High-throughput toxicology: Practical considerations

Current Opinion in Drug Discovery and Development

Volumn 3, Issue 1, 2000, Pages 42-47

  Robertson, Donald G ^a   Bulera, Steven J ^a  

^a PFIZER INC   (United States)

Author keywords

Genomics; High throughput toxicology; Metabonomics; NMR

Indexed keywords

ANALYTIC METHOD; ARTICLE; DRUG INDUSTRY; DRUG SAFETY; DRUG SCREENING; MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; TOXICITY TESTING;

EID: 0033951856     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. 1: Bayliss MK, Frick LW: High-throughput pharmacokinetics: Cassette dosing. CurrOpin Drug Discovery Dev (1999) 2:20-25.
2. Kennedy T: Managing the drug discovery/development interface. Drug Disc Today (1997) 2:436-444.
3. Sinko PJ: Drug selection in early drug development: Screening for acceptable pharmacokinetic properties using combined in vitro and computational approaches. Curr Opin Drug Discovery Dev (1999) 2:42-48.
4. Alden CL, Sagartz JE, Smith PF, Wilson AG, Bunch RT, Morris DL: The pathologist and toxicologist in pharmaceutical product discovery. Toxicol Pathol (1999) .27:104-106.
5. Schena M, Heller RA, Theriault TP, Konrad K, Lachenmeier E, Davis RW: Microarrays: biotechnology's discovery platform for functional genomics. Trends Biotechnol (1997) 16:301-306.
6. Debouck C, Goodfellow PN: DNA microarrays in drug discovery and development. Nature Genet (1999) 21:48-50.
7. Khan J, Bittner ML, Chen Y, Meltzer PS, Trent JM: DNA microarray technology: the anticipated impact on the study of human disease. Biochim Biophys Acta (1999) 1423:M17-M28.
8. An interesting article addressing the technical aspects of microarray technology.
9. Todd MD, Ulrich RG: Emerging technologies for accelerated toxicity evaluation of potential drug candidates. Curr Opin Drug Discovery Dev (1999) 2:58-68.
10. An outstanding review that discusses new technologies and provides a comprehensive reference list of articles pertaining to these technologies.
11. Farr S, Dunn II RT: Concise review: gene expression applied to toxicology. Toxicol Sci(1999) 50:1-9.
12. An important article describing the theories and concepts of toxicogenomics.
13. Nuwaysir EF, Bittner M, Trent J, Barrett JC, Afshari CA: Microarrays and toxicology: The advent of toxicogenomics. Mol Carcinog (1999) 24:153-159.
14. An interesting article addressing the uses and concepts of toxicogenomics.
15. Rodi CP, Bunch RT, Curtiss SW, Kier LD, Cabonce MA, Davila JC, Mitchell MD, Alden CL, Morris DL: Revolution through genomics in investigative and discovery toxicology. Toxicol Pathol (1999) 27:107-110.
16. Ulrich RG, Bacon JA, Cramer CT, Peng GW, Petrella DK, Stryd RP, Sun EL: Cultured hepatocytes as investigational models for hepatic toxicity: Practical applications in drug discovery and development Toxicol Lett (1995) 82-83:107-115.
17. Guillouzo A: Use of isolated and cultures hepatocytes for xenobiotic and cytotoxicity studies. In: Isolated and Cultured Hepatocytes. Guillouzo A, Guguen-Guillouzo C (Eds), EuroText Ltd/INSERM, France (1986):313-332.
18. Levy E, Path FC, Ruebner BH: Hepatic changes produced by a single dose of endotoxin in the mouse. Light microscopy and histochemistry. Am J Pathol (1968) 51:269-285.
19. Chieli E, Malvaldi G: Role of microsomal FAD-containing monooxygenase in the liver toxicity of thioacetamide Soxide. Toxicology(1984) 31:41-52.
20. Ledda-Columbano GM, Coni P, Curto M, Giacomini L, Faa G, Oliverio S, Piacentini M, Columbano A: Induction of two different modes of cell death, apoptosis and necrosis, in rat liver after a single dose of thioacetamide. Am J Pathol (1991)139:1099-1109.
21. Ermolaeva O, Rastogi M, Pruitt KD, Schuler GD, Bittner ML, Chen Y, Simon R, Meltzer P, Trent JM, Boguski MS: Data management and analysis for gene expression arrays. Nature Genet (1998) 20:19-23.
22. Törönen P, Kolehmainen M, Wong G, Castrén E: Analysis of gene expression data using self-organizing maps. FEBS Lett(1999) 451:142-146.
23. Nicholson JK, Wilson ID: High resolution proton NMR spectroscopy of biofluids. Prog NMR Spectrosc (1989) 21:444-501.
24. Holmes E, Bonner FW, Sweatman BC, Lindon JC, Beddell CR, Rah r E, Nicholson JK: Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury(II) chloride and 2-bromoethanamine. Mol Pharmacol (1992) 42:922-930.
25. Lindon JC, Nicholson JK, Everett JR: NMR spectroscopy of biofluids. Ann Rep NMR Spec (1999) 38:1-88.
26. A recent comprehensive review of NMR of biofluids including pattern recognition approaches.
27. Holmes E, Foxall PJ, Spraul M, Farrant RD, Nicholson JK, Lindon JC: 750 MHz 'H NMR spectroscopy characterization of the complex metabolic pattern of urine from patients with inborn errors of metabolism: 2-hydroxyglutaric aciduria and maple syrup urine disease. J Pharm Biomed Anal (1997) 15:1647-1659.
28. Lindon JC, Nicholson JK, Sidelmann UG, Wilson ID: Directly coupled HPLC-NMR and its application to drug metabolism. Drug Metab Rev (1997) 29:705-746.
29. A practical review of the use of NMR coupled with HPLC in drug metabolism studies.
30. Beckwith-Hall BM, Nicholson JK, Nicholls AW, Foxall PJD, Lindon JC, Connor SC, Abdi M, Connelly J, Holmes E: Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins. Chem Res 7bx;co/(1998) 11:260-272.
31. A significant paper demonstrating the power of NMR in toxicology, providing rich detail on how the technique can be applied.
32. Holmes E, Nicholls AW, Lindon JC, Ramos S, Spraul M, Neidig P, Connor SC, Connelly J, Damment SJ, Haselden J, Nicholson JK: Development of a model for classification of toxin-induced lesions using 'H NMR spectroscopy of urine combined with pattern recognition. NMR Biomed(1998) 11:235-244.
33. This work illustrates how NMR can be used in a toxicology setting to generate a model for in vivo assessment of toxicity that would be readily adaptable to a high-throughput paradigm.
34. Car BD, Robertson RT: Commentary: Discovery toxicology a nascent science. Toxicol Pathol (1999) 27:481-483.
35. Moka D, Vorreuther R, Schicha H, Spraul M, Humpfer E, Lipinski M, Foxall PJD, Nicholson JK, Lindon JC: Biochemical classification of kidney carcinoma biopsy samples using magic-angle-spinning 'H nuclear magnetic resonance spectroscopy. J Pharm Biomed Anal (1998) 17:125-132. An interesting paper demonstrating how the NMR technique of magic angle spinning can be used as an aid to pathology.
36. 1H NMR spectroscopic studies on intact rat renal cortex and medulla. Magon Reson Med(1999) 41:1108-1118.
37. Cronin MT: Computer-aided prediction of drug toxicity in high throughput screening. Pharm Pharmacol Comm (1998) 4:157-163.