Nerve growth factor and keratinocytes: A role in psoriasis

European Journal of Dermatology

Volumn 10, Issue 2, 2000, Pages 85-90

  Pincelli, Carlo ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Apoptosis; Innervation; Keratinocytes; Nerve growth factor; Neuropeptides; Psoriasis

Indexed keywords

CAMPTOTHECIN; COLECALCIFEROL; INTERLEUKIN 1ALPHA; K 252A; METHOTREXATE; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; NEUROPEPTIDE; PROTEIN TYROSINE KINASE;

APOPTOSIS; BINDING AFFINITY; CELL PROLIFERATION; DOWN REGULATION; HUMAN; KERATINOCYTE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PSORIASIS; REVIEW; SKIN INFLAMMATION;

APOPTOSIS; CELL DIVISION; HUMANS; KERATINOCYTES; NERVE FIBERS; NERVE GROWTH FACTORS; NEUROPEPTIDES; PSORIASIS; RECEPTORS, NERVE GROWTH FACTOR; SKIN;

EID: 0034001011     PISSN: 11671122     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (107)

1. 1. Snider WD. Functions of the neurotrophins during nervous system development: what the knockout are teaching us. Cell 1994; 77: 627-38.
2. 2. Levi-Montalcini R, Meyer H, Hamburger V. In vitro experiments on the effects of mouse sarcomas 180 and 37 on the spinal and sympathetic ganglia of the chick embro. Cancer Res 1954; 14: 49-57.
3. 3. Cohen S. Purification of a nerve-growth promoting protein from the mouse salivary gland and its neurocytotoxic antiserum. Proc Natl Acad Sci USA, 1960; 46: 302-11.
4. 4. Levi-Montalcini R. The nerve growth factor 35 years later. Science 1987; 237: 1154-62.
5. 5. Johnson D, Lanahan A, Randy Buck C, Sehgal A, Morgan C, Mercer E, Bothwell M, Chao M. Expression and structure of the human NGF receptor. Cell 1986; 47: 545-54.
6. 6. Kaplan DR, Hempstead BL, Martin-Zanca D, Chao MV Parada LF. The trk protooncogene product: a signal transducing receptor for nerve growth factor. Science (Wash) 1991; 252: 554-8.
7. 7. Bothwell M. Keeping track of neurotrophin receptors. Cell 1991; 65: 915-8.
8. 8. Barbacid M. Nerve growth factor: a tale of two receptors. Oncogene 1993; 8: 2033-42.
9. 9. Klein R, Jing S, Nanduri V, O'Rourke E, Barbacid M. The trk protoon-cogene encodes a receptor for nerve growth factor Cell 1991; 65: 189-97.
10. 10. Davies A. Neurotrophins: The Yin and Yang of nerve growth factor. Curr Biol 1997; 7: 38-40.
11. 11. Hempstead BL, Martin-Zanca D, Kaplan DR, Parada LF, Chao MV. High-affinity NGF binding requires co-expressionof the trk proto-oncogene and low-affinity NGF receptor. Nature (Lond.) 1991; 350: 678-83.
12. 12. Ross AH, Daou MC, McKinnon CA, Condon PJ, Lachyankar MB, Stephens RM, Kaplan DR, Wolf DE. The neurotrophin receptor, gp 75, forms a complex with the receptor tyrosine kinase trkA. J Cell Biol 1996; 132: 945-53.
13. 13. Maliartchouk S, Saragovi U. Optimal nerve growth factor trophic signals mediated by synergy of trkA and p75 receptor-specific ligands. J Neurosci 1997; 17: 6031-7.
14. 14. Carter BD, Kaltschmidt C, Kaltschmidt B, Offenhauser N, Bohm-Mattei R, Baeuerle PA, Barde YA. Selective activation of NFkB by nerve growth factor throughthe neurotrophin receptor p75. Science 1996; 272: 542-5.
15. 15. Chapman B. A region of the 75kDa neurotrophin receptor homologous to the death domains of TNFR-I and Fas. FEBS Letters 1995; 374: 216-20.
16. 16. Schulze-Osthoff K, Ferrari D, Los M, Wesselborg S, Peter ME. Apoptosis signaling by death receptors. Fur J Biochem 1998; 254: 439-59.
17. 17. Dobrowsky RT, Werner MH, Castellino AM, Chao MV, Hannun Y. Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science 1994; 265: 1569-99.
18. 18. Kaplan DR, Miller FD. Signal transduction by the neurotrophin receptors. Curr Opin Cell Biol 1997; 9: 213-21.
19. 19. Rice FL, Albers KM, Davis BM, Silos-Santiago I, Wilkinson GA, LeMaster AM Ernfors P, Smeyne RJ, Aldskogius H, Philips HS, Barbacid M, DeChiara TM, Yancopulos GD, Dunne CE, Fundin BT. Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors and p75 LNGFR. Dev Biol 1998; 198: 57-81.
20. 20. Davies AM, Bandtlow C, Heumann R, Korsching S, Rohrer H, Thoenen H. Timing and site of nerve growth factor synthesis in developing mouse skin in relation to innervation and expression of receptor. Nature 1987; 326: 353-8.
21. 21. Goodness TP, Albers KM, Davis FE, Davis BM. Overexpression of nerve growth factor in skin increases sensory neuron size and modulates Trk receptor expression. Eur J Neurosci 1997; 9: 1574-85.
22. 22. Davis BM, Goodnes TP, Soria A, Albers KM. Overexpression of NGF in skin causes the formation of novel sympathetic projections to trkA-positive sensory neurons. Neuroreport 1998; 9: 1103-7.
23. 23. Davis BM, Fundin BT, Albers KM, Goodness TP, Cronk KM, Rice FL. Overexpression of nerve growth factor in skin causes preferential increases among innervation to specific sensory targets. J Comp Neurol 1997; 387: 489-506.
24. 24. Kawamoto KT, Okada Y, Kannan H, Ushio H, Matsumoto M, Matsuda H. Nerve growth factor prevents apoptosis of rat peritoneal mast cells through the trk protooncogene receptor. Blood 1995; 86: 4638-44.
25. + T cell clones produce and release nerve growth factor and express high-affinity nerve growth factor receptors. J Allergy Clin Immunol 1997; 100: 408-14.
26. 26. Welker P, Grabbe J, Grutzkau A, Henz BM. Effects of nerve growth factor (NGF) and other fibroblast-derived growth factors on immature human mast cells (HMC-1). Immunology 1998; 94: 310-7.
27. 27. Braun A, Appel E, Baruch R, Herz U, Botchkarev V, Paus R, Brodie C, Renz H. Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma. Eur J Immunol 1998; 28: 3240-51.
28. 28. Torcia M, Bracci-Laudiero L, Lucibello M, Nencioni L, Labardi D, Rubartelli A, Cozzolino F, Aloe L, Garaci E. Nerve growth factor is an autocrine survival factor for memory B lymphocytes. Cell 1996; 85: 345-56.
29. 29. Kannan Y, Usami K, Okada M, Shimizu S and Matsuda H. Nerve growth factor suppresses apoptosis of murine neutrophils. Biochem Biophys Res Commun 1992; 186: 1050-6.
30. 30. Pincelli C, Sevignani C, Manfredini R, Grande A, Fantini F, Bracci-Laudiero L, Aloe L, Ferrari S, Cossarizza A and Giannetti A. Expression and function of nerve growth factor and nerve growth factor receptor on cultured keratinocytes. J Invest Dermatol 1994; 103: 13-8.
31. 31. Pincelli C, Yaar M. Nerve Growth Factor: its significance in cutaneous biology. J Invest Dermatol Symp Proc 1997; 2: 31-6.
32. 32. Zhai S, Yaar M, Doyle SM, Gilchrest BA. Nerve growth factor rescues pigment cells from ultraviolet-induced apoptosis by upregulating BCL-2 levels. Exp Cell Res 1996; 224: 335-43.
33. 33. Di Marco E, Marchisio PC, Bondanza S, Franzi AT Cancedda R, De Luca M. Growth-regulated synthesis and secretion of biologically active nerve growth factor by human keratinocytes. J Biol Chem 1991; 266: 21718-22.
34. 34. Pincelli C, Marconi A. Autocrine nerve growth factor in human keratinocytes. J Dermatol Sci 1999 (in press).
35. 35. Zhai S, Pincelli C, Yaar M, Gonsalves J, Gilchrest BA. The role of nerve growth factor in preventing keratinocyte apoptosis. J Invest Dermatol 1995; 104: 572 (abstr).
36. 36. Di Marco E, Mathor M, Bondanza S, Cutuli N, Marchisio PC, Cancedda R, De Luca M. Nerve growth factor binds to normal human keratinocytes through high and low affinity receptors and stimulates their growth by a novel autocrine loop. J Biol Chem 1993; 268: 22838-46.
37. 37. Marconi A, Vaschieri C, Zanoli S, Giannetti A, Pincelli C. Nerve growth factor protects human keratinocytes from ultraviolet-b-induced apoptosis. J Invest Dermatol 1999; 113: 920-7.
38. 38. Barde YA. Trophic factors and neuronal survival. Neuron 1989; 2: 1525-34.
39. 39. Raff MC. Social controls on cell survival and cell death. Nature 1992; 356: 397-400.
40. 40. Haake AR, Polakowska RR. Cell death by apoptosis in epidermal cell biology. J Invest Dermatol 1993; 101: 107-12.
41. 41. Pincelli C, Haake AR, Benassi L, Grassilli E, Magnoni C, Ottani D, Polakowska R, Franceschi C, Giannetti A. Autocrine nerve growth factor protects human keratinocytes from apoptosis through its high affinity receptor (trk): a role for bcl-2. J Invest Dermatol 1997; 109: 757-64.
42. 42. Budtz PE. Tissue Kinetic Homeostasis: Studies on toad epidermis. August Krogh Publications. Copenhagen, 1991.
43. 43. Polakowska RR, Haake AR. Apoptosis: the skin from a new perspective. Cell Death 1994; 1: 19-31.
44. 44. King KL, Cidlowski JA. Cell cycle and apoptosis: common pathways to life and death. J Cell Biochem 1995; 58: 175-80.
45. 45. Pandey S, Wang E. Cells en route to apoptosis are characterized by the up-regulation of c-fos, c-myc, c-jun, cdc2, and RB phosphorylation, resembling events of early cell cycle traverse. J Cell Biochem 1995; 58: 135-50.
46. 46. Rubin LL, Philpott KL, Brooks SF. The cell cycle and cell death. Curr Biol 1993; 3: 391-4.
47. 47. Ucker DS. Death by suicide: one way to go in mammalian cellular development? N Biol 1991; 3: 103-9.
48. 48. Haake AR, Polakowska RR. UV-induced apoptosis in skin equivalents: inhibition by phorbol ester and Bcl-2 overexpression. Cell Death and Diff 1995; 2: 183-93.
49. 49. Haake AR, Roublevskaia I, Cooklis M. Apoptosis: a role in skin aging? J Invest Dermatol Suppl Proc 1998; 3: 28-35.
50. 50. Danno K, Horio T. Formation of UV-induced apoptosis relates to the cell cycle. Br J Dermatol 1982; 107: 423-8.
51. 51. Norris DA, Middleton MH, Whang K, Schleicher M, McGovern T, Bennion SD, David-Bajar K, Davis D, Duke RC. Human keratinocytes maintain reversible anti-apoptotic defenses in vivo and in vitro. Apoptosis 1997; 2: 136-48.
52. 52. Yang E, Korsmeyer SJ. Molecular thanaptosis: a discourse on the bcl-2 family and cell death. Blood 1996; 88: 386-401.
53. 53. Kroemer G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nature Med 1997; 3: 614-20.
54. L. J Biol Chem 1996; 271: 6306-12.
55. 55. Boise LH, Thompson CB. Bcl-x (L) can inhibit apoptosis in cells that have undergone Fas-induced protease activation Proc Ntl Acad Sci 1997; 94: 3759-64.
56. 56. Vogelbaum MA, Tang JX, Rich KM. Developmental regulation of apoptosis in dorsal root ganglion neuron. J Neurosci 1998; 18: 8928-35.
57. 57. Miyaji EN, Menck CF. Human Bcl-2 expression delays ultraviolet-induced apoptosis in marsupial cells. Photochem-Photobiol 1998; 68: 719-24.
58. 58. Martin SJ, Newmeyer DD, Mathias S, Farscon DM, Wang HG, Reed JC, Kolesnick RN, Green DR. Cell-free reconstitution of Fas-, UV radiation-and ceramide-induced apoptosis. EMBO J 1995; 14: 5191-200.
59. 59. Gillardon F, Eschenfelder C, Uhlman E, Hartschuh W, Zimmerman M. Differential regulation of c-fos, fosB, c-jun, junB, bcl-2 and bax expression in rat skin following single or chronic unltraviolet irradiation and in vivo modulation by antisense oligodeoxynucleotide superfusion. Oncogene 1994; 9: 3210-25.
60. 60. Pena JC, Fuchs E, Thompson CB. Bcl-x expression influences keratinocyte cell survival but not terminal differentiation. Cell Growth & Diff 1997; 8: 619-29.
61. 61. O'Grady A, Kay EW, McKenna DB, Bennett MA, Murphy GM, Leader MB. Altered expression of the p53-regulated proteins, p21Waf1/Cip1, MDM2, and Bax in ultraviolet-irradiated human skin. Human Pathol 1998; 29: 559-64.
62. 62. Rodriguez-Villanueva J, Greenhalgh D, Wang XJ, Bundman D, Cho S, Delehedde M, Roop D, McDonnell TJ. Human keratin-1 bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation Oncogene 1998; 16: 853-63.
63. 63. Yee NS, Paek I, Besmer P. Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: basis for radiosensitivity ofWhite Spotting and Steel mutant mice. J Exp Med 1994; 179: 1777-87.
64. 64. Reynolds ML, Fitzgerald M. Long-term sensory hyperinnervation following neonatal skin wounds. J Comp Neurol 1995; 358: 487-98.
65. 65. Hermanson A, Dalsgaard CJ, Bjorklund H, Lindblom U. Sensory reinnervation and sensibility after superficial skin wounds in human patients. Neurosci Letter 1987; 74: 377-82.
66. 66. Donnerer J, Amann R, Schuligoi R, Skofitsch G. Complete recovery by nerve growth factor of neuropeptide content and function in capsaicin-impaired sensory neurons. Brain Res 1996; 741: 103-8.
67. 67. Amann R, Sirinathsinghji DJ, Donnerer J, Liebmann I, Schuligoi R. Stimulation by nerve growth factor of neuropeptide synthesis in the adult rat in vivo: bilateral response to unilateral intraplantar injections. Neurosci Lett 1996; 203: 171-4.
68. 68. Li AKC, Koroly MJ, Schattenkerk ME, Malt RA, Young M. Nerve growth factor: acceleration of the rate of wound healing in mice. Proc Ntl Acad Sci 1980; 77: 4379-81.
69. 69. Matsuda H, Koyama H, Sato H, Sawada J, Itakura A, Tanaka A, Matsumoto M, Konno K, Ushio H, Matsuda K. Role of nerve growth Factor in cutaneous wound healing: accelerating effects in normal and healing-impaired diabetic mice. J Exp Med 1998; 187: 297-306.
70. 70. Sarraf CE, Bowen ID. Proportions of mitotic and apoptosis cells in a range of untreated experimental tumors. Cell Tiss Kinet 1988; 21: 45-9.
71. 71. Delsite R, Djakiew D. Anti-proliferative effect of the kinase inhibitor K252a on human prostatic carcinoma cell lines. J Androl 1996; 17: 481-90.
72. 72. Kripke ML. Carcinogenesis: ultraviolet radiation. In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg I & Austen K editors, Dermatology in General Medicine. McGraw-Hill: New York 4th edition 1993, 796-804.
73. 73. Shea CR, Parrish JA. Non-ionizing radiation and the skin. In: Goldsmith LA, editor, Physiology, biochemistry and molecular biology of the skin, Oxford University Press, New York, Oxford, 1991, 910-27.
74. 74. Jonason AS, Kunala S, Price GJ, Restifo RJ, Spinelli HM, Persing JA, Leffel DJ, Tarone RE, Brash DE. Frequent clones of p53-mutated keratinocytes in normal human skin. Proc Ntl Acad Sci 1996; 93: 14025-29.
75. 75. Ziegler A, Jonason AS, Leffel DJ, Simon JA, Sharma HW, Kimmelman J, Remington L, Jacks T, Brash DE. Sunburn and p53 in the onset of skin cancer. Nature 1994; 372: 773-6.
76. 76. Kraemer KH. Sunlight and skin cancer: another link revealed. Proc Ntl Acad Sci 1997; 94: 11-4.
77. 77. Kemp CJ, Donehower LA, Bradley A, Balmain A: Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 1993; 74: 813-22.
78. 78. Weddel G, Cowan MA, Palmer E, Ramaswamy S. Psoriatic skin. Arch Dermatol 1965; 91: 252-66.
79. 79. Armagni C, Di Francesco C, Schaltegger H. Electron microscopy studies on dermal nerves in psoriasis. Acta Derm Venereol (Suppl) (Stockh) 1979; 87: 68-70.
80. 80. Anand P, Springall D, Blank M, Sellu D, Polak J, Bloom S. Neuropeptides in skin diseases: increased VIP in eczema and psoriasis but not axillary hyperhidrosis. Br J Dermatol 1991; 124: 547-9.
81. 81. Wallengren J, Ekman R, Möller H. Substance P and vasoactive intestinal peptide in bullous and inflammatory skin disease. Acta Derm Venereol 1986; 66: 23-8.
82. 82. Naukkarinen A, Nickoloff B.J, Farber E.M. Quantification of cutaneous sensory nerves and their Substance P content in psoriasis. J Invest Dermatol 1989; 92: 126-9.
83. 83. Fantini F, Pincelli C, Massimi P, Giannetti A. Neuropeptide-like immunoreactivity in skin lesions of atopic dermatitis and psoriasis. Br J Dermatol 1990; 122: 838-9.
84. 84. Pincelli C, Fantini F, Romualdi P, Sevignani C, Lesa G, Benassi L, Giannetti A. Substance P is diminished and vasoactive intestinal peptide is augmented in psoriatic lesions and these peptides exert disparate effects on the proliferation of cultured human keratinocytes. J Invest Dermatol 1992; 98: 421-7.
85. 85. Lindsay R, Harmar A. Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons. Nature 1989; 337: 362-4.
86. 86. Donnerer J, Schuligoi R, Stein C, Amann R. Upregulation, release and axonal transport of substance P and calcitonin gene-related peptide in adjuvant inflammation and regulatory function of nerve growth factor. Regul Pept 1993; 46: 150-4.
87. 87. Donnerer J, Schuligoi R, Stein C. Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: evidence for a regulatory function of nerve growth factor in vivo. Neuroscience 1992; 49 (3): 693-8.
88. 88. Pincelli C, Fantini F, Giannetti A. Neuropeptides and skin inflammation. Dermatology 1993; 187: 153-8.
89. 89. Gutwald J, Goebeler M, Sorg C. Neuropeptides enhance irritant and allergic contact dermatitis. J Invest Dermatol 1991; 96: 695-8.
90. 90. Pincelli C. Neuropeptides and Psoriasis In Psoriasis. Roenigk Jr. HH and Maibach HI ed. Marcel Dekker Inc. NY 1998: 393-7.
91. 91. Haegerstrand A, Jonzon B, Dalsgaard CJ, Nilsson J. Vasoactive intestinal polypeptide stimulates cell proliferation and adenyl cyclase activity of cultured human keratinocytes. Proc Natl Acad Sci 1989; 86: 5993-6.
92. 92. Griffiths CE. Immunological pathways in psoriasis In Psoriasis: Roenigk Jr. HH and Maibach HI ed. Marcel Dekker Inc. NY 1998: 341-8.
93. 93. Cooper KD, Hammerberg C, Baadsgaard O, Elder JT, Chan LS, Taylor RS, Voorhees JJ, Fisher G. Interleukin-1 in human skin: dysregulation in psoriasis. J Invest Dermatol 1990; 95: 24-65.
94. 94. Gearing AJ, Fincham NJ, Bird CR, Wadhwa M, Meager A, Cartwright JE, Camp RD. Cytokines in skin lesions of psoriasis. Cytokine 1990; 2: 68-75.
95. 95. Terui T, Hirao T, Sato Y, Uesugi T, Honda M, Iguchi M, Matsumura N, Kudoh K, Aiba S, Tagami H. An increased ratio of interleukin-1 receptor antagonist to interleukin-1 alpha in inflammatory skin diseases. Exp Dermatol 1998; 7: 327-34.
96. 96. Budtz PE. Epidermal homeostasis: a new model that includes apoptosis. In Tomei LD and Cope FO, editors, Apoptosis II: the molecular basis of apoptosis in disease. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. 1994, 165-85.
97. 97. Goldsmith LA. Toads and Psoriasis. Arch Dermatol 1986; 122: 939-40.
98. 98. Wrone-Smith T, Johnson T, Nelson B, Boise LH, Thompson CB, Nunez G, Nickoloff BJ. Discordant expression of bcl-x and bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo. Am J Pathol 1995; 146: 1079-88.
99. 99. Gutierrez-Stei C, Wrone-Smith T, Sun X, Krueger JG, Coven T, Nickoloff BJ. Sunlight-induced basal cell carcinoma tumor cells and ultraviolet-B-irradiated psoriatic plaques express Fas ligand (CD95L). J Clin Invest 1998; 101: 33-9.
100. 100. Wrone-Smith T, Mitra RS, Thompson CB, Jasty R, Castle VP, Nickoloff BJ. Keratinocytes derived from psoriatic plaques are resistant to apoptosis compared with normal skin. Am J Pathol 1997; 151: 1321-9.
101. 101. Heenen M, Laporte M, Noel JC, de Graef C. Methotrexate induces apoptotic cell death in human keratinocytes. Arch Dermatol Res 1998; 290: 240-5.
102. 102. Lin XR, Wilkinson DI, Farber EM. Camptothecin induces differentiation, tissue transglutaminase and apoptosis in cultured keratinocytes. Exp Dermatol 1998; 7: 179-83.
103. 103. Benassi L, Ottani D, Fantini F, Marconi A, Chiodino C, Giannetti A, Pincelli C. 1,25-dihydroxyvitamin D3, transforming growth factor b∂1, Calcium, and ultraviolet B radiation induce apoptosis in cultured human keratinocytes. J Invest Dermatol 1997; 109: 276-82.
104. 104. Fantini F, Magnoni C, Bracci-Laudiero L, Pincelli C. Nerve growth factor is increased in psoriatic skin. J Invest Dermatol 1995; 105: 854-5.
105. 105. Raychaudhuri SP, Jiang WY, Farber EM. Psoriatic keratinocytes express high levels of nerve growth factor. Acta Derm-Venereol 1998; 78: 84-6.
106. 106. Nanney LB, Stoscheck CM, Magid M, King LE. Altered 1251-epidermal growth factor binding and receptor distribution in psoriasis. J Invest Dermatol 1986; 86: 260-5.
107. 107. Chiodino C, Zoli M, Pincelli C, Giannetti A. Neurotrophin and neurotrophin receptor expression in normal and psoriatic skin: an in situ hybridization study. In "Psoriasis: from Gene to Clinic", London, December 1996.