Controlling the end of the cell cycle

Current Opinion in Genetics and Development

Volumn 10, Issue 1, 2000, Pages 65-69

  Cerutti, Lorenzo ^a   Simanis, Viesturs ^b  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE;

CELL CYCLE; CYTOKINESIS; ENZYME INACTIVATION; MITOSIS; MITOSIS SPINDLE; NONHUMAN; NUCLEOLUS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; REVIEW; SACCHAROMYCES CEREVISIAE;

EID: 0033994359     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(99)00044-1     Document Type: Review

References (51)

1. Nasmyth K. At the heart of the budding yeast cell cycle. Trends Genet. 12:1996;405-412.
2. Zachariae W., Nasmyth K. Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev. 13:1999;2039-2058.
3. Elledge S.J. Cell cycle checkpoints: preventing an identity crisis. Science. 274:1996;1664-1672.
4. Pines J. Four dimensional control of the cell cycle. Nat Cell Biol. 1:1999;E73-E79.
5. Hardwick K.G. The spindle checkpoint. Trends Genet. 14:1998;1-4.
6. Amon A. The spindle checkpoint. Curr Opin Genet Dev. 9:1999;69-75.
7. Taylor S.S. Dual control ensures fidelity. Curr Biol. 9:1999;R562-R564.
8. Elledge S.J. Mitotic arrest: Mad2 prevents sleepy from waking up the APC. Science. 279:1998;999-1000.
9. Pangilinan F., Spencer F. Abnormal kinetochore structure activates the spindle assembly checkpoint in budding yeast. Mol Biol Cell. 7:1996;1195-1208.
10. Wang Y., Burke D.J. Checkpoint genes required to delay cell division in response to nocodazole respond to impaired kinetochore function in the yeast Saccharomyces cerevisiae. Mol Cell Biol. 15:1995;6838-6844.
11. Shirayama M., Zachariae W., Ciosk R., Nasmyth K. The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae. EMBO J. 17:1998;1336-1349.
12. ••]) provides evidence that the spindle assembly checkpoint pathway is branched. It is shown that bub2/bfa1 mutants combined with any of the other mad/bub mutants totally abolish any cell cycle delay in response to loss of spindle function.
13. ••].
14. ••].
15. ••].
16. Li Y., Gorbea C., Mahaffey D., Rechsteiner M., Benezra R. MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity. Proc Natl Acad Sci USA. 94:1997;12431-12436.
17. He X., Patterson T.E., Sazer S. The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex. Proc Natl Acad Sci USA. 94:1997;7965-7970.
18. Hwang L.H., Lau L.F., Smith D.L., Mistrot C.A., Hardwick K.G., Hwang E.S., Amon A., Murray A.W. Budding yeast Cdc20: a target of the spindle checkpoint. Science. 279:1998;1041-1044.
19. Kim S.H., Lin D.P., Matsumoto S., Kitazono A., Matsumoto T. Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint. Science. 279:1998;1045-1047.
20. Fang G., Yu H., Kirschner M.W. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. Mol Cell. 2:1998;163-171.
21. Wassmann K., Benezra R. Mad2 transiently associates with an APC/p55Cdc complex during mitosis. Proc Natl Acad Sci USA. 95:1998;11193-11198.
22. Kallio M., Weinstein J., Daum J.R., Burke D.J., Gorbsky G.J. Mammalian p55CDC mediates association of the spindle checkpoint protein mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. J Cell Biol. 141:1998;1393-1406.
23. Jaspersen S.L., Charles J.F., Tinker-Kulberg R.L., Morgan D.O. A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol Biol Cell. 9:1998;2803-2817.
24. Glover D.M., Hagan I.M., Tavares A.A.M. Polo-like kinases: a team that plays throughout mitosis. Genes Dev. 12:1999;3777-3778.
25. Furge K.A., Wong K., Armstrong J., Balasubramanian M., Albright C.F. Byr4 and Cdc16 form a two-component GTPase-activating protein for the Spg1 GTPase that controls septation in fission yeast. Curr Biol. 8:1998;947-954. This paper demonstrates that byr4 and cdc16 encode a two-component GAP for spg1p, with cdc16p being the putative catalytic component, and byr4p presumably acting as a scaffold holding spg1p and cdc16p together.
26. ••]) establishes that Cdc14p is located in the nucleolus, and that its release from there to the rest of the cell requires signalling via the MEN proteins. It is also demonstrated that Net1p/Cfi1p is responsible for both retaining Cdc14p in the nucleus, and inhibiting its activity. It is also shown that the RENT complex is important for nucleolar sequestration of proteins involved in other processes, such as the establishment of heterochromatin.
27. ••].
28. ••].
29. Bachant J.B., Elledge S.J. Mitotic treasures in the nucleolus. Nature. 398:1999;756-757.
30. ••]), describe a second role for Pds1p in controlling mitotic exit as well as sister chromatid separation.
31. ••].
32. cdc20 to permit exit from mitosis.
33. Fankhauser C., Simanis V. The cdc7 protein kinase is a dosage dependent regulator of septum formation in fission yeast. EMBO J. 13:1994;3011-3019.
34. Ohkura H., Hagan I.M., Glover D.M. The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells. Genes Dev. 9:1995;1059-1073.
35. Balasubramanian M.K., McCollum D., Chang L., Wong K.C., Naqvi N.I., He X., Sazer S., Gould K.L. Isolation and characterization of new fission yeast cytokinesis mutants. Genetics. 149:1998;1265-1275.
36. Schmidt S., Sohrmann M., Hofmann K., Woollard A., Simanis V. The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe. Genes Dev. 11:1997;1519-1534.
37. Fankhauser C., Marks J., Reymond A., Simanis V. The S. pombe cdc16 gene is required both for maintenance of p34cdc2 kinase activity and regulation of septum formation: a link between mitosis and cytokinesis? EMBO J. 12:1993;2697-2704.
38. Song K., Mach K.E., Chen C.Y., Reynolds T., Albright C.F. A novel suppressor of ras1 in fission yeast, byr4, is a dosage-dependent inhibitor of cytokinesis. J Cell Biol. 133:1996;1307-1319.
39. LeGoff X., Utzig S., Simanis V. Controlling septation in fission yeast: finding the middle, and timing it right. Curr Genet. 35:1999;571-584.
40. Bahler J., Steever A.B., Wheatley S.I., Wang Y., Pringle J.R., Gould K.L., McCollum D. Role of polo kinase and mid1p in determining the site of cell division in fission yeast. J Cell Biol. 143:1998;1603-1616.
41. Yamano H., Gannon J., Hunt T. The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe. EMBO J. 15:1996;5268-5279.
42. Murone M., Simanis V. The fission yeast dma1 gene is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised. EMBO J. 15:1996;6605-6616.
43. Beltraminelli N., Murone M., Simanis V. The S. pombe zfs1 gene is required to prevent septation if mitotic progression is inhibited. J Cell Sci. 112:1999;3103-3114.
44. Li L., Ernsting B.R., Wishart M.J., Lohse D.L., Dixon J.E. A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. J Biol Chem. 272:1997;29403-29406.
45. Richardson P.M., Zon L.I. Molecular cloning of a cDNA with a novel domain present in the tre-2 oncogene and the yeast cell cycle regulators BUB2 and cdc16. Oncogene. 11:1995;1139-1148.
46. Sohrmann M., Schmidt S., Hagan I., Simanis V. Asymmetric segregation on spindle poles of the Schizosaccharomyces pombe septum-inducing protein kinase Cdc7p. Genes Dev. 12:1998;84-94. This paper demonstrates that components of the switch controlling septation in fission yeast are located on the spindle poles, and that some components are segregated asymmetrically during mitosis.
47. Cerutti L., Simanis V. Asymmetry of the spindle pole bodies:and spg1p GAP segregation during mitosis in fission yeast. J Cell Sci. 112:1999;2313-2321.
48. Sparks C., Morphew M., McCollum D. sid2p, a spindle pole body kinase that regulates the onset of cytokinesis. J Cell Biol. 146:1999;777-790.
49. Mulvihill D.P., Petersen J., Ohkura H., Glover D.M., Hagan I.M. Plo1 kinase recruitment to the spindle pole body and its role in cell division in Schizosaccharomyces pombe. Mol Biol Cell. 10:1999;2771-2785.
50. Adams R.R., Tavares A.A., Salzberg A., Bellen H.J., Glover D.M. pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis. Genes Dev. 12:1998;1483-1494.
51. Golsteyn R.M., Mundt K.E., Fry A.M., Nigg E.A. Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function. J Cell Biol. 129:1995;1617-1628.