Applicability of a 'speed' congenic strategy to dissect blood pressure quantitative trait loci on rat chromosome 2

Hypertension

Volumn 35, Issue 1 II, 2000, Pages 179-187

  Jeffs, Baxter ^a   Negrin, Cervantes D ^a   Graham, Delyth ^a   Clark, James S ^a   Anderson, Niall H ^a   Gauguier, Dominique ^b   Dominiczak, Anna F ^a,c  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c WESTERN INFIRMARY   (United Kingdom)

Author keywords

Genes; Hypertension, genetic; Rats, inbred strokeprone SHR

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; BLOOD PRESSURE; BREEDING; CHROMOSOME 2; CONFERENCE PAPER; CONGENIC STRAIN; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENOME; HEREDITARY HYPERTENSION; HETEROZYGOSITY; HOMOZYGOSITY; MALE; MOLECULAR CLONING; NONHUMAN; POSITION EFFECT; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0033966178     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.hyp.35.1.179     Document Type: Conference Paper

References (31)

1. Hubert P, Lindpaintner K, Beckmann JS, Serikawa T, Soubrier F, Dubay C, Cartwright P, De Gouyon B, Julier C, Takahasi S. Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature. 1991;353:521-529.
2. Jacob HJ, Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao YP, Ganten D, Dzau VJ, Lander ES. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell. 1991;67:213-224.
3. Clark JS, Jeffs B, Davidson AO, Lee WK, Anderson NH, Bihoreau MT, Brosnan MJ, Devlin AM, Kelman AW, Lindpaintner K, Dominiczak AF. Quantitative trait loci in genetically hypertensive rats: possible sex specificity. Hypertension. 1996;28:898-906.
4. Jeffs B, Clark JS, Anderson N, Gratton J, Brosnan MJ, Gauguier D, Reid JL, Macrae IM, Dominiczak A. Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus. Nat Genet. 1997;16:364-367.
5. Rapp JP, Deng AY. Detection and positional cloning of blood pressure quantitative trait loci: is it possible? Identifying the genes for genetic hypertension. Hypertension. 1995;25:1121-1128.
6. St Lezin E, Liu W, Wang JM, Wang N, Kren V, Krenova D, Musilova A, Zdobinska M, Zidek V, Lau D, Pravenec M. Genetic isolation of a chromosome 1 region affecting blood pressure in the spontaneously hypertensive rat. Hypertension. 1997;30:854-858.
7. Frantz SA, Kaiser M, Gardiner SM, Gauguier D, Vincent M, Thompson JR, Bennett T, Samani NJ. Successful isolation of a rat chromosome 1 blood pressure quantitative trait locus in reciprocal congenic strains. Hypertension. 1998;32:639-646.
8. Deng AY, Dene H, Rapp JP. Congenic strains for the blood pressure quantitative trait locus on rat chromosome 2. Hypertension. 1997;30: 199-202.
9. Cicila GT, Choi C, Dene H, Lee SJ, Rapp JP. Two blood pressure/cardiac mass quantitative trait loci on chromosome 3 in Dahl rats. Mammalian Genome. 1999;10:112-116.
10. Garrett MR, Dene H, Walder R, Zhang QY, Cicila GT, Assadnian S, Deng AY, Rapp JP. Genome scan and congenic strains for blood pressure QTL using Dahl salt- sensitive rats. Genome Res. 1998;8:711-723.
11. Cicila GT, Dukhanina OI, Kurtz TW, Walder R, Garrett MR, Dene H, Rapp JP. Blood pressure and survival of a chromosome 7 congenic strain bred from Dahl rats. Mammalian Genome. 1997;8:896-902.
12. Kren V, Pravenec M, Lu S, Krenova D, Wang JM, Wang N, Merriouns T, Wong A, St Lezin E, Lau D, Szpirer C, Szpirer J, Kurtz TW. Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat. J Clin Invest. 1997;99:577-581.
13. Rapp JP, Garrett MR, Dene H, Meng H, Hoebee B, Lathrop GM. Linkage analysis and construction of a congenic strain for a blood pressure QTL on rat chromosome 9. Genomics. 1998;51:191-196.
14. Dukhanina OI, Dene H, Deng AY, Choi CR, Hoebee B, Rapp JP. Linkage map and congenic strains to localize blood pressure QTL on rat chromosome 10. Mammalian Genome. 1997;8:229-235.
15. St Lezin EM, Pravenec M, Wong AL, Liu W, Wang N, Lu S, Jacob HJ, Roman RJ, Stec DE, Wang JM, Reid IA, Kurtz TW. Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats. J Clin Invest. 1996;97:522-527.
16. Zhang QY, Dene H, Deng AY, Garrett MR, Jacob HJ, Rapp JP. Interval mapping and congenic strains for a blood pressure QTL on rat chromosome 13. Mammalian Genome. 1997;8:636-641.
17. Jiang J, Stec DE, Drummond H, Simon JS, Koike G, Jacob HJ, Roman RJ. Transfer of a salt-resistant renin allele raises blood pressure in Dahl salt-sensitive rats. Hypertension. 1997;29:619-627.
18. St Lezin E, Zhang L, Yang Y, Wang JM, Wang N, Qi N, Steadman JS, Liu W, Kren V, Zidek V, Krenova D, Churchill PC, Churchill MC, Pravenec M. Effect of chromosome 19 transfer on blood pressure in the spontaneously hypertensive rat. Hypertension. 1999;33:256-260.
19. Lander ES, Schork NJ. Genetic dissection of complex traits. Science. 1994;265:2037-2048.
20. Wakeland E, Morel L, Achey K, Yui M, Longmate J. Speed congenics: a classic technique in the fast lane (relatively speaking). Immunol Today. 1997;18:472-477.
21. Markel P, Shu P, Ebeling C, Carlson GA, Nagle DL, Smutko JS, Moore KJ. Theoretical and empirical issues for marker-assisted breeding of congenic mouse strain. Nat Genet. 1997;17:280-284.
22. Yui MA, Muralidharan K, Moreno-Altamirano B, Perrin G, Chestnut K, Wakeland EK. Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits. Mammalian Genome. 1996;7:331-334.
23. Morel L, Yu Y, Blenman KR, Caldwell RA, Wakeland EK. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. Mammalian Genome. 1996;7:335-339.
24. Bihoreau MT, Gauguier D, Kato N, Hyne G, Lindpaintner K, Rapp JP, James MR, Lathrop GM. A linkage map of the rat genome derived from three F2 crosses. Genome Res. 1997;7:434-440.
25. Brown DM, Matise TC, Koike G, Simon JS, Winer ES, Zangen S, McLaughlin MG, Shiozawa M, Atkinson OS, Hudson JRJ, Chakravarti A, Lander ES, Jacob HJ. An integrated genetic linkage map of the laboratory rat. Mammalian Genome. 1998;9:521-530.
26. Brosnan MJ, Clark JS, Jeffs B, Negrin CD, Van Vooren P, Arribas SM, Carswell H, Aitman TJ, Szpirer C, Macrae IM, Dominiczak AF. Genes encoding atrial and brain natriuretic peptides as candidates for sensitivity to brain ischemia in stroke-prone hypertensive rats. Hypertension. 1999; 33:290-297.
27. Watanabe TK, Bihoreau MT, McCarthy LC, Kiguwan SL, Hishigaki H, Tsuji A, Browne J, Yamasaki Y, Mizoguchi-Miyakita A, Oga K, Ono T, Okuno S, Kanemoto N, Takahashi E, Tomita K, Hayashi H, Adachi M, Webber C, Davis M, Kiel S, Knights C, Smith A, Critcher R, Miller J, James MR. A radiation hybrid map of the rat genome containing 5,255 markers. War Genet. 1999;22:27-36.
28. Al-Majali KM, Glazier AM, Norsworthy PJ, Wahid FN, Cooper LD, Wallace CA, Scott J, Lausen B, Aitman TJ. A high-resolution radiation hybrid map of the proximal region of rat chromosome 4. Mammalian Genome. 1999;10:471-476.
29. Laird PW, Zijderveld A, Linders K, Rudnicki MA, Jaenisch R, Berns A. Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 1991;19:4293.
30. Davidson AO, Schork NJ, Jaques BC, Kelman AW, Sutcliffe RG, Reid JL, Dominiczak A. Blood pressure in genetically hypertensive rats: influence of the Y chromosome. Hypertension. 1995;26:452-459.
31. Rapp JP. Genetic analysis of inherited hypertension in the rat. Physiol Rev 1999. In press.