Molecular events in bronchogenic carcinoma and their implications for therapy

Seminars in Surgical Oncology

Volumn 18, Issue 2, 2000, Pages 91-99

  Toloza, Eric M ^a   Roth, Jack A ^a   Swisher, Stephen G ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Adenocarcinoma; Apoptosis; Bronchogenic carcinoma; Chromosome aberrations; Lung neoplasms; Lymphatic metastasis; Mucosa; Neoplasm invasiveness; Oncogenes; Prognosis; Risk factors; Smoking; Sputum; Squamous cell carcinoma; Survival rate; Tumor suppressor genes

Indexed keywords

CANCER GROWTH; CANCER INVASION; CANCER RECURRENCE; CANCER SURVIVAL; CANCER SUSCEPTIBILITY; GENE THERAPY; LUNG CARCINOMA; METASTASIS; PRECANCER; PRIORITY JOURNAL; REVIEW; TUMOR SUPPRESSOR GENE;

CARCINOMA, BRONCHOGENIC; CHEMOPREVENTION; CHROMOSOME ABERRATIONS; GENES, TUMOR SUPPRESSOR; HUMANS; LUNG NEOPLASMS; ONCOGENES;

EID: 0033974626     PISSN: 87560437     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2388(200003)18:2<91::AID-SSU2>3.0.CO;2-R     Document Type: Review

References (52)

1. Landis SH, Murray T, Bolden S, Wingo PA: Cancer statistics, 1999. CA Cancer J Clin 1999;49:8-31.
2. Pierce RJ, Kune GA, Kune S, et al: Dietary and alcohol intake, smoking pattern, occupational risk, and family history in lung cancer patients: results of a case-control study in males. Nutr Cancer 1989;12:237-248.
3. Bartsch H, Petruzzelli S, De Flora S, et al: Carcinogen metabolism in human lung tissues and the effect of tobacco smoking: results from a case-control multicenter study on lung cancer patients. Environ Health Perspect 1992;98:119-124.
4. Drakoulis N, Cascorbi I, Brockmoller J, et al: Polymorphisms in the human CYP1A1 gene as susceptibility factors for lung cancer: exon-7 mutation (4889 A to G), and a T to C mutation in toe 3′-flanking region. Clin Invest 1994;72:240-248.
5. Denissenko MF, Pao A, Tang MS, Pfeifer GP: Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in p53. Science 1996;274:430-432.
6. Wei Q, Cheng L, Hong WK, Spitz MR: Reduced DNA repair capacity in lung cancer patients. Cancer Res Adv Brief 1996;56:4103-4107.
7. Heckbert SR, Weiss NS, Hornung SK, et al: Glutathione S-transferase and epoxide hydrolase activity in human leukocytes in relation to risk of lung cancer and other smoking-related cancers. J Natl Cancer Inst 1992;84:414-422.
8. Sozzi G, Miozzo M, Tagliabue E, et al: Cytogenetic abnormalities and overexpression of receptors for growth factors in normal bronchial epithelium and tumor samples of lung cancer patients. Cancer Res 1991;51:400-404.
9. Leoncini L, Sforza V, Lavarini E, et al: Flow-cytometric assessment of DNA index and percent S phase cells in bronchogenic epidermoid carcinoma. Appl Pathol 1988;6:28-34.
10. Mao L, Lee JS, Kurie JM, et al: Clonal genetic alterations in the lungs of current and former smokers. J Natl Cancer Inst 1997;89:857-862.
11. Thiberville L, Payne P, Vielkinds J, et al: Evidence of cumulative gene losses with progression of premalignant epithelial lesions to carcinoma of the bronchus. Cancer Res 1995;55:5133-5139.
12. Barrett JC, Lamb PW, Wiseman RW: Multiple mechanisms for the carcinogenic effects of asbestos and other mineral fibers. Environ Health Perspect 1989;81:81-89.
13. Sundaresan V, Reeve JG, Wilson B, et al: Flow cytometric and immunohistochemical analysis of p62c-myc oncoprotein in the bronchial epithelium of lung cancer patients. Anticancer Res 1991;11:2111-2116.
14. Gosney JR, Field JK, Gosney MA, et al: c-myc oncoprotein in bronchial carcinoma: expression in all major morphological types. Anticancer Res 1990;10:623-628.
15. Sugio K, Kishimoto Y, Virmani AK, et al: K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas. Cancer Res 1994;54:5811-5815.
16. Reddel RR, Ke Y, Kaighn ME, et al: Human bronchial epithelial cells neoplastically transformed by v-Ki-ras: altered response to inducers of terminal squamous differentiation. Oncogene Res 1988;3:401-408.
17. Vaele D, Kerr N, Gibson GJ, et al: The relationship of quantitative epidermal growth factor receptor expression in non-small cell lung cancer to long term survival. Br J Cancer 1993;68:162-165.
18. Kern JA, Slebos JC, Top B, et al: C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas. J Clin Invest 1994;93:516-520.
19. Fontanini G, Vignati S, Bigini D, et al: Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype. Eur J Cancer 1995;31A:178-183.
20. Walker C, Robertson LJ, Myskow MW, et al: p53 expression in normal and dysplastic bronchial epithelium and in lung carcinomas. Br J Cancer 1994;70:297-303.
21. Willey JC, Harris CC: Cellular and molecular biological aspects of human bronchogenic carcinogenesis [Review]. Critical Review Oncol-Hematol 1990;10:181-209.
22. Gerwin, BI, Spillare E, Forrester K. et al: Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1. PNAS 1992;89:2759-2763.
23. Ihde DC, Minna JD: Non-small cell lung cancer. Part I: Biology, diagnosis, and staging. Curr Probl Cancer 1991;15:61-104.
24. Ten Have-Opbroek AA, Benfield JR, Hammond WG, et al: In favour of an oncofoetal concept of bronchogenic carcinoma development [Review]. Histol Histopathol 1994;9:375-384.
25. Shackney SE, Smith CA, Pollice A, et al: Genetic evolutionary staging of early non-small cell lung cancer: the p53-HER-2/neu-ras sequence. J Thorac Cardiovasc Surg 1999;118:259-269.
26. Schenk T, Ackermann J, Brunner C, et al: Detection of chromosomal aneuploidy by interphase fluorescence in situ hybridization in bronchoscopically gained cells from lung cancer patients. Chest 1997;111:1691-1696.
27. Tockman MS, Gupta PK, Myers JD, et al: Sensitive and specific monoclonal antibody recognition of human lung cancer antigen on preserved sputum cells: a new approach to early lung cancer detection. J Clin Oncol 1988;6:1685-1693.
28. Lam S, Kennedy T, Unger M, et al: Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy. Chest 1998;113:696-702.
29. Shinoura N, Ohashi M, Yoshida Y, et al: Construction, propagation, and titer estimation of recombinant adenoviruses carrying proapoptic genes. Hum Gene Ther 1998;9:2683-2689.
30. Kurie JM, Shin HJ, Lee JS, et al: Increased epidermal growth factor receptor expression in metaplastic bronchial epithelium. Clin Cancer Res 1996;2:1787-1793.
31. Ayoub J, Jean-Francois R, Cormier Y, et al: Placebo-controlled trial of 13-cis-retinoic acid activity on retinoic acid receptor-beta expression in a population at high risk: implications for chemoprevention of lung cancer. J Clin Oncol 1999;17:3546-3552.
32. Mukhopadhyay T, Tainsky M, Cavender AC, Roth JA: Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA. Cancer Res 1991;51:1744-1748.
33. Zhang YJ, Mukhopadhyay T, Donehower LW, et al: Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype. Hum Gene Ther 1993;4:451-460.
34. Schrump DS, Chen A, Consoli U: Inhibition of lung cancer proliferation by antisense cyclin D. Cancer Gene Ther 1996;3:131-135.
35. Chang JY, Xia WY, Shao RP, Hung MC: Inhibition of intratracheal lung cancer development by systemic delivery E1A. Oncogene 1996;13:1405-1412.
36. Takahashi T, Carbone D, Nau MM, et al: Wild type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions. Cancer Res 1992;52:2340-2343.
37. Cai DW, Mukhopadhyay, T, Liu Y, et al: Stable expression of the wild-type p53 gene in human lung cancer cells after retrovirus-mediated gene transfer. Hum Gene Ther 1993;4:617-624.
38. Zhang WW, Fang X, Mazur W, et al: High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus. Cancer Gene Ther 1994;1:5-13.
39. Roth JA, Nguyen D, Lawrence DD, et al: Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nat Med 1996;2:985-991.
40. Swisher SG, Roth JA, Nemunaitis J, et al: Adenoviral-mediated p53 gene transfer in advanced non-small cell lung cancer. J Natl Cancer Inst 1991;91:763-771.
41. Kagawa S, Pearson SA, Ji L, et al: A binary adenoviral vector system for expressing high levels of the proapoptotic gene bax. Gene Ther 1999:in press.
42. Batra RK, Guttridge DC, Brenner DA, et al: IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. Am J Respir Cell Mol Biol 1999;21:238-245.
43. Jin X, Nguyen D, Zhang WW, et al: Cell cycle arrest and inhibition of tumor cell proliferation by the p16INK4 gene mediated by an adenovirus vector. Cancer Res 1995;55:3250-3253.
44. Xu HJ, Zhou YL, Seigne J, et al: Enhanced tumor suppressor gene therapy via replication-deficient adenovirus vectors expressing an N-terminal truncated retinoblastoma protein. Cancer Res 1996;56:2245-2249.
45. Tseng JE, Kemp BL, Khuri FR, et al: Loss of FHIT is frequent in stage I non-small cell lung cancer and in the lungs of chronic smokers. Cancer Res 1999;59:4798-4803.
46. Ji L, Fang B, Yen N, et al: Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated FHIT gene overexpression. Cancer Res 1999;59:3333-3339.
47. Joshi US, Dergham ST, Chen YQ, et al: Inhibition of pancreatic tumor cell growth in culture by p21 (WAF1) recombinant adenovirus. Pancreas 1998;16:107-113.
48. Pardo FS, Su M, Borek C, et al: Transfection of rat embryo cells with mutant p53 increases the intrinsic radiation resistance. Radiat Res 1994;140:180-185.
49. Nguyen DM, Spitz FR, Yen N, et al: Gene therapy for lung cancer: enhancement of tumor suppression by a combination of sequential cisplatin and adenovirus-mediated p53 gene transfer. J Thorac Cardiovasc Surg 1996;112:1372-1377.
50. Spitz FR, Nguyen D, Skibber JM, et al: Adenoviral-mediated wild-type p53 gene expression sensitizes colorectal cancer cells to ionizing radiation. Clin Cancer Res 1996;2:1665-1671.
51. Nemunaitis J, Swisher SG, Timmons T, et al: Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small cell lung cancer. J Clin Oncol 1999;in press.
52. Gorski DH, Mauceri HJ, Salloum RM: Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin. Cancer Res 1998;58:5686-568.