND, F., BATRA, V., SETTE, A. and HÄFLER, D.A., Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand. Proc. nat. Acad Sci. (Wash.), 92, 4036-4040 (1995).
17. KUCHROO, V.K., GREER, J.M., KAUL, D., ISHIOKA, G., FRANCO, A., SETTE, A., SOBEL, R.A. and LEES, M.B., A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire. J. Immunol., 153, 3326-3336 (1994).
18. KUCHROO, V.K., MARTIN, C.A., GREER, J.M., JU, S.T., SOBEL, R.A. and DORK, M.E., Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. J. Immunol., 151, 4371-4382 (1993).
19. 27-35. Cancer Res., 58, 2433-2439 (1998).
20. MADRENAS, J., WANGE, R.L., WANG, J.L., ISAKOV, N., SAMELSON, L.E. and GERMAIN, R.N., Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science, 267, 515-518 (1995).
21. MARSHALL, J.L., HAWKINS, M.J., TSANG, K.Y., RICHMOND, E., PEDICANO, J., ZHU, M.Z. and SCHLOM, J., A phase I study in cancer patients of a replication defective avipox (ALVAC) recombinant vaccine that expresses human carcinoembryonic antigen (CEA). J. clin. Oncol., 17, 332-337 (1999a).
22. MARSHALL, J.L., RICHMOND, E., PEDICANO, J.E., TSANG, A. and SCHLOM, J., Phase I/II trial of rV-CEA (V) and ALVAC-CEA (A) in patients with advanced CEA-bearing tumors. Proc. Amer. Soc. clin. Oncol., 18, 1690a (1999b).
23. MORSE, M.A., DENG, Y., COLEMAN, D., HULL, S., KITRELL-FISHER, E., NAIR, S., SCHLOM, J., RYBACK, M.-E. and LYERLY, H.K., A phase I study of active immunotherapy with carcinoembryonic antigen peptide (CAP-1)-pulsed, autologous human cultured dendritic cells in patients with metastatic malignancies expressing carcinoembryonic antigen. Clin. Cancer Res., 5, 1331-1338 (1999).
24. MURARO, R., WUNDERLICH, D., THOR, A., LUNDY, J., NOGUCHI, P., CUNNINGHAM, R. and SCHLOM, J., Definition by monoclonal antibodies of a repertoire of epitopes of carcinoembryonic antigen differentially expressed in human colon carcinoma versus normal adult tissues. Cancer Res., 45, 5769-5780 (1995).
25. NAIR, S.K., BOCZKOWSKI, D., MORSE, M., CUMMING, R.I., LYERLY, H.K. and GILBOA, E., Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA. Nature (Biotech.), 16, 364-369 (1998).
26. NICHOLSON, L.B., GREER, J.M., SOBEL, R.A., LEES, M.B. and KUCHROO, V.K., An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity, 3, 397-405 (1995).
27. NICHOLSON, L.B. and KUCHROO, V.K., Manipulation of the Th1/Th2 balance in autoimmune disease. Curr. Opinion Immunol., 8, 837-842 (1996).
28. NICHOLSON, L.B., MURTAZA, A., HAFLER, B.P., SETTE, A. and KUCHROO, V.K., A T-cell receptor antagonist peptide induces T cells that mediate bystander suppression prevent autoimmune encephalomyelitis induced with multiple myelin antigens. Proc. nat. Acad. Sci. (Wash.). 94, 9279-9284 (1997).
29. NICHOLSON, L.B., WALDNER, H., CARRIZOSA, A.M., SETTE, A., COLLINS, M. and KUCHROO, V.K., Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: implications for autoimmunity. Proc. nat. Acad Sci. (Wash.), 95, 264-269 (1998).
30. RABINOWITZ, J.D., BEESON, C., WULFING, C., TATE, K., ALLEN, P.M., DAVIS, M.M. and MCCONNELL, H.M., Altered T cell receptor ligands trigger a subset of early T cell signals. Immunity, 5, 125-135 (1996).
31. + T cells in response to antagonist ligands. J. exp. Med., 184, 149-157 (1996).
32. + T cells with enhanced functional characteristics: implications for more effective immunotherapy. Cancer Res., 59, 301-306 (1999).
33. ROSENBERG, S.A. and 14 OTHERS, Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nature (Med.), 4, 321-327 (1998).
34. SKIPPER, J.C.A., HENDRICKSON, R.C., GULDEN, P.H., BRICHARD, V., VAN PEI, A., CHEN, Y., SHABANOWITZ, J., WÖLFEL, T., SLINGLUFF, C.L., JR., BOON, T., HUNT, D.F. and ENGELHARD, V.H., An HLA-A2-restricted tyrosinase antigen on melanoma cells results from post-translational modification and suggests a novel pathway for processing of membrane proteins. J. exp. Med., 183, 527-534 (1996).
35. SLOAN-LANCASTER, J., EVAVOLD, B.D. and ALLEN, P.M., Induction of T cell anergy by altered T-cell receptor ligand on live antigen-presenting cells. Nature (Lond.), 363, 156-159 (1993).
36. SLOAN-LANCASTER, J., SHAW, A.S., ROTHBARD, J.B. and ALLEN, P.M., Partial T cell signaling: altered phospho-zeta and lack of ZAP-70 recruitment in APL-induced T cell anergy. Cell, 79, 913-922 (1994).
37. TSANG, K.Y., ZAREMBA, S., NIERODA, C.A., ZHU, M.Z., HAMILTON, J.M. and SCHLOM, J., Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA vaccine. J. nat. Cancer Inst., 87, 982-990 (1995).
38. TSANG, K.Y., ZHU, M., NIERODA, C., CORREALE, P., ZAREMBA, S., HAMILTON, J.M., COLE, D., LAM, C. and SCHLOM, J., Phenotypic stability of a cytotoxic T-cell line directed against an immunodominant epitope of human carcinoembryonic antigen. Clin. Cancer Res., 3, 2439-2449 (1997).
39. VERGELLI, M., HEMMEI, B., UTZ, U., VOGT, A., KALBUS, M., TRANQUIL, L., CONLON, P., LING, N., STEINMAN, L., MCFARLAND, H.F. and MARTIN, R., Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87-95). Europ. J. Immunol., 26, 2624-2634 (1996).
40. WANGE, R.L. and SAMELSON, L.E., Complex complexes: signaling at the TCR. Immunity, 5, 197-205 (1996).
41. WEISS, A. and LITTMAN, D.R., Signal transduction by lymphocyte antigen receptors. Cell, 76, 263-274 (1994).
42. WINDHAGEN, A., SCHOLZ, C., HOLLSBERG, P., FUKAURA, H., SETTE, A. and HÄFLEF, D.A., Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand. Immunity, 2, 373-380 (1995).
43. ZAREMBA, S., BARZAGA, E., ZHU, M., SOARES, N., TSANG, K.Y. and SCHLOM, J., Identification of an enhancer agonist cytotoxic T lymphocyte peptide from human carcinoembryonic antigen. Cancer Res., 57, 4570-4577 (1997).