Anti-proliferative effect of the kinase inhibitor K252a on human prostatic carcinoma cell lines

Journal of Andrology

Volumn 17, Issue 5, 1996, Pages 481-490

  Delsite, Robert ^a   Djakiew, Daniel ^a,b,c  

^a GEORGETOWN UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

cell cycle; cytostasis; growth inhibition; Prostate tumor cells; receptor phosphorylation

Indexed keywords

K 252A; PROTEIN KINASE INHIBITOR;

ARTICLE; CARCINOMA CELL; CELL PROLIFERATION; CELL VIABILITY; CYTOSTASIS; CYTOTOXICITY; DNA SYNTHESIS; DRUG EFFECT; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOGENICITY; PRIORITY JOURNAL; PROSTATE CARCINOMA; STROMA CELL; TUMOR GROWTH;

ANTINEOPLASTIC AGENTS; CARBAZOLES; CELL CYCLE; CELL DIVISION; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; MALE; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR; TUMOR CELLS, CULTURED;

EID: 0029827112     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Barde Y-A, Edgar D, Thoenen H. Purification of a new neurotrophic factor from mammalian brain. EMBO J 1982;1:549-553.
2. Berg MM, Sternberg DW, Parada LF, Chao MV. K252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity. J Biol Chem 1992;267:13-16.
3. Berkemeier LR, Lottspeich F, Hohn A, Hofer M, Hengerer B, Masiakowski P, Thoenen A, Barde Y-A. Molecular cloning and expression of brain-derived neurotrophic factor. Nature 1989;341:149-152.
4. Berkemeier LR, Winslow JW, Kaplan DR, Nikolics K, Goeddel DV, Rosenthal A. Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron 1991;7:857-866.
5. Carter HB, Coffey DS. The prostate: an increasing medical problem. Prostate 1990;16:39-48.
6. Djakiew D, Delsite R, Pflug B, Wrathall J, Lynch JH, Onoda M. Regulation of growth by a nerve growth factor-like protein which modulates paracrine interactions between a neoplastic epithelial cell line and stromal cells of the human prostate. Cancer Res 1991;51:3304-3310.
7. Ernfors P, Ibàñez CF, Ebendal T, Olson L, Persson H. Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain. Proc Natl Acad Sci USA 1990;87:5454-5458.
8. Gloeckler Reis LA, Hankey BF, Edwards BK, eds. Cancer Statistics View, 1973-1987. Bethesda, Maryland. The Surveillance Program-DEPC, NIH, US Department of Health and Human Services; 1990:1-357.
9. Gotz R, Koster R, Winkler C, Raulf R, Lottspeich F, Schartl M, Thoenen H. Neurotrophin-6 is a new member of the nerve growth factor family. Nature 1994;372:266-269.
10. Graham CW, Lynch JH, Djakiew D. Distribution of nerve growth factor-like protein and nerve growth factor receptor in human benign prostatic hyperplasia and prostatic carcinoma. J Urol 1992;147:1444-1447.
11. Hallböök F, Ibàñez CF, Persson H. Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. Neuron 1991;6:845-858.
12. Harper GP, Barde Y-A, Burnstock G, Carstairs JR, Dennison ME, Suda K, Vernon CA. Guinea pig prostate is a rich source of nerve growth factor. Nature 1979;279:160-162.
13. Hohn A, Leibrock J, Bailey K, Barde Y-A. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature 1990;344:339-341.
14. Ip NY, Ibàñez CF, Nye SH, McClain J, Jones PF, Gies DR, Belluscio L, Le Beau MM, Espinosa R, Squinto SP, Persson H, Yancopoulos GD. Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. Proc Natl Acad Sci USA 1992;89:3060-3064.
15. Kaplan DR, Hempstead BL, Martin-Zanca D, Chao MV, Parada LF. The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science 1991a;252:554-558.
16. Kaplan DR, Martin-Zanca D, Parada LF. Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature 1991b;350:158-160.
17. Kase H, Iwahashi K, Matsuda Y. K252a, a potent inhibitor of protein kinase C from microbial origin. J Antibiotics 1986;39:1059-1065.
18. Kase H, Iwahashi K, Nakanishi S, Matsuda Y, Yamada K, Takahashi M, Murakata C, Sato A, Kaneko M. K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem Biophys Res Commun 1987;142:436-440.
19. Klein R, Jing SQ, Nanduri V, O'Rourke E, Barbacid M. The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 1991a;65: 189-197.
20. Klein R, Lamballe F, Bryant S, Barbacid M. The trkB tyrosine protein kinase is a receptor for neurotrophin-4. Neuron 1992;8:947-956.
21. Klein R, Nanduri V, Jing SQ, Lamballe F, Tapley P, Bryant S, Cordon-Cardo C, Jones KR, Reichardt LF, Barbacid M. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell 1991b;66:395-403.
22. Knüsel B, Hefti F. K-252 compounds: modulators of neurotrophin signal transduction. J Neurochem 1992;59:1987-1996.
23. Koizumi S, Contreras ML, Matsuda Y, Hama T, Lazarovici P, Guroff G. K-252a: a specific inhibitor of the action of nerve growth factor on PC12 cells. J Neurosci 1988;8:715-721.
24. Lamballe F, Klein R, Barbacid M. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 1991;66:967-979.
25. Lazarovici P, Levi B-Z, Lelkes PI, Koizumi S, Fujita K, Matsuda Y, Ozato K, Guroff G. K-252a inhibits the increase in c-fos transcription and the increase in intracellular calcium produced by nerve growth factor in PC12 cells. J Neurosci Res 1989;23:1-8.
26. Lee C, Sutkowski DM, Sansibar JA, Zelner D, Kim I, Amsel I, Shaw N, Prins GS, Kozlowski JM. Regulation of proliferation and production of prostate-specific antigen in androgen-sensitive prostatic cancer cells, LNCaP, by dihydrotestosterone. Endocrinology 1995;136:796-803.
27. Leibrock J, Lottspeich F, Hohn A, Hofer M, Hengerer B, Masiakowski P, Thoenen H, Barde Y-A. Molecular cloning and expression of brain-derived neurotrophic factor. Nature 1989;341:149-152.
28. Levi-Montalcini R, Hamburger V. Selective growth-stimulation effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo. J Exp Zool 1951;116:321-361.
29. Levitzki A, Gazit A. Tyrosine kinase inhibition: an approach to drug development. Science 1995;267:1782-1787.
30. Luke MC, Coffey DS. The male sex accessory tissues: structure, androgen action, and physiology. In: Knobil E, Neill JD, eds. The Physiology of Reproduction, 2nd ed. New York: Raven Press; 1994:1435-1488.
31. MacGrogan D, Saint-Andre JP, Dicou E. Expression of nerve growth factor and nerve growth factor receptor genes in human tissues and in prostatic adenocarcinoma cell lines. J Neurochem 1992;59:1381-1391.
32. Maisonpierre P, Belluscio L, Squinto S, Ip N, Furth M, Lindsay R, Yancopoulos G. Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Science 1990;247:1446-1451.
33. Nagashima K, Nakanishi S, Matsuda Y. Inhibition of nerve growth factor-induced neurite outgrowth of PC12 cells by a protein kinase inhibitor which does not permeate the cell membrane. FEBS Lett 1991;293: 119-123.
34. Nakayama T, Hashimoto Y, Kaneko Y, Yoshida M, Beppu T, Ohmi K, Yamashita S, Nonomura Y, Kurokawa K. K252a: a new blocker of the cell-cycle at G1 phase in a human hepatoma cell line. Experientia 1993;49:876-880.
35. Nye SH, Squinto SP, Glass DJ, Stilt TN, Hantzapoulos P, Macchi MJ, Lindsay NS, Ip NY, Yancopoulos GD. K252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses. Mol Biol Cell 1992;3:677-686.
36. Ohmi K, Yamashita S, Nonmura Y. Effect of K252a, a protein kinase inhibitor, on the proliferation of vascular smooth muscle cells. Biochem Biophys Res Commun 1990;173:976-981.
37. Ohmichi M, Decker SJ, Pang L, Saltiel AR. Inhibition of the cellular actions of nerve growth factor by staurosporine and K252a results from the attenuation of the activity of the trk tyrosine kinase. Biochemistry 1992;31:4034-4039.
38. Pflug BR, Dionne C, Kaplan DR, Lynch J, Djakiew D. Expression of a Trk high affinity nerve growth factor receptor in the human prostate. Endocrinology 1995;136:262-268.
39. Pflug BR, Onoda M, Lynch JH, Djakiew D. Reduced expression of the low affinity nerve growth factor in benign and malignant human prostate tissue and loss of expression in four human metastatic prostate tumor cell lines. Cancer Res 1992;52:5403-5406.
40. Rabizadeh S, Oh J, Zhong LT, Yang J, Bitler CM, Butcher LL, Bresden DE. Induction of apoptosis by the low-affinity NGF receptor. Science 1993;261:345-348.
41. Schwarz MA, Fisher D, Bradshaw RA, Isackson PJ. Isolation and sequence of a cDNA clone of β-nerve growth factor from the guinea pig prostate gland. J Neurochem 1989;52:1203-1209.
42. Soppet D, Escandon E, Maragos J, Middlemas DS, Reid SW, Blair J, Burton LE, Stanton BR, Kaplan DR, Hunter T, Nikolics K, Parada LF. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell 1991;65:895-903.
43. Squinto SP, Stitt TN, Aldrich TH, Davis S, Bianco SM, Radziejewski C, Glass DJ, Masikowski P, Furth ME, Valenzuela DM, Distefano PS, Yancopoulos GD. trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor. Cell 1991;65:885-893.
44. Taoka T, Tokuda M, Tasaka T, Hatase O, Irino S, Norman AW. Induction of differentiation of HL-60 cells by protein kinase C inhibitor, K252a. Biochem Biophys Res Commun 1990;170:1151-1156.
45. Tapley P, Lamballe F, Barbacid M. K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors. Oncogene 1992;7:371-381.
46. Usui T, Yoshida M, Abe K, Osada H, Isono K, Beppu T. Uncoupled cell cycle without mitosis induced by a protein kinase inhibitor, K-252a. J Cell Biol 1991;115:1275-1282.
47. Vindelov LL, Christensen IJ, Nissen NI. A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. Cylometry 1983;3:323-327.
48. Zong Z-p, Fujikawa-Yamamoto K, Teraoka K, Yamagishi H, Tanino M, Odashima S. Potentiation of K252a, a protein kinase inhibitor-induced polyploidization, by cAMP in cultured fibrosarcoma cell line. Biochem Biophys Res Commun 1994;205:746-750.