Genetic pattern, histological structure, and cellular phenotype in early and advanced gastric cancers: Evidence for structure-related genetic subsets and for loss of glandular structure during progression of some tumors

Human Pathology

Volumn 29, Issue 7, 1998, Pages 702-709

  Luinetti, Ombretta ^b   Fiocca, Roberto ^b   Villani, Laura ^b   Alberizzi, Paola ^b   Ranzani, Guglielmina Nadia ^b   Solcia, Enrico ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b NONE

Author keywords

Gastric cancer; Histopathology; Microsatellite instability; p53 gene; Tumor cell phenotype

Indexed keywords

PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER CYTODIAGNOSIS; CANCER STAGING; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOPHENOTYPING; MAJOR CLINICAL STUDY; MICROSATELLITE INSTABILITY; STOMACH CARCINOMA; TUMOR SUPPRESSOR GENE;

EID: 0031856626     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(98)90279-9     Document Type: Article

References (32)

1. Lauren P: The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand 64:31-49, 1965
2. Correa P: Human gastric carcinogenesis: A multistep and multifactorial process. First American Cancer Society award lecture on cancer epidemiology and prevention. Cancer Res 52:6735-6740, 1992
3. Ranzani GN, Luinetti O, Padovan LS, et al: p53 gene mutations and protein nuclear accumulation are early events in intestinal type gastric cancer but late events in diffuse type. Cancer Epidemiol Biomarkers Prev 4:223-231, 1995
4. Solcia E, Fiocca R, Luinetti O, et al: Intestinal and diffuse gastric cancer arise in a different background of Helicobacter pylori gastritis through different gene involvement. Am J Surg Pathol 20:S8-S22, 1996 (suppl 1)
5. Duarte I, Llanos O: Patterns of metastases in intestinal and diffuse type of carcinoma of the stomach. HUM PATHOL 12:237-242, 1981
6. Ishii T, Ikegami N, HosodaY, et al: The biological behaviour of gastric cancer. J Pathol 134:97-115, 1981
7. Kodama Y, Inokuchi K, Soejima K, et al: Growth patterns and prognosis in early gastric carcinoma. Cancer 51:320-326, 1983
8. Kubo T: Histologic appearance of gastric carcinoma in high and low mortality countries: Comparison between Kyushu, Japan, and Minnesota, USA. Cancer 28:726-734, 1971
9. Fiocca R, Villani L, Tenti P, et al: Characterization of four main cell types in gastric cancer: Foveolar, mucopeptic, intestinal columnar and goblet cells: An histopathologic, histochemical and ultrastructural study of "early" and "advanced" tumors. Pathol Res Pract 182:308-325, 1987
10. Fiocca R, Villani L, Tenti P, et al: Widespread expression of intestinal markers in gastric carcinoma: A light and electron microscopic study using BD-5 monoclonal antibody. J Clin Pathol 41:178-187, 1988
11. Fiocca R, Villani L, Tenti P, et al: The foveolar cell component of gastric cancer. HUM PATHOL 21:260-270, 1990
12. Carneiro F, Seixas M, Sobrinho-Simoes M: New elements for an updated classification of the carcinomas of the stomach. Pathol Res Pract 191:571-584, 1995
13. Tatematsu M, Furihata C, Katsuyama T, et al: Gastric and intestinal phenotypic expressions of human signet ring cell carcinomas revealed by their biochemistry, mucin histochemistry, and ultrastructure. Cancer Res 46:4866-4872, 1986
14. Munoz N, Correa P, Cuello C, et al: Histologic types of gastric carcinoma in high-risk and low-risk areas. Int J Cancer 5:809-818, 1968
15. Uchino S, Noguchi M, Ochiai A, et al: p53 mutation in gastric cancer: A genetic model for carcinogenesis is common to gastric and colorectal cancer. IntJ Cancer 54:759-764, 1993
16. Dos Santos, Seruca R, Constancia M, et al: Microsatellite instability at multiple loci in gastric carcinoma: Clinicopathologic implications and prognosis. Gastroenterology 100:38-44, 1996
17. Strickler JG, Zheng J, Shu Q, et al: p53 mutations and microsatellite instability on sporadic gastric cancer: When guardians fail. Cancer Res 54:4750-4755, 1994
18. Renault B, Calistri D, Buonsanti G, et al: Microsatellite instability and mutations of p53 and TGF-B RII genes in gastric cancer. Hum Genet 98:601-607, 1996
19. Buonsanti G, Calistri D, Padovan L, et al: Microsatellite instability in intestinal- and diffuse-type gastric carcinoma. J Pathol 182:167-173, 1997
20. Sessa F, Bonato M, Frigerio B, et al: Ductal cancers of the pancreas frequently express markers of gastrointestinal epithelial cells. Gastroenterology 98:1655-1665, 1990
21. Watanabe H, Jass JR, Sobin LH: Histological Typing of Oesophageal and Gastric Tumours (ed 2). Berlin, Germany, Springer-Verlag, WHO International Histological Classification of Tumours, 1990
22. Renault B, van den Broek M, Fodde R, et al: Base transitions are the most frequent genetic changes at p53 in gastric cancer. Cancer Res 53:2614-2617, 1993
23. Seruca R, Santos RN, David L, et al: Sporadic gastric carcinomas with microsatellite instability display a particular clinicopathologic profile. In J Cancer 64:32-36, 1995
24. Silva S, Filipe MI: Intestinal metaplasia and its variants in the gastric mucosa of Portuguese subjects: A comparative analysis of biopsy and gastrectomy material. HUM PATHOL 17:988-995, 1986
25. Doglioni C, Laurino L, Dei Tos A, et al: Pancreatic (acinar) metaplasia of the gastric mucosa. AmJ Surg Pathol 17:1134-1143, 1993
26. Kuipers EJ, Pérez-Pérez GI, Meuwissen SGM, et al: Helicobacter pylori and atrophic gastritis: Importance of the cagA status. J Natl Cancer Inst 87:1777-1780, 1995
27. Handa Y, Saitoh T, Kawaguchi M, et al: Association of Helicobacter pylori and diffuse type gastric cancer. J Gastroenterol 31:29-32, 1996 (suppl IX)
28. Sipponen P, Kekki M, Siurala M: Atrophic gastritis and intestinal metaplasia in gastric carcinoma: Comparison with a representative population sample. Cancer 52:1062-1068, 1983
29. Fiocca R, Luinetti O, Villani L, et al: High incidence of Helicobacter pylori colonisation in early gastric cancer and the possible relationship to carcinogenesis. Eur J Gastroenterol Hepatol 5:S2-S8, 1993 (suppl 2)
30. Mori M, Sakaguchi H, Akazawa K, et al: Correlation between metastatic site, histological type, and serum tumor markers of gastric carcinoma. HUM PATHOL 26:504-508, 1995
31. Mayer B, Johnson JP, Leid F, et al: E-cadherin expression in primary and metastatic gastric cancer: Down-regulation correlates with cellular dedifferentiation and glandular disintegration. Cancer Res 53:1690-1695, 1993
32. Matsui S, Shiozaki H, Inoue M, et al: Immunohistochemical evaluation of alpha-catenin expression in human gastric cancer. Virchows Arch 424:375-381, 1994