Role of the microsomal fad-containing monooxygenase in the liver toxicity of thioacetamide S-oxide

Toxicology

Volumn 31, Issue 1, 1984, Pages 41-52

  Chieli, Elisabetta ^a   Malvaldi, Gino ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; OXYGENASE; PROADIFEN; THIAMAZOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; INTOXICATION; LIVER; LIVER MICROSOME; LIVER TOXICITY; NONHUMAN; PROTOPORPHYRIN IX COBALT; RAT; THIOACETAMIDE S OXIDE;

ACETAMIDES; ANIMAL; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME SYSTEM; LIVER; MALE; MICROSOMES, LIVER; NECROSIS; OXYGENASES; PROADIFEN; RATS; RATS, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T; THIOACETAMIDE;

EID: 0021238748     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(84)90154-9     Document Type: Article

References (24)

1. Thioacetamid in der experimentellen Leberforschung
2. The metabolism of tritiated thioacetamide in the rat
3. Thioacetamide-sulfoxid, ein Stoffwechselprodukt des Thioacetamide
4. Acetamide-induced liver cell alterations in rats
5. Thioacetamide-induced hepatic necrosis I. Involvement of the mixed function oxidase system
6. Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes
7. Microsomal activation of thioacetamide S-oxide to a metabolite(s) that covalently binds to calf thymus DNA and other polynucleotides
8. Microsomal flavin-containing monooxygenase: oxygenation of nucleophilic nitrogen and sulfur compounds
9. Organic sulfur substrates for the microsomal flavin-containing monooxygenase
10. Studies on the mechanism of metabolism of thioacetamide S-oxide by rat liver microsomes
11. Hepatic microsomal mixed-function amine oxidase
12. S-oxidation of thioureylenes cata;yzed by a microsomal flavoprotein mixed-function oxidase
13. The relative participation of liver microsomal amine oxidase and cytochrome P-450 in N-demethylation reactions
14. The cytochrome P-450 depleted animal, an experimental model for in vivo studies in chemical biology
15. Microsomal oxidation of thiobenzamide. A photometric assay for the flavin-containing monooxygenase
16. Dimethylaniline N-oxidase and aminopyrine N-demethylase activities of human liver tissue
17. An improved assay of 7-ethoxycoumarin-O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin
18. ON THE MECHANISM OF DRUG HYDROXYLATION IN RAT LIVER MICROSOMES
19. Substrate inducible microsomal arylhydrocarbonhydroxylase in mammalian cell culture. I: assay and properties of induced enzyme
20. Quantitative determination of cytochrome P-450 in rat liver homogenate
21. Protein measurement with folin phenol reagent
22. Methimazole-induced modulation of thiobenzamide bioactivation and toxicity
23. Inhibition of hepatic mixed function oxidase activity in vitro and in vivo by various thiono-sulfur containing compounds
24. Effect of different chemicals on thioacetamide-induced liver necrosis